TGF-beta receptor family

Family of proteins involved in a TGF signaling pathway

See also: TGF beta receptor and TGFβ signaling pathway

Protein family

Ser/Thr protein kinase, TGFB receptor

Identifiers
Symbol| TGFb_receptor
InterPro| IPR000333
SCOP2| 1B6C / SCOPe / SUPFAM
Membranome| 1216

The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian hormone (AMH), and NODAL.[1]

## TGFβ family receptors

[edit]

TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]

### Type I

[edit]

Protein family

Transforming growth factor beta type I GS-motif

Identifiers
Symbol| TGF_beta_GS
Pfam| PF08515
InterPro| IPR003605
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

* ALK1 (ACVRL1)
* ALK2 (ACVR1A)
* ALK3 (BMPR1A)
* ALK4 (ACVR1B)
* ALK5 (TGFβR1)
* ALK6 (BMPR1B)
* ALK7 (ACVR1C)

### Type II

[edit]

* TGFβR2
* BMPR2
* ACVR2A
* ACVR2B
* AMHR2 (AMHR)

### Type III

[edit]

Unlike the Type I and II receptors which are kinases, TGFBR3 has a Zona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors.[6][7]

* TGFβR3 (β-glycan)

## References

[edit]

1. ^ "Prosite Documentation PDOC00223". Archived from the original on 2011-05-25. Retrieved 2006-07-01.
2. ^ Fliesler SJ, Kisselev OG (26 December 2007). Signal Transduction in the Retina. CRC Press. pp. 273–. ISBN 978-1-4200-0716-9.
3. ^ Thiriet M (14 December 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. pp. 666–. ISBN 978-1-4614-1991-4.
4. ^ Wrana JL, Attisano L, Cárcamo J, et al. (December 1992). "TGF beta signals through a heteromeric protein kinase receptor complex". Cell. 71 (6): 1003–14\. doi:10.1016/0092-8674(92)90395-S. PMID 1333888. S2CID 54397586.
5. ^ Huse, M; Muir, TW; Xu, L; Chen, YG; Kuriyan, J; Massagué, J (September 2001). "The TGF beta receptor activation process: an inhibitor- to substrate-binding switch". Molecular Cell. 8 (3): 671–82\. doi:10.1016/S1097-2765(01)00332-X. PMID 11583628.
6. ^ Andres JL, Stanley K, et al. (1989). "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145\. doi:10.1083/jcb.109.6.3137. PMC 2115961. PMID 2592419.
7. ^ Andres JL, DeFalcis D, et al. (1992). "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930\. doi:10.1016/S0021-9258(18)42643-9. PMID 1556106.

* v
* t
* e

Cell signaling: TGFβ signaling pathway

TGF beta superfamily of ligands|

| Ligand of ACVR or TGFBR|

* TGF beta family
* TGF-β1
* TGF-β2
* TGF-β3
* Activin and inhibin
* INHA
* INHBA
* INHBB
* INHBC
* Nodal

|

Ligand of BMPR|

* Bone morphogenetic proteins
* BMP2
* BMP3
* BMP4
* BMP5
* BMP6
* BMP7
* BMP8a
* BMP8b
* BMP10
* BMP15
* Growth differentiation factors
* GDF1
* GDF2
* GDF3
* GDF5
* GDF6
* GDF7
* Myostatin/GDF8
* GDF9
* GDF10
* GDF11
* GDF15
* Anti-müllerian hormone

TGF beta receptors
(Activin, BMP, family)|

| TGFBR1:|

* Activin type 1 receptors
* ACVR1
* ACVR1B
* ACVR1C
* ACVRL1
* BMPR1
* BMPR1A
* BMPR1B

|

TGFBR2:|

* Activin type 2 receptors
* ACVR2A
* ACVR2B
* AMHR2
* BMPR2

TGFBR3:|

* Betaglycan

Transducers/SMAD|

* R-SMAD (SMAD1
* SMAD2
* SMAD3
* SMAD5
* SMAD9)
* I-SMAD (SMAD6
* SMAD7)
* SMAD4

Ligand inhibitors|

* Cerberus
* Chordin
* Decorin
* Follistatin
* Gremlin
* Lefty
* LTBP1
* Noggin
* PARN
* THBS1

