Sexually transmitted infection

Infection transmitted through human sexual behavior

"STD" redirects here. For other uses, see STD (disambiguation).

"Sexually transmitted infections" redirects here. For the journal, see Sexually Transmitted Infections (journal).

"Sexual disease" redirects here; not to be confused with sexual dysfunction.

Medical condition

Sexually transmitted infection

Other names| Sexually transmitted disease (STD);
Venereal disease (VD)
Condom Museum, Bangkok
Specialty| Infectious disease
Symptoms| None, vaginal discharge, penile discharge, ulcers on or around the genitals, pelvic pain[1]
Complications| Infertility[1]
Causes| Infections commonly spread by sex[1]
Prevention| Sexual abstinence, vaccinations, condoms[2]
Frequency| 1.1 billion (STIs other than HIV/AIDS, 2015)[3]
Deaths| 108,000 (STIs other than HIV/AIDS, 2015)[4]

A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, oral sex, or sometimes manual sex.[1][5][6] STIs often do not initially cause symptoms,[1] which results in a risk of transmitting them on to others.[7][8] The term sexually transmitted infection is generally preferred over sexually transmitted disease or venereal disease, as it includes cases with no symptomatic disease.[9] Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain.[1] Some STIs can cause infertility.[1]

Bacterial STIs include chlamydia, gonorrhea, and syphilis.[1] Viral STIs include genital warts, genital herpes, and HIV/AIDS.[1] Parasitic STIs include trichomoniasis.[1] Most STIs are treatable and curable; of the most common infections, syphilis, gonorrhea, chlamydia, and trichomoniasis are curable, while HIV/AIDS and genital herpes are not curable.[1] Some vaccinations may decrease the risk of certain infections including hepatitis B and few types of HPV.[2] Safe sex practices such as use of condoms, having smaller number of sexual partners, and being in a relationship in which each person only has sex with the other also decreases STIs risk.[1][2] Comprehensive sex education may also be useful.[10]

STI diagnostic tests are usually easily available in the developed world, but they are often unavailable in the developing world.[1] There is often shame and stigma associated with STIs.[1] In 2015, STIs other than HIV resulted in 108,000 deaths worldwide.[4] Globally, in 2015, about 1.1 billion people had STIs other than HIV/AIDS.[3] About 500 million have either syphilis, gonorrhea, chlamydia or trichomoniasis.[1] At least an additional 530 million have genital herpes, and 290 million women have human papillomavirus.[1] Historical documentation of STIs in antiquity dates back to at least the Ebers Papyrus (c. 1550 BCE) and the Hebrew Bible/Old Testament (8th/7th C. BCE).[11]

## Signs and symptoms

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This section needs expansion. You can help by making an edit requestadding to it . (July 2018)

|

Not all STIs are symptomatic, and symptoms may not appear immediately after infection. In some instances a disease can be carried with no symptoms, which leaves a greater risk of passing the disease on to others. Depending on the disease, some untreated STIs can lead to infertility, chronic pain or death.[12]

The presence of an STI in prepubescent children may indicate sexual abuse.[13]

## Cause

[edit]

### Transmission

[edit]

A sexually transmitted infection present in a pregnant woman may be passed on to the infant before or after birth.[14]

Risk of transmission per unprotected sexual act with an infected person[15][16][17][18][19][20][21][22][23][24][25][26][27]

| Known risks  | Possible
Performing oral sex on a man |

* Throat chlamydia[15]
* Throat gonorrhea[15] (25–30%)
* Herpes (rare)
* HPV[16]
* Syphilis[15] (1%)[17]

* Hepatitis B (low risk)[18]
* HIV (0.01%)[19]
* Hepatitis C (unknown)

Performing oral sex on a woman |

* Herpes
* HPV[16]

* Throat gonorrhea[15]
* Throat chlamydia[15]

Receiving oral sex—man |

* Chlamydia
* Gonorrhea[15]
* Herpes
* Syphilis[15] (1%)[17]

* HPV

Receiving oral sex—woman |

* Herpes

* HPV
* Bacterial vaginosis[15]
* Gonorrhea[15]

Vaginal sex—man |

* Chlamydia (30–50%)[18]
* Crabs
* Scabies
* Gonorrhea (22%)[20]
* Hepatitis B
* Herpes (0.07% for HSV-2)[21]
* HIV (0.05%)[19][21]
* HPV (high: around 40–50%)[22]
* Mycoplasma hominis infection[28][29][30][31][32]
* Mycoplasma genitalium[33][34][35]
* Syphilis
* Trichomoniasis
* Ureaplasma infection[36][37][32]

* Hepatitis C

Vaginal sex—woman |

* Chlamydia (30–50%)[18]
* Crabs
* Scabies
* Gonorrhea (47%)[23]
* Hepatitis B (50–70%)
* Herpes
* HIV (0.1%)[19]
* HPV (high;[18] around 40–50%)[22]
* Mycoplasma hominis infection[28][29][32]
* Syphilis
* Trichomoniasis
* Ureaplasma infection[36][37][32]

* Hepatitis C

Anal sex—insertive  |

* Chlamydia
* Crabs
* Scabies (40%)
* Gonorrhea
* Hepatitis B
* Herpes
* HIV (0.62%)[25]
* HPV
* Syphilis (14%)[17]

* Hepatitis C

Anal sex—receptive  |

* Chlamydia
* Crabs
* Scabies
* Gonorrhea
* Hepatitis B
* Herpes
* HIV (1.7%)[25]
* HPV
* Syphilis (1.4%)[17]

* Hepatitis C

Anilingus |

* Amoebiasis
* Cryptosporidiosis (1%)
* Giardiasis[38]
* Hepatitis A[39](1%)
* Shigellosis[40] (1%)

* HPV (1%)

### Bacterial

[edit]

* Chancroid (Haemophilus ducreyi)[41]
* Chlamydia (Chlamydia trachomatis)[42]
* Gonorrhea (Neisseria gonorrhoeae)[43]
* Granuloma inguinale or (Klebsiella granulomatis)[44]
* Mycoplasma genitalium[29][45][46][47]
* Mycoplasma hominis[28][29][30][31][48]
* Syphilis (Treponema pallidum)[49]
* Ureaplasma infection[36][37]

### Viral

[edit]

Micrograph showing the viral cytopathic effect of herpes (ground glass nuclear inclusions, multi-nucleation). Pap test. Pap stain.

