Thiamine transporter 1

Mammalian protein found in Homo sapiens

SLC19A2

Identifiers
Aliases| SLC19A2, TC1, THMD1, THT1, THTR1, TRMA, solute carrier family 19 member 2
External IDs| OMIM: 603941 MGI: 1928761 HomoloGene: 38258 GeneCards: SLC19A2
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1q24.2| Start| 169,463,909 bp[1]
End| 169,485,944 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 1 (mouse)[2]

Band| 1 H2.2|1 71.56 cM| Start| 164,076,615 bp[2]
End| 164,092,954 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* secondary oocyte

* gastrocnemius muscle

* tibialis anterior muscle

* biceps brachii

* deltoid muscle

* gastric mucosa

* body of tongue

* thoracic diaphragm

* vastus lateralis muscle

* palpebral conjunctiva

| Top expressed in

* retinal pigment epithelium

* left lobe of liver

* facial motor nucleus

* medullary collecting duct

* cornea

* interventricular septum

* motor neuron

* cumulus cell

* spermatocyte

* conjunctival fornix

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* folic acid transmembrane transporter activity
* protein binding
* thiamine transmembrane transporter activity
* vitamin transmembrane transporter activity

Cellular component|

* integral component of membrane
* plasma membrane
* membrane

Biological process|

* thiamine-containing compound metabolic process
* thiamine transport
* folic acid transport
* thiamine transmembrane transport
* vitamin transport
* transmembrane transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

10560

116914

Ensembl| |

ENSG00000117479

ENSMUSG00000040918

UniProt| |

O60779

Q9EQN9

RefSeq (mRNA)| |

NM_006996
NM_001319667

NM_001276455
NM_054087

RefSeq (protein)| |

NP_001306596
NP_008927

NP_001263384
NP_473428

Location (UCSC)| Chr 1: 169.46 – 169.49 Mb| Chr 1: 164.08 – 164.09 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene.[5] SLC19A2 is a thiamine transporter. Mutations in this gene cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.[6][7][8]

## Structure[edit]

The SLC19A2 gene is located on the q arm of chromosome 1 in position 24.2 and spans 22,062 base pairs.[7] The gene produces a 55.4 kDa protein composed of 497 amino acids.[9][10] In the encoded protein (TC1), a multi-pass membrane protein located in the cell membrane, the N-terminus and C-terminus face the cytosol.[11][12] This gene has 6 exons while the protein has 12 putative transmembrane domains, with 3 phosphorylation sites in putative intracellular domains, 2 N-glycolysation sites in putative extracellular domains, and a 17-amino acid long G protein-coupled receptor signature sequence. The thiamine transporter protein encoded by SLC19A2 has a 40% shared amino acid identity with the folate transporter SLC19A1.[13] The N-terminal domain and the sequence between the C-terminal domain and sixth transmembrane domain are required for proper localization of this protein to the cell membrane.[14][15]

## Function[edit]

The encoded protein is a high-affinity transporter specific to the intake of thiamine.[11][12] Thiamine transport is not inhibited by other organic cations nor affected by sodium ion concentration; it is stimulated by a proton gradient directed outward, with an optimal pH between 8.0 and 8.5.[13] TC1 is transported to the cell membrane by intracellular vesicles via microtubules.[14][15]

## Clinical significance[edit]

Mutations in the SLC19A2 gene can cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness. Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially. The anemia, and sometimes the diabetes, improves with high doses of thiamine. Other more variable features include optic atrophy, congenital heart defects, short stature, and stroke.[11][12]

A 3.8 kb transcript is expressed variably in most tissues, highest in skeletal and cardiac muscle, followed by medium expression placenta, heart, liver, kidney cells and low expression in lung cells. In melanocytic cells SLC19A2 gene expression may be regulated by MITF.[16]

