Solute carrier family

Family of membrane transport proteins

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families.[1][2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.

Solutes that are transported by the various SLC group members are extremely diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia.

As is typical of integral membrane proteins, SLCs contain a number of hydrophobic transmembrane alpha helices connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero-oligomers. Many SLC families are members of the major facilitator superfamily.

## Scope

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By convention of the nomenclature system, members within an individual SLC family have greater than 20-25% sequence identity to each other. In contrast, the homology between SLC families is very low to non-existent.[3] Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute).

The SLC group include examples of transport proteins that are:

* facilitative transporters (allow solutes to flow downhill with their electrochemical gradients)
* secondary active transporters (allow solutes to flow uphill against their electrochemical gradient by coupling to transport of a second solute that flows downhill with its gradient such that the overall free energy change is still favorable)

The SLC series does not include members of transport protein families that have previously been classified by other widely accepted nomenclature systems including:

* primary active transporters (allow flow uphill against electrochemical gradients) such as ABC (ATP Binding Cassette) transporters by coupling transport to an energy releasing event such as ATP hydrolysis
* ion channels
* aquaporins (water channels)

## Subcellular distribution

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Most members of the SLC group are located in the cell membrane, but some members are located in mitochondria (the most notable one being SLC family 25) or other intracellular organelles.

## Nomenclature system

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Names of individual SLC members have the following format:[4]

SLCnXm {\displaystyle {\ce {SLCnXm}}}

where:

* SLC is the root name (SoLute Carrier)
* n = an integer representing a family (e.g., 1-52)
* X = a single letter (A, B, C, ...) denoting a subfamily
* m = an integer representing an individual family member (isoform).

For example, SLC1A1 is the first isoform of subfamily A of SLC family 1.

An exception occurs with SLC family 21[5] (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number.

While the HGNC only assign nomenclature to human genes, by convention vertebrate orthologs of these genes adopt the same nomenclature (e.g., VGNC-assigned orthologs of SLC10A1). For rodents, the case of the symbols differs from other vertebrates by using title case, i.e. Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene.

## Families

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The following families are named under SLC:[6]

