Signaling peptide receptor

Cell surface receptors

Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins.

An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin.

## Adiponectin receptor

[edit]

Main article: Adiponectin receptor

### AdipoR1

[edit]

Main article: Adiponectin receptor 1

* Agonists
* Peptide
* Adiponectin
* ADP-355
* ADP-399
* Non-peptide
* AdipoRon
* (–)-Arctigenin
* Arctiin
* Gramine
* Matairesinol
* Antagonists
* Peptide
* ADP-400

### AdipoR2

[edit]

Main article: Adiponectin receptor 2

* Agonists
* Peptide
* Adiponectin
* ADP-355
* ADP-399
* Non-peptide
* AdipoRon
* Deoxyschizandrin
* Parthenolide
* Syringing
* Taxifoliol
* Antagonists
* Peptide
* ADP-400

## Angiotensin receptor

[edit]

Main article: Angiotensin receptor

## Bradykinin receptor

[edit]

Main article: Bradykinin receptor

* Agonists
* Bradykinin
* Kallidin
* Antagonists
* FR-173657
* Icatibant
* LF22-0542

## Calcitonin gene-related peptide receptor

[edit]

Main article: Calcitonin gene-related peptide receptor

* Agonists
* Amylin
* CGRP
* Pramlintide
* Antagonists
* Atogepant
* BI 44370 TA
* CGRP (8-37)
* MK-3207
* Olcegepant
* Rimegepant
* SB-268262
* Telcagepant
* Ubrogepant
* Antibodies
* Eptinezumab
* Erenumab
* Fremanezumab
* Galcanezumab

## Cholecystokinin receptor

[edit]

Main article: Cholecystokinin receptor

### CCKA

[edit]

Main article: Cholecystokinin A receptor

* Agonists
* Cholecystokinin
* Antagonists
* Amiglumide
* Asperlicin
* Devazepide
* Dexloxiglumide
* Lintitript
* Lorglumide
* Loxiglumide
* Pranazepide
* Proglumide
* Tarazepide
* Tomoglumide

### CCKB

[edit]

Main article: Cholecystokinin B receptor

* Agonists
* Cholecystokinin
* CCK-4
* Gastrin
* Pentagastrin (CCK-5)
* Antagonists
* Ceclazepide
* CI-988 (PD-134308)
* Itriglumide
* L-365,360
* Netazepide
* Proglumide
* Spiroglumide

### Unsorted

[edit]

* Antagonists
* Nastorazepide

## Corticotropin-releasing hormone receptor

[edit]

Main article: Corticotropin-releasing hormone receptor

### CRF1

[edit]

Main article: Corticotropin-releasing hormone receptor 1

* Agonists
* Cortagine
* Corticorelin
* Corticotropin-releasing hormone
* Sauvagine
* Stressin I
* Urocortin
* Antagonists
* Antalarmin
* Astressin-B
* CP-154,526
* Emicerfont
* Hypericin
* LWH-234
* NBI-27914
* NBI-74788
* Pexacerfont
* R-121919
* TS-041
* Verucerfont

### CRF2

[edit]

Main article: Corticotropin-releasing hormone receptor 2

* Agonists
* Corticorelin
* Corticotropin-releasing hormone
* Sauvagine
* Urocortin
* Antagonists
* Astressin-B

## Cytokine receptor

[edit]

Main article: Cytokine receptor

## Endothelin receptor

[edit]

Main article: Endothelin receptor

* Agonists
* Endothelin 1
* Endothelin 2
* Endothelin 3
* IRL-1620
* Sarafotoxin
* Antagonists
* A-192621
* Ambrisentan
* Aprocitentan
* Atrasentan
* Avosentan
* Bosentan
* BQ-123
* BQ-788
* Clazosentan
* Darusentan
* Edonentan
* Enrasentan
* Fandosentan
* Feloprentan
* Macitentan
* Nebentan
* Sitaxentan
* Sparsentan
* Tezosentan
* Zibotentan

## Galanin receptor

[edit]

Main article: Galanin receptor

### GAL1

[edit]

Main article: Galanin receptor 1

* Agonists
* Galanin
* Galanin (1-15)
* Galanin-like peptide
* Galmic
* Galnon
* NAX 810-2
* Antagonists
* C7
* Dithiepine-1,1,4,4-tetroxide
* Galantide (M15)
* M32
* M35
* M40
* SCH-202596

### GAL2

[edit]

Main article: Galanin receptor 2

* Agonists
* Galanin
* Galanin (1-15)
* Galanin (2-11)
* Galanin-like peptide
* Galmic
* Galnon
* J18
* NAX 810-2
* Antagonists
* C7
* Galantide (M15)
* M32
* M35
* M40
* M871

