TARBP1

Protein-coding gene in the species Homo sapiens

TARBP1

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2HA8

Identifiers
Aliases| TARBP1, TRM3, TRP-185, TRP185, TAR (HIV-1) RNA binding protein 1, TRMT3
External IDs| OMIM: 605052 MGI: 4936930 HomoloGene: 38082 GeneCards: TARBP1
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1q42.2| Start| 234,391,313 bp[1]
End| 234,479,179 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 8 (mouse)[2]

Band| 8|8 E2| Start| 127,152,068 bp[2]
End| 127,201,804 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* right uterine tube

* Brodmann area 9

* nucleus accumbens

* rectum

* pituitary gland

* anterior pituitary

* caudate nucleus

* body of pancreas

* tibial nerve

* lymph node

| Top expressed in

* aortic valve

* hair follicle

* ascending aorta

* cumulus cell

* Paneth cell

* primitive streak

* secondary oocyte

* ureter

* arm

* upper arm

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* methyltransferase activity
* RNA methyltransferase activity
* transferase activity
* tRNA (guanine) methyltransferase activity
* RNA binding
* rRNA (guanosine-2'-O-)-methyltransferase activity

Cellular component|

* nucleus

Biological process|

* regulation of transcription by RNA polymerase II
* methylation
* RNA processing
* tRNA methylation
* enzyme-directed rRNA 2'-O-methylation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

6894

212728

Ensembl| |

ENSG00000059588

ENSMUSG00000090290

UniProt| |

Q13395

E9Q368

RefSeq (mRNA)| |

NM_005646

NM_001159907

RefSeq (protein)| |

NP_005637

NP_001153379

Location (UCSC)| Chr 1: 234.39 – 234.48 Mb| Chr 8: 127.15 – 127.2 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.[5][6]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.[6]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000059588 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090290 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Wu F, Garcia J, Sigman D, Gaynor R (Dec 1991). "tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185". Genes Dev. 5 (11): 2128–40. doi:10.1101/gad.5.11.2128. PMID 1936997.
6. ^ a b "Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1".

## Further reading[edit]

* Sheline CT, Milocco LH, Jones KA (1992). "Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin". Genes Dev. 5 (12B): 2508–20. doi:10.1101/gad.5.12b.2508. PMID 1752441.
* Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
* Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
* Wu-Baer F, Lane WS, Gaynor RB (1996). "The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA". EMBO J. 14 (23): 5995–6009. doi:10.1002/j.1460-2075.1995.tb00288.x. PMC 394719. PMID 8846792.
* Yedavalli VS, Benkirane M, Jeang KT (2003). "Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1". J. Biol. Chem. 278 (8): 6404–10. doi:10.1074/jbc.M209162200. PMID 12458222.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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* 2ha8: Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1

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