1. high-affinity glutamate and neutral amino acid transporter[7]
* (SLC1A1, SLC1A2, SLC1A3, SLC1A4, SLC1A5, SLC1A6, SLC1A7)
2. facilitative GLUT transporter[8]
* (SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6, SLC2A7, SLC2A8, SLC2A9, SLC2A10, SLC2A11, SLC2A12, SLC2A13, SLC2A14)
3. heavy subunits of heterodimeric amino acid transporters[9]
* (SLC3A1, SLC3A2)
4. bicarbonate transporter[10]
* (SLC4A1, SLC4A2, SLC4A3, SLC4A4, SLC4A5, SLC4A6, SLC4A7, SLC4A8, SLC4A9, SLC4A10, SLC4A11)
5. sodium glucose cotransporter[11]
* (SLC5A1, SLC5A2, SLC5A3, SLC5A4, SLC5A5, SLC5A6, SLC5A7, SLC5A8, SLC5A9, SLC5A10, SLC5A11, SLC5A12)
6. sodium\- and chloride-dependent sodium:neurotransmitter symporters[12]
* (SLC6A1, SLC6A2, SLC6A3, SLC6A4, SLC6A5, SLC6A6, SLC6A7, SLC6A8, SLC6A9, SLC6A10, SLC6A11, SLC6A12, SLC6A13, SLC6A14, SLC6A15, SLC6A16, SLC6A17, SLC6A18, SLC6A19, SLC6A20)
7. cationic amino acid transporter/glycoprotein-associated[13]
* cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4)
* glycoprotein-associated/light or catalytic subunits of heterodimeric amino acid transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A10, SLC7A11, SLC7A13, SLC7A14)
8. Na+/Ca2+ exchanger[14]
* (SLC8A1, SLC8A2, SLC8A3)
9. Na+/H+ exchanger[15]
* (SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9A8, SLC9A9, SLC9A10, SLC9A11, SLC9B1, SLC9B2)
10. sodium bile salt cotransport[16]
* (SLC10A1, SLC10A2, SLC10A3, SLC10A4, SLC10A5, SLC10A6, SLC10A7)
11. proton coupled metal ion transporter[17]
* (SLC11A1, SLC11A2)
12. electroneutral cation-Cl cotransporter[18]
* (SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9)
13. Na+-sulfate/carboxylate cotransporter[19]
* (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5)
14. urea transporter[20]
* (SLC14A1, SLC14A2)
15. proton oligopeptide cotransporter[21]
* (SLC15A1, SLC15A2, SLC15A3, SLC15A4)
16. monocarboxylate transporter[22]
* (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14)
17. vesicular glutamate transporter[23]
* (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9)
18. vesicular amine transporter[24]
* (SLC18A1, SLC18A2, SLC18A3)
19. folate/thiamine transporter[25]
* (SLC19A1, SLC19A2, SLC19A3)
20. type III Na+-phosphate cotransporter[26]
* (SLC20A1, SLC20A2)
21. organic anion transporting[27]
* subfamily 1 (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1)
* subfamily 2 (SLCO2A1, SLCO2B1)
* subfamily 3 (SLCO3A1)
* subfamily 4 (SLCO4A1, SLCO4C1)
* subfamily 5 (SLCO5A1)
* subfamily 6 (SLCO6A1)
22. organic cation/anion/zwitterion transporter[28]
* (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A18AS, SLC22A19, SLC22A20, SLC22A23, SLC22A24, SLC22A25, SLC22A31)
23. Na+-dependent ascorbic acid transporter[29]
* (SLC23A1, SLC23A2, SLC23A3, SLC23A4)
24. Na+/(Ca2+-K+) exchanger[30]
* (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6)
25. mitochondrial carrier[31]
* (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, UCP1(SLC25A7), UCP2(SLC25A8), UCP3(SLC25A9), SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46), SLC25A47, SLC25A48, MTCH1(SLC25A49), MTCH2(SLC25A50), SLC25A51, SLC25A52, SLC25A53
26. multifunctional anion exchanger[32]
* (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11)
27. fatty acid transport proteins[33]
* (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6)
