Sudan I

Sudan I  Sudan I

Names
IUPAC name

1-(Phenyldiazenyl)naphthalen-2-ol

Other names

* Solvent Yellow 14
* C.I. Solvent Yellow 14
* Solvent Orange R
* 1-Phenylazo-2-naphthol

Identifiers

CAS Number

* 842-07-9 Y

3D model (JSmol)

* Interactive image

ChEBI |

* CHEBI:30958 Y

ChEMBL |

* ChEMBL1397023

ChemSpider |

* 10296256 Y

ECHA InfoCard | 100.011.517
EC Number |

* 212-668-2

KEGG |

* C19525 N

PubChem CID

* 13297

UNII |

* 48I7IBB68J Y

CompTox Dashboard (EPA)

* DTXSID90873447 DTXSID4021135, DTXSID90873447

InChI

* InChI=1S/C16H12N2O/c19-15-11-10-12-6-4-5-9-14(12)16(15)18-17-13-7-2-1-3-8-13/h1-11,19H/b18-17+ Y

Key: MRQIXHXHHPWVIL-ISLYRVAYSA-N Y

* InChI=1/C16H12N2O/c19-15-11-10-12-6-4-5-9-14(12)16(15)18-17-13-7-2-1-3-8-13/h1-11,19H/b18-17+

Key: MRQIXHXHHPWVIL-ISLYRVAYBO

SMILES

* Oc3ccc1ccccc1c3/N=N/c2ccccc2

Properties

Chemical formula

| C16H12N2O
Molar mass | 248.28 g/mol
Density | 1.2g/cm3
Melting point | 131 °C (268 °F; 404 K)
Boiling point | 443.7 °C (830.7 °F; 716.8 K)

Magnetic susceptibility (χ)

| −1.376×10−4 cm3/mol
Hazards
GHS labelling:

Pictograms

Signal word

| Warning

Hazard statements

| H317, H341, H351, H413

Precautionary statements

| P201, P202, P261, P272, P273, P280, P281, P302+P352, P308+P313, P321, P333+P313, P363, P405, P501
Flash point | 290.2 °C

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)

Infobox references

Chemical compound

Sudan I (also known as CI Solvent Yellow 14 or Solvent Orange R)[1] is an organic compound typically classified as an azo dye.[2] It is an orange-red solid, used to color waxes, oils, petrol, solvents, and polishes. Historically, Sudan I used to serve as a food coloring agent, notably for curry powder and chili powder. However, along with its derivatives Sudan III and Sudan IV, the compound has been banned for use in food in many countries (including the United States and the European Union)[3][4][5] due to its classification as a category 3 carcinogen by the International Agency for Research on Cancer (not classifiable as to its carcinogenicity in humans).[6] Nevertheless, Sudan I remains valuable as a coloring reagent for non-food-related uses, such as in the formulation of orange-colored smoke.

## Application

[edit]

The Sudan dyes are a group of azo compounds which have been used to color hydrocarbon solvents, oils, fats, waxes, shoes, and floor polishes. As recently as 1974, about 270,000 kg (600,000 lb) of Sudan I, 236,000 kg (520,000 lb) of Sudan II, 70,000 kg (150,000 lb) of Sudan III, and 1,075,000 kg (2,370,000 lb) of Sudan IV was produced in the United States.[citation needed]

Sudan I and Sudan III (1-(4-(phenyldiazenyl)phenyl) azo naphthalen-2-ol) are primarily used for the same application.[7]

Sudan III melts at a 68°C (154.4°F), a much lower temperature than Sudan I, which melts at 131°C (268°F).

## Synthesis

[edit]

There are two steps in synthesizing this compound:

The first step is the preparation of a benzene diazonium chloride solution, a diazonium salt created from the reaction of aniline with nitrous acid generated by the reaction of sodium nitrite and hydrochloric acid.

The second step involves adding the solution of the diazonium salt to 2-naphthol, to produce the diazo dye.