### GAL3

[edit]

Main article: Galanin receptor 3

* Agonists
* Galanin
* Galanin (1-15)
* Galmic
* Galnon
* Antagonists
* C7
* Galantide (M15)
* GalR3ant
* HT-2157
* M32
* M35
* M40
* SNAP-37889
* SNAP-398299

## Growth hormone secretagogue receptor

[edit]

Main article: Growth hormone secretagogue receptor

## Growth hormone receptor

[edit]

Main article: Growth hormone receptor

## Growth-hormone-releasing hormone receptor

[edit]

Main article: Growth-hormone-releasing hormone receptor

## Glucagon-like peptide receptor

[edit]

### GLP-1

[edit]

Main article: Glucagon-like peptide-1 receptor

* Agonists
* Albiglutide
* Beinaglutide
* Dulaglutide
* Efpeglenatide
* Exenatide
* GLP-1
* Langlenatide
* Liraglutide
* Lixisenatide
* Oxyntomodulin
* Pegapamodutide
* Semaglutide
* Taspoglutide

### GLP-2

[edit]

Main article: Glucagon-like peptide-2 receptor

* Agonists
* Apraglutide
* Elsiglutide
* Glepaglutide
* GLP-2
* Teduglutide

### Others

[edit]

* Propeptides
* Preproglucagon
* Proglucagon

## Glucagon receptor

[edit]

Main article: Glucagon receptor

* Agonists
* Dasiglucagon
* Glucagon
* Oxyntomodulin
* Antagonists
* Adomeglivant
* L-168,049
* LGD-6972
* Propeptides
* Preproglucagon
* Proglucagon

## Gonadotropin-releasing hormone receptor

[edit]

Main article: Gonadotropin-releasing hormone receptor

## Gonadotropin receptor

[edit]

Main article: Gonadotropin receptor

## Growth factor receptor

[edit]

Main article: Growth factor receptor

## Insulin receptor

[edit]

Main article: Insulin receptor

* Agonists
* Chaetochromin (4548-G05)
* Insulin-like growth factor 1
* Insulin-like growth factor 2
* Insulin
* Insulin aspart
* Insulin degludec
* Insulin detemir
* Insulin glargine
* Insulin glulisine
* Insulin lispro
* Mecasermin
* Mecasermin rinfabate
* Antagonists
* BMS-754807
* S661
* S961
* Kinase inhibitors
* Linsitinib
* Antibodies
* Xentuzumab (against IGF-1 and IGF-2)

## KiSS1-derived peptide receptor

[edit]

Main article: KiSS1-derived peptide receptor

* Agonists
* Kisspeptin (kisspeptin-54, metastin)
* Kisspeptin-10
* KISS1-305
* MVT-602 (RVT-602, TAK-448)
* TAK-683
* Antagonists
* Kisspeptin-234

## Leptin receptor

[edit]

Main article: Leptin receptor

* Agonists
* Leptin
* Metreleptin

## Melanin-concentrating hormone receptor

[edit]

Main article: Melanin-concentrating hormone receptor

### MCH1

[edit]

Main article: Melanin-concentrating hormone receptor 1

* Agonists
* Melanin-concentrating hormone
* Antagonists
* ATC-0065
* ATC-0175
* GW-803430
* NGD-4715
* SNAP-7941
* SNAP-94847

### MCH2

[edit]

Main article: Melanin-concentrating hormone receptor 2

* Agonists
* Melanin-concentrating hormone

## Melanocortin receptor

[edit]

Main article: Melanocortin receptor

## Neuropeptide FF receptor

[edit]

Main article: Neuropeptide FF receptor

* Agonists
* Neuropeptide AF
* Neuropeptide FF
* Neuropeptide SF (RFRP-1)
* Neuropeptide VF (RFRP-3)
* Antagonists
* BIBP-3226
* RF9

## Neuropeptide S receptor

[edit]

Main article: Neuropeptide S receptor

* Agonists
* Neuropeptide S
* Antagonists
* ML-154
* SHA-68

## Neuropeptide Y receptor

[edit]

Main article: Neuropeptide Y receptor

### Y1

[edit]

Main article: Neuropeptide Y receptor Y1

* Agonists
* Neuropeptide Y
* Peptide YY
* Antagonists
* BIBO-3304
* BIBP-3226
* BVD-10
* GR-231118
* PD-160170

### Y2

[edit]

Main article: Neuropeptide Y receptor Y2

* Agonists
* 2-Thiouridine 5'-triphosphate
* Neuropeptide Y
* Neuropeptide Y (13-36)
* Peptide YY
* Peptide YY (3-36)
* Antagonists
* BIIE-0246
* JNJ-5207787
* SF-11

### Y4

[edit]

