Transcription factor II H

Protein complex

general transcription factor IIH, polypeptide 1, 62kDa

Identifiers
Symbol| GTF2H1
Alt. symbols| BTF2
NCBI gene| 2965
HGNC| 4655
OMIM| 189972
RefSeq| NM_005316
UniProt| P32780
Other data
Locus| Chr. 11 p15.1-p14
| Search for

Structures| Swiss-model
Domains| InterPro
general transcription factor IIH, polypeptide 2, 44kDa

Identifiers
Symbol| GTF2H2
Alt. symbols| BTF2, TFIIH, BTF2P44, T-BTF2P44
NCBI gene| 2966
HGNC| 4656
OMIM| 601748
RefSeq| NM_001515
UniProt| Q13888
Other data
Locus| Chr. 5 q12.2-13.3
| Search for

Structures| Swiss-model
Domains| InterPro
general transcription factor IIH, polypeptide 3, 34kDa

Identifiers
Symbol| GTF2H3
Alt. symbols| BTF2, TFIIH
NCBI gene| 2967
HGNC| 4657
OMIM| 601750
RefSeq| NM_001516
UniProt| Q13889
Other data
Locus| Chr. 12 q24.31
| Search for

Structures| Swiss-model
Domains| InterPro

Transcription factor II H (TFIIH) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TFIIH first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an indispensable transcription factor in vitro. This factor was also isolated from yeast and finally named TFIIH in 1992.[1][2]

TFIIH consists of ten subunits, 7 of which (ERCC2/XPD, ERCC3/XPB, GTF2H1/p62, GTF2H4/p52, GTF2H2/p44, GTF2H3/p34 and GTF2H5/TTDA) form the core complex. The cyclin-activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein.[3] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube, these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled.

Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle. Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair.

## History of TFIIH

[edit]

Before TFIIH identified it, it had several names. It was isolated in 1989 isolated from rat liver, known by factor transcription delta. When identified from cancer cells it was known that time as Basic transcription factor 2. Also, when isolated from yeast it was termed transcription factor B. Finally, in 1992 known as TFIIH.[4]

## Structure of TFIIH

[edit]

TFIIH is a ten‐subunit complex; seven of these subunits comprise the “core” whereas three comprise the dissociable “CAK” (CDK Activating Kinase) module.[5] The core consists of subunits XPB, XPD, p62, p52, p44, p34 and p8 while CAK is composed of CDK7, cyclin H, and MAT1.[5]

## Functions

[edit]

General function of TFIIH:

1. Initiation transcription of protein- coding gene.[6]
2. DNA nucleotide repairing.[6]

(NER)TFIIH is a general transcription factor that acts to recruit RNA Pol II to the promoters of genes. It functions as a DNA translocase, tracking along the DNA, reeling DNA into the Pol II cleft, and creating torsional strain leading to DNA unwinding[7]. It also unwinds DNA after a DNA lesion has been recognized by either the global genome repair (GGR) pathway or the transcription-coupled repair (TCR) pathway of NER.[8][9] Purified TFIIH has role in stopping further RNA synthesis by activating the cyclic peptide α-amanitin.

## Trichothiodystrophy

[edit]

Mutation in genes ERCC3 (XPB), ERCC2 (XPD) or GTF2H5 (TTDA) cause trichothiodystrophy, a condition characterized by photosensitivity, ichthyosis, brittle hair and nails, intellectual impairment, decreased fertility and/or short stature.[10]

## Disease

[edit]

Genetic polymorphisms of genes that encode subunits of TFIIH are known to be associated with increased cancer susceptibility in many tissues, e.g.; skin tissue, breast tissue and lung tissue. Mutations in the subunits (such as XPD and XPB) can lead to a variety of diseases, including xeroderma pigmentosum (XP) or XP combined with Cockayne syndrome.[11] In addition to genetic variations, virus-encoded proteins also target TFIIH.[12]

## DNA repair

[edit]

TFIIH participates in nucleotide excision repair (NER) by opening the DNA double helix after damage is initially recognized. NER is a multi-step pathway that removes a wide range of different damages that distort normal base pairing, including bulky chemical damages and UV-induced damages. Individuals with mutational defects in genes specifying protein components that catalyze the NER pathway, including the TFIIH components, often display features of premature aging[10][13] (see DNA damage theory of aging).