* Viral hepatitis (hepatitis B virus)—saliva, venereal fluids.
(Note: hepatitis A and hepatitis E are transmitted via the fecal–oral route; hepatitis C is rarely sexually transmittable,[50] and the route of transmission of hepatitis D (only if infected with B) is uncertain, but may include sexual transmission.[51][52][53])
* Herpes simplex (Herpes simplex virus 1, 2) skin and mucosal, transmissible with or without visible blisters
* HIV (Human Immunodeficiency Virus)—venereal fluids, semen, breast milk, blood
* HPV (Human Papillomavirus)—skin and mucosal contact. 'High risk' types of HPV cause almost all cervical cancers, as well as some anal, penile, and vulvar cancer.[54] Some other types of HPV cause genital warts.
* Molluscum contagiosum (molluscum contagiosum virus MCV)—close contact[55]
* Zika virus[56]

### Parasites

[edit]

* Crab louse, colloquially known as "crabs" or "pubic lice" (Pthirus pubis).[57][58][59] The infestation and accompanying inflammation is Pediculosis pubis
* Scabies (Sarcoptes scabiei)
* Trichomoniasis (Trichomonas vaginalis), colloquially known as "trich"

### Main types

[edit]

Sexually transmitted infections include:

* Chlamydia is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. In women, symptoms may include abnormal vaginal discharge, burning during urination, and bleeding in between periods, although most women do not experience any symptoms.[60] Symptoms in men include pain when urinating, and abnormal discharge from their penis.[61] If left untreated in both men and women, chlamydia can infect the urinary tract and potentially lead to pelvic inflammatory disease (PID). PID can cause serious problems during pregnancy and even has the potential to cause infertility. It can cause a woman to have a potentially deadly ectopic pregnancy, in which the egg implants outside of the uterus. However, chlamydia can be cured with antibiotics.
* The two most common forms of herpes are caused by infection with herpes simplex virus (HSV). HSV-1 is typically acquired orally and causes cold sores; HSV-2 is usually acquired during sexual contact and affects the genitals; however, either strain may affect either site.[62] Some people are asymptomatic or have very mild symptoms. Those that do experience symptoms usually notice them 2 to 20 days after exposure which lasts 2 to 4 weeks. Symptoms can include small fluid-filled blisters, headaches, backaches, itching or tingling sensations in the genital or anal area, pain during urination, flu like symptoms, swollen glands, or fever. Herpes is spread through skin contact with a person infected with the virus. The virus affects the areas where it entered the body. This can occur through kissing, vaginal intercourse, oral sex or anal sex. The virus is most infectious during times when there are visible symptoms; however, those who are asymptomatic can still spread the virus through skin contact.[63] The initial infection and symptoms are usually the most severe because the body does not have any antibodies built up. After the primary attack, one might have recurring attacks that are milder or might not even have future attacks. There is no cure for the disease but there are antiviral medications that treat its symptoms and lower the risk of transmission (Valtrex). Although HSV-1 is typically the "oral" version of the virus, and HSV-2 is typically the "genital" version of the virus, a person with HSV-1 orally can transmit that virus to their partner genitally. The virus, either type, will settle into a nerve bundle either at the top of the spine, producing the "oral" outbreak, or a second nerve bundle at the base of the spine, producing the genital outbreak.
* The human papillomavirus (HPV) is the most common STI in the United States.[64] There are more than 40 different strands of HPV and many do not cause any health problems. In 90% of cases, the body's immune system clears the infection naturally within two years.[65] Some cases may not be cleared and can lead to genital warts (bumps around the genitals that can be small or large, raised or flat, or shaped like cauliflower) or cervical cancer and other HPV related cancers. Symptoms might not show up until advanced stages. It is important for women to get pap smears in order to check for and treat cancers. There are also two vaccines available for women (Cervarix and Gardasil) that protect against the types of HPV that cause cervical cancer. HPV can be passed through genital-to-genital contact as well as during oral sex. The infected partner might not have any symptoms.
* Gonorrhea is caused by bacterium that lives on moist mucous membranes in the urethra, vagina, rectum, mouth, throat, and eyes. The infection can spread through contact with the penis, vagina, mouth, or anus. Symptoms of gonorrhea usually appear two to five days after contact with an infected partner; however, some men might not notice symptoms for up to a month. Symptoms in men include burning and pain while urinating, increased urinary frequency, discharge from the penis (white, green, or yellow in color), red or swollen urethra, swollen or tender testicles, or sore throat. Symptoms in women may include vaginal discharge, burning or itching while urinating, painful sexual intercourse, severe pain in lower abdomen (if infection spreads to fallopian tubes), or fever (if infection spreads to fallopian tubes); however, many women do not show any symptoms.[66] Antibiotic resistant strains of Gonorrhea are a significant concern, but most cases can be cured with existing antibiotics.

Secondary syphilis

* Syphilis is an STI caused by a bacterium. Untreated, it can lead to complications and death.[67] Clinical manifestations of syphilis include the ulceration of the uro-genital tract, mouth or rectum; if left untreated the symptoms worsen. In recent years, the prevalence of syphilis has declined in Western Europe, but it has increased in Eastern Europe (former Soviet states). A high incidence of syphilis can be found in places such as Cameroon, Cambodia, Papua New Guinea.[68] Syphilis infections are increasing in the United States.[69]
* Trichomoniasis is a common STI that is caused by infection with a protozoan parasite called Trichomonas vaginalis.[70] Trichomoniasis affects both women and men, but symptoms are more common in women.[71] Most patients are treated with an antibiotic called metronidazole, which is very effective.[72]
* HIV (human immunodeficiency virus) damages the body's immune system, which interferes with its ability to fight off disease-causing agents. The virus kills CD4 cells, which are white blood cells that help fight off various infections. HIV is carried in body fluids and is spread by sexual activity. It can also be spread by contact with infected blood, breastfeeding, childbirth, and from mother to child during pregnancy.[73] When HIV is at its most advanced stage, an individual is said to have AIDS (acquired immunodeficiency syndrome).[74] There are different stages of the progression of and HIV infection. The stages include primary infection, asymptomatic infection, symptomatic infection, and AIDS. In the primary infection stage, an individual will have flu-like symptoms (headache, fatigue, fever, muscle aches) for about two weeks. In the asymptomatic stage, symptoms usually disappear, and the patient can remain asymptomatic for years. When HIV progresses to the symptomatic stage, the immune system is weakened and has a low cell count of CD4+ T cells. When the HIV infection becomes life-threatening, it is called AIDS. People with AIDS fall prey to opportunistic infections and die as a result.[60] When the disease was first discovered in the 1980s, those who had AIDS were not likely to live longer than a few years. There are now antiretroviral drugs (ARVs) available to treat HIV infections. There is no known cure for HIV or AIDS but the drugs help suppress the virus. By suppressing the amount of virus in the body, people can lead longer and healthier lives. Even though their virus levels may be low they can still spread the virus to others.[75]