Coreceptors|

* BAMBI
* Cripto

Other|

* SARA

* v
* t
* e

Receptors: growth factor receptors

Type I cytokine receptor|

* Nerve growth factors: Ciliary neurotrophic factor
* Erythropoietin

Receptor protein serine/threonine kinase|

* TGF pathway: TGF-beta
* 1
* 2
* Activin
* 1
* 2
* Bone morphogenetic protein
* 1
* 2

Receptor tyrosine kinase|

* Fibroblast growth factor
* 1
* 2
* 3
* 4

* Nerve growth factors: high affinity Trk
* TrkA
* TrkB
* TrkC

* Hepatocyte growth factor

* Somatomedin
* Insulin-like growth factor 1

* ErbB/Epidermal growth factor

* VEGF
* 1
* 2
* 3

Tumor necrosis factor receptor|

* Nerve growth factors: Low affinity/p75

Ig superfamily|

* Platelet-derived growth factor
* A
* B
* Stem cell factor

Other/ungrouped|

* Somatomedin
* Insulin-like growth factor 2

* v
* t
* e

Cytokine receptors

Chemokine receptor
(GPCRs)|

| CC|

* CCR1 / CCRL1
* CCR2
* CCRL2
* CCR3
* CCR4
* CCR5
* CCR6
* CCR7
* CCR8
* CCR9
* CCR10

|

CXC|

* IL-8
* CXCR1
* CXCR2
* CXCR3
* CXCR4
* CXCR5
* CXCR6
* CXCR7

Other|

* CX3C
* CX3CR1
* XC
* XCR1
* CCBP2
* CMKLR1

TNF receptor|

| 1-10|

* TNFR1 (TNFRSF1A)
* TNFR2 (TNFRSF1B)
* LTBR (TNFRSF3)
* CD134 (TNFRSF4)
* CD40 (TNFRSF5)
* Fas receptor (TNFRSF6)
* DcR3 (TNFRSF6B)
* CD27 (TNFRSF7)
* CD30 (TNFRSF8)
* CD137 (TNFRSF9)

|

11-20|

* DR4 (TNFRSF10A)
* DR5 (TNFRSF10B)
* DcR1 (TNFRSF10C)
* DcR2 (TNFRSF10D)
* RANK (TNFRSF11A)
* Osteoprotegerin (TNFRSF11B)
* TweakR (TNFRSF12A)
* TACI (TNFRSF13B)
* BAFFR (TNFRSF13C)
* HVEM (TNFRSF14)
* NGFR (TNFRSF16)
* BCMA (TNFRSF17)
* GITR (TNFRSF18)
* TAJ/TROY (TNFRSF19)

21-27|

* DR6 (TNFRSF21)
* DR3 (TNFRSF25)
* EDA2R (TNFRSF27)

JAK-STAT|

| Type I|

| γ-chain|

* Interleukin receptors
* IL2R / IL2RA/IL2RB / IL15R
* IL4R / IL13R / IL13RA1 / IL13RA2
* IL7R / IL7RA
* IL9R
* IL21R

|

β-chain|

* Interleukin receptors
* IL3R / IL3RA
* IL5R / IL5RA
* GM-CSF

gp130|

* Interleukin receptors
* IL6RA
* 11/IL11RA
* 27/IL27RA
* OSMR
* LIFR
* CNTFR

IL12RB1|

* Interleukin receptors
* IL12R/IL12RB1/IL12RB2
* IL23R

Other|

* other CSF receptors
* EPO
* G-CSF
* Thrombopoietin

* hormone receptor: GH
* prolactin

Type II|

* Interleukin receptors
* IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
* IL20R / IL20RA / IL20RB
* IL28R
* Interferon receptors
* -α/β / IFNAR1/IFNAR2
* -γ/IFNGR1 / IFNGR2

Ig superfamily|

*   * IL1
* IL1R1
* IL1R2
* IL18R / IL18R1

IL 17 family|

* IL17
* IL17RA
* IL17RB
* IL17RC
* IL17RD
* IL17RE

Enzyme-linked receptor|

* Tyr
* CSF1R
* KIT
* Ser/Thr: TGF-beta
* TGFBR1
* TGFBR2
* family

* v
* t
* e

Cell surface receptors: enzyme-linked receptors

Receptor protein serine/threonine kinase|

* Bone morphogenetic protein receptors
* BMPR1
* BMPR1A
* BMPR1B
* BMPR2
* ACVR1
* ACVR1B
* ACVR1C
* ACVR2A
* ACVR2B
* ACVRL1
* Anti-Müllerian hormone receptor