## Inhibitors

[edit]

Potent, bioactive natural products like triptolide that inhibit mammalian transcription via inhibition of the XPB subunit of the general transcription factor TFIIH has been recently reported as a glucose conjugate for targeting hypoxic cancer cells with increased glucose transporter expression.[14]

## Mechanism of TFIIH repairing DNA damaged sequence

[edit]

Mechanism of TFIIH repairing DNA damaged sequence

## References

[edit]

1. ^ Flores O, Lu H, Reinberg D (February 1992). "Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH". The Journal of Biological Chemistry. 267 (4): 2786–93\. doi:10.1016/S0021-9258(18)45947-9. PMID 1733973.2786-93&rft.date=1992-02&rft_id=info:doi/10.1016/S0021-9258(18)45947-9&rft_id=info:pmid/1733973&rft.aulast=Flores&rft.aufirst=O&rft.au=Lu,+H&rft.au=Reinberg,+D&rft_id=https://doi.org/10.1016%2FS0021-9258%2818%2945947-9&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
2. ^ Kim TK, Ebright RH, Reinberg D (May 2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science. 288 (5470): 1418–22\. Bibcode:2000Sci...288.1418K. doi:10.1126/science.288.5470.1418. PMID 10827951.1418-22&rft.date=2000-05&rft_id=info:pmid/10827951&rft_id=info:doi/10.1126/science.288.5470.1418&rft_id=info:bibcode/2000Sci...288.1418K&rft.aulast=Kim&rft.aufirst=TK&rft.au=Ebright,+RH&rft.au=Reinberg,+D&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
3. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annual Review of Genetics. 34: 77–137\. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.77-137&rft.date=2000&rft_id=info:doi/10.1146/annurev.genet.34.1.77&rft_id=info:pmid/11092823&rft.aulast=Lee&rft.aufirst=TI&rft.au=Young,+RA&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
4. ^ Rimel JK, Taatjes DJ (June 2018). "The essential and multifunctional TFIIH complex". Protein Science. 27 (6): 1018–1037\. doi:10.1002/pro.3424. PMC 5980561. PMID 29664212.1018-1037&rft.date=2018-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980561#id-name=PMC&rft_id=info:pmid/29664212&rft_id=info:doi/10.1002/pro.3424&rft.aulast=Rimel&rft.aufirst=JK&rft.au=Taatjes,+DJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980561&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
5. ^ a b Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature. 368 (6473): 769–72\. Bibcode:1994Natur.368..769D. doi:10.1038/368769a0. PMID 8152490. S2CID 4363484.769-72&rft.date=1994-04&rft_id=info:doi/10.1038/368769a0&rft_id=https://api.semanticscholar.org/CorpusID:4363484#id-name=S2CID&rft_id=info:pmid/8152490&rft_id=info:bibcode/1994Natur.368..769D&rft.aulast=Drapkin&rft.aufirst=R&rft.au=Reardon,+JT&rft.au=Ansari,+A&rft.au=Huang,+JC&rft.au=Zawel,+L&rft.au=Ahn,+K&rft.au=Sancar,+A&rft.au=Reinberg,+D&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
6. ^ a b Compe E, Egly JM (May 2012). "TFIIH: when transcription met DNA repair". Nature Reviews. Molecular Cell Biology. 13 (6): 343–54\. doi:10.1038/nrm3350. PMID 22572993. S2CID 29077515.343-54&rft.date=2012-05&rft_id=https://api.semanticscholar.org/CorpusID:29077515#id-name=S2CID&rft_id=info:pmid/22572993&rft_id=info:doi/10.1038/nrm3350&rft.aulast=Compe&rft.aufirst=E&rft.au=Egly,+JM&rft_id=https://doi.org/10.1038%2Fnrm3350&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
7. ^ Fishburn, James; Tomko, Eric; Galburt, Eric; Hahn, Steven (2015). "Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation". Proceedings of the National Academy of Sciences. 112 (13): 3961–3966\. Bibcode:2015PNAS..112.3961F. doi:10.1073/pnas.1417709112. PMC 4386358. PMID 25775526.3961-3966&rft.date=2015&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386358#id-name=PMC&rft_id=info:pmid/25775526&rft_id=info:doi/10.1073/pnas.1417709112&rft_id=info:bibcode/2015PNAS..112.3961F&rft.aulast=Fishburn&rft.aufirst=James&rft.au=Tomko,+Eric&rft.au=Galburt,+Eric&rft.au=Hahn,+Steven&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386358&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