### Viruses in semen

[edit]

Twenty-seven different viruses have been identified in semen. Information on whether or not transmission occurs or whether the viruses cause disease is uncertain. Some of these microbes are known to be sexually transmitted.[76]

## Pathophysiology

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Many STIs are (more easily) transmitted through the mucous membranes of the penis, vulva, rectum, urinary tract and (less often—depending on type of infection) the mouth, throat, respiratory tract and eyes.[77] The visible membrane covering the head of the penis is a mucous membrane, though it produces no mucus (similar to the lips of the mouth). Mucous membranes differ from skin in that they allow certain pathogens into the body. The amount of contact with infective sources which causes infection varies with each pathogen but in all cases, a disease may result from even light contact from fluid carriers like venereal fluids onto a mucous membrane.[citation needed]

Some STIs such as HIV can be transmitted from mother to child either during pregnancy or breastfeeding.[78][79] Healthcare professionals suggest safer sex, such as the use of condoms, as a reliable way of decreasing the risk of contracting sexually transmitted infections during sexual activity, but safer sex cannot be considered to provide complete protection from an STI. The transfer of and exposure to bodily fluids, such as blood transfusions and other blood products, sharing injection needles, needle-stick injuries (when medical staff are inadvertently jabbed or pricked with needles during medical procedures), sharing tattoo needles, and childbirth are other avenues of transmission. These different means put certain groups, such as medical workers, and haemophiliacs and drug users, particularly at risk.[citation needed]

It is possible to be an asymptomatic carrier of sexually transmitted infections. In particular, sexually transmitted infections in women often cause the serious condition of pelvic inflammatory disease.[80]

## Diagnosis

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World War II US Army poster warning of venereal disease

Testing may be for a single infection, or consist of a number of tests for a range of STIs, including tests for syphilis, trichomonas, gonorrhea, chlamydia, herpes, hepatitis, and HIV. No procedure tests for all infectious agents.

STI tests may be used for a number of reasons:

* as a diagnostic test to determine the cause of symptoms or illness
* as a screening test to detect asymptomatic or presymptomatic infections
* as a check that prospective sexual partners are free of disease before they engage in sex without safer sex precautions (for example, when starting a long term mutually monogamous sexual relationship, in fluid bonding, or for procreation).
* as a check prior to or during pregnancy, to prevent harm to the baby
* as a check after birth, to check that the baby has not caught an STI from the mother
* to prevent the use of infected donated blood or organs
* as part of the process of contact tracing from a known infected individual
* as part of mass epidemiological surveillance

Early identification and treatment results in less chance to spread disease, and for some conditions may improve the outcomes of treatment. There is often a window period after initial infection during which an STI test will be negative. During this period, the infection may be transmissible. The duration of this period varies depending on the infection and the test. Diagnosis may also be delayed by reluctance of the infected person to seek a medical professional. One report indicated that people turn to the Internet rather than to a medical professional for information on STIs to a higher degree than for other sexual problems.[81]

### Classification

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A poster from the Office for Emergency Management, Office of War Information, 1941–1945

Until the 1990s,[citation needed] STIs were commonly known as venereal diseases, an antiquated euphemism derived from the Latin venereus, being the adjectival form of Venus, the Roman goddess of love.[82] However, in the post-classical education era the euphemistic effect was entirely lost, and the common abbreviation "VD" held only negative connotations. Other former euphemisms for STIs include "blood diseases" and "social diseases".[83] The present euphemism is in the use of the initials "STI" rather than in the words they represent. The World Health Organization (WHO) has recommended the more inclusive term sexually transmitted infection since 1999.[9] Public health officials originally introduced the term sexually transmitted infection, which clinicians are increasingly using alongside the term sexually transmitted disease in order to distinguish it from the former.[citation needed]

## Prevention

[edit]

Main article: Safe sex

Strategies for reducing STI risk include: vaccination, mutual monogamy, reducing the number of sexual partners, and abstinence.[84] Also potentially helpful is behavioral counseling for sexually active adolescents and for adults who are at increased risk.[85] Such interactive counseling, which can be resource-intensive, is directed at a person's risk, the situations in which risk occurs, and the use of personalized goal-setting strategies.[86]

The most effective way to prevent sexual transmission of STIs is to avoid contact of body parts or fluids which can lead to transfer with an infected partner. Not all sexual activities involve contact: cybersex, phone sex or masturbation from a distance are methods of avoiding contact. Proper use of condoms reduces contact and risk. Although a condom is effective in limiting exposure, some disease transmission may occur even with a condom.[87]

"Syphilis is a dangerous disease, but it can be cured". Poster encouraging treatment. Published between 1936 and 1938.

Both partners can get tested for STIs before initiating sexual contact, or before resuming contact if a partner engaged in contact with someone else. Many infections are not detectable immediately after exposure, so enough time must be allowed between possible exposures and testing for the tests to be accurate. Certain STIs, particularly certain persistent viruses like HPV, may be impossible to detect.[medical citation needed]

Some treatment facilities use in-home test kits and have the person return the test for follow-up. Other facilities strongly encourage that those previously infected return to ensure that the infection has been eliminated. Novel strategies to foster re-testing have been the use of text messaging and email as reminders. These types of reminders are now used in addition to phone calls and letters.[88] After obtaining a sexual history, a healthcare provider can encourage risk reduction by providing prevention counseling. Prevention counseling is most effective if provided in a nonjudgmental and empathetic manner appropriate to the person's culture, language, gender, sexual orientation, age, and developmental level. Prevention counseling for STIs is usually offered to all sexually active adolescents and to all adults who have received a diagnosis, have had an STI in the past year, or have multiple sex partners.[86]

### Vaccines

[edit]

Vaccines are available that protect against some viral STIs, such as hepatitis A, hepatitis B, and some types of HPV.[89] Vaccination before initiation of sexual contact is advised to assure maximal protection. The development of vaccines to protect against gonorrhea is ongoing.[90]

### Condoms

[edit]

