Tylonycteris bat coronavirus HKU4

Species of virus

Tylonycteris bat coronavirus HKU4

Virus classification
(unranked):  | Virus
Realm:  | Riboviria
Kingdom:  | Orthornavirae
Phylum:  | Pisuviricota
Class:  | Pisoniviricetes
Order:  | Nidovirales
Family:  | Coronaviridae
Genus:  | Betacoronavirus
Subgenus:  | Merbecovirus
Species:  |

Tylonycteris bat coronavirus HKU4

Tylonycteris bat coronavirus HKU4 (Bat-CoV HKU4) is an enveloped, positive-sense single-stranded RNA virus mammalian Group 2 Betacoronavirus that has been found to be genetically related to the Middle East respiratory syndrome-related coronavirus (MERS-CoV) that is responsible for the 2012 Middle East respiratory syndrome coronavirus outbreak in Saudi Arabia, Jordan, United Arab Emirates, the United Kingdom, France, and Italy.[1][2][3][4]

## Transmission

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The exact means of transmission to humans is not yet well known. However, it has been demonstrated that betaCoV's including HKU4 have the propensity to recombine and cause interspecies transmission. However, this is not seen in Group C betaCov's to which MERS-CoV is most closely related.[5]

## See also

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* Severe acute respiratory syndrome (SARS)
* Tylonycteris
* Pipistrellus
* Human coronavirus HKU1
* Human coronavirus OC43
* Pipistrellus bat coronavirus HKU5
* RNA virus
* Positive/negative-sense
* London1 novel CoV/2012

## References

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1. ^ Woo, Patrick CY; Lau, Susanna KP; Li, Kenneth SM; Tsang, Alan KL; Yuen, Kwok-Yung (2012). "Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5". Emerging Microbes & Infections. 1 (11): e35–. doi:10.1038/emi.2012.45. PMC 3630921. PMID 26038405.
2. ^ Zaki, Ali M.; Van Boheemen, Sander; Bestebroer, Theo M.; Osterhaus, Albert D.M.E.; Fouchier, Ron A.M. (2012). "Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia". New England Journal of Medicine. 367 (19): 1814–20\. doi:10.1056/NEJMoa1211721. PMID 23075143.1814-20&rft.date=2012&rft_id=info:doi/10.1056/NEJMoa1211721&rft_id=info:pmid/23075143&rft.aulast=Zaki&rft.aufirst=Ali+M.&rft.au=Van+Boheemen,+Sander&rft.au=Bestebroer,+Theo+M.&rft.au=Osterhaus,+Albert+D.M.E.&rft.au=Fouchier,+Ron+A.M.&rft_id=https://doi.org/10.1056%2FNEJMoa1211721&rfr_id=info:sid/en.wikipedia.org:Tylonycteris+bat+coronavirus+HKU4" class="Z3988">
3. ^ Woo, Patrick C.Y.; Lau, Susanna K.P.; Li, Kenneth S.M.; Poon, Rosana W.S.; Wong, Beatrice H.L.; Tsoi, Hoi-wah; Yip, Bethanie C.K.; Huang, Yi; Chan, Kwok-Hung; Yuen, Kwok-Yung (2006). "Molecular diversity of coronaviruses in bats". Virology. 351 (1): 180–7\. doi:10.1016/j.virol.2006.02.041. PMC 7111821. PMID 16647731.180-7&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111821#id-name=PMC&rft_id=info:pmid/16647731&rft_id=info:doi/10.1016/j.virol.2006.02.041&rft.aulast=Woo&rft.aufirst=Patrick+C.Y.&rft.au=Lau,+Susanna+K.P.&rft.au=Li,+Kenneth+S.M.&rft.au=Poon,+Rosana+W.S.&rft.au=Wong,+Beatrice+H.L.&rft.au=Tsoi,+Hoi-wah&rft.au=Yip,+Bethanie+C.K.&rft.au=Huang,+Yi&rft.au=Chan,+Kwok-Hung&rft.au=Yuen,+Kwok-Yung&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111821&rfr_id=info:sid/en.wikipedia.org:Tylonycteris+bat+coronavirus+HKU4" class="Z3988">
4. ^ Lau, S. K. P.; Li, K. S. M.; Tsang, A. K. L.; Lam, C. S. F.; Ahmed, S.; Chen, H.; Chan, K.-H.; Woo, P. C. Y.; Yuen, K.-Y. (2013). "Genetic characterization of betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: Implications for the origin of the novel Middle East respiratory syndrome coronavirus". Journal of Virology. 87 (15): 8638–50\. doi:10.1128/JVI.01055-13. PMC 3719811. PMID 23720729.8638-50&rft.date=2013&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719811#id-name=PMC&rft_id=info:pmid/23720729&rft_id=info:doi/10.1128/JVI.01055-13&rft.aulast=Lau&rft.aufirst=S.+K.+P.&rft.au=Li,+K.+S.+M.&rft.au=Tsang,+A.+K.+L.&rft.au=Lam,+C.+S.+F.&rft.au=Ahmed,+S.&rft.au=Chen,+H.&rft.au=Chan,+K.-H.&rft.au=Woo,+P.+C.+Y.&rft.au=Yuen,+K.-Y.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719811&rfr_id=info:sid/en.wikipedia.org:Tylonycteris+bat+coronavirus+HKU4" class="Z3988">
5. ^ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung (2010). "Coronavirus Genomics and Bioinformatics Analysis". Viruses. 2 (8): 1804–20\. doi:10.3390/v2081803. PMC 3185738. PMID 21994708.1804-20&rft.date=2010&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185738#id-name=PMC&rft_id=info:pmid/21994708&rft_id=info:doi/10.3390/v2081803&rft.aulast=Woo&rft.aufirst=Patrick+C.+Y.&rft.au=Huang,+Yi&rft.au=Lau,+Susanna+K.+P.&rft.au=Yuen,+Kwok-Yung&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185738&rfr_id=info:sid/en.wikipedia.org:Tylonycteris+bat+coronavirus+HKU4" class="Z3988">