8. ^ Hoogstraten D, Nigg AL, Heath H, Mullenders LH, van Driel R, Hoeijmakers JH, Vermeulen W, Houtsmuller AB (November 2002). "Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo". Molecular Cell. 10 (5): 1163–74\. doi:10.1016/s1097-2765(02)00709-8. PMID 12453423.1163-74&rft.date=2002-11&rft_id=info:doi/10.1016/s1097-2765(02)00709-8&rft_id=info:pmid/12453423&rft.aulast=Hoogstraten&rft.aufirst=D&rft.au=Nigg,+AL&rft.au=Heath,+H&rft.au=Mullenders,+LH&rft.au=van+Driel,+R&rft.au=Hoeijmakers,+JH&rft.au=Vermeulen,+W&rft.au=Houtsmuller,+AB&rft_id=https://doi.org/10.1016%2Fs1097-2765%2802%2900709-8&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
9. ^ Assfalg R, Lebedev A, Gonzalez OG, Schelling A, Koch S, Iben S (January 2012). "TFIIH is an elongation factor of RNA polymerase I". Nucleic Acids Research. 40 (2): 650–9\. doi:10.1093/nar/gkr746. PMC 3258137. PMID 21965540.650-9&rft.date=2012-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258137#id-name=PMC&rft_id=info:pmid/21965540&rft_id=info:doi/10.1093/nar/gkr746&rft.aulast=Assfalg&rft.aufirst=R&rft.au=Lebedev,+A&rft.au=Gonzalez,+OG&rft.au=Schelling,+A&rft.au=Koch,+S&rft.au=Iben,+S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258137&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
10. ^ a b Theil AF, Hoeijmakers JH, Vermeulen W (November 2014). "TTDA: big impact of a small protein". Experimental Cell Research. 329 (1): 61–8\. doi:10.1016/j.yexcr.2014.07.008. PMID 25016283.61-8&rft.date=2014-11&rft_id=info:doi/10.1016/j.yexcr.2014.07.008&rft_id=info:pmid/25016283&rft.aulast=Theil&rft.aufirst=AF&rft.au=Hoeijmakers,+JH&rft.au=Vermeulen,+W&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
11. ^ Oh KS, Khan SG, Jaspers NG, Raams A, Ueda T, Lehmann A, Friedmann PS, Emmert S, Gratchev A, Lachlan K, Lucassan A, Baker CC, Kraemer KH (November 2006). "Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome". Human Mutation. 27 (11): 1092–103\. doi:10.1002/humu.20392. PMID 16947863. S2CID 22852219.1092-103&rft.date=2006-11&rft_id=https://api.semanticscholar.org/CorpusID:22852219#id-name=S2CID&rft_id=info:pmid/16947863&rft_id=info:doi/10.1002/humu.20392&rft.aulast=Oh&rft.aufirst=KS&rft.au=Khan,+SG&rft.au=Jaspers,+NG&rft.au=Raams,+A&rft.au=Ueda,+T&rft.au=Lehmann,+A&rft.au=Friedmann,+PS&rft.au=Emmert,+S&rft.au=Gratchev,+A&rft.au=Lachlan,+K&rft.au=Lucassan,+A&rft.au=Baker,+CC&rft.au=Kraemer,+KH&rft_id=https://doi.org/10.1002%2Fhumu.20392&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
12. ^ Le May N, Dubaele S, Proietti De Santis L, Billecocq A, Bouloy M, Egly JM (February 2004). "TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus". Cell. 116 (4): 541–50\. doi:10.1016/s0092-8674(04)00132-1. PMID 14980221. S2CID 14312462.541-50&rft.date=2004-02&rft_id=https://api.semanticscholar.org/CorpusID:14312462#id-name=S2CID&rft_id=info:pmid/14980221&rft_id=info:doi/10.1016/s0092-8674(04)00132-1&rft.aulast=Le+May&rft.aufirst=N&rft.au=Dubaele,+S&rft.au=Proietti+De+Santis,+L&rft.au=Billecocq,+A&rft.au=Bouloy,+M&rft.au=Egly,+JM&rft_id=https://doi.org/10.1016%2Fs0092-8674%2804%2900132-1&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
13. ^ Edifizi D, Schumacher B (August 2015). "Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms". Biomolecules. 5 (3): 1855–69\. doi:10.3390/biom5031855. PMC 4598778. PMID 26287260.1855-69&rft.date=2015-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598778#id-name=PMC&rft_id=info:pmid/26287260&rft_id=info:doi/10.3390/biom5031855&rft.aulast=Edifizi&rft.aufirst=D&rft.au=Schumacher,+B&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598778&rfr_id=info:sid/en.wikipedia.org:Transcription+factor+II+H" class="Z3988">
14. ^ Datan E, Minn I, Peng X, He QL, Ahn H, Yu B, Pomper MG, Liu JO (2020). "A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia". iScience. 23 (9): 101536. Bibcode:2020iSci...23j1536D. doi:10.1016/j.isci.2020.101536. PMC 7509213. PMID 33083765.