Condoms and female condoms only provide protection when used properly as a barrier, and only to and from the area that they cover. Uncovered areas are still susceptible to many STIs.[citation needed]

In the case of HIV, sexual transmission routes almost always involve the penis, as HIV cannot spread through unbroken skin; therefore, properly shielding the penis with a properly worn condom from the vagina or anus effectively stops HIV transmission. An infected fluid to broken skin borne direct transmission of HIV would not be considered "sexually transmitted", but can still theoretically occur during sexual contact. This can be avoided simply by not engaging in sexual contact when presenting open, bleeding wounds.[citation needed]

Other STIs, even viral infections, can be prevented with the use of latex, polyurethane or polyisoprene condoms as a barrier. Some microorganisms and viruses are small enough to pass through the pores in natural skin condoms but are still too large to pass through latex or synthetic condoms.[citation needed]

Proper male condom usage entails:[citation needed]

* Not putting the condom on too tight at the tip by leaving 1.5 centimetres (0.6 in) room for ejaculation. Putting the condom on too tightly can and often does lead to failure.
* Wearing a condom too loose can defeat the barrier
* Avoiding inverting or spilling a condom once worn, whether it has ejaculate in it or not
* If a user attempts to unroll the condom, but realizes they have it on the wrong side, then this condom may not be effective
* Being careful with the condom if handling it with long nails
* Avoiding the use of oil-based lubricants (or anything with oil in it) with latex condoms, as oil can eat holes into them
* Using flavored condoms for oral sex only, as the sugar in the flavoring can lead to yeast infections if used to penetrate

In order to best protect oneself and the partner from STIs, the old condom and its contents are to be treated as infectious and properly disposed of. A new condom is used for each act of intercourse, as multiple usages increase the chance of breakage, defeating the effectiveness as a barrier.[citation needed]

In the case of female condoms, the device consists of two rings, one in each terminal portion. The larger ring should fit snugly over the cervix and the smaller ring remains outside the vagina, covering the vulva. This system provides some protection of the external genitalia.[91]

### Other

[edit]

The cap was developed after the cervical diaphragm. Both cover the cervix and the main difference between the diaphragm and the cap is that the latter must be used only once, using a new one in each sexual act. The diaphragm, however, can be used more than once. These two devices partially protect against STIs (they do not protect against HIV).[92]

Researchers had hoped that nonoxynol-9, a vaginal microbicide would help decrease STI risk. Trials, however, have found it ineffective[93] and it may put women at a higher risk of HIV infection.[94] There is evidence that vaginal dapivirine probably reduces HIV in women who have sex with men, other types of vaginal microbicides have not demonstrated effectiveness for HIV or STIs.[95]

There is little evidence that school-based interventions such as sexual and reproductive health education programmes on contraceptive choices and condoms are effective on improving the sexual and reproductive health of adolescents. Incentive-based programmes may reduce adolescent pregnancy but more data is needed to confirm this.[96]

## Screening

[edit]

Specific age groups, persons who participate in risky sexual behavior, or those have certain health conditions may require screening. The CDC recommends that sexually active women under the age of 25 and those over 25 at risk should be screened for chlamydia and gonorrhea yearly. Appropriate times for screening are during regular pelvic examinations and preconception evaluations.[97] Nucleic acid amplification tests are the recommended method of diagnosis for gonorrhea and chlamydia.[98] This can be done on either urine in both men and women, vaginal or cervical swabs in women, or urethral swabs in men.[98] Screening can be performed:

* to assess the presence of infection and prevent tubal infertility in women
* during the initial evaluation before infertility treatment
* to identify HIV infection
* for men who have sex with men
* for those who may have been exposed to hepatitis C
* for HCV[98]

## Management

[edit]

In the case of rape, the person can be treated prophylacticly with antibiotics.[99]

An option for treating partners of patients (index cases) diagnosed with chlamydia or gonorrhea is patient-delivered partner therapy, which is the clinical practice of treating the sex partners of index cases by providing prescriptions or medications to the patient to take to their partner without the health care provider first examining the partner.[100][needs update] In term of preventing reinfection in sexually transmitted infection, treatment with both patient and the sexual partner of patient resulted in more successful than treatment of the patient without the sexual partner. There is no difference in reinfection prevention whether the sexual partner treated with medication without medical examination or after notification by patient.[101]

## Epidemiology

[edit]

See also: List of sexually transmitted infections by prevalence

Age-standardized, disability-adjusted life years WHO estimates for STIs (excluding HIV) per 100,000 inhabitants in 2004:[102]

No data

< 60

60–120

120–180

180–240

240–300

300–360

360–420

420–480

480–540

540–600

600–1000

> 1000

|

STI (excluding HIV) deaths per million persons in 2012:[citation needed]

0–0

1–1

2–3

4–9

10–18

19–31

32–55

56–139

In 2008, it was estimated that 500 million people were infected with either syphilis, gonorrhea, chlamydia or trichomoniasis.[1] At least an additional 530 million people have genital herpes and 290 million women have human papillomavirus (HPV).[1] STIs other than HIV resulted in 142,000 deaths in 2013.[103] In the United States there were 19 million new cases of sexually transmitted infections in 2010.[104]

In 2010, 19 million new cases of sexually transmitted infections occurred in women in the United States.[5] A 2008 CDC study found that 25–40% of U.S. teenage girls has a sexually transmitted infection.[105][106] Out of a population of almost 295,270,000 people[107] there were 110 million new and existing cases of eight sexually transmitted infections.[108]

Over 400,000 sexually transmitted infections were reported in England in 2017, about the same as in 2016, but there were more than 20% increases in confirmed cases of gonorrhoea and syphilis. Since 2008 syphilis cases have risen by 148%, from 2,874 to 7,137, mostly among men who have sex with men. The number of first cases of genital warts in 2017 among girls aged 15–17 years was just 441, 90% less than in 2009 – attributed to the national HPV immunisation programme.[109]

AIDS is among the leading causes of death in present-day Sub-Saharan Africa.[110] HIV/AIDS is transmitted primarily via unprotected sexual intercourse. More than 1.1 million persons are living with HIV/AIDS in the United States,[111] and it disproportionately impacts African Americans.[112] Hepatitis B is also considered a sexually transmitted infection because it can be spread through sexual contact.[113] The highest rates are found in Asia and Africa and lower rates are in the Americas and Europe.[114] Approximately two billion people worldwide have been infected with the hepatitis B virus.[115]

## History

[edit]

