TIRAP

Protein-coding gene in the species Homo sapiens

TIRAP

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2Y92, 3UB2, 3UB3, 3UB4, 4FZ5, 4LQD

Identifiers
Aliases| TIRAP, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein
External IDs| OMIM: 606252; MGI: 2152213; HomoloGene: 14285; GeneCards: TIRAP; OMA:TIRAP - orthologs
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11q24.2| Start| 126,283,065 bp[1]
End| 126,298,845 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 9 (mouse)[2]

Band| 9|9 A4| Start| 35,095,847 bp[2]
End| 35,111,587 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* buccal mucosa cell

* monocyte

* bone marrow cells

* islet of Langerhans

* rectum

* smooth muscle tissue

* left ovary

* right ovary

* right lobe of liver

* minor salivary glands

| Top expressed in

* granulocyte

* triceps brachii muscle

* vastus lateralis muscle

* muscle of thigh

* conjunctival fornix

* sternocleidomastoid muscle

* primitive streak

* temporal muscle

* knee joint

* parotid gland

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein-macromolecule adaptor activity
* protein homodimerization activity
* Toll-like receptor 2 binding
* Toll-like receptor 4 binding
* protein binding
* protein heterodimerization activity
* phosphatidylinositol-4,5-bisphosphate binding
* protein kinase C binding
* identical protein binding

Cellular component|

* cytoplasm
* cytosol
* membrane
* plasma membrane
* endocytic vesicle
* ruffle membrane

Biological process|

* myeloid cell differentiation
* regulation of innate immune response
* cellular response to bacterial lipopeptide
* positive regulation of toll-like receptor 3 signaling pathway
* positive regulation of interleukin-12 production
* positive regulation of chemokine (C-X-C motif) ligand 1 production
* positive regulation of chemokine (C-X-C motif) ligand 2 production
* immune system process
* positive regulation of JNK cascade
* MyD88-dependent toll-like receptor signaling pathway
* positive regulation of interleukin-15 production
* positive regulation of protein homodimerization activity
* cell surface receptor signaling pathway
* response to lipopolysaccharide
* TIRAP-dependent toll-like receptor 4 signaling pathway
* cellular response to lipoteichoic acid
* positive regulation of B cell proliferation
* regulation of interferon-beta production
* positive regulation of NF-kappaB transcription factor activity
* positive regulation of interleukin-8 production
* positive regulation of ERK1 and ERK2 cascade
* positive regulation of neutrophil chemotaxis
* positive regulation of tumor necrosis factor production
* positive regulation of toll-like receptor 4 signaling pathway
* positive regulation of I-kappaB kinase/NF-kappaB signaling
* positive regulation of toll-like receptor 2 signaling pathway
* 3'-UTR-mediated mRNA stabilization
* inflammatory response
* signal transduction
* defense response to Gram-positive bacterium
* innate immune response
* activation of NF-kappaB-inducing kinase activity

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

114609

117149

Ensembl| |

ENSG00000150455

ENSMUSG00000032041

UniProt| |

P58753

Q99JY1

RefSeq (mRNA)| |

NM_001039661
NM_052887
NM_148910
NM_001318776
NM_001318777

NM_001177845
NM_001177846
NM_001177847
NM_054096

RefSeq (protein)| |

NP_001034750
NP_001305705
NP_001305706
NP_683708

NP_001171316
NP_001171317
NP_001171318
NP_473437

Location (UCSC)| Chr 11: 126.28 – 126.3 Mb| Chr 9: 35.1 – 35.11 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

## See also

[edit]

* Myd88

## External links

[edit]

* TIRAP+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

* v
* t
* e

Signaling pathway: TLR signaling pathway

TLRs|

* TLR1
* TLR2
* TLR3
* TLR4
* TLR5
* TLR6
* TLR7
* TLR8
* TLR9
* TLR10
* TLR11
* TLR12
* TLR13

Other receptors|

* CD14
* LBP
* MD2

Downstream signalling|

* IRAK1
* IRAK2
* IRAK3
* IRAK4
* IRF3
* MAP3K7
* MYD88
* TAB1
* TICAM1
* TIRAP
* TOLLIP
* TRAF6

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150455 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032041 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template