## Interactions[edit]

This protein interacts with CERS2.[17]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117479 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040918 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Neufeld EJ, Mandel H, Raz T, Szargel R, Yandava CN, Stagg A, Fauré S, Barrett T, Buist N, Cohen N (December 1997). "Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping". American Journal of Human Genetics. 61 (6): 1335–41. doi:10.1086/301642. PMC 1716091. PMID 9399900.
6. ^ Bay A, Keskin M, Hizli S, Uygun H, Dai A, Gumruk F (October 2010). "Thiamine-responsive megaloblastic anemia syndrome". International Journal of Hematology. 92 (3): 524–6. doi:10.1007/s12185-010-0681-y. PMID 20835854. S2CID 21487938.
7. ^ a b "Entrez Gene: solute carrier family 19 (thiamine transporter)". This article incorporates text from this source, which is in the public domain.
8. ^ Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K, Gregory S, Cohen N (July 1999). "Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness". Nature Genetics. 22 (3): 300–4. doi:10.1038/10372. PMID 10391221. S2CID 26615141.
9. ^ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
10. ^ "SLC19A2 - Thiamine transporter 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
11. ^ a b c "SLC19A2 - Thiamine transporter 1 - Homo sapiens (Human) - SLC19A2 gene & protein". www.uniprot.org. Retrieved 2018-08-21. This article incorporates text available under the CC BY 4.0 license.
12. ^ a b c "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.
13. ^ a b Dutta B, Huang W, Molero M, Kekuda R, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (November 1999). "Cloning of the human thiamine transporter, a member of the folate transporter family". The Journal of Biological Chemistry. 274 (45): 31925–9. doi:10.1074/jbc.274.45.31925. PMID 10542220.
14. ^ a b Subramanian VS, Marchant JS, Parker I, Said HM (February 2003). "Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms". The Journal of Biological Chemistry. 278 (6): 3976–84. doi:10.1074/jbc.M210717200. PMID 12454006.
15. ^ a b Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: {603941}: {11/22/2017}: . World Wide Web URL: https://omim.org/
16. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
17. ^ IntAct. "IntAct Portal". www.ebi.ac.uk. Retrieved 2018-08-23.