The first well-recorded European outbreak of what is now known as syphilis occurred in 1494 when it broke out among French troops besieging Naples in the Italian War of 1494–98.[116] The disease may have originated from the Columbian Exchange.[117][118] From Naples, the disease swept across Europe, killing more than five million people.[119] As Jared Diamond describes it, "[W]hen syphilis was first definitely recorded in Europe in 1495, its pustules often covered the body from the head to the knees, caused flesh to fall from people's faces, and led to death within a few months," rendering it far more fatal than it is today. Diamond concludes, "[B]y 1546, the disease had evolved into the disease with the symptoms so well known to us today."[120][better source needed] Gonorrhea is recorded at least up to 700 years ago and associated with a district in Paris formerly known as "Le Clapiers". This is where the prostitutes were to be found at that time.[90]

Prior to the invention of modern medicines, sexually transmitted infections were generally incurable, and treatment was limited to treating the symptoms of the infection. The first voluntary hospital for STIs was founded in 1746 at London Lock Hospital.[121] Treatment was not always voluntary: in the second half of the 19th century, the Contagious Diseases Acts were used to arrest suspected prostitutes. In 1924, a number of states concluded the Brussels Agreement, whereby states agreed to provide free or low-cost medical treatment at ports for merchant seamen with STIs. A proponent of these approaches was Nora Wattie, OBE, Venereal Diseases Officer in Glasgow from 1929, encouraged contact tracing and volunteering for treatment, rather than the prevailing more judgemental view and published her own research on improving sex education and maternity care.[122]

The first effective treatment for a sexually transmitted infection was salvarsan, a treatment for syphilis. With the discovery of antibiotics, a large number of sexually transmitted infections became easily curable, and this, combined with effective public health campaigns against STIs, led to a public perception during the 1960s and 1970s that they have ceased to be a serious medical threat.[citation needed]

During this period, the importance of contact tracing in treating STIs was recognized. By tracing the sexual partners of infected individuals, testing them for infection, treating the infected and tracing their contacts, in turn, STI clinics could effectively suppress infections in the general population.[citation needed]

In the 1980s, first genital herpes and then AIDS emerged into the public consciousness as sexually transmitted infections that could not be cured by modern medicine. AIDS, in particular, has a long asymptomatic period—during which time HIV (the human immunodeficiency virus, which causes AIDS) can replicate and the disease can be transmitted to others—followed by a symptomatic period, which leads rapidly to death unless treated. HIV/AIDS entered the United States from Haiti in about 1969.[123] Recognition that AIDS threatened a global pandemic led to public information campaigns and the development of treatments that allow AIDS to be managed by suppressing the replication of HIV for as long as possible. Contact tracing continues to be an important measure, even when diseases are incurable, as it helps to contain infection.

* World War II–era British poster urging men to be tested for sexually transmitted infections before marriage

* U.S. propaganda poster targeted at World War II servicemen appealed to their patriotism in urging them to protect themselves. The text at the bottom of the poster reads, "You can't beat the Axis if you get VD".

## See also

[edit]

* Human sexuality portal
* Medicine portal

* List of sexually transmitted infections by prevalence

## References

[edit]

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## Further reading

[edit]

* Aral SO (2008). Behavioral Interventions for Prevention and Control of Sexually Transmitted Diseases. Springer Singapore Pte. Limited. ISBN 978-0-387-85768-8.
* Faro S (2003). Sexually transmitted diseases in women. Lippincott Williams & Wilkins. ISBN 978-0-397-51303-1.
* Ford CA, Bowers ES (2009). Living with Sexually Transmitted Diseases. Facts on File. ISBN 978-0-8160-7672-7. "Sexually transmitted disease."
* Edmund O (1911). "Venereal Diseases" . In Chisholm H (ed.). Encyclopædia Britannica. Vol. 27 (11th ed.). Cambridge University Press. pp. 983–85.983-85&rft.edition=11th&rft.pub=Cambridge+University+Press&rft.date=1911&rft.aulast=Edmund&rft.aufirst=O&rfr_id=info:sid/en.wikipedia.org:Sexually+transmitted+infection" class="Z3988"> This provides an overview of pre-modern medicine's approach to the diseases.
* Sehgal VN (2003). Sexually Transmitted Diseases (4th ed.). Jaypee Bros. Medical Publishers. ISBN 978-81-8061-105-6.
* Shoquist J, Stafford D (2003). The encyclopedia of sexually transmitted diseases. Facts on File. ISBN 978-0-8160-4881-6.
* Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, et al. (July 2021). "Sexually Transmitted Infections Treatment Guidelines, 2021" (PDF). MMWR Recomm Rep. 70 (4): 1–187\. doi:10.15585/mmwr.rr7004a1. PMC 8344968. PMID 34292926.1-187&rft.date=2021-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344968#id-name=PMC&rft_id=info:pmid/34292926&rft_id=info:doi/10.15585/mmwr.rr7004a1&rft.aulast=Workowski&rft.aufirst=KA&rft.au=Bachmann,+LH&rft.au=Chan,+PA&rft.au=Johnston,+CM&rft.au=Muzny,+CA&rft.au=Park,+I&rft.au=Reno,+H&rft.au=Zenilman,+JM&rft.au=Bolan,+GA&rft_id=https://www.cdc.gov/mmwr/volumes/70/rr/pdfs/rr7004a1-H.pdf&rfr_id=info:sid/en.wikipedia.org:Sexually+transmitted+infection" class="Z3988">

## External links

[edit]

Wikipedia's health care articles can be viewed offline with the Medical Wikipedia app.