Receptor tyrosine kinase|

| EGF receptor family|

* EGFR
* ERBB2
* ERBB3
* ERBB4

|

Insulin receptor family|

* IGF1R
* INSR
* INSRR

PDGF receptor family|

* CSF1R
* FLT3
* KIT
* PDGFR
* PDGFRA
* PDGFRB

FGF receptor family|

* FGFR1
* FGFR2
* FGFR3
* FGFR4

VEGF receptors family|

* VEGFR1
* VEGFR2
* VEGFR3
* VEGFR4

HGF receptor family|

* MET
* RON

Trk receptor family|

* NTRK1
* NTRK2
* NTRK3

EPH receptor family|

* EPHA1
* EPHA2
* EPHA3
* EPHA4
* EPHA5
* EPHA6
* EPHA7
* EPHA8
* EPHB1
* EPHB2
* EPHB3
* EPHB4
* EPHB5
* EPHB6
* EPHX

LTK receptor family|

* LTK
* ALK

TIE receptor family|

* TIE
* TEK

ROR receptor family|

* ROR1
* ROR2

DDR receptor family|

* DDR1
* DDR2

PTK7 receptor family|

* PTK7

RYK receptor family|

* RYK

MuSK receptor family|

* MUSK

ROS receptor family|

* ROS1

AATYK receptor family|

* AATYK
* AATYK2
* AATYK3

AXL receptor family|

* AXL
* MER
* TYRO3

RET receptor family|

* RET

uncategorised|

* STYK1

Guanylate cyclase-coupled receptor|

* ANP: NPR1
* NPR2

* GUCY2C
* GUCY2D

Receptor tyrosine phosphatase|

* PTPRA
* PTPRB
* PTPRC
* PTPRD
* PTPRE
* PTPRF
* PTPRG
* PTPRH
* PTPRJ
* PTPRK
* PTPRM
* PTPRN
* PTPRN2
* PTPRO
* PTPRQ
* PTPRR
* PTPRS
* PTPRT
* PTPRU
* PTPRZ

* v
* t
* e

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

| Non-specific serine/threonine protein kinases (EC 2.7.11.1)|

* LATS1
* LATS2
* MAST1
* MAST2
* STK38
* STK38L
* CIT
* ROCK1
* SGK
* SGK2
* SGK3
* Protein kinase B
* AKT1
* AKT2
* AKT3
* Ataxia telangiectasia mutated
* mTOR
* EIF-2 kinases
* PKR
* HRI
* EIF2AK3
* EIF2AK4
* Wee1
* WEE1

|

Pyruvate dehydrogenase kinase (EC 2.7.11.2)|

* PDK1
* PDK2
* PDK3
* PDK4

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)|

* AMP-activated protein kinase α
* PRKAA1
* PRKAA2
* β
* PRKAB1
* PRKAB2
* γ
* PRKAG1
* PRKAG2
* PRKAG3

3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)|

* BCKDK
* BCKDHA
* BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)|

* IDH2
* IDH3A
* IDH3B
* IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)|

* STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)|

* Aurora kinase
* Aurora A kinase
* Aurora B kinase
* Aurora C kinase

Fas-activated serine/threonine kinase (EC 2.7.11.8)|

* FASTK
* STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)|

* -

IκB kinase (EC 2.7.11.10)|

* CHUK
* IKK2
* TBK1
* IKBKE
* IKBKG
* IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)|

* Protein kinase A
* PRKACG
* PRKACB
* PRKACA
* PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)|

* Protein kinase G
* PRKG1

Protein kinase C (EC 2.7.11.13)|

* Protein kinase C
* Protein kinase Cζ
* PKC alpha
* PRKCB1
* PRKCD
* PRKCE
* PRKCH
* PRKCG
* PRKCI
* PRKCQ
* Protein kinase N1
* PKN2
* PKN3

Rhodopsin kinase (EC 2.7.11.14)|

* Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)|

* Beta adrenergic receptor kinase
* Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)|

