TRIP4

Protein-coding gene in the species Homo sapiens

TRIP4

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2E5O

Identifiers
Aliases| TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs| OMIM: 604501; MGI: 1928469; HomoloGene: 9426; GeneCards: TRIP4; OMA:TRIP4 - orthologs
| Gene location (Human)

Chr.| Chromosome 15 (human)[1]

Band| 15q22.31| Start| 64,387,748 bp[1]
End| 64,455,303 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 9 (mouse)[2]

Band| 9|9 C| Start| 65,736,212 bp[2]
End| 65,816,076 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* sural nerve

* amniotic fluid

* mucosa of transverse colon

* jejunal mucosa

* monocyte

* gonad

* right lobe of thyroid gland

* left lobe of thyroid gland

* ganglionic eminence

* anterior pituitary

| Top expressed in

* pineal gland

* granulocyte

* spermatocyte

* left lobe of liver

* zygote

* spermatid

* lumbar spinal ganglion

* secondary oocyte

* substantia nigra

* cumulus cell

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protease binding
* transcription coactivator activity
* zinc ion binding
* estrogen receptor binding
* protein binding
* histone acetyltransferase binding
* nuclear receptor binding
* ubiquitin-like protein ligase binding
* metal ion binding
* protein kinase binding

Cellular component|

* cytoplasm
* cytosol
* cytoskeleton
* nucleus
* nucleoplasm
* microtubule organizing center
* neuromuscular junction
* nuclear body
* activating signal cointegrator 1 complex
* centrosome
* protein-containing complex

Biological process|

* positive regulation of transcription, DNA-templated
* toxin transport
* intracellular estrogen receptor signaling pathway
* transcription, DNA-templated
* regulation of transcription, DNA-templated
* regulation of myoblast differentiation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

9325

56404

Ensembl| |

ENSG00000103671

ENSMUSG00000032386

UniProt| |

Q15650

Q9QXN3

RefSeq (mRNA)| |

NM_016213
NM_001321924

NM_001170907
NM_019797
NM_001357872

RefSeq (protein)| |

NP_001308853
NP_057297

NP_001164378
NP_062771
NP_001344801

Location (UCSC)| Chr 15: 64.39 – 64.46 Mb| Chr 9: 65.74 – 65.82 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.[5][6]

## Interactions

[edit]

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.[7]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54\. doi:10.1210/mend.9.2.7776974. PMID 7776974.
6. ^ "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
7. ^ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32\. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

## Further reading

[edit]

* Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8\. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
* Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101\. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11\. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
* Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93\. doi:10.1074/jbc.274.48.34283. PMID 10567404.
* Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32\. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

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