## External links

[edit]

* Transcription+Factor+TFIIH at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Transcription factors and intracellular receptors

(1) Basic domains

| (1.1) Basic leucine zipper (bZIP)|

* Activating transcription factor
* AATF
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* AP-1
* c-Fos
* FOSB
* FOSL1
* FOSL2
* JDP2
* c-Jun
* JUNB
* JunD
* BACH
* 1
* 2
* BATF
* BLZF1
* C/EBP
* α
* β
* γ
* δ
* ε
* ζ
* CREB
* 1
* 3
* L1
* CREM
* DBP
* DDIT3
* GABPA
* GCN4
* HLF
* MAF
* B
* F
* G
* K
* NFE
* 2
* L1
* L2
* L3
* NFIL3
* NRL
* NRF
* 1
* 2
* 3
* XBP1

|

(1.2) Basic helix-loop-helix (bHLH)|

| Group A|

* AS-C
* ASCL1
* ASCL2
* ATOH1
* HAND
* 1
* 2
* MESP2
* Myogenic regulatory factors
* MyoD
* Myogenin
* MYF5
* MYF6
* NeuroD
* 1
* 2
* Neurogenins
* 1
* 2
* 3
* OLIG
* 1
* 2
* Paraxis
* TCF15
* Scleraxis
* SLC
* LYL1
* TAL
* 1
* 2
* Twist

|

Group B|

* FIGLA
* Myc
* c-Myc
* l-Myc
* n-Myc
* MXD4
* TCF4

Group C
bHLH-PAS|

* AhR
* AHRR
* ARNT
* ARNTL
* ARNTL2
* CLOCK
* HIF
* 1A
* EPAS1
* 3A
* NPAS
* 1
* 2
* 3
* PER
* 1
* 2
* 3
* Period
* SIM
* 1
* 2

Group D|

* BHLH
* 2
* 3
* 9
* Pho4
* ID
* 1
* 2
* 3
* 4

Group E|

* HES
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* HEY
* 1
* 2
* L

Group F
bHLH-COE|

* EBF1

(1.3) bHLH-ZIP|

* AP-4
* MAX
* MXD1
* MXD3
* MITF
* MNT
* MLX
* MLXIPL
* MXI1
* Myc
* SREBP
* 1
* 2
* USF1

(1.4) NF-1|

* NFI
* A
* B
* C
* X
* SMAD
* R-SMAD
* 1
* 2
* 3
* 5
* 9
* I-SMAD
* 6
* 7
* 4)

(1.5) RF-X|

* RFX
* 1
* 2
* 3
* 4
* 5
* 6
* ANK

(1.6) Basic helix-span-helix (bHSH)|

* AP-2
* α
* β
* γ
* δ
* ε

(2) Zinc finger DNA-binding domains

| (2.1) Nuclear receptor (Cys4)|

| subfamily 1|

* Thyroid hormone
* α
* β
* CAR
* FXR
* LXR
* α
* β
* PPAR
* α
* β/δ
* γ
* PXR
* RAR
* α
* β
* γ
* ROR
* α
* β
* γ
* Rev-ErbA
* α
* β
* VDR

