TRIP6

Protein-coding gene in the species Homo sapiens

TRIP6

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

1X61, 2DLO

Identifiers
Aliases| TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDs| OMIM: 602933; MGI: 1343458; HomoloGene: 37757; GeneCards: TRIP6; OMA:TRIP6 - orthologs
| Gene location (Human)

Chr.| Chromosome 7 (human)[1]

Band| 7q22.1| Start| 100,867,387 bp[1]
End| 100,873,454 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G2| Start| 137,307,916 bp[2]
End| 137,312,666 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* body of uterus

* right lobe of thyroid gland

* palpebral conjunctiva

* canal of the cervix

* left uterine tube

* nipple

* ectocervix

* left lobe of thyroid gland

* ascending aorta

* gastric mucosa

| Top expressed in

* external carotid artery

* internal carotid artery

* vas deferens

* condyle

* ascending aorta

* efferent ductule

* aortic valve

* fossa

* vestibular membrane of cochlear duct

* dermis

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* kinase binding
* protein binding
* interleukin-1 receptor binding
* metal ion binding
* thyroid hormone receptor binding
* RNA binding

Cellular component|

* cell junction
* plasma membrane
* interleukin-1 receptor complex
* cytoskeleton
* nucleus
* focal adhesion
* cytoplasm
* cytosol
* stress fiber

Biological process|

* focal adhesion assembly
* cell adhesion
* regulation of transcription, DNA-templated
* transcription, DNA-templated
* positive regulation of cell migration
* positive regulation of NIK/NF-kappaB signaling
* signal transduction

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

7205

22051

Ensembl| |

ENSG00000087077

ENSMUSG00000023348

UniProt| |

Q15654

Q9Z1Y4

RefSeq (mRNA)| |

NM_003302

NM_011639

RefSeq (protein)| |

NP_003293

NP_035769

Location (UCSC)| Chr 7: 100.87 – 100.87 Mb| Chr 5: 137.31 – 137.31 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.[5][6][7]

## Function

[edit]

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]

## Interactions

[edit]

TRIP6 has been shown to interact with LPAR2,[8] BCAR1[8][9] and HOXA9.[10]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087077 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023348 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6\. doi:10.1006/geno.1998.5248. PMID 9598321.
6. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54\. doi:10.1210/mend.9.2.7776974. PMID 7776974.
7. ^ a b "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6".
8. ^ a b Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68\. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.
9. ^ Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9\. doi:10.1074/jbc.M106922200. PMID 11782456.
10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8\. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

## Further reading

[edit]

* Williams JM, Chen GC, Zhu L, Rest RF (Jan 1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Molecular Microbiology. 27 (1): 171–86\. doi:10.1046/j.1365-2958.1998.00670.x. PMID 9466265. S2CID 36570024.
* Murthy KK, Clark K, Fortin Y, Shen SH, Banville D (Jul 1999). "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". The Journal of Biological Chemistry. 274 (29): 20679–87\. doi:10.1074/jbc.274.29.20679. PMID 10400701.
* Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD (2000). "LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor". Gene Expression. 8 (4): 207–17\. PMC 6157364. PMID 10794523.
* Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B, Hendriks W (Apr 2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". European Journal of Cell Biology. 79 (4): 283–93\. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.
* Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, Koop BF (Mar 2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Research. 29 (6): 1352–65\. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
* Wang Y, Gilmore TD (Apr 2001). "LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1538 (2–3): 260–72\. doi:10.1016/S0167-4889(01)00077-5. PMID 11336797.2–3&rft.pages=260-72&rft.date=2001-04&rft_id=info:doi/10.1016/S0167-4889(01)00077-5&rft_id=info:pmid/11336797&rft.aulast=Wang&rft.aufirst=Y&rft.au=Gilmore,+TD&rft_id=https://doi.org/10.1016%2FS0167-4889%2801%2900077-5&rfr_id=info:sid/en.wikipedia.org:TRIP6" class="Z3988">
* Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9\. doi:10.1074/jbc.M106922200. PMID 11782456.
* Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (Feb 2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biology of Reproduction. 68 (2): 543–52\. doi:10.1095/biolreprod.102.009076. PMC 3158802. PMID 12533418.
* Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68\. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.
* Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, Banville D, Vary CP, Bernabéu C (Jul 2004). "Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins". The Journal of Biological Chemistry. 279 (31): 32858–68\. doi:10.1074/jbc.M400843200. hdl:10261/73323. PMID 15148318.
* Kassel O, Schneider S, Heilbock C, Litfin M, Göttlicher M, Herrlich P (Oct 2004). "A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters". Genes & Development. 18 (20): 2518–28\. doi:10.1101/gad.322404. PMC 529539. PMID 15489293.
* Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB (Feb 2005). "TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways" (PDF). Journal of Cell Science. 118 (Pt 3): 555–63\. doi:10.1242/jcs.01641. PMID 15657077. S2CID 21632160.
* Petit MM, Crombez KR, Vervenne HB, Weyns N, Van de Ven WJ (Sep 2005). "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins". FEBS Letters. 579 (22): 5061–8\. doi:10.1016/j.febslet.2005.08.012. PMID 16137684. S2CID 43629118.

## External links

[edit]

* Overview of all the structural information available in the PDB for UniProt: Q15654 (Thyroid receptor-interacting protein 6) at the PDBe-KB.

* v
* t
* e

PDB gallery

* 1x61: Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)

* 2dlo: Solution structure of the second LIM domain of human Thyroid receptor-interacting protein 6

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