Substituted phenethylamine

Chemical class of organic compounds

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Substituted phenethylamine

Drug class

The structural formula of phenethylamine with marked substitution points. Phenethylamine is obtained when
R2=R3=R4=R5=R6=RN=Rα=Rβ=H.

Class identifiers
Chemical class| Substituted derivatives of phenethylamine
Legal status
In Wikidata

Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure;[note 1] the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens.

## Structural classification

[edit]

The structure of the parent phenethylamine

The structural formula of any substituted phenethylamine contains a phenyl ring that is joined to an amino (NH) group via a two-carbon sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a specific group of atoms. Several classes of substances can be considered phenylethylamine derivatives such as Substituted amphetamines, where there is a methyl group substituted at the alpha position on the ethyl chain, Substituted methylenedioxyphenethylamines, where a methylenedioxy group is joined at the 3 and 4 positions on the phenyl ring, and Substituted cathinones, which have a carbonyl group substituted at the beta position on the ethyl chain, most of which also have a methyl group substituted at the alpha positioning making most cathinones substituted amphetamines as well.

## Pharmacology

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Most substituted phenethylamines are psychoactive drugs which belong to a variety of different drug classes, including central nervous system stimulants (e.g., amphetamine), hallucinogens (e.g., 3,4,5-trimethoxyphenethylamine a.k.a. mescaline), 2,5-dimethoxy-4-methylamphetamine a.k.a. DOM), entactogen (e.g. MDA), appetite suppressants (e.g. phentermine), nasal decongestants and bronchodilators (e.g., levomethamphetamine and pseudoephedrine), antidepressants (e.g. bupropion and phenelzine), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others.[1][2] Many of these psychoactive compounds exert their pharmacological effects primarily by modulating monoamine neurotransmitter systems; however, there is no known mechanism of action or biological target that is common to all members of this subclass.[medical citation needed]

## Examples

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Numerous endogenous compounds – including hormones, catecholamines such as dopamine and noradrenaline, and many trace amines (e.g. adrenaline, phenethylamine itself, tyramine, thyronamine, and iodothyronamine) – are substituted phenethylamines. Several notable recreational drugs, such as MDPV (Monkey Dust), MDMA (ecstasy), methamphetamine, and cathinone, are also members of the class. Many well-known prescription drugs are from the phenylethylamine class such as Adderall which uses Amphetamine, Desoxyn which uses methamphetamine, and Sudafed which uses pseudoephedrine.

## List of substituted phenethylamines

[edit]

Selected Phenethylamines  Structure  | Short Name  | RN | Rα | Rβ | R2 | R3 | R4 | R5 | Full Name  | Biologic activity