28. Na+-coupled nucleoside transport[34]
* (SLC28A1, SLC28A2, SLC28A3)
29. facilitative nucleoside transporter[35]
* (SLC29A1, SLC29A2, SLC29A3, SLC29A4)
30. zinc transporter[36]
* (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)
31. copper transporter[37]
* (SLC31A1, SLC31A2)
32. vesicular inhibitory amino acid transporter[38]
* (SLC32A1)
33. Acetyl-CoA transporter[39]
* (SLC33A1)
34. type II Na+-phosphate cotransporter[40]
* (SLC34A1, SLC34A2, SLC34A3)
35. nucleotide-sugar transporter[41]
* subfamily A (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5)
* subfamily B (SLC35B1, SLC35B2, SLC35B3, SLC35B4)
* subfamily C (SLC35C1, SLC35C2)
* subfamily D (SLC35D1, SLC35D2, SLC35D3)
* subfamily E (SLC35E1, SLC35E2A, SLC35E2B, SLC35E3, SLC35E4)
* subfamily F (SLC35F1, SLC35F2, SLC35F3, SLC35F4, SLC35F5)
* subfamily G (SLC35G1, SLC35G3, SLC35G4, SLC35G5, SLC35G6)
36. proton-coupled amino acid transporter[42]
* (SLC36A1, SLC36A2, SLC36A3, SLC36A4)
37. sugar-phosphate/phosphate exchanger[43]
* (SLC37A1, SLC37A2, SLC37A3, SLC37A4)
38. System A & N, sodium-coupled neutral amino acid transporter[44]
* (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A7, SLC38A8, SLC38A9, SLC38A10, SLC38A11)
39. metal ion transporter[45]
* (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14)
40. basolateral iron transporter[46]
* (SLC40A1)
41. MgtE-like magnesium transporter
* (SLC41A1, SLC41A2, SLC41A3)
42. Ammonia transporter[47][48]
* (RHAG(SLC42A1), RHBG(SLC42A2), RHCG(SLC42A3))
43. Na+-independent, system-L like amino acid transporter
* (SLC43A1, SLC43A2, SLC43A3)
44. Choline-like transporter
* (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5)
45. Putative sugar transporter
* (SLC45A1, SLC45A2, SLC45A3, SLC45A4)
46. Folate transporter
* (SLC46A1, SLC46A2, SLC46A3)
47. multidrug and toxin extrusion
* (SLC47A1, SLC47A2)
48. Heme transporter family
* (SLC48A1)
49. Heme transporter
* (FLVCR1(SLC49A1), FLVCR2(SLC49A2), SLC49A3, SLC49A4)
50. Sugar efflux transporters of the SWEET family
* (SLC50A1)
51. Transporters of steroid-derived molecules
* (SLC51A, SLC51B)
52. Riboflavin transporter family RFVT/SLC52
* (SLC52A1, SLC52A2, SLC52A3)
53. Phosphate carriers
* (XPR1(SLC53A1)
54. Mitochondrial pyruvate carriers
* (MPC1(SLC54A1), MPC2(SLC54A2), MPC1L(SLC54A3))
55. Mitochondrial cation/proton exchangers
* (LETM1(SLC55A1), LETM2(SLC55A2), LETMD1(SLC55A3))
56. Sideroflexins
* (SFXN1(SLC56A1), SFXN2(SLC56A2), SFXN3(SLC56A3), SFXN4(SLC56A4), SFXN5(SLC56A5))
57. NiPA-like magnesium transporter family
* (NIPA1(SLC57A1), NIPA2(SLC57A2), NIPAL1(SLC57A3), NIPAL2(SLC57A4), NIPAL3(SLC57A5), NIPAL4(SLC57A6))
58. MagT-like magnesium transporter family
* (MAGT1(SLC58A1), TUSC3(SLC58A2))
59. Sodium-dependent lysophosphatidylcholine symporter family
* (MFSD2A(SLC59A1), MFSD2B(SLC59A2))
60. Glucose transporters
* (MFSD4A(SLC60A1), MFSD4B(SLC60A2))
61. Molybdate transporter family
* (MFSD5(SLC61A1))
62. Pyrophosphate transporters
* (ANKH(SLC62A1))
63. Sphingosine-phosphate transporters
* (SPNS1(SLC63A1), SPNS2(SLC63A2), SPNS3(SLC63A3))
64. Golgi Ca2+/H+ exchangers
* (TMEM165(SLC64A1))
65. NPC-type cholesterol transporters
* (NPC1(SLC65A1), NPC1L1(SLC65A2))
66. Cationic amino acid exporters
* (SLC66A1, SLC66A2, SLC66A3, CTNS(SLC66A4), MPDU1(SLC66A5))