Sexually transmitted infection at Wikipedia's sister projects

* Definitions from Wiktionary
* Media from Commons
* News from Wikinews
* Quotations from Wikiquote
* Texts from Wikisource
* Textbooks from Wikibooks
* Resources from Wikiversity
* Data from Wikidata

* CDC Sexually Transmitted Diseases Treatment Guidelines, 2010
* STD photo library Archived 21 July 2010 at the Wayback Machine at Dermnet
* UNFPA: Breaking the Cycle of Sexually Transmitted Infections at UNFPA
* STDs In Color: Sexually Transmitted Disease Facts and Photos
* CDC: Sexually transmitted diseases in the U.S.
* STI Watch: World Health Organization

Classification|

* ICD-10: A64
* ICD-9-CM: 099.9
* MeSH: D012749
* DiseasesDB: 27130

|

External resources|

* Patient UK: Sexually transmitted infection

* v
* t
* e

Sexual and reproductive health

Rights|

* Reproductive Justice
* Compulsory sterilization
* Contraceptive security
* Abortion-rights movements
* Genital integrity
* Circumcision controversy
* Intersex human rights

Education|

* Sex education
* Genetic counseling
* Pre-conception counseling

Planning|

* Childfreeness/childlessness
* Birth spacing
* Parenting
* adoption
* foster care
* Sperm theft

Contraception|

* Hormonal contraception
* Male contraception
* Safe sex
* Condom
* Intrauterine device
* Sterilization

Assisted
reproduction|

* In vitro fertilization
* ICSI
* Gamete Cryopreservation
* Egg
* Sperm
* Sperm bank
* fertility fraud

Health|

* Men's
* Women's
* vulvovaginal
* Research
* self-report sexual risk behaviors

Pregnancy|

* Maternal health
* Obstetrics
* Unintended pregnancy
* childbirth
* Abortion
* Options counseling
* Pregnancy from rape
* Pregnant patients' rights
* Prenatal care
* Teenage pregnancy
* Precocious puberty and pregnancy

Identity|

* Gender identity
* Sexual orientation
* Intersex
* Transgender
* Genital modification

Medicine|

* Andrology
* Genitourinary medicine
* Gynaecology
* Obstetrics and gynaecology
* Reproductive endocrinology and infertility
* Sexual medicine
* Transgender health care

Disorders|

* Disorders of sex development
* Infertility
* Reproductive system disease
* Sexual dysfunction
* Sexually transmitted infections
* clinic
* Gender dysphoria

By country|

* China
* India
* Iran
* Ireland
* Pakistan
* Philippines
* Singapore
* United Kingdom
* teen
* United States
* teen pregnancy
* birth control

History|

* Birth control movement in the United States
* History of condoms
* Social hygiene movement
* Timeline of reproductive rights legislation

Policy|

* One-child policy
* Two-child policy
* Three-child policy
* Financial
* baby bonus
* bachelor tax
* child benefit
* tax on childlessness
* Abortion law

* v
* t
* e

Human sexuality and sexology

Sexual relationship
phenomena

* Aromanticism
* Asexuality
* Gray asexuality
* Demisexuality
* Fictosexuality
* Bisexuality
* Pansexuality
* Casual relationship
* Casual sex
* Celibacy
* Love shyness
* Celibacy syndrome
* Herbivore men
* Committed relationship
* Conventional sex
* Flirting
* Free love
* Foreplay
* Friends with benefits relationships
* Group sex
* Heterosexuality
* Homosexuality
* Hypersexuality
* LGBT
* Marriage
* One-night stand
* Polyamory
* Promiscuity
* Female
* Romantic love
* Romantic orientation
* Queer heterosexuality
* Sex life
* Sexual abstinence
* Sexual orientation
* Sexual partner
* Sexual repression
* Single person
* Split attraction model
* Swinging

Sexual dynamics|

* Hypergamy
* Physical attractiveness
* Sexual attraction
* Sexual capital
* Sexual ethics
* Sexual frustration
* Sociosexuality

See also|

* Abortion-rights movement
* Adolescent sexuality
* Age of consent
* Decriminalization of sex work
* Dogging (sexual slang)
* Human female sexuality
* Human male sexuality
* LGBTQ rights by country or territory
* Porn for women
* Public sex
* Reproductive rights
* Right to privacy
* Right to sexuality
* Sex Addicts Anonymous
* Sex and drugs
* Sex worker movements
* Sex workers' rights
* Sexecology
* Sex-positive feminism
* Sex-positive movement
* Sexual addiction
* Sexual and reproductive health and rights
* Sexual jealousy
* Sexual norm
* Sexual revolution
* Sexual surrogate
* Sexuality and disability
* Stanley v. Georgia
* Women's erotica

* v
* t
* e

Outline of human sexuality

Physiology
and biology|

* Clitoral erection
* Erogenous zones
* Insemination
* Intersex
* Libido
* Nocturnal emission
* Orgasm
* Female and male ejaculation
* Pelvic thrust
* Penile erection
* Pre-ejaculate
* Pregnancy
* Sexual arousal
* Sexual response cycle
* Sexual stimulation
* Vaginal lubrication

Health and
education|

* Birth control
* Condom
* Male contraceptive
* Masters and Johnson
* Obesity and sexuality
* Reproductive medicine
* Andrology
* Gynaecology
* Urology
* Safe sex
* Sex education
* Sex therapy (PLISSIT model)
* Sexology
* Sexual dysfunction
* Erectile dysfunction
* Hypersexuality
* Hyposexuality
* Sexual medicine
* Sexual surrogate
* Sexually transmitted infection

Identity and diversity|

* Gender binary
* Gender identity
* Men who have sex with men
* Sexual identity
* Sexual orientation
* Women who have sex with women

Law|

* Age of consent
* Criminal transmission of HIV
* Child sexual abuse
* Incest
* Indecent exposure
* Obscenity
* Sexual abuse
* Cybersex trafficking
* Rape
* Sex trafficking
* Sexual assault
* Sexual harassment
* Sexual misconduct
* Sexual slavery
* Sexual violence
* Revenge pornography

History|

* Blue Movie
* Counterculture of the 1960s
* Feminist sex wars
* Golden Age of Porn
* History of erotic depictions
* Sexual revolution

Relationships
and society|

* Anarchism and love/sex
* Extramarital sex
* Family planning
* Flirting
* Free love
* Marriage
* Modesty
* Orgasm gap
* Polyamory
* Premarital sex
* Promiscuity
* Romance
* Sex-positive movement
* Sexual abstinence
* Sexual addiction
* Sexual attraction
* Sexual capital
* Sexual ethics
* Sexual objectification
* Sexual repression
* Sexual slang
* Split attraction model

By country|

* Ancient Rome
* China
* India
* Japan
* Philippines
* South Korea
* United States

Sexual activities|

* Conventional sex
* Anal sex
* Bareback
* BDSM
* Child sex
* Creampie
* Edging
* Erotic sexual denial
* Facial
* Fetishism
* Fisting
* Foot fetishism
* Footjob
* Forced orgasm
* Frot
* Gang bang
* Group sex
* Mammary intercourse
* Manual sex
* Anal fingering
* Fingering
* Handjob
* Masturbation
* Mechanics of sex
* Nipple stimulation
* Non-penetrative sex
* Oral sex
* 69
* Anilingus
* Cunnilingus
* Fellatio
* Irrumatio
* Paraphilia
* Pompoir
* Quickie
* Sexercise
* Sex in space
* Sex positions
* Sexual fantasy
* Sexual fetishism
* Sexual intercourse
* Foreplay
* Sexual penetration
* Sumata
* Swinging
* Tribadism
* Urethral intercourse
* Urolagnia
* Virtual sex
* Cybersex
* Erotic talk
* Wet T-shirt contest