Sudan I is prone to photodegradation when exposed to light. This process involves the breakdown of the dye due to the interaction with singlet oxygen and free radicals. As a result, the colorfastness of Sudan I on materials is poor.[8]

## Degradation and metabolism

[edit]

The metabolism of Sudan I, as characterized in rabbits, involves both oxidative and reductive reactions.[9]

The biological breakdown of the nitrogen-nitrogen bond by hydrogenation of the Sudan I molecule (azo-reduction) produces aniline and 1-amino-2-naphthol. This reaction appears to contribute to the detoxification observed in animal studies. After oxidation of Sudan I, C-hydroxylated metabolites are formed as major oxidation products and are excreted in urine. These metabolites are also found after oxidation with rat hepatic microsomes in vitro.[citation needed]

The C-hydroxylated metabolites may be considered as the detoxification products, while the benzene diazonium ion (BDI), formed by the microsome-catalyzed enzymatic splitting of the azo group of Sudan I, reacts with DNA in vitro.[10][11] The major DNA adduct formed from this reaction is the 8-(phenylazo)guanine adduct, which was also found in the liver DNA of rats who were exposed to Sudan I.

The formation of C-hydroxylated metabolites and DNA-adducts from Sultan I oxidation was also demonstrated with human cytochrome P450 (CYP) enzymes, with CYP1A1 being the major enzyme involved in the oxidation of Sudan I in human tissues rich in this enzyme, while CYP3A4 is also active in human liver.[citation needed]

CYP1A1 constitutes less than 0.7% of the total hepatic CYP expression in human livers but can be responsible for up to 30% of the oxidation of Sudan I in a set of human liver microsomes.[12] Moreover, Sudan I strongly induces CYP1A1 in rats and human cells in culture due to the activation of the cytosolic aryl hydrocarbon receptor.[13]

In addition to oxidation by CYP enzymes, Sudan I and its C-hydroxylated metabolites are oxidized by peroxidases, such as a model plant peroxidase and the mammalian enzyme cyclooxygenase. In bladder tissue, CYP enzymes are not detectable, but relatively high levels of peroxidases are expressed. As a consequence, DNA, RNA, and protein adducts are formed.[a] Therefore, peroxidase-catalyzed activation of Sudan I has been suggested as mechanism. This is similar to other carcinogens, such as the carcinogenic aromatic amines.[b]

It has been suggested that a CYP- or peroxidase-mediated activation of Sudan I or a combination of both mechanisms may be responsible for the organ specificity of this carcinogen for the liver and urinary bladder in animals.[24] The Sudan I metabolites formed by peroxidase are much less likely to be formed at physiological conditions because in vivo there are many nucleophilic molecules present which scavenge the Sudan I reactive species.[25] Hence, the formation of adducts in the Sudan I reactive species with nucleophilic species (such as DNA, tRNA, proteins, polynucleotides, and polydeoxynucleotides) seems to be the preferred reaction under physiological conditions, with deoxyguanosine as the major target for Sudan-I DNA binding, followed by deoxyadenosine.[11]

## Effect on humans

[edit]

Sudan I is determined to be a health hazard by EU chemical regulators as well as the IARC.[26] It may cause allergic skin reactions and skin irritation. Exposure to the skin can happen by textile workers being subjected to direct exposure, or by wearing tight-fitting textiles dyed with Sudan I. Allergic reactions are induced when the azo dye binds to the human serum albumin (HSA), forming a dye-HSA conjugate which immunoglobulin E binds to, leading to an eventual release of histamine.[27]

Sudan I is also suspected of causing genetic defects. The mutagenicity and genetic hazard have been evaluated with the Ames test and animal experiments. Furthermore, it is suspected of causing cancer. The carcinogenicity was estimated merely through animal testing. It has not been verified in human subjects yet.[27]

## Safety and regulation

[edit]

The regulation of Sudan I in Europe started in 2003, after repeated notifications were published in the EU rapid alert system. The EU rapid alert system announced that Sudan I was found in chili powder and other foods that were prepared with it. Due to the suspicion of genotoxicity and mutagenicity of Sudan I, a daily intake was not tolerable. The European Commission therefore prohibited the import of chili and hot chili products.[28] The German Federal Institute for Risk Assessment was asked its opinion and came to the conclusion that Sudan dyes are harmful to health.[citation needed] Sudan I was classified as a category three carcinogen and category three mutagen in Annex I of Directive 67/548/EC. This classification was based on findings from animal experiments from this organisation.[citation needed]

The regulation of azo colorants by ‘The EU azo Colorants Directive 2002/61/EC’ has been replaced by the REACH regulation in 2009, when azo dyes were put on the REACH Restriction list Annex XVII.[29] This includes that said dyes are forbidden to be used in textiles and leather, that may come in direct and prolonged contact with the skin or oral cavity. No textiles made of leather material are allowed to be coloured with azo dyes, a specific list of which items can be found in the Official Journal of the European Union.[30] Furthermore, it is prohibited, in the European Union, to place any textile or leather articles coloured with azo dyes on the market.[30]

A certificate for azo dyes exists to ensure that dyes that cleave to one of the forbidden amines are not being used for dyeing. All dyers should ensure that the supply company is fully informed about the legislation of the prohibited azo dyes. To ensure this, they should be members of the ETAD (Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers) from which they can receive their certificate. Non-ETAD member suppliers will be correlated with doubt about the origin and safety of their dyes. Dyes without certification are not advised to be used.[29]

## Toxicology, genotoxicity, and mutagenesis

[edit]

### Humans

[edit]

No specific information exists on Sudan I related to the toxic, genotoxic, and mutagenic effect on humans.