* GRK4
* GRK5
* GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)|

* BRSK2
* CAMK1
* CAMK1A
* CAMK1B
* CAMK1D
* CAMK1G
* CAMK2
* CAMK2A
* CAMK2B
* CAMK2D
* CAMK2G
* CAMK4
* MLCK
* CASK
* CHEK1
* CHEK2
* DAPK1
* DAPK2
* DAPK3
* STK11
* MAPKAPK2
* MAPKAPK3
* MAPKAPK5
* MARK1
* MARK2
* MARK3
* MARK4
* MELK
* MKNK1
* MKNK2
* NUAK1
* NUAK2
* OBSCN
* PASK
* PHKG1
* PHKG2
* PIM1
* PIM2
* PKD1
* PRKD2
* PRKD3
* PSKH1
* SNF1LK2
* KIAA0999
* STK40
* SNF1LK
* SNRK
* SPEG
* TSSK2
* Kalirin
* TRIB1
* TRIB2
* TRIB3
* TRIO
* Titin
* DCLK1

Myosin light-chain kinase (EC 2.7.11.18)|

* MYLK
* MYLK2
* MYLK3
* MYLK4

Phosphorylase kinase (EC 2.7.11.19)|

* PHKA1
* PHKA2
* PHKB
* PHKG1
* PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)|

* EEF2K
* STK19

Polo kinase (EC 2.7.11.21)|

* PLK1
* PLK2
* PLK3
* PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

| Polo kinase (EC 2.7.11.21)|

* PLK1
* PLK2
* PLK3
* PLK4

|

Cyclin-dependent kinase (EC 2.7.11.22)|

* CDK1
* CDK2
* CDKL2
* CDK3
* CDK4
* CDK5
* CDKL5
* CDK6
* CDK7
* CDK8
* CDK9
* CDK10
* CDK12
* CDC2L5
* PCTK1
* PCTK2
* PCTK3
* PFTK1
* CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)|

* RPS6KA5
* RPS6KA4
* P70S6 kinase
* P70-S6 Kinase 1
* RPS6KB2
* RPS6KA2
* RPS6KA3
* RPS6KA1
* RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)|

* Extracellular signal-regulated
* MAPK1
* MAPK3
* MAPK4
* MAPK6
* MAPK7
* MAPK12
* MAPK15
* C-Jun N-terminal
* MAPK8
* MAPK9
* MAPK10
* P38 mitogen-activated protein
* MAPK11
* MAPK13
* MAPK14

MAP3K (EC 2.7.11.25)|

* MAP kinase kinase kinases
* MAP3K1
* MAP3K2
* MAP3K3
* MAP3K4
* MAP3K5
* MAP3K6
* MAP3K7
* MAP3K8
* RAFs
* ARAF
* BRAF
* KSR1
* KSR2
* MLKs
* MAP3K12
* MAP3K13
* MAP3K9
* MAP3K10
* MAP3K11
* MAP3K7
* ZAK
* CDC7
* MAP3K14

Tau-protein kinase (EC 2.7.11.26)|

* TPK1
* TTK
* GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)|

* -

Tropomyosin kinase (EC 2.7.11.28)|

* -

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)|

* -

Receptor protein serine/threonine kinase (EC 2.7.11.30)|

* Bone morphogenetic protein receptors
* BMPR1
* BMPR1A
* BMPR1B
* BMPR2
* ACVR1
* ACVR1B
* ACVR1C
* ACVR2A
* ACVR2B
* ACVRL1
* Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

| MAP2K|

* MAP2K1
* MAP2K2
* MAP2K3
* MAP2K4
* MAP2K5
* MAP2K6
* MAP2K7

|

* v
* t
* e

TGFβ receptor superfamily modulators

Type I|

| ALK1 (ACVRL1)|

* Agonists: Activin (A, B, AB)
* Avotermin
* BMP (10)
* Cetermin
* GDF (2 (BMP9))
* TGFβ (1, 2, 3)

* Antibodies: Ascrinvacumab

* Kinase inhibitors: K-02288
* ML-347 (LDN-193719, VU0469381)

* Decoy receptors: Dalantercept

* Other inhibitors: Disitertide

|

ALK2 (ACVR1A)|

* Agonists: Activin (A, B, AB)
* AMH (MIS)
* Avotermin
* BMP (5, 6, 7, 8A, 8B)
* Eptotermin alfa
* TGFβ (1, 2, 3)

* Kinase inhibitors: DMH-1
* DMH-2
* Dorsomorphin (BML-275)
* K-02288
* ML-347 (LDN-193719, VU0469381)

ALK3 (BMPR1A)|

* Agonists: AMH (MIS)
* BMP (2, 4, 5, 6, 7, 8A, 8B)
* Dibotermin alfa
* Eptotermin alfa

* Kinase inhibitors: DMH-2
* Dorsomorphin (BML-275)
* K-02288

ALK4 (ACVR1B)|

* Agonists: Activin (A, B, AB)
* GDF (1, 3, 11 (BMP11))
* Myostatin (GDF8)
* Nodal