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| meta-Tyramine |  |  |  |  | OH |  |  | 3-hydroxyphenethylamine | Trace amine
| para-Tyramine |  |  |  |  |  | OH |  | 4-hydroxyphenethylamine | Trace amine
| Dopamine |  |  |  |  | OH | OH |  | 3,4-dihydroxyphenethylamine | Catecholamine neurotransmitter
| Epinephrine (Adrenaline) | CH3 |  | OH |  | OH | OH |  | β,3,4-trihydroxy-N-methylphenethylamine | Catecholamine neurotransmitter/Fight or Flight hormone
| Norepinephrine (Noradrenaline) |  |  | OH |  | OH | OH |  | β,3,4-trihydroxyphenethylamine | Catecholamine neurotransmitter/Fight or Flight hormone
| Norfenefrine |  |  | OH |  | OH |  |  | β,3-dihydroxyphenethylamine | Trace amine
| para-Octopamine |  |  | OH |  |  | OH |  | β,4-dihydroxyphenethylamine | Trace aminergic α-adrenoceptor agonist
| Oxidopamine |  |  |  | OH |  | OH | OH | 2,4,5-trihydroxyphenethylamine | neurotoxic agent for the dopamine and norepinephrine receptors
| Phenylephrine | CH3 |  | OH |  | OH |  |  | β,3-dihydroxy-N-methylphenethylamine | α-adrenergic agonist; decongestant
| Isoprenaline | CH(CH3)2 |  | OH  |  | OH  | OH  |  | β,3-dihydroxy-N-isopropylphenethylamine  | β-adrenergic agonist; decongestant
| Salbutamol | C(CH3)3 |  | OH |  | CH2OH | OH |  | β,4-dihydroxy-3-hydroxymethyl-N-tert-butylphenethylamine | Short-action β2-adrenergic agonist
| β-Methylphenethylamine |  |  | CH3 |  |  |  |  | β-methylphenethylamine | Stimulant
| Amphetamine |  | CH3 |  |  |  |  |  | α-methylphenethylamine | Monoamine releasing agent; Stimulant
| N-Methylphenethylamine | CH3 |  |  |  |  |  |  | N-methylphenethylamine | Trace amine; endogenous amphetamine isomer
| N,N-Dimethylphenethylamine | (CH3)2 |  |  |  |  |  |  | N,N-dimethylphenethylamine | Trivial effects (used as a food additive and flavoring agent)
| Methamphetamine | CH3 | CH3 |  |  |  |  |  | N-methylamphetamine; N,α-dimethylphenethylamine | Monoamine releasing agent; stimulant; neurotoxin
| Phentermine |  | (CH3)2 |  |  |  |  |  | α-methylamphetamine; α,α-dimethylphenethylamine | Stimulant, anorectic
| Ortetamine |  | CH3 |  | CH3 |  |  |  | 2-methylamphetamine; 2,α-dimethylphenethylamine | Stimulant, anorectic
| Phenelzine | NH2 |  |  |  |  |  |  | β-phenylethylhydrazine  | Monoamine oxidase inhibitor
| Tranylcypromine |  | -CH2\-  |  |  |  |  | 2-phenylcyclopropylamine  | Monoamine oxidase inhibitor
| Selegiline | -CH2-C≡CH  | CH3 |  |  |  |  |  | N,α-dimethyl-N-2-propynylphenethylamine  | MAO-B selective monoamine oxidase inhibitor
| Methylphenidate | -CH2-CH2-CH2-CH2- | C(OCH3)=O |  |  |  |  | N,α-butylene-β-methoxycarbonylphenethylamine | NDRI; Stimulant
| Ephedrine / Pseudoephedrine | CH3 | CH3 | OH |  |  |  |  | N-methyl-β-hydroxyamphetamine | Releasing agent; stimulant; decongestant
| Cathine |  | CH3 | OH |  |  |  |  | d-β-hydroxyamphetamine | Moderately selective norepinephrine releasing agent
| Cathinone |  | CH3 | =O |  |  |  |  | β-ketoamphetamine | Selective norepinephrine and dopamine releasing agent
| Methcathinone | CH3 | CH3 | =O |  |  |  |  | N-methylcathinone | Selective norepinephrine and dopamine releasing agent
| Mephedrone | CH3 | CH3 | =O |  |  | CH3 |  | 4-methylmethcathinone | Stimulant, unknown pharmacodynamic actions
| Ethcathinone | CH2CH3 | CH3 | =O |  |  |  |  | N-ethylcathinone | Stimulant and norepinephrine releasing agent
| Amfepramone (diethylpropion) | C2H5, C2H5[note 2] | CH3 | =O |  |  |  |  | N-diethyl-β-ketoamphetamine | Anorectic
| Bupropion | C(CH3)3 | CH3 | =O |  |  |  | Cl | 5-chloro-N-tert-butyl-β-ketoamphetamine | NDRI
| Norfenfluramine |  | CH3 |  |  | CF3 |  |  | 3-trifluoromethyl-amphetamine | SSRA
| Fenfluramine | CH2CH3 | CH3 |  |  | CF3 |  |  | 3-trifluoromethyl-N-ethylamphetamine | SSRA
| 5-APB |  | CH3 |  |  | -CH=CH-O- |  | 5-(2-aminopropyl)benzofuran | Stimulant, entactogen
| 6-APB |  | CH3 |  |  | -O-CH=CH- |  | 6-(2-aminopropyl)benzofuran | Stimulant, entactogen
| MDA |  | CH3 |  |  | -O-CH2-O- |  | 3,4-methylenedioxy-amphetamine | Stimulant, psychedelic, entactogen
| MDEA | CH2CH3 | CH3 |  |  | -O-CH2-O- |  | 3,4-methylenedioxy-N-ethylamphetamine | Psychedelic, entactogen, and releasing agent
| MDMA | CH3 | CH3 |  |  | -O-CH2-O- |  | 3,4-methylenedioxy-N-methylamphetamine | Psychedelic, entactogen, and releasing agent
| MDMC | CH3 | CH3 | =O |  | -O-CH2-O- |  | 3,4-methylenedioxymethcathinone | Psychedelic, entactogen, and releasing agent
| MMDA |  | CH3 |  |  | -O-CH2-O- | OCH3 | 5-methoxy-3,4-methylenedioxy-amphetamine | Stimulant, psychedelic and entactogen
| MMDMA | CH3 | CH3 |  |  | -O-CH2-O- | OCH3 | 5-methoxy-3,4-methylenedioxy-N-methylamphetamine | Psychedelic, entactogen, and releasing agent
| Lophophine |  |  |  |  | -O-CH2-O- | OCH3 | 5-methoxy-3,4-methylenedioxyphenethylamine | Psychedelic and entactogen
| Mescaline |  |  |  |  | OCH3 | OCH3 | OCH3 | 3,4,5-trimethoxyphenethylamine | Psychedelic and entactogen
| Proscaline |  |  |  |  | OCH3 | OCH2CH2CH3 | OCH3 | 2-(3,5-dimethoxy-4-propoxyphenyl)ethanamine | Psychedelic and entactogen
| Metaescaline |  |  |  |  | OCH2CH3 | OCH3 | OCH3 | 2-(3-ethoxy-4,5-dimethoxyphenyl)ethanamine | Psychedelic and entactogen
| Allylescaline |  |  |  |  | OCH3 | OCH2CH1CH2 | OCH3 | 4-Allyloxy-3,5-dimethyloxyphenylethylamine | Psychedelic and entactogen
| Methallylescaline |  |  |  |  | OCH3 | OCH2C(CH2CH3) | OCH3 | 4-Methallyloxy-3,5-dimethoxyphenethylamine | Psychedelic and entactogen
| Asymbescaline |  |  |  |  | OCH2CH3 | OCH2CH3 | OCH3 | 3,4-Diethoxy-5-methoxyphenethylamine | Psychedelic and euphoriant
| DOM |  | CH3 |  | OCH3 |  | CH3 | OCH3 | 2,5-dimethoxy-4-methylamphetamine | Psychedelic
| DOB |  | CH3 |  | OCH3 |  | Br | OCH3 | 2,5-dimethoxy-4-bromoamphetamine | Psychedelic
| DOC |  | CH3 |  | OCH3 |  | Cl | OCH3 | 2,5-dimethoxy-4-chloroamphetamine | Psychedelic
| DOI |  | CH3 |  | OCH3 |  | I | OCH3 | 2,5-dimethoxy-4-iodoamphetamine | Psychedelic
| DON |  | CH3 |  | OCH3 |  | NO2 | OCH3 | 2,5-dimethoxy-4-nitroamphetamine | Stimulant
| 2C-B |  |  |  | OCH3 |  | Br | OCH3 | 2,5-dimethoxy-4-bromophenethylamine | Psychedelic, stimulant, entactogen and euphoriant
| βk-2C-B |  |  | =O | OCH3 |  | Br | OCH3 | 2,5-dimethoxy-4-bromo-β-ketophenethylamine | Psychedelic, stimulant, entactogen and euphoriant
| 2C-C |  |  |  | OCH3 |  | Cl | OCH3 | 2,5-dimethoxy-4-chlorophenethylamine | Psychedelic
| 2C-F |  |  |  | OCH3 |  | F | OCH3 | 2,5-dimethoxy-4-fluorophenethylamine | Psychedelic
| 2C-I |  |  |  | OCH3 |  | I | OCH3 | 2,5-dimethoxy-4-iodophenethylamine | Psychedelic, stimulant
| 2C-D |  |  |  | OCH3 |  | CH3 | OCH3 | 2,5-dimethoxy-4-methylphenethylamine | Psychedelic, stimulant
| 2C-E |  |  |  | OCH3 |  | CH2-CH3 | OCH3 | 2,5-dimethoxy-4-ethylphenethylamine | Psychedelic
| 2C-P |  |  |  | OCH3 |  | CH2-CH3-CH3 | OCH3 | 2,5-dimethoxy-4-propylphenethylamine | Entactogen, euphoriant and Psychedelic
| 2C-N |  |  |  | OCH3 |  | NO2 | OCH3 | 2,5-dimethoxy-4-nitrophenethylamine | euphoriant
| 2C-O-4 |  |  |  | OCH3 |  | (CH3)2CHO | OCH3 | 2,5-Dimethoxy-4-propoxyphenethylamine | Hallucinogen, psychedelic and entheogenic[3]
| 2C-T-2 |  |  |  | OCH3 |  | S-CH2CH3 | OCH3 | 2,5-dimethoxy-4-ethylthio-phenethylamine | Psychedelic
| 2C-T-4 |  |  |  | OCH3 |  | S-CH(CH3)2 | OCH3 | 2,5-dimethoxy-4-isopropylthio-phenethylamine | Psychedelic
| 2C-T-7 |  |  |  | OCH3 |  | S-CH2CH2CH3 | OCH3 | 2,5-dimethoxy-4-propylthio-phenethylamine | Psychedelic
| 2C-T-8 |  |  |  | OCH3 |  | S-CH2-C3H5 | OCH3 | 2,5-dimethoxy-4-cyclopropylmethylthio-phenethylamine | Psychedelic
| 2C-T-19 |  |  |  | OCH3 |  | S-C(CH3)3 | OCH3 | 2,5-dimethoxy-4-tert-butylthio-phenethylamine | Psychedelic
| 2C-T-21 |  |  |  | OCH3 |  | S-CH2-CH2-F | OCH3 | 2,5-dimethoxy-4-(2-fluoroethylthio)-phenethylamine | Psychedelic and euphoriant
| 25B-NBOMe[4] | CH2-C6H4-OCH3 |  |  | OCH3 |  | Br | OCH3 | 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25C-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | Cl | OCH3 | 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25F-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | F | OCH3 | 2-(4-fluoro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25I-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | I | OCH3 | 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25D-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | CH2 | OCH3 | 2-(4-methyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25E-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | CH2-CH3 | OCH3 | 2-(4-ethyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| 25P-NBOMe | CH2-C6H4-OCH3 |  |  | OCH3 |  | CH2-CH3-CH3 | OCH3 | 2-(4-propyl-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | Psychedelic
| Mescaline-NBOMe | CH2-C6H4-OCH3 |  |  |  | OCH3 | OCH3 | OCH3 | N-(2-Methoxybenzyl)-2-(3,4,5-trimethoxyphenyl)ethanamine | Psychedelic
| 25B-NBOH | CH2–C6H4–OH |  |  | OCH3 |  | Br | OCH3 | N-(2-hydroxybenzyl)-2,5-dimethoxy-4-bromo-phenethylamine | Psychedelic
| 25C-NBOH | CH2–C6H4–OH |  |  | OCH3 |  | Cl | OCH3 | N-(2-hydroxybenzyl)-2,5-dimethoxy-4-chloro-phenethylamine | Psychedelic
| 25I-NBOH | CH2–C6H4–OH |  |  | OCH3 |  | I | OCH3 | N-(2-hydroxybenzyl)-2,5-dimethoxy-4-iodo-phenethylamine | Psychedelic
| 25I-NBF | CH2–C6H4–F |  |  | OCH3 |  | I | OCH3 | N-(2-fluorobenzyl)-2,5-dimethoxy-4-iodo-phenethylamine | Psychedelic
| Short Name  | RN | Rα | Rβ | R2 | R3 | R4 | R5 | Full Name  | Biologic activity

## Detection

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This section needs expansion. You can help by adding to it. (December 2015)

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Method  | Requirement

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UV spectrometry  | Reagent needed

Detection of substituted phenethylamines, which include compounds such as 2C-B, MDMA, and other designer drugs, involves various analytical methods aimed at identifying these psychoactive substances. These compounds are structurally similar to amphetamines, making their detection challenging due to potential cross-reactivity in standard drug tests. Techniques like gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), and immunoassay screenings are commonly employed for accurate identification. Advanced methods like high-performance liquid chromatography (HPLC) allow for precise separation and quantification of these substances even at low concentrations. Given the rising use of these drugs in recreational settings, developing sensitive and specific detection techniques remains crucial in forensic toxicology and clinical diagnostics.[citation needed]

## Cyclized phenethylamines

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There are many cyclized phenethylamines. Examples include the following:

* Phenylalkylpyrrolidines like α-PVP, pyrovalerone, and prolintane
* Tetrahydroisoquinolines like anhalinine, pellotine, lophophorine, DOM-CR, nomifensine, tetrabenazine, and zelandopam
* Isoquinolines like perafensine, quinisocaine, and tilisolol
* Dihydroindoles and aminochromes like adrenochrome and adrenolutin
* 2-Aminoindanes like 2-aminoindane, MDAI, MMAI, and DOM-AI
* 2-Aminotetralins like 2-aminotetralin, MDAT, DOM-AT, 8-OH-DPAT, and rotigotine
* 1-Aminomethylindanes like 2CB-Ind, AMMI, and jimscaline
* Benzazepines like fenoldopam and lorcaserin
* Benzocyclobutenes like 2CBCB-NBOMe, S33005, TCB-2, and tomscaline
* Tetrahydrobenzopyranylamines like CT-5126
* Benzoxepins like TFMBOX
* 2-Benzylpiperidines and phenidates like 2-benzylpiperidine and methylphenidate
* Phenylcyclopropylamines like tranylcypromine, TMT, and DMCPA
* 3-Phenylpiperidines like 3-phenylpiperidine, 3-PPP, OSU-6162 (PNU-96391), LPH-5, LPH-48, and Z3517967757 (Z7757)
* 2-Phenylmorpholines like 2-phenylmorpholine, phenmetrazine, manifaxine, radafaxine, flumexadol, oxaflozane, and PF-219,061
* Phenyloxazolamines or aminorex analogues like aminorex and pemoline
* Tricyclic compounds like benzoctamine and dizocilpine
* Ergolines and lysergamides like LSD
* Partial ergolines and lysergamides like NDTDI, RU-27849, DEIMDHPCA, and DEMPDHPCA
* Pyridopyrroloquinoxalines like lumateperone, IHCH-7113, IHCH-7086, and ITI-1549
* Others like 6-AB, 2-ADN, 2C-B-PYR, 2CBecca, 2CJP, 2CLisaB, 2CLisaH, 2-naphthylamine, GYKI-52895, ivabradine, milnacipran, Org 6582, rimiterol, and ZC-B

Other cyclized phenethylamines have also been described.[5][6][7]

Other related families include phenylpiperazines, benzylpiperazines, and 4-phenylpiperidines.

## See also

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* Substituted amphetamine
* Substituted methylenedioxyphenethylamine
* Substituted cathinone
* Substituted phenylmorpholine
* Substituted methoxyphenethylamine
* 2C, DOx, 4C, Ψ-PEA, scaline, 3C, 25-NB, FLY
* Substituted tryptamine
* PiHKAL
* The Shulgin Index

## Notes

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1. ^ In other words, all of the compounds that belong to this class are structural analogs of phenethylamine.
2. ^ Two ethyl groups attached to the amine group

## References

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1. ^ Inan F, Brunt TM, Contrucci RR, Hondebrink L, Franssen EJ (April 2020). "Novel Phenethylamines and Their Potential Interactions With Prescription Drugs: A Systematic Critical Review". Therapeutic Drug Monitoring. 42 (2): 271–281\. doi:10.1097/ftd.0000000000000725. PMID 32022784.
2. ^ Wills B, Erickson T (9 March 2012). "Psychoactive Phenethylamine, Piperazine, and Pyrrolidinophenone Derivatives". In Barceloux DG (ed.). Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Wiley. pp. 156–192\. doi:10.1002/9781118105955.ch10. ISBN 978-0-471-72760-6.
3. ^ Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. 2C-O-4 Entry in PiHKAL
4. ^ Custodio RJ, Sayson LV, Botanas CJ, Abiero A, You KY, Kim M, et al. (November 2020). "25B-NBOMe, a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: Evidence of abuse potential". Addiction Biology. 25 (6): e12850. doi:10.1111/adb.12850. PMID 31749223.
5. ^ Nichols DE (August 1981). "Structure-activity relationships of phenethylamine hallucinogens". J Pharm Sci. 70 (8): 839–849\. doi:10.1002/jps.2600700802. PMID 7031221.
6. ^ Wolters RJ, Bej AJ, Tanner NS (September 1974). "Conformationally constrained analogs of mescaline". J Pharm Sci. 63 (9): 1379–1382\. doi:10.1002/jps.2600630909. PMID 4427260.
7. ^ Wolters RJ. "Synthesis of Conformationally Constrained Analogs of Mescaline as Potential Psychotomimetics". ProQuest. Retrieved 2 June 2025.

* v
* t
* e

Phenethylamines

Phenethylamines|

* Psychedelics: 3,4-DMPEA-NDEPA
* 25B-NBOMe
* 25C-NBOMe
* 25D-NBOMe
* 25D-NM-NDEAOP
* 25H-NBOMe
* 25I-NBOMe
* 25N-NBOMe
* 25O-NBOMe
* 2C-B
* 2C-B-AN
* 2C-Bn
* 2C-Bu
* 2C-C
* 2C-CN
* 2C-CP
* 2C-D
* 2C-E
* 2C-EF
* 2C-F
* 2C-G
* 2C-G-2
* 2C-G-3
* 2C-G-4
* 2C-G-5
* 2C-G-6
* 2C-G-N
* 2C-H
* 2C-I
* 2C-iBu
* 2C-iP
* 2C-N
* 2C-NH2
* 2C-O
* 2C-O-2
* 2C-O-4
* 2C-P
* 2C-Ph
* 2C-SE
* 2C-T
* 2C-T-2
* 2C-T-3
* 2C-T-4
* 2C-T-5
* 2C-T-6
* 2C-T-7
* 2C-T-8
* 2C-T-9
* 2C-T-10
* 2C-T-11
* 2C-T-12
* 2C-T-13
* 2C-T-14
* 2C-T-15
* 2C-T-16
* 2C-T-17
* 2C-T-18
* 2C-T-19
* 2C-T-20
* 2C-T-21
* 2C-T-22
* 2C-T-22.5
* 2C-T-23
* 2C-T-24
* 2C-T-25
* 2C-T-27
* 2C-T-28
* 2C-T-30
* 2C-T-31
* 2C-T-32
* 2C-T-33
* 2C-tBu
* 2C-TFE
* 2C-TFM
* 2C-YN
* 2C-V
* Allylescaline
* CT-5172
* DESOXY
* Escaline
* Isoproscaline
* M-NDEPA
* Macromerine
* MEPEA
* Mescaline
* Metaescaline
* Methallylescaline
* N-DEAOP-NMPEA
* N-Methylmescaline
* Proscaline
* Psi-2C-T-4

* Stimulants: Phenylethanolamine
* Hordenine
* Phenethylamine
* Phenpromethamine
* α-Methylphenethylamine (amphetamine)
* β-Methylphenethylamine
* m-Methylphenethylamine
* N-Methylphenethylamine
* o-Methylphenethylamine
* p-Methylphenethylamine
* Phenacylamine (β-ketophenethylamine)
* Solriamfetol

* Entactogens: Lophophine
* MDPEA
* MDMPEA

* Others: Amidephrine
* ASR-2001
* Biscaline
* BOH
* Buscaline
* Denopamine
* Desvenlafaxine
* DMPEA
* F-17475
* Phenibut
* Pronethalol
* Salbutamol
* Levosalbutamol
* Trichocereine
* Venlafaxine

Amphetamines|

* Psychedelics: 3C-AL
* 3C-BZ
* 3C-E
* 3C-MAL
* 3C-P
* Aleph
* Beatrice
* Bromo-DragonFLY
* D-Deprenyl
* DMA
* DMMDA
* DOB
* DOB-NDEPA
* DOC
* DOEF
* DOET
* DOI
* DOI-NDEPA
* DOM
* DOM-NDEPA
* DON
* DOPR
* DOTFM
* DOTFM-NDEPA
* Ganesha
* MMDA
* MMDA-2
* Psi-DOM
* TMA
* TMA-2
* TMA-2-NDEPA
* TeMA
* ZDCM-04

* Stimulants: 2-FA
* 2-FMA
* 3-FA
* 3-FMA
* β-Phenylmethamphetamine
* Acridorex
* Alfetamine
* Amfecloral
* Amfepentorex
* Amphetamine
* Dextroamphetamine
* Levoamphetamine
* Amphetaminil
* Benfluorex
* Benzphetamine
* Cathine
* Clobenzorex
* Dimethylamphetamine
* Ephedrine
* Ephenidine
* Etafedrine
* Etilamfetamine
* Famprofazone
* Fencamfamin
* Fencamine
* Fenethylline
* Fenfluramine
* Dexfenfluramine
* Levofenfluramine
* Fenproporex
* Flucetorex
* Fludorex
* Formetorex
* Furfenorex
* Gepefrine
* 4-Hydroxyamphetamine
* Iofetamine
* Isopropylamphetamine
* Lefetamine
* Lisdexamfetamine
* Mefenorex
* Metaraminol
* Methamphetamine
* Dextromethamphetamine
* Levomethamphetamine
* Methoxamine
* Methoxyphenamine
* MMA
* Morforex
* Norfenfluramine
* L-Norpseudoephedrine
* α,N-Diethylphenylethylamine
* Oxifentorex
* Oxilofrine
* Ortetamine
* PBA
* PBMA
* PCA
* PCMA
* PFA
* PFMA
* PIA
* PIMA
* PMA
* PMEA
* PMMA
* Phenylpropanolamine
* Pholedrine
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Sibutramine
* Tiflorex
* Xylopropamine
* Zylofuramine