### Animal experiments

[edit]

Sudan I was associated with a significant increase in neoplastic nodules and carcinomas in both male and female rats.[31] Other studies, however, showed no significantly increased incidence of micro-nucleated hepatocytes after the administration of Sudan I. These results suggest that the liver carcinogenicity may not be due to the genotoxic effects of Sudan I. No carcinogenic effects were visible in livers of mice after the application of Sudan I.[12] But when Sudan I is applied subcutaneously to mice, liver tumors were found.

Furthermore, DNA damage was depicted in the stomach and liver cells of mice.[32] In rats, no significant increase was found in the amount of micro-nucleated epithelial cells of the gastrointestinal tract. This indicates the absence of genotoxic compounds in the gastrointestinal epithelial cells in rats.[12]

Contradictory to the findings in the gastrointestinal tract and liver, there was an increase in micro-nucleated cells found in the bone marrow. The frequency of micro-nucleated bone marrow cells increased in a dose-dependent manner. Significantly higher frequencies of micro-nucleated immature erythrocytes (MNIME) were found at a dose of 150mg/day or more. This supports the explanation that Sudan I is oxidized or activated by peroxidase in the blood cells, thereby forming micro-nucleated cells.[12]

Guanosine DNA adducts derived from peroxidase metabolites of Sudan I were also found in vivo, in the bladder of rats. The bladder also contains high levels of tissue peroxidase.[19]

### Toxicology

[edit]

Sudan I is genotoxic. It is also carcinogenic in rats.[33] Comparisons between experimental animals and human Cytochrome P450 (CYP) suggest animal carcinogenicity data may be extrapolated to humans, although the IARC has not done this.[34]

Sudan I is also present as an impurity in Sunset Yellow FCF, which is its desulfonated water-soluble version.

## Food scare

[edit]

In February 2005, Sudan I gained attention, particularly in the United Kingdom. It was identified as a contaminant in Worcestershire sauce produced by Premier Foods. The Food Standards Agency traced the source of the contamination to adulterated chili powder.[35]

## See also

[edit]

* Para Red

## Notes

[edit]

1. ^ Attributed to multiple references:[10][11][14][15][16][17][18][19]
2. ^ Attributed to multiple references:[20][21][22][23]

## References

[edit]