|

subfamily 2|

* COUP-TF
* (I
* II
* Ear-2
* HNF4
* α
* γ
* PNR
* RXR
* α
* β
* γ
* Testicular receptor
* 2
* 4
* TLX

subfamily 3|

* Steroid hormone
* Androgen
* Estrogen
* α
* β
* Glucocorticoid
* Mineralocorticoid
* Progesterone
* Estrogen related
* α
* β
* γ

subfamily 4|

* NUR
* NGFIB
* NOR1
* NURR1

subfamily 5|

* LRH-1
* SF1

subfamily 6|

* GCNF

subfamily 0|

* DAX1
* SHP

(2.2) Other Cys4|

* GATA
* 1
* 2
* 3
* 4
* 5
* 6
* MTA
* 1
* 2
* 3
* TRPS1

(2.3) Cys2His2|

* General transcription factors
* TFIIA
* TFIIB
* TFIID
* TFIIE
* 1
* 2
* TFIIF
* 1
* 2
* TFIIH
* 1
* 2
* 4
* 2I
* 3A
* 3C1
* 3C2

* ATBF1
* BCL
* 6
* 11A
* 11B
* CTCF
* E4F1
* EGR
* 1
* 2
* 3
* 4
* ERV3
* GFI1
* GLI family
* 1
* 2
* 3
* REST
* S1
* S2
* YY1
* HIC
* 1
* 2
* HIVEP
* 1
* 2
* 3
* IKZF
* 1
* 2
* 3
* ILF
* 2
* 3
* Sp/KLF family
* KLF
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 17
* SP
* 1
* 2
* 4
* 7
* 8
* MTF1
* MYT1
* OSR1
* PRDM9
* SALL
* 1
* 2
* 3
* 4
* TSHZ3
* WT1
* Zbtb7
* 7A
* 7B
* ZBTB
* 11
* 16
* 17
* 20
* 21
* 32
* 33
* 40
* zinc finger
* 3
* 7
* 9
* 10
* 19
* 22
* 24
* 33B
* 34
* 35
* 41
* 43
* 44
* 51
* 74
* 143
* 146
* 148
* 165
* 202
* 217
* 219
* 238
* 239
* 259
* 267
* 268
* 281
* 300
* 318
* 330
* 346
* 350
* 365
* 366
* 384
* 423
* 451
* 452
* 471
* 593
* 638
* 644
* 649
* 655
* 804A

(2.4) Cys6|

* HIVEP1

(2.5) Alternating composition|

* AIRE
* DIDO1
* GRLF1
* ING
* 1
* 2
* 4
* JARID
* 1A
* 1B
* 1C
* 1D
* 2
* JMJD1B

(2.6) WRKY|

* WRKY

(3) Helix-turn-helix domains

| (3.1) Homeodomain|

| Antennapedia
ANTP class|

| protoHOX
Hox-like|

* ParaHox
* Gsx
* 1
* 2
* Xlox
* PDX1
* Cdx
* 1
* 2
* 4
* extended Hox: Evx1
* Evx2
* MEOX1
* MEOX2
* Homeobox
* A1
* A2
* A3
* A4
* A5
* A7
* A9
* A10
* A11
* A13
* B1
* B2
* B3
* B4
* B5
* B6
* B7
* B8
* B9
* B13
* C4
* C5
* C6
* C8
* C9
* C10
* C11
* C12
* C13
* D1
* D3
* D4
* D8
* D9
* D10
* D11
* D12
* D13
* GBX1
* GBX2
* MNX1

|

metaHOX
NK-like|

* BARHL1
* BARHL2
* BARX1
* BARX2
* BSX
* DBX
* 1
* 2
* DLX
* 1
* 2
* 3
* 4
* 5
* 6
* EMX
* 1
* 2
* EN
* 1
* 2
* HHEX
* HLX
* LBX1
* LBX2
* MSX
* 1
* 2
* NANOG
* NKX
* 2-1
* 2-2
* 2-3
* 2-5
* 3-1
* 3-2
* HMX1
* HMX2
* HMX3
* 6-1
* 6-2
* NOTO
* TLX1
* TLX2
* TLX3
* VAX1
* VAX2