* Entactogens: 4-FA
* 4-FMA
* 4-MA
* 4-MMA
* 4-MTA
* 5-APB
* 5-APDB
* 5-EAPB
* 5-IT
* 5-MAPB
* 5-MAPDB
* 6-APB
* 6-APDB
* 6-Chloro-MDMA
* 6-EAPB
* 6-IT
* 6-MAPB
* 6-MAPDB
* EDA
* IAP
* 2,3-MDA
* 3,4-MDA (tenamfetamine)
* MDEA
* MDHMA
* MDMA (midomafetamine)
* MDOH
* Methamnetamine
* MMDMA
* Naphthylaminopropane
* TAP

* Others: 3,4-DCA
* Amiflamine
* Cafedrine
* Deprenyl
* D-Deprenyl
* Selegiline (L-deprenyl)
* DiFMDA
* Thiamphenicol
* UWA-101 (α-cPr-MDMA)

Phentermines|

* Stimulants: Chlorphentermine
* Cloforex
* Clortermine
* Etolorex
* Mephentermine
* Pentorex
* Phentermine

* Entactogens: MDPH
* MDMPH

* Others: Cericlamine

Cathinones|

* Stimulants: 3-FMC
* 4-MC
* 4-BMC
* 4-CMC
* 4-EMC
* 4-FMC
* 4-MEC
* 4-MeMABP
* 4-MPD
* Amfepramone
* Benzedrone
* Brephedrone
* Buphedrone
* Bupropion
* Cathinone
* Dimethylcathinone
* Ethcathinone
* Eutylone
* Hydroxybupropion
* Methcathinone
* Methedrone
* NEB
* N-Ethylhexedrone
* N-Ethylpentedrone
* Pentedrone
* Pentylone

* Entactogens: 3,4-DMMC
* 3-MMC
* Butylone
* Ethylone
* Methylone
* Methylenedioxycathinone
* Mephedrone
* Propylone

Phenylisobutylamines
(and further-extended)|

* Entactogens: 4-CAB
* 4-MAB
* Ariadne
* BDB
* Butylone
* EBDB
* Eutylone
* MBDB

* Stimulants: α-Propylphenethylamine
* Hexapradol
* Phenylisobutylamine (α-ethylphenethylamine)

Catecholamines
(and close relatives)|

* 6-FNE
* 6-OHDA
* α-Me-DA
* α-Me-TRA
* Adrenochrome
* Arbutamine
* Ciladopa
* D-DOPA (dextrodopa)
* Dimetofrine
* Dobutamine
* Dopamine
* Dopexamine
* Epinephrine (adrenaline)
* Epinine
* Etilefrine
* Ethylnorepinephrine
* Fenclonine
* Ibopamine
* Isoprenaline
* Isoetarine
* L-DOPA (levodopa)
* L-DOPS (droxidopa)
* L-Phenylalanine
* L-Tyrosine
* m-Tyramine
* Metanephrine
* Metaraminol
* Metaterol
* Metirosine
* Methyldopa
* N,N-Dimethyldopamine
* Nordefrin
* Levonordefrin
* Norepinephrine (noradrenaline)
* Norfenefrine (m-octopamine)
* Normetanephrine
* Orciprenaline
* p-Octopamine
* p-Tyramine
* Phenylephrine
* Synephrine
* Theodrenaline

Cyclized
phenethylamines|

| Phenylalkylpyrrolidines|

* α-PBP
* α-PHP
* α-PPP
* α-PVP
* MDPBP
* MDPPP
* MDPV
* 4-MePBP
* 4-MePHP
* 4-MePPP
* Fluorolintane
* MOPPP
* MOPVP
* MPBP
* MPHP
* MPPP
* Naphyrone
* PEP
* Prolintane
* Pyrovalerone

|

2-Benzylpiperidines
(phenidates)|

* 2-Benzylpiperidine
* 3-Bromomethylphenidate
* 3-Chloromethylphenidate
* 3-Methylmethylphenidate
* 3,4-Dichloro-2-benzylpiperidine
* 3,4-Dichloroethylphenidate
* 3,4-Dichloromethylphenidate
* 4-Bromoethylphenidate
* 4-Bromomethylphenidate
* 4-Chloromethylphenidate
* 4-Fluoroethylphenidate
* 4-Fluoroisopropylphenidate
* 4-Fluoromethylphenidate
* 4-Methyl-2-benzylpiperidine
* 4-Methylisopropylphenidate
* 4-Methylmethylphenidate
* 4-Nitromethylphenidate
* α-Acetyl-2-benzylpiperidine
* α-Keto-2-benzylpiperidine
* CPMBP
* Desoxypipradrol (2-DPMP)
* Difemetorex
* Ethylnaphthidate (HDEP-28)
* Ethylphenidate
* Isopropylnaphthidate
* Isopropylphenidate
* MDMPH
* Methylnaphthidate (HDMP-28)
* Methylphenidate
* Phacetoperane
* Pipradrol
* Propylphenidate
* Rimiterol
* Ritalinamide
* Ritalinic acid
* SCH-5472
* Serdexmethylphenidate

Phenylmorpholines
(phenmetrazines)|

* (2R,3R)-Hydroxybupropion
* 2-(2,5-Dimethoxy-4-bromophenyl)morpholine
* 2-Fluorophenmetrazine
* 2-Methylphenmetrazine
* 2-Phenylmorpholine
* 2-Phenyl-3,6-dimethylmorpholine
* 3-Chlorophenmetrazine (PAL-594)
* 3-Fluorophenetrazine
* 3-Fluorophenmetrazine (PAL-593)
* 3-Methoxyphenmetrazine
* 3-Methylphenmetrazine (PAL-773)
* 4-Fluorophenmetrazine (PAL-748)
* 4-Methylphendimetrazine
* 4-Methylphenmetrazine (PAL-747)
* 2C-B-morpholine
* Fenbutrazate
* Fenmetramide
* Flumexadol
* G-130
* Isophenmetrazine
* Manifaxine
* Methylenedioxyphenmetrazine
* Morazone
* N-Ethylphenmetrazol
* Naphthylmetrazine (PAL-704)
* Naphthylmorpholine (PAL-678)
* Oxaflozane
* PDM-35
* PF-219,061)
* Phendimetrazine
* Phenetrazine
* Phenmetetrazine
* Phenmetrazine
* Phenmetrazol
* Pseudophenmetrazine
* Radafaxine ((2S,3S)-hydroxybupropion)

Phenyloxazolamines
(aminorexes)|

* 3-Methylaminorex
* 4-Ethylaminorex (4-EAR)
* 4'-Fluoroaminorex
* 4-Methylaminorex (4-MAR)
* 4,4'-Dimethylaminorex (4,4'-DMAR)
* 2C-B-aminorex
* 2F-MAR
* 4B-MAR
* 4C-MAR
* 4F-MAR
* Aminorex
* Clominorex
* Cyclazodone
* Ephedroxane
* Fenozolone
* Fluminorex
* MDMAR
* Methylenedioxyaminorex (MDAR)
* N-Methylcyclazodone
* N,N-Dimethylaminorex
* Pemoline
* Thozalinone

