Spi-1 (PU.1) 5′ UTR regulatory element

RNA element in Spi-1 mRNA

Spi-1 (PU.1) 5′ UTR regulatory element

Predicted secondary structure and sequence conservation of Spi-1

Identifiers
Symbol| Spi-1
Rfam| RF00232
Other data
RNA type| Cis-reg
Domain(s)| Eukaryota
SO| SO:0000204
PDB structures| PDBe

The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.[1]

## See also

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* InvR

## References

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1. ^ a b Hensold JO, Stratton CA, Barth D (July 1997). "The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo". Nucleic Acids Research. 25 (14): 2869–2876. doi:10.1093/nar/25.14.2869. PMC 146829. PMID 9207037.

## External links

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*   * Page for Spi-1 (PU.1) 5′ UTR regulatory element at Rfam

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