Sex industry|

* Adult video games
* Erotica
* Pornography
* Film actor
* Prostitution
* Sacred
* Survival sex
* Red-light district
* Sex museum
* Sex shop
* Sex tourism
* Child
* Female
* Sex worker
* Sex toy
* Doll
* Strip club
* Webcam model

Religion and
sexuality|

* Buddhism and Hinduism
* Tantric sex
* Christianity and sexual orientation
* Christian demonology
* Clerical celibacy
* Buddhist monasticism
* Catholic Church
* Hindu monasticism
* Jain monasticism
* Daoism
* Islam
* Judaism
* LGBTQ people
* LGBTQ-affirming religions
* Mormonism
* Sacred prostitution
* Ancient Greece
* Thelema
* Sex magic

* Human sexuality portal

* v
* t
* e

Sexually transmitted infections (STI)

Bacterial|

* Chancroid (Haemophilus ducreyi)
* Chlamydia, lymphogranuloma venereum (Chlamydia trachomatis)
* Donovanosis (Klebsiella granulomatis)
* Gonorrhea (Neisseria gonorrhoeae)
* Mycoplasma hominis infection (Mycoplasma hominis)
* Syphilis (Treponema pallidum)
* Ureaplasma infection (Ureaplasma urealyticum)

Protozoal|

* Trichomoniasis (Trichomonas vaginalis)

Parasitic|

* Crab louse
* Scabies

Viral|

* AIDS (HIV-1/HIV-2)
* Cancer
* cervical
* vulvar
* penile
* anal
* Human papillomavirus (HPV)
* Genital warts (condyloma)
* Hepatitis B (Hepatitis B virus)
* Herpes simplex
* HSV-1 & HSV-2
* Molluscum contagiosum (MCV)
* Zika fever (Zika virus)

General
inflammation|

female
Cervicitis
Pelvic inflammatory disease (PID)

male
Epididymitis
Prostatitis

either
Proctitis
Urethritis/Non-gonococcal urethritis (NGU)

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Public health

General|

* Auxology
* Biological hazard
* Chief Medical Officer
* Cultural competence
* Deviance
* Environmental health
* Eugenics
* History of
* Liberal
* Euthenics
* Genomics
* Globalization and disease
* Harm reduction
* Health economics
* Health literacy
* Health policy
* Health system
* Health care reform
* Housing First
* Human right to water and sanitation
* Management of depression
* Public health law
* National public health institute
* Health politics
* Labor rights
* Maternal health
* Medical anthropology
* Medical sociology
* Mental health (Ministers)
* Occupational safety and health
* Pharmaceutical policy
* Pollution
* Air
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* Public health laboratory
* Right to food
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* Right to a healthy environment
* Right to housing
* Right to rest and leisure
* Right to sit
* Security of person
* Sexual and reproductive health
* Social psychology
* Sociology of health and illness
* Unisex changing rooms
* Unisex public toilets
* Workers' right to access the toilet

Preventive healthcare|

* Behavior change
* Theories
* Drug checking
* Family planning
* Harm reduction
* Health promotion
* Human nutrition
* Healthy diet
* Preventive nutrition
* Hygiene
* Food safety
* Hand washing
* Infection control
* Oral hygiene
* Needle and syringe programmes
* Occupational safety and health
* Human factors and ergonomics
* Hygiene
* Controlled Drugs
* Injury prevention
* Medicine
* Nursing
* Patient safety
* Organization
* Pharmacovigilance
* Reagent testing
* Safe sex
* Sanitation
* Emergency
* Fecal–oral transmission
* Open defecation
* Sanitary sewer
* Waterborne diseases
* Worker
* School hygiene
* Smoking cessation
* Supervised injection site
* Vaccination
* Vector control

Population health|

* Biostatistics
* Child mortality
* Community health
* Epidemiology
* Global health
* Health impact assessment
* Health system
* Infant mortality
* Open-source healthcare software
* Multimorbidity
* Public health informatics
* Social determinants of health
* Commercial determinants of health
* Health equity
* Race and health
* Social medicine

Biological and
epidemiological statistics|

* Case–control study
* Randomized controlled trial
* Relative risk
* Statistical hypothesis testing
* Analysis of variance (ANOVA)
* Regression analysis
* ROC curve
* Student's t-test
* Z-test
* Statistical software

Infectious and epidemic
disease prevention|

* Asymptomatic carrier
* Epidemics
* List
* Notifiable diseases
* List
* Public health surveillance
* Disease surveillance
* Quarantine
* Sexually transmitted infection
* Social distancing
* Tropical disease
* Vaccine trial
* WASH

Food hygiene and
safety management|

* Food
* Additive
* Chemistry
* Engineering
* Microbiology
* Processing
* Safety
* Safety scandals
* Good agricultural practice
* Good manufacturing practice
* HACCP
* ISO 22000

Health behavioral
sciences|

* Diffusion of innovations
* Health belief model
* Health communication
* Health psychology
* Positive deviance
* PRECEDE–PROCEED model
* Social cognitive theory
* Social norms approach
* Theory of planned behavior
* Transtheoretical model

Organizations,
education
and history|

| Organizations|

* Caribbean
* Caribbean Public Health Agency
* China
* Center for Disease Control and Prevention
* Europe
* Centre for Disease Prevention and Control
* Committee on the Environment, Public Health and Food Safety
* Russia
* Rospotrebnadzor
* India
* Ministry of Health and Family Welfare
* Canada
* Health Canada
* Public Health Agency
* U.S.
* Centers for Disease Control and Prevention
* Health departments in the United States
* Council on Education for Public Health
* Public Health Service
* World Health Organization
* World Toilet Organization
* (Full list)

|

Education|

* Health education
* Higher education
* Bachelor of Science in Public Health
* Doctor of Public Health
* Professional degrees of public health
* Schools of public health

History|

* History of public health in the United Kingdom
* History of public health in the United States
* History of public health in Australia
* Sara Josephine Baker
* Samuel Jay Crumbine
* Carl Rogers Darnall
* Joseph Lister
* Margaret Sanger
* John Snow
* Typhoid Mary
* Radium Girls
* Germ theory of disease
* Social hygiene movement

