TECR

Protein-coding gene in the species Homo sapiens

TECR

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2DZJ

Identifiers
Aliases| TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase
External IDs| OMIM: 610057; MGI: 1915408; HomoloGene: 36231; GeneCards: TECR; OMA:TECR - orthologs
| Gene location (Human)

Chr.| Chromosome 19 (human)[1]

Band| 19p13.12| Start| 14,517,085 bp[1]
End| 14,565,980 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 8 (mouse)[2]

Band| 8 C2|8 40.22 cM| Start| 84,298,327 bp[2]
End| 84,334,600 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* right hemisphere of cerebellum

* left testis

* right testis

* skin of abdomen

* skin of leg

* C1 segment

* minor salivary glands

* muscle of thigh

* right adrenal cortex

* right frontal lobe

| Top expressed in

* central gray substance of midbrain

* cerebellar cortex

* cerebellar vermis

* dorsal tegmental nucleus

* ventromedial nucleus

* medial vestibular nucleus

* primary visual cortex

* supraoptic nucleus

* lobe of cerebellum

* pontine nuclei

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* oxidoreductase activity, acting on the CH-CH group of donors
* protein binding
* very-long-chain-acyl-CoA dehydrogenase activity
* oxidoreductase activity
* very-long-chain enoyl-CoA reductase activity

Cellular component|

* cytoplasm
* integral component of membrane
* integral component of endoplasmic reticulum membrane
* endoplasmic reticulum membrane
* endoplasmic reticulum
* nucleus
* membrane

Biological process|

* fatty acid elongation
* fatty acid biosynthetic process
* long-chain fatty-acyl-CoA biosynthetic process
* very long-chain fatty acid biosynthetic process
* fatty acid metabolic process
* lipid metabolism
* sphingolipid metabolic process

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

9524

106529

Ensembl| |

ENSG00000099797

ENSMUSG00000031708

UniProt| |

Q9NZ01

Q9CY27

RefSeq (mRNA)| |

NM_004868
NM_138501
NM_001321170

NM_027179
NM_134118

RefSeq (protein)| |

NP_001308099
NP_612510

NP_081455
NP_598879

Location (UCSC)| Chr 19: 14.52 – 14.57 Mb| Chr 8: 84.3 – 84.33 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.[5]

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[5]

## Clinical relevance

[edit]

Mutations in this gene have been shown to cause non-syndromic mental retardation.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099797 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031708 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: Trans-2,3-enoyl-CoA reductase". Retrieved 2011-12-30.
6. ^ Çalışkan M, Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C (April 2011). "Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13". Hum. Mol. Genet. 20 (7): 1285–9\. doi:10.1093/hmg/ddq569. PMC 3115579. PMID 21212097.

## Further reading

[edit]

* Moon, Y. -A.; Horton, J. D. (2002). "Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade". Journal of Biological Chemistry. 278 (9): 7335–7343\. doi:10.1074/jbc.M211684200. PMID 12482854.
* Hashmi, G.; Shariff, T.; Seul, M.; Vissavajjhala, P.; Hue-Roye, K.; Charles-Pierre, D.; Lomas-Francis, C.; Chaudhuri, A.; Reid, M. E. (2005). "A flexible array format for large-scale, rapid blood group DNA typing". Transfusion. 45 (5): 680–688\. doi:10.1111/j.1537-2995.2005.04362.x. PMID 15847654. S2CID 40662473.
* Lehner, R.; Kuksis, A. (1996). "Biosynthesis of triacylglycerols". Progress in Lipid Research. 35 (2): 169–201\. doi:10.1016/0163-7827(96)00005-7. PMID 8944226.
* Mao, M.; Fu, G.; Wu, J. S.; Zhang, Q. H.; Zhou, J.; Kan, L. X.; Huang, Q. H.; He, K. L.; Gu, B. W.; Han, Z. -G.; Shen, Y.; Gu, J.; Yu, Y. -P.; Xu, S. -H.; Wang, Y. -X.; Chen, S. -J.; Chen, Z. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180\. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

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Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor|

* Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
* 7-Dehydrocholesterol reductase
* Biliverdin reductase
* 2,4 Dienoyl-CoA reductase
* Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor|

* Dihydroorotate dehydrogenase
* Coproporphyrinogen III oxidase
* Protoporphyrinogen oxidase
* Bilirubin oxidase
* Acyl-CoA oxidase
* Dihydrouracil oxidase
* Tetrahydroberberine oxidase
* Secologanin synthase
* Tryptophan alpha,beta-oxidase
* Pyrroloquinoline-quinone synthase
* L-galactonolactone oxidase

1.3.5: Quinone|

* Succinate dehydrogenase
* SDHA
* SDHB
* SDHC
* SDHD

1.3.99: Other acceptors|

* Fumarate reductase
* Butyryl-CoA dehydrogenase
* Acyl CoA dehydrogenase
* ACADSB
* ACADS
* 5α-reductase
* SRD5A1
* SRD5A2
* SRD5A3
* Glutaryl-CoA dehydrogenase
* Isovaleryl coenzyme A dehydrogenase
* 3-oxo-5beta-steroid 4-dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

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