## Further reading[edit]

* Scharfe C, Hauschild M, Klopstock T, Janssen AJ, Heidemann PH, Meitinger T, Jaksch M (September 2000). "A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I". Journal of Medical Genetics. 37 (9): 669–73. doi:10.1136/jmg.37.9.669. PMC 1734685. PMID 10978358.
* Guerrini I, Thomson AD, Cook CC, McQuillin A, Sharma V, Kopelman M, Reynolds G, Jauhar P, Harper C, Gurling HM (August 2005). "Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS)". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 137B (1): 17–9. doi:10.1002/ajmg.b.30194. PMID 16015585. S2CID 37693278.
* Subramanian VS, Mohammed ZM, Molina A, Marchant JS, Vaziri ND, Said HM (July 2007). "Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation". The Journal of Physiology. 582 (Pt 1): 73–85. doi:10.1113/jphysiol.2007.128843. PMC 2075275. PMID 17463047.
* Ashokkumar B, Vaziri ND, Said HM (October 2006). "Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms". American Journal of Physiology. Renal Physiology. 291 (4): F796–805. doi:10.1152/ajprenal.00078.2006. PMID 16705148.
* Nabokina SM, Reidling JC, Said HM (September 2005). "Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms". The Journal of Biological Chemistry. 280 (38): 32676–82. doi:10.1074/jbc.M505243200. PMID 16055442.
* Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
* Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A (December 2009). "Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study". European Journal of Human Genetics. 17 (12): 1650–7. doi:10.1038/ejhg.2009.94. PMC 2783544. PMID 19536175.
* Olsen BS, Hahnemann JM, Schwartz M, Østergaard E (August 2007). "Thiamine-responsive megaloblastic anaemia: a cause of syndromic diabetes in childhood". Pediatric Diabetes. 8 (4): 239–41. doi:10.1111/j.1399-5448.2007.00251.x. PMID 17659067. S2CID 24093373.
* Subramanian VS, Marchant JS, Said HM (July 2007). "Targeting and intracellular trafficking of clinically relevant hTHTR1 mutations in human cell lines". Clinical Science. 113 (2): 93–102. doi:10.1042/CS20060331. PMID 17331069.
* Pei LJ, Zhu HP, Li ZW, Zhang W, Ren AG, Zhu JH, Li Z (June 2005). "Interaction between maternal periconceptional supplementation of folic acid and reduced folate carrier gene polymorphism of neural tube defects". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 22 (3): 284–7. PMID 15952116.
* Haas RH (1988). "Thiamin and the brain". Annual Review of Nutrition. 8: 483–515. doi:10.1146/annurev.nu.08.070188.002411. PMID 3060175.
* Ricketts CJ, Minton JA, Samuel J, Ariyawansa I, Wales JK, Lo IF, Barrett TG (January 2006). "Thiamine-responsive megaloblastic anaemia syndrome: long-term follow-up and mutation analysis of seven families". Acta Paediatrica. 95 (1): 99–104. doi:10.1080/08035250500323715. PMID 16373304.
* Lagarde WH, Underwood LE, Moats-Staats BM, Calikoglu AS (March 2004). "Novel mutation in the SLC19A2 gene in an African-American female with thiamine-responsive megaloblastic anemia syndrome". American Journal of Medical Genetics. Part A. 125A (3): 299–305. doi:10.1002/ajmg.a.20506. PMID 14994241. S2CID 12191136.
* Ashton LJ, Gifford AJ, Kwan E, Lingwood A, Lau DT, Marshall GM, Haber M, Norris MD (July 2009). "Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia". Leukemia. 23 (7): 1348–51. doi:10.1038/leu.2009.67. PMID 19340000.
* Bergmann AK, Campagna DR, McLoughlin EM, Agarwal S, Fleming MD, Bottomley SS, Neufeld EJ (February 2010). "Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations". Pediatric Blood & Cancer. 54 (2): 273–8. doi:10.1002/pbc.22244. PMC 2843911. PMID 19731322.
* Subramanian VS, Marchant JS, Said HM (February 2006). "Targeting and trafficking of the human thiamine transporter-2 in epithelial cells". The Journal of Biological Chemistry. 281 (8): 5233–45. doi:10.1074/jbc.M512765200. PMID 16371350.
* Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM (July 2009). "Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations". American Journal of Physiology. Gastrointestinal and Liver Physiology. 297 (1): G197–206. doi:10.1152/ajpgi.00092.2009. PMC 2711754. PMID 19423748.
* Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, Huang QY, Mori S, Sham PC, Kung AW (February 2009). "Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation". Human Molecular Genetics. 18 (4): 679–87. doi:10.1093/hmg/ddn397. PMID 19064610.
* Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

## External links[edit]

* GeneReviews/NIH/NCBI/UW entry on Thiamine-Responsive Megaloblastic Anemia or Rogers Syndrome
* SLC19A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

| (1):|

* high affinity glutamate and neutral amino-acid transporter
* SLC1A1
* 2
* 3
* 4
* 5
* 6
* 7

|

(2):|

* facilitative GLUT transporter
* SLC2A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14

(3):|

* heavy subunits of heterodimeric amino-acid transporters
* SLC3A1
* 2

(4):|

* bicarbonate transporter
* SLC4A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11

(5):|

* sodium glucose cotransporter
* SLC5A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12

(6):|

* sodium\- and chloride\- dependent sodium:neurotransmitter symporters
* SLC6A1
* SLC6A2
* SLC6A3
* SLC6A4
* SLC6A5
* SLC6A6
* SLC6A7
* SLC6A8
* SLC6A9
* SLC6A10
* SLC6A11
* SLC6A12
* SLC6A13
* SLC6A14
* SLC6A15
* SLC6A16
* SLC6A17
* SLC6A18
* SLC6A19
* SLC6A20

(7):|

* cationic amino-acid transporter/glycoprotein-associated
* SLC7A1
* SLC7A2
* SLC7A3
* SLC7A4
* glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters
* SLC7A5
* SLC7A6
* SLC7A7
* SLC7A8
* SLC7A9
* SLC7A10
* SLC7A11
* SLC7A13
* SLC7A14