* Agonists
* GR-231118
* Neuropeptide Y
* Pancreatic polypeptide
* Peptide YY
* Antagonists
* UR-AK49

### Y5

[edit]

Main article: Neuropeptide Y receptor Y5

* Agonists
* BWX-46
* Neuropeptide Y
* Peptide YY
* Antagonists
* CGP-71683
* FMS-586
* L-152,804
* Lu AA-33810
* MK-0557
* NTNCB
* Velneperit (S-2367)

## Neurotensin receptor

[edit]

Main article: Neurotensin receptor

### NTS1

[edit]

Main article: Neurotensin receptor 1

* Agonists
* Neurotensin
* Neuromedin N
* Antagonists
* Meclinertant
* SR-142948

### NTS2

[edit]

Main article: Neurotensin receptor 2

* Agonists
* Neurotensin
* Antagonists
* Levocabastine
* SR-142948

## Opioid receptor

[edit]

Main article: Opioid receptor

## Orexin receptor

[edit]

Main article: Orexin receptor

## Oxytocin receptor

[edit]

Main article: Oxytocin receptor

## Prolactin receptor

[edit]

Main article: Prolactin receptor

## Parathyroid hormone receptor

[edit]

Main article: Parathyroid hormone receptor

* Agonists
* Abaloparatide
* Parathyroid hormone
* Parathyroid hormone-related protein (PTHrP)
* Semparatide
* Teriparatide

## Relaxin receptor

[edit]

Main article: Relaxin receptor

* Agonists
* Insulin-like factor 3
* Relaxin (1, 2, 3)
* Serelaxin

## Somatostatin receptor

[edit]

Main article: Somatostatin receptor

## Tachykinin receptor

[edit]

Main article: Tachykinin receptor

## Thyrotropin-releasing hormone receptor

[edit]

Main article: Thyrotropin-releasing hormone receptor

* Agonists
* Azetirelin
* JTP-2942
* Montirelin
* Orotirelin
* Posatirelin
* Protirelin
* Rovatirelin
* RX-77368 (thymoliberin)
* Taltirelin
* TRH (TRF)

## Thyrotropin receptor

[edit]

Main article: Thyrotropin receptor

* Agonists
* Thyrotropin alfa
* TSH (thyrotropin)

## Vasopressin receptor

[edit]

Main article: Vasopressin receptor

## Vasoactive intestinal peptide receptor and Pituitary adenylate cyclase-activating peptide

[edit]

Main article: Vasopressin receptor

### VIPR1

[edit]

Main article: VIPR1

* Agonists
* Peptide
* Bay 55-9837
* LBT-3393
* PACAP
* VIP

### VIPR2

[edit]

Main article: VIPR2

* Agonists
* Peptide
* LBT-3627
* PACAP
* VIP

### PAC1

[edit]

Main article: ADCYAP1R1

* Agonists
* PACAP
* PACAP (1-27)
* PACAP (1-38)
* Antagonists
* PACAP (6-38)

### Unsorted

[edit]

* PHI
* PHM
* PHV

## Others

[edit]

* Endogenous
* Adrenomedullin
* Apelin
* Asprosin
* Bombesin
* Calcitonin
* Carnosine
* CART
* CLIP
* DSIP
* Enteroglucagon
* Formyl peptide
* GALP
* GIP
* GRP
* Integrin ligands
* collagens
* fibrinogen
* fibronectin
* laminins
* ICAM-1
* ICAM-2
* osteopontin
* VCAM-1
* vitronectin
* Kininogens
* Motilin
* Natriuretic peptides
* ANP
* BNP
* CNP
* urodilatin
* Nesfatin-1
* Neuromedin B
* Neuromedin N
* Neuromedin S
* Neuromedin U
* Obestatin
* Osteocalcin
* Resistin
* Secretin
* Thymopoietin
* Thymosins
* Thymulin
* Urotensin-II
* VGF
* Exogenous
* Lifitegrast (LFA-1 antagonist)

## See also

[edit]

* Neuropeptide receptor
* Neurotransmitter receptor

## References

[edit]

## External links

[edit]

* Peptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a (1
* 2))
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Taste, bitter|

* TAS2R
* 1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor type 1

|

Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRB
* Brain-specific angiogenesis inhibitor
* 1
* 2
* 3
* ADGRC
* Cadherin
* 1
* 2
* 3
* ADGRE
* EMR
* 1
* 2
* 3
* CD97
* ADGRG
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* ADGRL
* Latrophilin
* 1
* 2
* 3
* ELTD1

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Calcitonin
* CALCRL
* Corticotropin-releasing hormone (1
* 2)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste, sweet|

* TAS1R
* 1
* 2
* 3
* Vomeronasal receptor, type 2

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

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