Isoquinolines and
tetrahydroisoquinolines|

* Anhalamine
* Anhalidine
* Anhalinine
* Anhalonidine
* Anhalonine
* Anhalotine
* Arizonine
* Calycotomine
* Carnegine (pectenine)
* Corypalline
* Debrisoquine
* Deglucopterocereine
* Deutetrabenazine
* Diclofensine
* DOB-CR
* DOM-CR
* Esproquin
* Gigantine
* Hedycarine
* Heliamine
* Hydrastinine
* Hydrocotarnine
* Hydrohydrastinine (MDMTHIQ; MDMA-CR)
* Isoanhalamine
* Isoanhalidine
* Isoanhalonidine
* Isocorypalline
* Isopellotine
* Isosalsoline
* Lemaireocereine
* Longimammamine
* Longimammatine
* Longimammidine
* Longimammosine
* Lophocerine
* Lophophorine
* Lophotine
* MDMA-CR
* Mescalotam
* N-Methylanhalinine
* N-Methylheliamine
* N-Methylisosalsoline
* N-Methyl-DOM-CR (Beatrice-CR)
* N-Methyl-THIQ (METH-CR)
* Nomifensine
* Norsalsolinol
* Nortehaunine
* Norweberine
* O-Methylanhalonidine
* O-Methylpellotine
* Pachycereine
* Pellotine
* Perafensine
* Peyoglutam
* Peyophorine
* Peyotine
* PMMA-CR
* Quinisocaine
* Reticuline
* Salsolidine
* Salsoline
* Salsolinol
* TDIQ (MDTHIQ, MDA-CR)
* Tehaunine
* Tehaunine N-oxide
* Tepenine
* Tetrabenazine
* Tetrahydroisoquinoline (THIQ; AMPH-CR)
* Tetrahydropapaveroline
* Tilisolol
* Tretoquinol
* Uberine
* Valbenazine
* Weberidine
* Weberine
* Zelandopam

2-Aminoindanes|

* 2-Aminoindane (2-AI)
* 5-IAI
* Aprindine
* BFAI
* BFMAI
* DHAI
* DOM-AI
* ETAI
* Indanorex
* Indantadol
* MDAI
* MDMAI
* MEAI (5-MeO-AI)
* MMAI
* NM-2-AI
* PNU-99,194
* TAI

2-Aminotetralins|

* 2-Aminotetralin (2-AT)
* 5-OH-DPAT
* 6-CAT
* 7-OH-DPAT
* 8-OH-DPAT
* AS-19
* CHF-1024
* DOM-AT
* MDAT
* MDMAT
* Nolomirole
* UH-232

Others / unsorted|

* 1-Aminomethylindanes (e.g., 2CB-Ind, AMMI, bromojimscaline, jimscaline)
* 2-ADN
* 2-Benzhydrylpyrrolidine
* 2C-B-5-hemiFLY-α6 (BNAP)
* 2C-B-PYR
* 2CBecca
* 2CJP
* 2CLisaB
* 2CLisaH
* 3-Benzhydrylmorpholine
* 3-Phenylpiperidines (e.g., 3-phenylpiperidine, 3-PPP, OSU-6162 (PNU-96391), LPH-5, LPH-48, Z3517967757 (Z7757))
* 6-AB
* AL-1095
* Aminochromes (e.g., adrenochrome, adrenolutin)
* Benzazepines (e.g., fenoldopam, lorcaserin, SCHEMBL5334361)
* Benzocyclobutenes (e.g., 2CBCB-NBOMe, bromotomscaline, S33005, TCB-2, tomscaline)
* Benzoxepins (e.g., BBOX, IBOX, TFMBOX)
* Butyltolylquinuclidine
* Camfetamine
* Cypenamine (trans-2-phenylcyclopentylamine)
* Diphenidine
* Diphenylprolinol
* DMBMPP
* Ergolines (e.g., LSD)
* Fencamfamin
* GYKI-52895
* HDMP-29
* Ivabradine
* Methoxphenidine
* Methylmorphenate
* Milnacipran
* MT-45
* 2-Naphthylamine
* Org 6582
* Partial ergolines (e.g., NDTDI, RU-27849, DEIMDHPCA, DEMPDHPCA, DEMPDHPCA-2C-D, RU-27251)
* PF-592,379
* Phenylcyclopropylamines (e.g., DMCPA, TMT, tranylcypromine)
* Phenylpiracetams (e.g., phenylpiracetam, MRZ-9547, RGPU-95)
* Pyridopyrroloquinoxalines (e.g., lumateperone, deulumateperone, IHCH-7079, IHCH-7086, IHCH-7113, ITI-1549)
* Tetrahydrobenzopyranylamines (e.g., CT-5126)
* Tolazoline
* Tricyclics (e.g., AMDA, AMDH, benzoctamine, dizocilpine, SpAMDA)
* ZC-B

Related compounds|

* 2-Furylethylamine
* 2-Pyrrolylethylamine
* 3-Pyrrolylethylamine
* 3-Pyrrolylpropylamine
* 2-Tetrahydrofurylethylamine
* 4-Benzylpiperidine
* 7-AB
* Alkylamines (e.g., 1,3-DMBATooltip 1,3-dimethylbutylamine, 1,4-DMAATooltip 1,4-dimethylamylamine, heptaminol, iproheptine, isometheptene, methylhexanamine/1,3-DMAA, octodrine, oenethyl, tuaminoheptane)
* Benzylamines (e.g., benzylamine, α-methylbenzylamine, MDM1EA, ALPHA, M-ALPHA, pargyline)
* Benzylpiperazines (e.g., benzylpiperazine, MDBZP, fipexide)
* Cyclohexylaminopropanes (e.g., propylhexedrine, norpropylhexedrine)
* Cyclopentylaminopropanes (e.g., isocyclamine, cyclopentamine)
* Phenoxyethylamines (e.g., 3,4,5-trimethoxyphenoxyethylamine, CT-4719, ORG-37684)
* Phenylalkenylamines (e.g., phenylbutenamine)
* Phenylalkynylamines (e.g., phenylbutynamine)
* Phenylpiperazines (e.g., 1-phenylpiperazine, mCPPTooltip meta-chlorophenylpiperazine, TFMPPTooltip trifluoromethylphenylpiperazine, oMPPTooltip ortho-methylphenylpiperazine, pFPPTooltip para-fluorophenylpiperazine, pMeOPPTooltip para-methoxyphenylpiperazine)
* Phenylpropylamines (e.g., phenylpropylamine, homo-MDA, homo-MDMA)
* Thienylaminopropanes (thiopropamines) (e.g., thiopropamine, methiopropamine, thiothinone)

* See also: Tryptamines
* Ergolines and lysergamides
* Stimulants
* Entactogens
* Psychedelics

* v
* t
* e

Chemical classes of psychoactive drugs

Stimulants|

* Amphetamine-type/dopamine releasing agents: Alkylamines
* Cycloalkylaminopropanes
* Arylpiperazines
* Benzylpiperazines
* Phenylpiperazines
* Phenethylamines
* Aminorexes/phenyloxazolamines
* Amphetamines/α-methylphenethylamines
* Cathinones/β-ketoamphetamines
* β-Hydroxyamphetamines/cathinols
* Naphthylaminopropanes
* Phentermines
* Phenylisobutylamines/α-ethylphenethylamines
* α-Propylphenethylamines
* Phenylmorpholines/phenmetrazines
* Thiopropamines/thienylaminopropanes

* Cocaine-type/typical dopamine reuptake inhibitors: Phenethylamines
* Phenidates/benzylpiperidines
* Phenylethylpyrrolidines
* Pyrrolidinophenones
* Phenyltropanes/cocaine analogues

* Modafinil-type/atypical dopamine reuptake inhibitors: Modafinil analogues
* Phenylpiracetams

* Caffeine-type/adenosine receptor antagonists: Xanthines/methylxanthines

* Nicotine-type/nicotinic acetylcholine receptor agonists: Nicotine analogues

Depressants|

* GABAA receptor positive allosteric modulators: Alcohols/ethanol analogues
* Barbiturates
* Benzodiazepines
* Pyrrolobenzodiazepines
* Thienobenzodiazepines
* Thienodiazepines
* Thienotriazolodiazepines
* Triazolobenzodiazepines
* Carbamates
* Ethers
* Neuroactive steroids
* Nonbenzodiazepines
* β-Carbolines
* Cyclopyrrolones
* Imidazopyridines
* Pyrazolopyrimidines
* Phenols
* Piperidinediones
* Quinazolinones

* GABAA receptor agonists: Isoxazoles

* GHB receptor agonists: 1,4-Butanediols

* α2δ subunit-containing voltage-gated calcium channel blockers: Gabapentinoids

* Opioids/μ-opioid receptor agonists: Benzimidazoles
* Nitazenes
* Fentanyl analogues/phenylpiperidines
* Mitragyna alkaloids
* Morphinans/phenanthrenes
* Opiates/opium alkaloids
* Utopioids

* Antihistamines/H1 receptor antagonists: Benzimidazoles
* Diarylmethanes
* Ethylenediamines
* Tricyclics
* Dibenzocycloheptenes