* Category
* Commons
* WikiProject

* v
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* e

Concepts in infectious disease (Outline)

Determinants|

| Agent|

* Biofilm
* Germ theory of disease
* Infectivity
* Infectious dose
* Pathogenicity
* Attack rate
* Quorum sensing
* Virulence
* Endotoxin
* Exotoxin
* Case fatality rate
* factors
* Antimicrobial resistance
* Drug resistance
* Horizontal gene transfer
* Multidrug-resistant bacteria
* Host tropism

|

Host|

* Burn
* Comorbidity
* Diabetes
* Host–pathogen interaction
* Immune response
* Immunodeficiency
* Immunosuppression
* Microbiome health
* Opportunistic infection
* Risk of infection
* Susceptible individual
* Age
* Gender
* Nutrition status
* Vaccination status
* Genetic predisposition
* Behavioral/lifestyle factors
* Smoking
* Pregnancy
* Stress levels

Environment|

* Access to water, sanitation and hygiene
* Air quality
* Biodiversity loss
* Climate change
* Climate zones
* El Niño
* Tropical diseases
* Commerce
* Deforestation
* Ecology
* Humidity
* Injection drug use
* Natural disaster
* Flood
* Poultry and livestock
* Poverty
* Travel
* Urbanization
* Vector control
* War and conflict

Transmission|

| Basic
concepts|

* Asymptomatic carrier
* Chain of infection
* Fomite
* Host
* Incubation period
* Index case
* Infectious period
* Latent period
* Natural reservoir
* Opportunistic infection
* Silent/Subclinical infection
* Superinfection
* Super-spreader
* Viral load
* Window period

|

Modes|

| Endogenous|

* Endogenous overgrowth
* Normal flora overgrowth
* Endogenous reactivation
* Microbial translocation
* Endogenous seeding
* Biofilm formation

|

Exogenous|

| Cross-species|

* Spillover infection
* Vector
* Zoonosis
* Reverse zoonosis

|

Human-to-human
/Cross-infection|

* Contagious disease
* Source
* Nosocomial/Hospital
* Iatrogenic/Medical care
* Generational difference
* Vertical/Congenital
* Prenatal
* Perinatal
* Neonatal
* Horizontal
* Breakthrough infection

Environment-
to-human|

* Sapronosis

Routes|

| Respiratory|

* Air
* Bioaerosol
* Aerosol-generating procedure
* Dental aerosol
* Respiratory droplet

|

Linked to
Vascular system|

* Blood-borne disease
* Percutaneous inoculation
* Injection site
* Intravenous line
* Insect bite
* Animal bite
* Surgical intervention
* Postoperative wound
* Surgical site infection
* Vector-borne
* Mosquito
* Tick

Gastrointestinal|

* Food
* Contamination
* Breastmilk
* Water
* Feces

Cutaneous|

* Burn
* Fomite
* Soil
* Open wound

Genitourinary|

* Sex

Trans-placental|

* Prenatal

Cervico-vaginal|

* Perinatal

Other|

* Ocular (Eye) mucosal membrane

Modelling|

* Agent-based model
* Animal disease model
* Attack rate
* Basic reproduction number
* Compartmental models in epidemiology
* Critical community size
* Force of infection
* Herd immunity
* Infection rate
* Machine learning
* Multiplicity of infection
* Serial interval
* WAIFW matrix

Occurrence
in population|

* Cluster
* Endemic
* Epidemic
* Curve
* Farr's laws
* Holoendemic
* Hyperendemic
* Incidence
* Inequality
* Mesoendemic
* Outbreak
* Pandemic
* Prevalence
* Seasonality
* Geographic distribution
* Sporadic
* Syndemic
* Twindemic

Anatomical
location|

* Respiratory
* Ear-Nose-Throat/Upper respiratory tract
* Chest/Lower respiratory tract
* Gastrointestinal
* Intestinal
* Genitourinary
* Nervous system
* Skin
* Soft tissue
* Bone
* Joint
* Cardiovascular
* Systemic/Generalized
* Blood
* Tooth
* Mouth
* Fetus
* Eye

Prevention
and Control
measures|

| Pharmaceutical|

* Antibiotic
* prophylactic
* Antifungal
* Anthelmintic
* Ascaricide
* Antimicrobial
* Antimicrobial stewardship
* Antiseptic
* Antiviral
* Asepsis
* Combination
* Drug safety
* Immunization
* Immunotherapy
* Monoclonal antibody therapy
* Inoculation
* Phage therapy
* Pre-exposure prophylaxis
* Post-exposure prophylaxis
* Repurposed drugs
* Vaccination
* efficacy/effectiveness
* booster
* resistance
* Vaccine-preventable disease
* Ring vaccination

|

Non-
pharmaceutical|

* Contact tracing
* Cordon sanitaire
* Disease surveillance
* Disinfection
* Flattening the curve
* Hygiene
* Food hygiene
* Hand washing
* Gloves
* Isolation
* Barrier nursing
* Lockdown
* Notification
* list
* Protective sequestration
* Public health
* Community health services
* Health communication
* Health education
* Outbreak response
* Quarantine
* Respiratory source control
* N95 respirator
* Surgical mask
* PPE
* Safe sex
* Sanitation
* Screening
* Social distancing
* Sterilization
* Transmission-based precautions
* Travel restrictions
* Universal precautions
* Vector control
* Wastewater surveillance
* Zoning

Emerging
infections|

* Antigenic drift
* Antigenic shift
* Antimicrobial resistance surveillance
* EARS-Net
* Biosecurity
* CRISPR
* Disease X
* Emergent virus
* Evolutionary epidemiology
* Genetic epidemiology
* Global Health Initiatives
* Microbial phylogenetics
* One Health Model
* Genomic reassortment
* Re-emerging disease
* Reverse zoonosis
* Selection pressure
* Synthetic biology
* Viral phylodynamics

Other|

* Discovery
* Eradication
* Economics of Infectious Diseases
* Infectious disease (medical specialty)
* Infectious disease informatics
* Microbial bioterrorism
* Pandemic prevention
* Tropical disease
* Tropical medicine

Authority control databases

International|

* FAST

National|

* United States
* France
* BnF data
* Czech Republic
* Spain
* Israel

Other|

* Encyclopedia of Modern Ukraine

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