other|

* ARX
* CRX
* CUTL1
* FHL
* 1
* 2
* 3
* HESX1
* HOPX
* LMX
* 1A
* 1B
* NOBOX
* TALE
* IRX
* 1
* 2
* 3
* 4
* 5
* 6
* MKX
* MEIS
* 1
* 2
* PBX
* 1
* 2
* 3
* PKNOX
* 1
* 2
* SIX
* 1
* 2
* 3
* 4
* 5
* PHF
* 1
* 3
* 6
* 8
* 10
* 16
* 17
* 20
* 21A
* POU domain
* PIT-1
* BRN-3: A
* B
* C
* Octamer transcription factor: 1
* 2
* 3/4
* 6
* 7
* 11
* SATB2
* ZEB
* 1
* 2

(3.2) Paired box|

* PAX
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* PRRX
* 1
* 2
* PROP1
* PHOX
* 2A
* 2B
* RAX
* SHOX
* SHOX2
* VSX1
* VSX2
* Bicoid
* GSC
* BICD2
* OTX
* 1
* 2
* PITX
* 1
* 2
* 3

(3.3) Fork head / winged helix|

* E2F
* 1
* 2
* 3
* 4
* 5
* FOX proteins
* A1
* A2
* A3
* B1
* B2
* C1
* C2
* D1
* D2
* D3
* D4
* D4L1
* D4L3
* D4L4
* D4L5
* D4L6
* E1
* E3
* F1
* F2
* G1
* H1
* I1
* I2
* I3
* J1
* J2
* J3
* K1
* K2
* L1
* L2
* M1
* N1
* N2
* N3
* N4
* O1
* O3
* O4
* O6
* P1
* P2
* P3
* P4
* Q1
* R1
* R2
* S1

(3.4) Heat shock factors|

* HSF
* 1
* 2
* 4

(3.5) Tryptophan clusters|

* ELF
* 2
* 4
* 5
* EHF
* ELK
* 1
* 3
* 4
* ERF
* ETS
* 1
* 2
* ERG
* SPIB
* ETV
* 1
* 4
* 5
* 6
* FLI1
* Interferon regulatory factors
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* MYB
* MYBL2

(3.6) TEA domain|

* transcriptional enhancer factor
* 1
* 2
* 3
* 4

(4) β-Scaffold factors with minor groove contacts

| (4.1) Rel homology region|

* NF-κB
* NFKB1
* NFKB2
* REL
* RELA
* RELB
* NFAT
* C1
* C2
* C3
* C4
* 5

|

(4.2) STAT|

* STAT
* 1
* 2
* 3
* 4
* 5
* 6

(4.3) p53-like|

* p53 p63 p73 family
* p53
* TP63
* p73
* TBX
* 1
* 2
* 3
* 5
* 19
* 21
* 22
* TBR1
* TBR2
* TFT
* MYRF

(4.4) MADS box|

* Mef2
* A
* B
* C
* D
* SRF

(4.6) TATA-binding proteins|

* TBP
* TBPL1

(4.7) High-mobility group|

* BBX
* HMGB
* 1
* 2
* 3
* 4
* HMGN
* 1
* 2
* 3
* 4
* HNF
* 1A
* 1B
* SOX
* 1
* 2
* 3
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 17
* 18
* 21
* SRY
* SSRP1
* TCF/LEF
* TCF
* 1
* 3
* 4
* LEF1
* TOX
* 1
* 2
* 3
* 4

(4.9) Grainyhead|

* TFCP2

(4.10) Cold-shock domain|

* CSDA
* YBX1

(4.11) Runt|

* CBF
* CBFA2T2
* CBFA2T3
* RUNX1
* RUNX2
* RUNX3
* RUNX1T1

(0) Other transcription factors

| (0.2) HMGI(Y)|

* HMGA
* 1
* 2
* HBP1

|

(0.3) Pocket domain|

* Rb
* RBL1
* RBL2

(0.5) AP-2/EREBP-related factors|

* Apetala 2
* EREBP
* B3

(0.6) Miscellaneous|

* ARID
* 1A
* 1B
* 2
* 3A
* 3B
* 4A
* CAP
* IFI
* 16
* 35
* MLL
* 2
* 3
* T1
* MNDA
* NFY
* A
* B
* C
* Rho/Sigma

see also transcription factor/coregulator deficiencies

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