Hallucinogens|

* Serotonergic psychedelics/serotonin 5-HT2A receptor agonists: Arylpiperazines
* Phenylpiperazines
* Quinolinylpiperazines
* Cyclized tryptamines
* Azepinoindoles
* Ibogalogs
* Iboga alkaloids
* β-Carbolines
* Harmala alkaloids
* Ergolines
* Lysergamides
* Simplified/partial lysergamides
* Phenethylamines (methoxyphenethylamines)
* 2Cs
* 25-NB/NBOMes
* 2C-Os
* 2C-Ts
* HOT-x
* TWEETIOs
* Amphetamines/α-methylphenethylamines
* 3Cs
* Dimethoxyamphetamines/DMAs
* DOx
* Alephs
* Methylenedioxyamphetamines/MDxx
* Trimethoxyamphetamines/TMAs
* BOx
* FLYs/benzofurans
* Phenylisobutylamines/α-ethylphenethylamines
* 4Cs
* Scalines
* Tryptamines
* α-Alkyltryptamines
* α-Alkyl-β-ketotryptamines
* 4-Hydroxytryptamines
* 5-Hydroxytryptamines
* 5-Methoxytryptamines
* Miscellaneous

* Dissociatives/NMDA receptor antagonists: Adamantanes
* Arylcyclohexylamines
* Diarylethylamines
* Morphinans

* κ-Opioid receptor agonists: Benzomorphans
* Salvinorins

* GABAA receptor agonists: Isoxazoles

* Deliriants/anticholinergics/muscarinic acetylcholine receptor antagonists: Diarylmethanes
* Tropanes

* Others: Cyclized tryptamines
* Azepinoindoles
* Iboga alkaloids
* (Phyto)cannabinoids

Entactogens|

* Serotonin releasing agents: Phenethylamines
* Aminoindanes
* Aminotetralins
* Amphetamines
* Benzofuranylaminopropanes
* Benzothiophenylaminopropanes
* Ethylenedioxyamphetamines
* Indanylaminopropanes
* Indolylaminopropanes
* Methylenedioxyamphetamine/MDxx
* Tetralinylaminopropanes
* Tryptamines
* α-Alkyltryptamines
* Miscellaneous

Psychiatric drugs|

* Anxiolytics: Azapirones
* Benzodiazepines
* Pyrrolobenzodiazepines
* Thienobenzodiazepines
* Thienodiazepines
* Thienotriazolodiazepines
* Triazolobenzodiazepines

* Antidepressants: Tricyclic antidepressants
* Dibenzazepines
* Dibenzocycloheptenes
* Dibenzothiepins
* Dibenzoxazepines
* Dibenzoxepins
* Tetracyclic antidepressants

* Antipsychotics/dopamine D2 receptor antagonists or partial agonists: Benzamides
* Benzimidazoles
* Benzisothiazoles
* Benzisoxazoles
* Butyrophenones
* Diphenylbutylpiperidines
* Phenylpiperazines
* Tricyclics
* Dibenzazepines
* Dibenzodiazepines
* Dibenzothiazepines
* Dibenzothiepins
* Dibenzoxazepines
* Phenothiazines
* Thienobenzodiazepines

* Mood stabilizers/anticonvulsants: Gabapentinoids
* Tricyclics
* Dibenzazepines
* Valproates

Others|

* Nootropics: Racetams
* Phenylpiracetams

* Miscellaneous: Adamantanes
* Catecholamines
* Tetrahydroisoquinolines
* Yohimbans

* v
* t
* e

Monoamine releasing agents

DRAsTooltip Dopamine releasing agents|

* Morpholines: Fenbutrazate
* Fenmetramide
* Morazone
* Morforex
* Phendimetrazine
* Phenmetrazine
* Pseudophenmetrazine

* Oxazolines: 4-MAR
* Aminorex
* Clominorex
* Cyclazodone
* Fenozolone
* Fluminorex
* Pemoline
* Thozalinone

* Phenethylamines: 2-OH-PEA
* 4-CAB
* 4-FA
* 4-FMA
* 4-MA
* 4-MMA
* Alfetamine
* Amfecloral
* Amfepentorex
* Amfepramone
* Amphetamine (Dextroamphetamine
* Levoamphetamine)
* Amphetaminil
* β-Me-PEA
* BDB
* BOH
* Benzphetamine
* Buphedrone
* Butylone
* Cathine
* Cathinone
* Clobenzorex
* Clortermine
* D-Deprenyl
* DMA
* DMMA
* Dimethylamphetamine
* Ephedrine
* Ethcathinone
* EBDB
* Ethylone
* Etilamfetamine
* Famprofazone
* Fenethylline
* Fenproporex
* Flephedrone
* Fludorex
* Furfenorex
* Hordenine
* 4-Hydroxyamphetamine
* Iofetamine (123I)
* Lisdexamfetamine
* Lophophine
* Mefenorex
* Mephedrone
* Metamfepramone
* Methamphetamine
* Dextromethamphetamine
* Levomethamphetamine
* Methcathinone
* Methedrone
* MMDA
* MMDMA
* MBDB
* MDA (tenamfetamine)
* MDEA
* MDMA (midomafetamine)
* MDMPEA
* MDOH
* MDPEA
* Methylone
* Morforex
* Ortetamine
* pBA
* pCA
* pIA
* Pholedrine
* Phenethylamine
* Pholedrine
* Phenpromethamine
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Tiflorex
* Tyramine
* Xylopropamine
* Zylofuramine

* Piperazines: 2C-B-BZP
* BZP
* MBZP
* MDBZP
* MeOPP
* oMPP

* Others: 2-ADN
* 2-AI
* 2-AT
* 4-BP
* 5-APDI
* 5-IAI
* Amineptine
* Clofenciclan
* Cyclopentamine
* Cypenamine
* Cyprodenate
* Feprosidnine
* Gilutensin
* Heptaminol
* Hexacyclonate
* Indanorex
* Isometheptene
* Methylhexanamine
* Naphthylaminopropane
* Octodrine
* Phthalimidopropiophenone
* Phenylbiguanide
* Propylhexedrine

NRAsTooltip Norepinephrine releasing agents|

* Morpholines: Fenbutrazate
* Fenmetramide
* Morazone
* Morforex
* Phendimetrazine
* Phenmetrazine
* Pseudophenmetrazine

* Oxazolines: 4-MAR
* Aminorex
* Clominorex
* Cyclazodone
* Fenozolone
* Fluminorex
* Pemoline
* Thozalinone

* Phenethylamines: 2-OH-PEA
* 4-CAB
* 4-FA
* 4-FMA
* 4-MA
* 4-MMA
* Alfetamine
* Amfecloral
* Amfepentorex
* Amfepramone
* Amphetamine
* Dextroamphetamine
* Levoamphetamine
* Amphetaminil
* β-Me-PEA
* BDB
* Benzphetamine
* BOH
* Buphedrone
* Butylone
* Cathine
* Cathinone
* Clobenzorex
* Clortermine
* Dimethylamphetamine
* DMA
* DMMA
* EBDB
* Ephedrine
* Ethcathinone
* Ethylone
* Etilamfetamine
* Famprofazone
* Fenethylline
* Fenproporex
* Flephedrone
* Fludorex
* Furfenorex
* Hordenine
* 4-Hydroxyamphetamine
* 5-APDI (IAP)
* Iofetamine (123I)
* Lisdexamfetamine
* Lophophine
* MBDB
* MDA (tenamfetamine)
* MDEA
* MDMA (midomafetamine)
* Metamfepramone
* MDMPEA
* MDOH
* MDPEA
* Mefenorex
* Mephedrone
* Mephentermine
* Methamphetamine
* Dextromethamphetamine
* Levomethamphetamine
* Methcathinone
* Methedrone
* Methylone
* Morforex
* Naphthylaminopropane
* Ortetamine
* pBA
* pCA
* Pentorex
* Phenethylamine
* Pholedrine
* Phenpromethamine
* Phentermine
* Phenylpropanolamine
* pIA
* Prenylamine
* Propylamphetamine
* Pseudoephedrine
* Selegiline (also D-Deprenyl)
* Tiflorex
* Tyramine
* Xylopropamine
* Zylofuramine

* Piperazines: 2C-B-BZP
* BZP
* MBZP
* mCPP
* MDBZP
* MeOPP
* oMPP
* pFPP

* Others: 2-ADN
* 2-AI
* 2-AT
* 2-BP
* 4-BP
* 5-IAI
* Clofenciclan
* Cyclopentamine
* Cypenamine
* Cyprodenate
* Feprosidnine
* Gilutensin
* Heptaminol
* Hexacyclonate
* Indanorex
* Isometheptene
* Methylhexanamine
* Octodrine
* Phthalimidopropiophenone
* Propylhexedrine
* Tuaminoheptane