## Putative SLCs

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Putative SLCs, also called atypical SLCs, are novel, plausible secondary active or facilitative transporter proteins that share ancestral background with the known SLCs. [2][49] The atypical SLCs of MFS type can, however, be subdivided into 15 Putative MFS Transporter Families (AMTF).[49]

All the putative SLCs are plausible SLC transporters. Some are only "atypical" when it comes to their nomenclature; the genes have an SLC assignment but as an alias, and have retained their already assigned "non-SLC" gene symbol as the approved symbol.

Here are some Putative SLCs listed: OCA2, CLN3, TMEM104, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1,[50] MFSD2A, MFSD2B, MFSD3,[50] MFSD4A,[51] MFSD4B, MFSD5,[52] MFSD6, MFSD6L, MFSD8, MFSD9,[51] MFSD10, MFSD11,[52] MFSD12, MFSD13A, MFSD14A,[53] MFSD14B,[53] UNC93A[54][55] and UNC93B1.

## References

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33. ^ Stahl A (February 2004). "A current review of fatty acid transport proteins (SLC27)". Pflügers Archiv. 447 (5): 722–727\. doi:10.1007/s00424-003-1106-z. PMID 12856180. S2CID 2769738.
34. ^ Gray JH, Owen RP, Giacomini KM (February 2004). "The concentrative nucleoside transporter family, SLC28". Pflügers Archiv. 447 (5): 728–734\. doi:10.1007/s00424-003-1107-y. PMID 12856181. S2CID 24749954.
35. ^ Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (February 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Archiv. 447 (5): 735–743\. doi:10.1007/s00424-003-1103-2. PMID 12838422. S2CID 8817821.
36. ^ Palmiter RD, Huang L (February 2004). "Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers". Pflügers Archiv. 447 (5): 744–751\. doi:10.1007/s00424-003-1070-7. PMID 12748859. S2CID 725350.
37. ^ Petris MJ (February 2004). "The SLC31 (Ctr) copper transporter family". Pflügers Archiv. 447 (5): 752–755\. doi:10.1007/s00424-003-1092-1. PMID 12827356. S2CID 23340930.
38. ^ Gasnier B (February 2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers Archiv. 447 (5): 756–759\. doi:10.1007/s00424-003-1091-2. PMID 12750892. S2CID 24669893.
39. ^ Hirabayashi Y, Kanamori A, Nomura KH, Nomura K (February 2004). "The acetyl-CoA transporter family SLC33". Pflügers Archiv. 447 (5): 760–762\. doi:10.1007/s00424-003-1071-6. PMID 12739170. S2CID 21247182.
40. ^ Murer H, Forster I, Biber J (February 2004). "The sodium phosphate cotransporter family SLC34" (PDF). Pflügers Archiv. 447 (5): 763–767\. doi:10.1007/s00424-003-1072-5. PMID 12750889. S2CID 34041192.
41. ^ Ishida N, Kawakita M (February 2004). "Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)". Pflügers Archiv. 447 (5): 768–775\. doi:10.1007/s00424-003-1093-0. PMID 12759756. S2CID 8690030.
42. ^ Boll M, Daniel H, Gasnier B (February 2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis". Pflügers Archiv. 447 (5): 776–779\. doi:10.1007/s00424-003-1073-4. PMID 12748860. S2CID 25655241.
43. ^ Bartoloni L, Antonarakis SE (February 2004). "The human sugar-phosphate/phosphate exchanger family SLC37". Pflügers Archiv. 447 (5): 780–783\. doi:10.1007/s00424-003-1105-0. PMID 12811562. S2CID 24776306.
44. ^ Mackenzie B, Erickson JD (February 2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflügers Archiv. 447 (5): 784–795\. doi:10.1007/s00424-003-1117-9. PMID 12845534. S2CID 35457147.
45. ^ Eide DJ (February 2004). "The SLC39 family of metal ion transporters". Pflügers Archiv. 447 (5): 796–800\. doi:10.1007/s00424-003-1074-3. PMID 12748861. S2CID 11765308.
46. ^ McKie AT, Barlow DJ (February 2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflügers Archiv. 447 (5): 801–806\. doi:10.1007/s00424-003-1102-3. PMID 12836025. S2CID 27340247.
47. ^ Nakhoul NL, Hamm LL (February 2004). "Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters". Pflügers Archiv. 447 (5): 807–812\. doi:10.1007/s00424-003-1142-8. PMID 12920597. S2CID 24601165.
48. ^ Boron WF (December 2010). "Sharpey-Schafer lecture: gas channels". Experimental Physiology. 95 (12): 1107–1130\. doi:10.1113/expphysiol.2010.055244. PMC 3003898. PMID 20851859.
49. ^ a b Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
50. ^ a b Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214\. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
51. ^ a b Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC 5648162. PMID 29049335.
52. ^ a b Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
53. ^ a b Lekholm E, Perland E, Eriksson MM, Hellsten SV, Lindberg FA, Rostami J, Fredriksson R (2017). "Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability". Frontiers in Molecular Neuroscience. 10: 11. doi:10.3389/fnmol.2017.00011. PMC 5263138. PMID 28179877.
54. ^ Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
55. ^ Ceder MM, Aggarwal T, Hosseini K, Maturi V, Patil S, Perland E, et al. (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8: 580291. doi:10.3389/fcell.2020.580291. PMC 7591606. PMID 33163493.

