thiomorpholine-carboxylate dehydrogenase

Identifiers
EC no.| 1.5.1.25
CAS no.| 115232-54-7
Databases
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KEGG| KEGG entry
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In enzymology, a thiomorpholine-carboxylate dehydrogenase (EC 1.5.1.25) is an enzyme that catalyzes the chemical reaction

thiomorpholine 3-carboxylate + NAD(P)+  ⇌ {\displaystyle \rightleftharpoons } 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+

The 3 substrates of this enzyme are thiomorpholine 3-carboxylate, NAD+, and NADP+, whereas its 4 products are 3,4-dehydro-thiomorpholine-3-carboxylate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase. Other names in common use include ketimine reductase, and ketimine-reducing enzyme.

CRYM, a taxon-specific crystallin protein that also binds thyroid hormones has thiomorpholine-carboxylate dehydrogenase activity.

## References

[edit]

* Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D (1988). "Purification and characterization of a ketimine-reducing enzyme". Eur. J. Biochem. 173 (3): 689–94\. doi:10.1111/j.1432-1033.1988.tb14053.x. PMID 3371353.

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Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor|

* Dihydrofolate reductase
* Saccharopine dehydrogenase
* Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor|

* Dihydrobenzophenanthridine oxidase
* Sarcosine oxidase
* Proline oxidase

1.5.5: quinone acceptor|

* Electron-transferring-flavoprotein dehydrogenase

1.5.99|

* Sarcosine dehydrogenase
* Cytokinin dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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