SRAsTooltip Serotonin releasing agents|

* Aminoindanes: 5-IAI
* AMMI
* ETAI
* MDAI
* MDMAI
* MMAI
* TAI

* Aminotetralins: 6-CAT
* 8-OH-DPAT
* MDAT
* MDMAT

* Oxazolines: 4-Methylaminorex
* Aminorex
* Clominorex
* Fluminorex

* Phenethylamines: 2-Methyl-MDA
* 4-CAB
* 4-FA
* 4-FMA
* 4-HA
* 4-MTA
* 5-APDB
* 5-Methyl-MDA
* 6-APDB
* 6-Methyl-MDA
* AEMMA
* Amiflamine
* BDB
* BOH
* Brephedrone
* Butylone
* Chlorphentermine
* Cloforex
* Amfepramone
* Metamfepramone
* DCA
* Dexfenfluramine
* DFMDA
* DMA
* DMMA
* EBDB
* EDMA
* Ethylone
* Etolorex
* Fenfluramine
* Flephedrone
* Flucetorex
* IAP
* Iofetamine
* Levofenfluramine
* Lophophine
* MBDB
* MDA (tenamfetamine)
* MDEA
* MDHMA
* MDMA (midomafetamine)
* MDMPEA
* MDOH
* MDPEA
* Mephedrone
* Methedrone
* Methylone
* MMA
* MMDA
* MMDMA
* MMMA
* NAP
* Norfenfluramine
* 4-TFMA
* pBA
* pCA
* pIA
* PMA
* PMEA
* PMMA
* TAP

* Piperazines: 2C-B-BZP
* 3-MeOPP
* BZP
* DCPP
* MBZP
* mCPP
* MDBZP
* MeOPP
* Mepiprazole
* oMPP
* pCPP
* pFPP
* pTFMPP
* TFMPP

* Tryptamines: 4-Methyl-αET
* 4-Methyl-αMT
* 5-CT
* 5-MeO-αET
* 5-MeO-αMT
* 5-MT
* αET
* αMT
* DMT
* Tryptamine

* Others: Indeloxazine
* Viqualine

Others|

* DAT modulators: Agonist-like: SoRI-9804
* SoRI-20040; Antagonist-like: SoRI-20041

* Adrenergic release blockers: Bethanidine
* Bretylium
* Guanadrel
* Guanazodine
* Guanethidine
* Guanoxan

See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins

* v
* t
* e

Serotonin receptor modulators

5-HT1|

| 5-HT1A|

* Agonists: 8-OH-DPAT
* Adatanserin
* Amphetamine
* Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)
* Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)
* Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
* Bay R 1531
* Befiradol
* BMY-14802
* Cannabidiol
* Dimemebfe
* Dopamine
* Ebalzotan
* Eltoprazine
* Enciprazine
* Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
* F-11461
* F-12826
* F-13714
* F-14679
* F-15063
* F-15599
* Flesinoxan
* Flibanserin
* Flumexadol
* Hypidone
* Lesopitron
* LY-293284
* LY-301317
* mCPP
* MKC-242
* Naluzotan
* NBUMP
* Osemozotan
* Oxaflozane
* Pardoprunox
* Piclozotan
* Rauwolscine
* Repinotan
* Roxindole
* RU-24969
* S-14506
* S-14671
* S-15535
* Sarizotan
* Serotonin (5-HT)
* SSR-181507
* Sunepitron
* Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
* TGBA01AD
* U-92016-A
* Urapidil
* Vilazodone
* Xaliproden
* Yohimbine

* Positive allosteric modulators: Oleamide

* Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
* AV965
* Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)
* BMY-7378
* CSP-2503
* Dotarizine
* Ergolines (e.g., metergoline)
* FCE-24379
* Flopropione
* GR-46611
* Isamoltane
* Lecozotan
* Mefway
* Metitepine (methiothepin)
* MIN-117 (WF-516)
* MPPF
* NAN-190
* Robalzotan
* S-15535
* SB-649915
* SDZ 216-525
* Spiperone
* Spiramide
* Spiroxatrine
* UH-301
* WAY-100135
* WAY-100635
* Xylamidine

* Unknown/unsorted: Acetryptine
* Carvedilol
* Ergolines (e.g., ergometrine (ergonovine))

5-HT1B|

* Agonists: Anpirtoline
* CGS-12066A
* CP-93129
* CP-94253
* CP-122288
* CP-135807
* Eltoprazine
* Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
* mCPP
* RU-24969
* Serotonin (5-HT)
* Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
* TFMPP
* Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
* Vortioxetine

* Antagonists: AR-A000002
* Beta blockers (e.g., alprenolol, carteolol, isamoltane, oxprenolol, penbutolol, propranolol, tertatolol)
* Elzasonan
* Ergolines (e.g., metergoline)
* GR-127935
* Isamoltane
* LY-393558
* Metitepine (methiothepin)
* SB-216641
* SB-224289
* SB-236057
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., cabergoline, ergometrine (ergonovine), lisuride)

5-HT1D|

* Agonists: CP-122288
* CP-135807
* CP-286601
* Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
* GR-46611
* L-694247
* L-772405
* mCPP
* PNU-109291
* PNU-142633
* Serotonin (5-HT)
* TGBA01AD
* Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
* Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)

* Antagonists: Alniditan
* BRL-15572
* Elzasonan
* Ergolines (e.g., metergoline)
* GR-127935
* Ketanserin
* LY-310762
* LY-367642
* LY-393558
* LY-456219
* LY-456220
* Metitepine (methiothepin)
* Mianserin
* Ritanserin
* Yohimbine
* Ziprasidone

* Unknown/unsorted: Acetryptine
* Ergolines (e.g., lisuride, lysergol, pergolide)

5-HT1E|

* Agonists: BRL-54443
* Ergolines (e.g., methysergide)
* Serotonin (5-HT)
* Triptans (e.g., eletriptan)
* Tryptamines (e.g., tryptamine)

* Antagonists: Metitepine (methiothepin)

* Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine), lysergol, methylergometrine (methylergonovine)

5-HT1F|

* Agonists: BRL-54443
* CP-122288
* Ergolines (e.g., bromocriptine, lysergol, methylergometrine (methylergonovine) methysergide)
* Lasmiditan
* LY-334370
* LY-344864
* Serotonin (5-HT)
* Triptans (e.g., eletriptan, naratriptan, sumatriptan)
* Tryptamines (e.g., 5-MT)

* Antagonists: Metitepine (methiothepin)
* Mianserin

5-HT2|

| 5-HT2A|

* Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
* 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
* 2C-B-FLY
* 2CB-Ind
* 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
* α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
* AL-34662
* AL-37350A
* Bromo-DragonFLY
* Dimemebfe
* DMBMPP
* DOx (e.g., DOB, DOC, DOI, DOM)
* Efavirenz
* Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
* Flumexadol
* IHCH-7113
* Jimscaline
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* O-4310
* Oxaflozane
* PHA-57378
* PNU-22394
* PNU-181731
* RH-34
* SCHEMBL5334361
* Phenethylamines (e.g., lophophine, mescaline)
* Piperazines (e.g., BZP, quipazine, TFMPP)
* Serotonin (5-HT)
* TCB-2
* TFMFly
* Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)

* Positive allosteric modulators: CTW0404
* CTW0419
* JPC0323
* (R)-Glaucine
* Oleamide

* Antagonists: 5-I-R91150
* 5-MeO-NBpBrT
* AC-90179
* Adatanserin
* Altanserin
* Antihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)
* AMDA
* Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
* Chlorprothixene
* Cinanserin
* CSP-2503
* Deramciclane
* Dotarizine
* Eplivanserin
* Ergolines (e.g., amesergide, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
* Fananserin
* Flibanserin
* Glemanserin
* Irindalone
* Ketanserin
* KML-010
* Landipirdine
* LY-393558
* mCPP
* Medifoxamine
* Metitepine (methiothepin)
* MIN-117 (WF-516)
* Naftidrofuryl
* Nantenine
* Nelotanserin
* Opiranserin (VVZ-149)
* Pelanserin
* Phenoxybenzamine
* Pimavanserin
* Pirenperone
* Pizotifen
* Pruvanserin
* Rauwolscine
* Ritanserin
* Roluperidone
* S-14671
* Sarpogrelate
* Serotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)
* SR-46349B
* TGBA01AD
* Teniloxazine
* Temanogrel
* Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
* Tricyclic antidepressants (e.g., amitriptyline)
* Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)
* Volinanserin
* Xylamidine
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., dihydroergotamine, nicergoline)