1. ^ "Substance Name: C.I. Solvent Yellow 14". ChemIDplus, Toxnet Database. Retrieved 15 March 2022.
2. ^ Hunger, Klaus; Mischke, Peter; Rieper, Wolfgang; et al. (2005). "Azo Dyes". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_245. ISBN 978-3-527-30673-2.
3. ^ Refat NA, Ibrahim ZS, Moustafa GG, et al. (2008). "The induction of cytochrome P450 1A1 by sudan dyes". J. Biochem. Mol. Toxicol. 22 (2): 77–84\. doi:10.1002/jbt.20220. PMID 18418879. S2CID 206010951.
4. ^ Pan, Hongmiao; Feng, Jinhui; He, Gui-Xin; Cerniglia, Carl E.; Chen, Huizhong (May 2012). "Evaluation of impact of exposure of Sudan azo dyes and their metabolites on human intestinal bacteria". Anaerobe. 18 (4): 445–453\. doi:10.1016/j.anaerobe.2012.05.002. ISSN 1075-9964. PMC 5870115. PMID 22634331.
5. ^ Genualdi, Susie; MacMahon, Shaun; Robbins, Katherine; Farris, Samantha; Shyong, Nicole; DeJager, Lowri (April 2016). "Method development and survey of Sudan I–IV in palm oil and chilli spices in the Washington, DC, area". Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 33 (4): 583–591\. doi:10.1080/19440049.2016.1147986. ISSN 1944-0049. PMC 4888373. PMID 26824489.
6. ^ "List of Classifications - IARC Monographs". monographs.iarc.who.int. Retrieved 11 July 2024.
7. ^ Chailapakul, O.; Wonsawat, W.; Siangproh, W.; et al., Analysis of Sudan I, Sudan II, Sudan III, and Sudan IV in food by HPLC with electrochemical detection: Comparison of glassy carbon electrode with carbon nanotube-ionic liquid gel modified electrode. Food Chemistry 2008, 109 (4), 876-882
8. ^ Griffiths, J.; Hawkins, C., Synthesis and photochemical stability of 1-phenylazo-2-naphthol dyes containing insulated singlet oxygen quenching groups. Journal of Applied Chemistry and Biotechnology 1977, 27 (4), 558-564
9. ^ Childs, J. J.; Clayson, D. B., The metabolism of 1-phenylazo-2-naphthol in the rabbit. Biochemical Pharmacology 1966, 15 (9), 1247-1258
10. ^ a b Stiborova, M.; Asfaw, B.; Anzenbacher, P.; Hodek, P., A New Way To Carcinogenicity Of Azo Dyes - The Benzenediazonium Ion Formed From A Non-Aminoazo Dye, 1-Phenylazo-2-Hydroxynaphthalene (Sudan-I) By Microsomal-Enzymes Binds To Deoxyguanosine Residues Of DNA. Cancer Letters 1988, 40 (3), 327-333
11. ^ a b c Stiborova, M.; Asfaw, B.; Frei, E., Peroxidase-Activated Carcinogenic Azo-Dye Sudan-I (Solvent Yellow-14) Binds To Guanosine In Transfer-Ribonucleic-Acid. General Physiology and Biophysics 1995, 14 (1), 39-49
12. ^ a b c d Matsumura, S.; Ikeda, N.; Hamada, S.; et al., Repeated-dose liver and gastrointestinal tract micronucleus assays with CI Solvent Yellow 14 (Sudan I) using young adult rats. Mutation research. Genetic toxicology and environmental mutagenesis 2015, 780-781, 76-80
13. ^ Lubet, R. A.; Connolly, G.; Kouri, R. E.; et al., Biological effects of the Sudan dyes: role of the Ah cytosolic receptor. Biochemical Pharmacology 1983, 32 (20), 3053-3058
14. ^ Stiborova, M.; Frei, E.; Klokow, K.; et al., PEROXIDASE-MEDIATED REACTION OF THE CARCINOGENIC NON-AMINOAZO DYE 1-PHENYLAZO-2-HYDROXYNAPHTHALENE WITH TRANSFER-RIBONUCLEIC-ACID. Carcinogenesis 1990, 11 (10), 1789-1794
15. ^ Stiborova, M.; Frei, E.; Schmeiser, H. H.; et al., MECHANISM OF FORMATION AND P-32 POSTLABELING OF DNA ADDUCTS DERIVED FROM PEROXIDATIVE ACTIVATION OF CARCINOGENIC NON-AMINOAZO DYE 1-PHENYLAZO-2-HYDROXYNAPHTHALENE (SUDAN-I). Carcinogenesis 1990, 11 (10), 1843-1848
16. ^ Stiborova, M.; Frei, E.; Anzenbacher, P., STUDY ON OXIDATION AND BINDING TO MACROMOLECULES OF THE CARCINOGENIC NON-AMINOAZO DYE 1-PHENYLAZO-2-HYDROXYNAPHTALENE CATALYZED BY HORSERADISH (AMORACIA-RUSTICANA L) PEROXIDASE. Biochemie Und Physiologie Der Pflanzen 1991, 187 (3), 227-236
17. ^ Stiborova, M.; Frei, E.; Schmeiser, H. H.; Wiessler, M., P-32 POSTLABELING ANALYSIS OF ADDUCTS FORMED FROM 1-PHENYLAZO-2-HYDROXYNAPHTHALENE (SUDAN I, SOLVENT YELLOW 14) WITH DNA AND HOMOPOLYDEOXYRIBONUCLEOTIDES. Carcinogenesis 1992, 13 (7), 1221-1225
18. ^ Stiborova, M.; Frei, E.; Schmeiser, H. H.; et al., DETOXICATION PRODUCTS OF THE CARCINOGENIC AZODYE SUDAN-I (SOLVENT YELLOW 14) BIND TO NUCLEIC-ACIDS AFTER ACTIVATION BY PEROXIDASE. Cancer Letters 1993, 68 (1), 43-47