SLC Tables. SLCtables

## External links

[edit]

* Outline of families
* Datasets and Reagents on the Solute Carrier Family
* List of proteins at HGNC website

* v
* t
* e

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

| (1):|

* high affinity glutamate and neutral amino-acid transporter
* SLC1A1
* 2
* 3
* 4
* 5
* 6
* 7

|

(2):|

* facilitative GLUT transporter
* SLC2A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14

(3):|

* heavy subunits of heterodimeric amino-acid transporters
* SLC3A1
* 2

(4):|

* bicarbonate transporter
* SLC4A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11

(5):|

* sodium glucose cotransporter
* SLC5A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12

(6):|

* sodium\- and chloride\- dependent sodium:neurotransmitter symporters
* SLC6A1
* SLC6A2
* SLC6A3
* SLC6A4
* SLC6A5
* SLC6A6
* SLC6A7
* SLC6A8
* SLC6A9
* SLC6A10
* SLC6A11
* SLC6A12
* SLC6A13
* SLC6A14
* SLC6A15
* SLC6A16
* SLC6A17
* SLC6A18
* SLC6A19
* SLC6A20

(7):|

* cationic amino-acid transporter/glycoprotein-associated
* SLC7A1
* SLC7A2
* SLC7A3
* SLC7A4
* glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters
* SLC7A5
* SLC7A6
* SLC7A7
* SLC7A8
* SLC7A9
* SLC7A10
* SLC7A11
* SLC7A13
* SLC7A14

(8):|

* Na+/Ca2+ exchanger
* SLC8A1
* SLC8A2
* SLC8A3

(9):|

* Na+/H+ exchanger
* SLC9A1
* SLC9A2
* SLC9A3
* SLC9A4
* SLC9A5
* SLC9A6
* SLC9A7
* SLC9A8
* SLC9A9
* SLC9A10
* SLC9A11

(10):|

* sodium bile salt cotransport
* SLC10A1
* SLC10A2
* SLC10A3
* SLC10A4
* SLC10A5
* SLC10A6
* SLC10A7
* 10A1
* 10A2
* 10A3
* 10A7

SLC11–20

| (11):|

* proton coupled metal ion transporter
* SLC11A1
* SLC11A211A3

|

(12):|

* electroneutral cation-Cl cotransporter
* SLC12A1
* SLC12A2
* SLC12A3
* SLC12A4
* SLC12A5
* SLC12A6
* SLC12A7
* SLC12A8
* SLC12A9

(13):|

* human Na+-sulfate/carboxylate cotransporter
* SLC13A1
* SLC13A2
* SLC13A3
* SLC13A4
* SLC13A5

(14):|

* urea transporter
* SLC14A1
* SLC14A2

(15):|

* proton oligopeptide cotransporter
* SLC15A1
* SLC15A2
* SLC15A3
* SLC15A4

(16):|

* monocarboxylate transporter
* SLC16A1
* SLC16A2
* SLC16A3
* SLC16A4
* SLC16A5
* SLC16A6
* SLC16A7
* SLC16A8
* SLC16A9
* SLC16A10
* SLC16A11
* SLC16A12
* SLC16A13
* SLC16A14

(17):|

* Vesicular glutamate transporter 1
* SLC17A1
* SLC17A2
* SLC17A3
* SLC17A4
* SLC17A5
* SLC17A6
* SLC17A7
* SLC17A8
* SLC17A9