(8):|

* Na+/Ca2+ exchanger
* SLC8A1
* SLC8A2
* SLC8A3

(9):|

* Na+/H+ exchanger
* SLC9A1
* SLC9A2
* SLC9A3
* SLC9A4
* SLC9A5
* SLC9A6
* SLC9A7
* SLC9A8
* SLC9A9
* SLC9A10
* SLC9A11

(10):|

* sodium bile salt cotransport
* SLC10A1
* SLC10A2
* SLC10A3
* SLC10A4
* SLC10A5
* SLC10A6
* SLC10A7
* 10A1
* 10A2
* 10A3
* 10A7

SLC11–20

| (11):|

* proton coupled metal ion transporter
* SLC11A1
* SLC11A211A3

|

(12):|

* electroneutral cation-Cl cotransporter
* SLC12A1
* SLC12A2
* SLC12A3
* SLC12A4
* SLC12A5
* SLC12A6
* SLC12A7
* SLC12A8
* SLC12A9

(13):|

* human Na+-sulfate/carboxylate cotransporter
* SLC13A1
* SLC13A2
* SLC13A3
* SLC13A4
* SLC13A5

(14):|

* urea transporter
* SLC14A1
* SLC14A2

(15):|

* proton oligopeptide cotransporter
* SLC15A1
* SLC15A2
* SLC15A3
* SLC15A4

(16):|

* monocarboxylate transporter
* SLC16A1
* SLC16A2
* SLC16A3
* SLC16A4
* SLC16A5
* SLC16A6
* SLC16A7
* SLC16A8
* SLC16A9
* SLC16A10
* SLC16A11
* SLC16A12
* SLC16A13
* SLC16A14

(17):|

* Vesicular glutamate transporter 1
* SLC17A1
* SLC17A2
* SLC17A3
* SLC17A4
* SLC17A5
* SLC17A6
* SLC17A7
* SLC17A8
* SLC17A9

(18):|

* vesicular monoamine transporter
* SLC18A1
* SLC18A2
* SLC18A3

(19):|

* folate/thiamine transporter
* SLC19A1
* SLC19A2
* SLC19A3

(20):|

* type III Na+-phosphate cotransporter
* SLC20A1
* SLC20A2

SLC21–30

| (21):|

* Organic anion-transporting polypeptide
* SLCO1A2
* SLCO1B1
* SLCO1B3
* SLCO1B4
* SLCO1C1
*     * SLCO2A1
* SLCO2B1
*     * SLCO3A1
*     * SLCO4A1
* SLCO4C1
*     * SLCO5A1(SLCO6A1)

|

(22):|

* organic cation/anion/zwitterion transporter
* SLC22A1
* SLC22A2
* SLC22A3
* SLC22A4
* SLC22A5
* SLC22A6
* SLC22A7
* SLC22A8
* SLC22A9
* SLC22A10
* SLC22A11
* SLC22A12
* SLC22A13
* SLC22A14
* SLC22A15
* SLC22A16
* SLC22A17
* SLC22A18
* SLC22A19
* SLC22A20

(23):|

* Na+-dependent ascorbic acid transporter
* SLC23A1
* SLC23A2
* SLC23A3
* SLC23A4

(24):|

* Na+/(Ca2+-K+) exchanger
* SLC24A1
* SLC24A2
* SLC24A3
* SLC24A4
* SLC24A5
* SLC24A6

(25):|

* mitochondrial carrier
* SLC25A1
* SLC25A2
* SLC25A3
* SLC25A4
* SLC25A5
* SLC25A6
* SLC25A7
* SLC25A8
* SLC25A9
* SLC25A10
* SLC25A11
* SLC25A12
* SLC25A13
* SLC25A14
* SLC25A15
* SLC25A16
* SLC25A17
* SLC25A18
* SLC25A19
* SLC25A20
* SLC25A21
* SLC25A22
* SLC25A23
* SLC25A24
* SLC25A25
* SLC25A26
* SLC25A27
* SLC25A28
* SLC25A29
* SLC25A30
* SLC25A31
* SLC25A32
* SLC25A33
* SLC25A34
* SLC25A35
* SLC25A36
* SLC25A37
* SLC25A38
* SLC25A39
* SLC25A40
* SLC25A41
* SLC25A42
* SLC25A43
* SLC25A44
* SLC25A45
* SLC25A46