19. ^ a b Stiborova, M.; Schmeiser, H. H.; Breuer, A.; Frei, E., P-32-postlabelling analysis of DNA adducts with 1-(phenylazo)-2-naphthol (Sudan I, Solvent Yellow 14) formed in vivo in Fisher 344 rats. Collection of Czechoslovak Chemical Communications 1999, 64 (8), 1335-1347
20. ^ (a) Frederick, C.; Hammons, G.; Beland, F.; et al., N-oxidation of primary aromatic amines in relation to chemical carcinogenesis. Biological Oxidation of Nitrogen in Organic Molecules: Chemistry, Toxicology and Pharmacology (Gorrod JW, Damani LA, eds). England: Ellis Horwood Ltd 1985, 131-148
21. ^ Wise, R. W.; Zenser, T. V.; Kadlubar, F. F.; Davis, B. B., Metabolic activation of carcinogenic aromatic amines by dog bladder and kidney prostaglandin H synthase. Cancer research 1984, 44 (5), 1893-1897
22. ^ Eling, T.; Thompson, D.; Foureman, G.; et al., Prostaglandin H synthase and xenobiotic oxidation. Annual review of pharmacology and toxicology 1990, 30 (1), 1-45
23. ^ Wanibuchi, H.; Yamamoto, S.; Chen, H.; et al., Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in rats. Carcinogenesis 1996, 17 (11), 2435-4239
24. ^ Stiborová, M.; Martínek, V.; Rýdlová, H.; et al., Sudan I Is a Potential Carcinogen for Humans Evidence for Its Metabolic Activation and Detoxication by Human Recombinant Cytochrome P450 1A1 and Liver Microsomes. Cancer Research 2002, 62 (20), 5678-5684
25. ^ Semanska, M.; Dracinsky, M.; Martinek, V.; et al., A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase. Neuro Endocrinology Letters 2008, 29 (5), 712-716
26. ^ Fox, M. R., Dye-makers of Great Britain. 1856-1976: A History of Chemists, Companies, Products and Changes ICI: Manchester, 1987
27. ^ a b Hunger, K., Toxicology and toxicological testing of colorants. Review of Progress in Coloration and Related Topics 2005, 35 (1), 76-89
28. ^ "Press corner". European Commission - European Commission. Retrieved 2024-08-05.
29. ^ a b "AZO Dyes | AZO Testing |Directive 2002/61/EC | CIRS" (PDF). www.cirs-reach.com. Retrieved 2024-08-05.
30. ^ a b Evaluation, Authorisation and Restriction of Chemicals (REACH) as regards Annex XVII. Commission, E., Ed. 2009
31. ^ Maronpot, R.; Boorman, G., Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicologic Pathology 1982, 10 (2), 71-78
32. ^ Tsuda, S.; Matsusaka, N.; Madarame, H.; et al., The comet assay in eight mouse organs: results with 24 azo compounds. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2000, 465 (1), 11-26
33. ^ Larsen, John Chr. (2008). "Legal and illegal colours". Trends in Food Science & Technology. 19: S64 – S69. doi:10.1016/j.tifs.2008.07.008.
34. ^ Stiborová M, Martínek V, Rýdlová H, et al. (October 2002). "Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes". Cancer Res. 62 (20): 5678–84\. PMID 12384524.
35. ^ Botha, Sean, ed. (2005-03-04). "Sudan outraged at namesake dye". BBC. Retrieved 2008-09-08.

## External links

[edit]

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*[CID]: Compound ID
*[EPA]: U.S. Environmental Protection Agency
*[H317]: H317: May cause an allergic skin reaction
*[H341]: H341: Suspected of causing genetic defects
*[H351]: H351: Suspected of causing cancer
*[H413]: H413: May cause long lasting harmful effects to aquatic life
*[P201]: P201: Obtain special instructions before use.
*[P202]: P202: Do not handle until all safety precautions have been read and understood.
*[P261]: P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
*[P272]: P272: Contaminated work clothing should not be allowed out of the workplace.
*[P273]: P273: Avoid release to the environment.
*[P280]: P280: Wear protective gloves/protective clothing/eye protection/face protection.
*[P281]: P281: Use personal protective equipment as required.
*[P302+P352]: P302+P352: IF ON SKIN: Wash with soap and water.
*[P308+P313]: P308+P313: IF exposed or concerned: Get medical advice/attention.
*[P321]: P321: Specific treatment (see ... on this label).
*[P333+P313]: P333+P313: If skin irritation or a rash occurs: Get medical advice/attention.
*[P363]: P363: Wash contaminated clothing before reuse.
*[P405]: P405: Store locked up.
*[P501]: P501: Dispose of contents/container to ...
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