(18):|

* vesicular monoamine transporter
* SLC18A1
* SLC18A2
* SLC18A3

(19):|

* folate/thiamine transporter
* SLC19A1
* SLC19A2
* SLC19A3

(20):|

* type III Na+-phosphate cotransporter
* SLC20A1
* SLC20A2

SLC21–30

| (21):|

* Organic anion-transporting polypeptide
* SLCO1A2
* SLCO1B1
* SLCO1B3
* SLCO1B4
* SLCO1C1
*     * SLCO2A1
* SLCO2B1
*     * SLCO3A1
*     * SLCO4A1
* SLCO4C1
*     * SLCO5A1(SLCO6A1)

|

(22):|

* organic cation/anion/zwitterion transporter
* SLC22A1
* SLC22A2
* SLC22A3
* SLC22A4
* SLC22A5
* SLC22A6
* SLC22A7
* SLC22A8
* SLC22A9
* SLC22A10
* SLC22A11
* SLC22A12
* SLC22A13
* SLC22A14
* SLC22A15
* SLC22A16
* SLC22A17
* SLC22A18
* SLC22A19
* SLC22A20

(23):|

* Na+-dependent ascorbic acid transporter
* SLC23A1
* SLC23A2
* SLC23A3
* SLC23A4

(24):|

* Na+/(Ca2+-K+) exchanger
* SLC24A1
* SLC24A2
* SLC24A3
* SLC24A4
* SLC24A5
* SLC24A6

(25):|

* mitochondrial carrier
* SLC25A1
* SLC25A2
* SLC25A3
* SLC25A4
* SLC25A5
* SLC25A6
* SLC25A7
* SLC25A8
* SLC25A9
* SLC25A10
* SLC25A11
* SLC25A12
* SLC25A13
* SLC25A14
* SLC25A15
* SLC25A16
* SLC25A17
* SLC25A18
* SLC25A19
* SLC25A20
* SLC25A21
* SLC25A22
* SLC25A23
* SLC25A24
* SLC25A25
* SLC25A26
* SLC25A27
* SLC25A28
* SLC25A29
* SLC25A30
* SLC25A31
* SLC25A32
* SLC25A33
* SLC25A34
* SLC25A35
* SLC25A36
* SLC25A37
* SLC25A38
* SLC25A39
* SLC25A40
* SLC25A41
* SLC25A42
* SLC25A43
* SLC25A44
* SLC25A45
* SLC25A46

(26):|

* multifunctional anion exchanger
* SLC26A1
* SLC26A2
* SLC26A3
* SLC26A4
* SLC26A5
* SLC26A6
* SLC26A7
* SLC26A8
* SLC26A9
* SLC26A10
* SLC26A11

(27):|

* fatty acid transport proteins
* SLC27A1
* SLC27A2
* SLC27A3
* SLC27A4
* SLC27A5
* SLC27A6

(28):|

* Na+-coupled nucleoside transport (SLC28A1
* SLC28A2
* SLC28A3

(29):|

* facilitative nucleoside transporter
* SLC29A1
* SLC29A2
* SLC29A3
* SLC29A4

(30):|

* zinc efflux
* SLC30A1
* SLC30A2
* SLC30A3
* SLC30A4
* SLC30A5
* SLC30A6
* SLC30A7
* SLC30A8
* SLC30A9
* SLC30A10

SLC31–40

| (31):|

* copper transporter
* SLC31A1

|

(32):|

* Vesicular glutamate transporter 1
* SLC32A1

(33):|

* Acetyl-CoA transporter
* SLC33A1

(34):|

* type II Na+-phosphate cotransporter
* SLC34A1
* SLC34A2
* SLC34A3

(35):|

* nucleoside-sugar transporter
* SLC35A1
* SLC35A2
* SLC35A3
* SLC35A4
* SLC35A5
*     * SLC35B1
* SLC35B2
* SLC35B3
* SLC35B4
*     * SLC35C1
* SLC35C2
*     * SLC35D1
* SLC35D2
* SLC35D3
*     * SLC35E1
* SLC35E2
* SLC35E3
* SLC35E4

(36):|

* proton-coupled amino-acid transporter
* SLC36A1
* SLC36A2
* SLC36A3
* SLC36A436A2