## External links

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* London1-nCoV-2012 phylogenetic tree
* Coronaviruses
* Viralzone: Betacoronavirus
* Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae

* v
* t
* e

Taxonomy of the Coronaviridae

Higher taxonomy: Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae

Orthocoronavirinae

Alphacoronavirus|

| Colacovirus|

* Bat coronavirus CDPHE15

Decacovirus|

* Bat coronavirus HKU10
* Rhinolophus ferrumequinum alphacoronavirus HuB-2013

Duvinacovirus|

* Human coronavirus 229E

Luchacovirus|

* Lucheng Rn rat coronavirus

Minacovirus|

* Mink coronavirus 1

Minunacovirus|

* Miniopterus bat coronavirus 1
* Miniopterus bat coronavirus HKU8

Myotacovirus|

* Myotis ricketti alphacoronavirus Sax-2011

Nyctacovirus|

* Nyctalus velutinus alphacoronavirus SC-2013
* Pipistrellus kuhlii coronavirus 3398

Pedacovirus|

* Porcine epidemic diarrhea virus
* Scotophilus bat coronavirus 512

Rhinacovirus|

* Rhinolophus bat coronavirus HKU2

Setracovirus|

* Human coronavirus NL63
* NL63-related bat coronavirus strain BtKYNL63-9b

Soracovirus|

* Sorex araneus coronavirus T14

Sunacovirus|

* Suncus murinus coronavirus X74

Tegacovirus|

* Alphacoronavirus 1
* Feline coronavirus
* Canine coronavirus
* Canine coronavirus HuPn-2018
* Transmissible gastroenteritis virus

Betacoronavirus|

| Embecovirus|

* Betacoronavirus 1
* Bovine coronavirus
* Human coronavirus OC43
* China Rattus coronavirus HKU24
* Human coronavirus HKU1
* Murine coronavirus
* Rat coronavirus
* Myodes coronavirus 2JL14

Hibecovirus|

* Bat Hp-betacoronavirus Zhejiang2013

Merbecovirus|

* Hedgehog coronavirus 1
* Middle East respiratory syndrome-related coronavirus
* London1_novel CoV/2012
* MERS coronavirus EMC/2012
* Pipistrellus bat coronavirus HKU5
* Tylonycteris bat coronavirus HKU4

Nobecovirus|

* Eidolon bat coronavirus C704
* Rousettus bat coronavirus GCCDC1
* Rousettus bat coronavirus HKU9

Sarbecovirus|

* SARS-related coronavirus
* SARS-CoV-1
* SARS-CoV-2
* Variants
* BANAL-52
* Bat SARS-like coronavirus WIV1
* RacCS203
* RaTG13
* RmYN02
* RpYN06
* SHC014-CoV

Gammacoronavirus|

| Brangacovirus|

* Goose coronavirus CB17

Cegacovirus|

* Beluga whale coronavirus SW1

Igacovirus|

* Avian coronavirus
* Avian coronavirus 9203
* Duck coronavirus 2714

Deltacoronavirus|

| Andecovirus|

* Wigeon coronavirus HKU20

Buldecovirus|

* Bulbul coronavirus HKU11
* Common moorhen coronavirus HKU21
* Coronavirus HKU15
* Munia coronavirus HKU13
* White-eye coronavirus HKU16

Herdecovirus|

* Night heron coronavirus HKU19

Letovirinae

| Alphaletovirus|

| Milecovirus|

* Microhyla letovirus 1

Source: ICTV ––  Wikispecies

Taxon identifiers

Tylonycteris bat coronavirus HKU4|

* Wikidata: Q16993274
* Wikispecies: Tylonycteris bat coronavirus HKU4
* CoL: 59TJ4
* EoL: 11621406
* IRMNG: 11461140
* NCBI: 694007

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