(26):|

* multifunctional anion exchanger
* SLC26A1
* SLC26A2
* SLC26A3
* SLC26A4
* SLC26A5
* SLC26A6
* SLC26A7
* SLC26A8
* SLC26A9
* SLC26A10
* SLC26A11

(27):|

* fatty acid transport proteins
* SLC27A1
* SLC27A2
* SLC27A3
* SLC27A4
* SLC27A5
* SLC27A6

(28):|

* Na+-coupled nucleoside transport (SLC28A1
* SLC28A2
* SLC28A3

(29):|

* facilitative nucleoside transporter
* SLC29A1
* SLC29A2
* SLC29A3
* SLC29A4

(30):|

* zinc efflux
* SLC30A1
* SLC30A2
* SLC30A3
* SLC30A4
* SLC30A5
* SLC30A6
* SLC30A7
* SLC30A8
* SLC30A9
* SLC30A10

SLC31–40

| (31):|

* copper transporter
* SLC31A1

|

(32):|

* Vesicular glutamate transporter 1
* SLC32A1

(33):|

* Acetyl-CoA transporter
* SLC33A1

(34):|

* type II Na+-phosphate cotransporter
* SLC34A1
* SLC34A2
* SLC34A3

(35):|

* nucleoside-sugar transporter
* SLC35A1
* SLC35A2
* SLC35A3
* SLC35A4
* SLC35A5
*     * SLC35B1
* SLC35B2
* SLC35B3
* SLC35B4
*     * SLC35C1
* SLC35C2
*     * SLC35D1
* SLC35D2
* SLC35D3
*     * SLC35E1
* SLC35E2
* SLC35E3
* SLC35E4

(36):|

* proton-coupled amino-acid transporter
* SLC36A1
* SLC36A2
* SLC36A3
* SLC36A436A2

(37):|

* sugar-phosphate/phosphate exchanger
* SLC37A1
* SLC37A2
* SLC37A3
* SLC37A4

(38):|

* System A & N, sodium-coupled neutral amino-acid transporter
* SLC38A1
* SLC38A2
* SLC38A3
* SLC38A4
* SLC38A5
* SLC38A6
* SLC38A10

(39):|

* metal ion transporter
* SLC39A1
* SLC39A2
* SLC39A3
* SLC39A4
* SLC39A5
* SLC39A6
* SLC39A7
* SLC39A8
* SLC39A9
* SLC39A10
* SLC39A11
* SLC39A12
* SLC39A13
* SLC39A14

(40):|

* basolateral iron transporter
* SLC40A1

SLC41–48

| (41):|

* Magnesium transporter E
* SLC41A1
* SLC41A2
* SLC41A3

|

(42):|

* Ammonia transporter
* RhAG
* RhBG
* RhCG

(43):|

* Na+-independent, system-L like amino-acid transporter
* SLC43A1
* SLC43A2
* SLC43A3

(44):|

* Choline-like transporter
* SLC44A1
* SLC44A2
* SLC44A3
* SLC44A4
* SLC44A5

(45):|

* Putative sugar transporter
* SLC45A1
* SLC45A2
* SLC54A3
* SLC45A4

(46):|

* Folate transporter
* SLC46A1
* SLC46A2

(47):|

* multidrug and toxin extrusion
* SLC47A1
* SLC47A2

(48):|

* Heme transporter

SLCO1–4

* O1A2
* O1B1
* O1B3
* O2B1
* O431
* O4A1

Ion pumps

| Symporter, Cotransporter|

* Na+/K+,Cl−
* Na+/Pi3
* Na+/Cl−
* Na+/glucose
* Na+/I−
* Cl−/K+
* 4
* 5

|

Antiporter (exchanger)|

* Na+/H+
* Na+/Ca2+
* Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
* Cl−-formate
* Cl−-oxalate

see also solute carrier disorders

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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