(37):|

* sugar-phosphate/phosphate exchanger
* SLC37A1
* SLC37A2
* SLC37A3
* SLC37A4

(38):|

* System A & N, sodium-coupled neutral amino-acid transporter
* SLC38A1
* SLC38A2
* SLC38A3
* SLC38A4
* SLC38A5
* SLC38A6
* SLC38A10

(39):|

* metal ion transporter
* SLC39A1
* SLC39A2
* SLC39A3
* SLC39A4
* SLC39A5
* SLC39A6
* SLC39A7
* SLC39A8
* SLC39A9
* SLC39A10
* SLC39A11
* SLC39A12
* SLC39A13
* SLC39A14

(40):|

* basolateral iron transporter
* SLC40A1

SLC41–48

| (41):|

* Magnesium transporter E
* SLC41A1
* SLC41A2
* SLC41A3

|

(42):|

* Ammonia transporter
* RhAG
* RhBG
* RhCG

(43):|

* Na+-independent, system-L like amino-acid transporter
* SLC43A1
* SLC43A2
* SLC43A3

(44):|

* Choline-like transporter
* SLC44A1
* SLC44A2
* SLC44A3
* SLC44A4
* SLC44A5

(45):|

* Putative sugar transporter
* SLC45A1
* SLC45A2
* SLC54A3
* SLC45A4

(46):|

* Folate transporter
* SLC46A1
* SLC46A2

(47):|

* multidrug and toxin extrusion
* SLC47A1
* SLC47A2

(48):|

* Heme transporter

SLCO1–4

* O1A2
* O1B1
* O1B3
* O2B1
* O431
* O4A1

Ion pumps

| Symporter, Cotransporter|

* Na+/K+,Cl−
* Na+/Pi3
* Na+/Cl−
* Na+/glucose
* Na+/I−
* Cl−/K+
* 4
* 5

|

Antiporter (exchanger)|

* Na+/H+
* Na+/Ca2+
* Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
* Cl−-formate
* Cl−-oxalate

see also solute carrier disorders

* v
* t
* e

Genetic disorder, membrane: Solute carrier disorders

1-10|

* SLC1A3
* Episodic ataxia 6
* SLC1A4
* SPATCCM
* SLC2A1
* De Vivo disease
* SLC2A2
* Fanconi-Bickel syndrome
* SLC2A5
* Fructose malabsorption
* SLC2A10
* Arterial tortuosity syndrome
* SLC3A1
* Cystinuria
* SLC4A1
* Hereditary spherocytosis 4/Hereditary elliptocytosis 4
* SLC4A11
* Congenital endothelial dystrophy type 2
* Fuchs' dystrophy 4
* SLC5A1
* Glucose-galactose malabsorption
* SLC5A2
* Renal glycosuria
* SLC5A5
* Thyroid dyshormonogenesis type 1
* SLC6A19
* Hartnup disease
* SLC7A7
* Lysinuric protein intolerance
* SLC7A9
* Cystinuria

11-20|

* SLC11A1
* Crohn's disease
* SLC12A3
* Gitelman syndrome
* SLC16A1
* HHF7
* SLC16A2
* Allan–Herndon–Dudley syndrome
* SLC17A3
* Von Gierke's disease, GSD-Ic
* SLC17A5
* Salla disease
* SLC17A8
* DFNA25

21-40|

* SLC26A2
* Multiple epiphyseal dysplasia 4
* Achondrogenesis type 1B
* Recessive multiple epiphyseal dysplasia
* Atelosteogenesis, type II
* Diastrophic dysplasia
* SLC26A4
* Pendred syndrome
* SLC35C1
* CDOG 2C
* SLC37A4
* Von Gierke's disease, GSD-Ib
* SLC39A4
* Acrodermatitis enteropathica
* SLC40A1
* African iron overload

51-60|

* SLC54A1 (Mitochondrial pyruvate carrier deficiency)

see also solute carrier family
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