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Kinase inhibitors: A 83-01
* SB-431542
* SB-505124

ALK5 (TGFβR1)|

* Agonists: Avotermin
* GDF (10 (BMP3B), 11 (BMP11))
* TGFβ (1, 2, 3)

* Antibodies: Fresolimumab
* Lerdelimumab
* Metelimumab

* Kinase inhibitors: A 83-01
* D-4476
* GW-788388
* LY-364947
* LY-2109761
* Galunisertib (LY-2157299)
* R-268712
* RepSox (E-616452, SJN-2511)
* SB-431542
* SB-505124
* SB-525334
* SD-208

ALK6 (BMPR1B)|

* Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
* Dibotermin alfa
* Eptotermin alfa
* GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
* Radotermin

* Kinase inhibitors: DMH-2
* Dorsomorphin (BML-275)
* K-02288

ALK7 (ACVR1C)|

* Agonists: GDF (1, 3, 11 (BMP11))
* Nodal

* Antagonists: Lefty (1, 2)

* Kinase inhibitors: A 83-01
* SB-431542
* SB-505124

Type II|

| TGFβR2|

* Agonists: Avotermin
* GDF (10 (BMP3B))
* TGFβ (1, 2, 3)

* Antibodies: Fresolimumab
* Lerdelimumab
* Metelimumab

* Kinase inhibitors: DMH-2
* LY-364947

|

BMPR2|

* Agonists: BMP (2, 4, 6, 7, 10)
* Dibotermin alfa
* Eptotermin alfa
* GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
* Radotermin

* Antagonists: Inhibin (A, B)

ACVR2A (ACVR2)|

* Agonists: Activin (A, B, AB)
* BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
* Dibotermin alfa
* Eptotermin alfa
* GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
* Myostatin (GDF8)
* Nodal
* Radotermin

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Decoy receptors: Sotatercept

ACVR2B|

* Agonists: Activin (A, B, AB)
* BMP (2, 4, 6, 7)
* Dibotermin alfa
* Eptotermin alfa
* GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
* Myostatin (GDF8)
* Nodal
* Osteogenin (BMP3, BMP3A)
* Radotermin

* Antagonists: Inhibin (A, B)
* Lefty (1, 2)

* Decoy receptors: Ramatercept

AMHR2 (AMHR)|

* Agonists: AMH (MIS)

Type III|

| TGFβR3 (β-glycan)|

* Ligands: Avotermin
* Inhibin (A, B)
* TGFβ (1, 2, 3)

|

Unsorted|

* Endogenous antagonists/inhibitors: BAMBI
* Cerberus (CER1)
* Chordin
* DAN (PARN)
* Decorin
* Follistatin
* Gremlin (Drm)
* LTBP1
* Noggin
* TGIF
* Thrombospondin 1 (THBS1)
* Tomoregulin 1

* Antibodies: Stamulumab (against myostatin)
* TRC105 (against endoglin)

* Others: Endoglin

Portal:

* Biology

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|

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[TGFβ]: Transforming growth factor beta
*[ALK1]: Activin receptor-like kinase 1
*[ACVRL1]: Activin A receptor-like type 1
*[ALK2]: Activin receptor-like kinase 2
*[ACVR1A]: Activin A receptor type 1A
*[ALK3]: Activin receptor-like kinase 3
*[BMPR1A]: Bone morphogenetic protein receptor type 1A
*[ALK4]: Activin receptor-like kinase 4
*[ACVR1B]: Activin A receptor type 1B
*[ALK5]: Activin receptor-like kinase 5
*[TGFβR1]: Transforming growth factor beta receptor 1
*[ALK6]: Activin receptor-like kinase 6
*[BMPR1B]: Bone morphogenetic protein receptor type 1B
*[ALK7]: Activin receptor-like kinase 7
*[ACVR1C]: Activin A receptor type 1C
*[TGFβR2]: Transforming growth factor beta receptor 2
*[BMPR2]: Bone morphogenetic protein receptor type 2
*[ACVR2A]: Activin receptor type 2A
*[ACVR2]: Activin receptor type 2
*[ACVR2B]: Activin receptor type 2B
*[AMHR2]: Anti-Müllerian hormone receptor type 2
*[AMHR]: Anti-Müllerian hormone receptor
*[TGFβR3]: Transforming growth factor beta receptor 3