5-HT2B|

* Agonists: 4-Methylaminorex
* Aminorex
* Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
* BW-723C86
* DOx (e.g., DOB, DOC, DOI, DOM)
* Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* Piperazines (e.g., TFMPP)
* PNU-22394
* Ro60-0175
* Serotonin (5-HT)
* Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)

* Antagonists: Agomelatine
* Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N-desalkylquetiapine (norquetiapine), N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)
* Cyproheptadine
* EGIS-7625
* Ergolines (e.g., amesergide, bromocriptine, lisuride, LY-53857, LY-272015, mesulergine)
* Ketanserin
* LY-393558
* mCPP
* Metadoxine
* Metitepine (methiothepin)
* Pirenperone
* Pizotifen
* Propranolol
* PRX-08066
* Rauwolscine
* Ritanserin
* RS-127445
* Sarpogrelate
* SB-200646
* SB-204741
* SB-206553
* SB-215505
* SB-221284
* SB-228357
* SDZ SER-082
* Tegaserod
* Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
* Trazodone
* Typical antipsychotics (e.g., chlorpromazine)
* TIK-301
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine))

5-HT2C|

* Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
* 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
* α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
* A-372159
* AL-38022A
* Alstonine
* CP-809101
* Dimemebfe
* DOx (e.g., DOB, DOC, DOI, DOM)
* Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
* Flumexadol
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* MK-212
* ORG-12962
* ORG-37684
* Oxaflozane
* PHA-57378
* Phenethylamines (e.g., lophophine, mescaline)
* Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
* PNU-22394
* PNU-181731
* Ro60-0175
* Ro60-0213
* Serotonin (5-HT)
* Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
* Vabicaserin
* WAY-629
* WAY-161503
* YM-348

* Positive allosteric modulators: CTW0415
* CYD-1-79
* JPC0323
* Oleamide
* PNU-69176E
* VA012
* VA240

* Antagonists: Adatanserin
* Agomelatine
* Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
* Captodiame
* CEPC
* Cinanserin
* Cyproheptadine
* Deramciclane
* Desmetramadol
* Dotarizine
* Eltoprazine
* Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
* Etoperidone
* Fluoxetine
* FR-260010
* Irindalone
* Ketanserin
* Ketotifen
* Latrepirdine (dimebolin)
* Medifoxamine
* Metitepine (methiothepin)
* Nefazodone
* Pirenperone
* Pizotifen
* Propranolol
* Ritanserin
* RS-102221
* S-14671
* SB-200646
* SB-206553
* SB-221284
* SB-228357
* SB-242084
* SB-243213
* SDZ SER-082
* Tedatioxetine
* Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
* TIK-301
* Tramadol
* Trazodone
* Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
* Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
* Xylamidine

* Unknown/unsorted: Efavirenz
* Ergolines (e.g., ergometrine (ergonovine), methylergometrine (methylergonovine))

5-HT3–7|

| 5-HT3|

* Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)
* m-CPBG
* Phenylbiguanide
* Piperazines (e.g., BZP, mCPP, quipazine)
* RS-56812
* Serotonin (5-HT)
* SR-57227
* SR-57227A
* Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
* Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
* YM-31636

* Positive allosteric modulators: 5-Aminoindole
* 5-Chloroindole
* 5-Hydroxyindole
* Catechol
* Chloroform
* meta-Chlorophenylbiguanide (mCPBG)
* Colchicine
* Ethanol (alcohol)
* Halothane
* Indole
* Isoflurane
* TMPPAA

* Antagonists: Alosetron
* Anpirtoline
* Arazasetron
* AS-8112
* Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
* Azasetron
* Batanopride
* Bemesetron (MDL-72222)
* Cilansetron
* CSP-2503
* Dazopride
* Dolasetron
* Galanolactone
* Granisetron
* Lerisetron
* Memantine
* Ondansetron
* Palonosetron
* Ramosetron
* Renzapride
* Ricasetron
* Tedatioxetine
* Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
* Thujone
* Tropanserin
* Tropisetron
* Typical antipsychotics (e.g., loxapine)
* Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
* Vortioxetine
* Zacopride
* Zatosetron

* Negative allosteric modulators: Bupropion
* Colchicine
* Hydroxybupropion

* Unknown/unsorted: LY-53857
* Piperazines (e.g., naphthylpiperazine)

5-HT4|

* Agonists: 5-MT
* BIMU8
* Capeserod
* Cinitapride
* Cisapride
* CJ-033466
* Dazopride
* Metoclopramide
* Minesapride
* Mosapride
* Prucalopride
* PRX-03140
* Renzapride
* RS-67333
* RS-67506
* Serotonin (5-HT)
* Tegaserod
* Usmarapride
* Velusetrag
* Zacopride

* Antagonists: GR-113808
* GR-125487
* L-Lysine
* Piboserod
* RS-39604
* RS-67532
* SB-203186
* SB-204070

5-HT5A|

* Agonists: Ergolines (e.g., 2-Br-LSD (BOL-148), ergotamine, LSD)
* Serotonin (5-HT)
* Tryptamines (e.g., 5-CT)
* UCSF648
* Valerenic acid

* Antagonists: Asenapine
* Latrepirdine (dimebolin)
* Metitepine (methiothepin)
* Ritanserin
* SB-699551

* Unknown/unsorted: Ergolines (e.g., metergoline, methysergide)
* Piperazines (e.g., naphthylpiperazine)

5-HT6|

* Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
* Hypidone
* Serotonin (5-HT)
* Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, ST-1936, tryptamine)
* WAY-181187
* WAY-208466

* Antagonists: ABT-354
* Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
* AVN-101
* AVN-211
* AVN-322
* AVN-397
* BGC20-760
* BVT-5182
* BVT-74316
* Cerlapirdine
* EGIS-12233
* GW-742457
* Idalopirdine
* Ketanserin
* Landipirdine
* Latrepirdine (dimebolin)
* Masupirdine
* Metitepine (methiothepin)
* MS-245
* PRX-07034
* Ritanserin
* Ro 04-6790
* Ro 63-0563
* SB-258585
* SB-271046
* SB-357134
* SB-399885
* SB-742457
* Tetracyclic antidepressants (e.g., amoxapine, mianserin)
* Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
* Typical antipsychotics (e.g., chlorpromazine, loxapine)

* Unknown/unsorted: Ergolines (e.g., 2-Br-LSD (BOL-148), bromocriptine, lergotrile, pergolide)
* Piperazines (e.g., naphthylpiperazine)

5-HT7|

* Agonists: 8-OH-DPAT
* AS-19
* Bifeprunox
* E-55888
* Ergolines (e.g., LSD)
* LP-12
* LP-44
* LP-211
* RU-24969
* Sarizotan
* Serotonin (5-HT)
* Triptans (e.g., frovatriptan)
* Tryptamines (e.g., 5-CT, 5-MT, bufotenin, N-Me-5-HT)

* Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
* Butaclamol
* DR-4485
* EGIS-12233
* Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215840, mesulergine, metergoline, methysergide, sergolexole)
* JNJ-18038683
* Ketanserin
* LY-215840
* Metitepine (methiothepin)
* Ritanserin
* SB-258719
* SB-258741
* SB-269970
* SB-656104
* SB-656104A
* SB-691673
* SLV-313
* SLV-314
* Spiperone
* SSR-181507
* Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
* Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
* Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
* Vortioxetine

* Negative allosteric modulators: Oleamide

* Unknown/unsorted: Ergolines (e.g., lisuride, pergolide)
* Piperazines (e.g., naphthylpiperazine)

* See also: Receptor/signaling modulators
* Adrenergics
* Dopaminergics
* Melatonergics
* Monoamine reuptake inhibitors and releasing agents
* Monoamine metabolism modulators
* Monoamine neurotoxins

Authority control databases

National|

* Germany
* United States
* Israel

Other|

* Yale LUX

*[a.k.a.]: also known as
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[1,3-DMBA]: 1,3-dimethylbutylamine
*[1,4-DMAA]: 1,4-dimethylamylamine
*[1,3-DMAA]: 1,3-dimethylamylamine
*[mCPP]: meta-chlorophenylpiperazine
*[TFMPP]: trifluoromethylphenylpiperazine
*[oMPP]: ortho-methylphenylpiperazine
*[pFPP]: para-fluorophenylpiperazine
*[pMeOPP]: para-methoxyphenylpiperazine
*[DRAs]: Dopamine releasing agents
*[NRAs]: Norepinephrine releasing agents
*[SRAs]: Serotonin releasing agents