UTY (gene)

Protein-coding gene in the species Homo sapiens

UTY

| Available structures

PDB| Human UniProt search: PDBe RCSB
| List of PDB id codes

3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L

Identifiers
Aliases| UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs| OMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs
| Gene location (Human)

Chr.| Y chromosome (human)[1]

Band| Yq11.221| Start| 13,234,577 bp[1]
End| 13,480,673 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* gonad

* corpus callosum

* testicle

* tendon of biceps brachii

* rectum

* right lung

* prostate

* cartilage tissue

* corpus epididymis

* middle frontal gyrus

n/a

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* oxidoreductase activity
* dioxygenase activity
* histone H3-tri/di-methyl-lysine-27 demethylase activity
* metal ion binding
* histone demethylase activity
* RNA polymerase II cis-regulatory region sequence-specific DNA binding
* chromatin binding
* chromatin DNA binding
* sequence-specific DNA binding

Cellular component|

* nucleus
* nucleoplasm
* MLL3/4 complex

Biological process|

* regulation of gene expression
* histone H3-K27 demethylation
* chromatin organization

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

7404

n/a

Ensembl| |

ENSG00000183878

n/a

UniProt| |

O14607

n/a

RefSeq (mRNA)| | NM_001258249
NM_001258250
NM_001258251
NM_001258252
NM_001258253

NM_001258254
NM_001258255
NM_001258256
NM_001258257
NM_001258258
NM_001258259
NM_001258260
NM_001258261
NM_001258262
NM_001258263
NM_001258264
NM_001258265
NM_001258266
NM_001258267
NM_001258268
NM_001258269
NM_001258270
NM_007125
NM_182659
NM_182660
NM_001400170
NM_001400171
NM_001400173
NM_001400175
NM_001400177
NM_001400178
NM_001400181
NM_001400183
NM_001400185
NM_001400187
NM_001400189
NM_001400192
NM_001400195
NM_001400199

n/a

RefSeq (protein)| | NP_001245178
NP_001245179
NP_001245180
NP_001245181
NP_001245182

NP_001245183
NP_001245184
NP_001245185
NP_001245186
NP_001245187
NP_001245188
NP_001245189
NP_001245190
NP_001245191
NP_001245192
NP_001245193
NP_001245194
NP_001245195
NP_001245196
NP_001245197
NP_001245198
NP_001245199
NP_009056
NP_872600
NP_872601
NP_001245196.1
NP_001245192.1
NP_001245178.1
NP_001245194.1
NP_001245186.1
NP_001245191.1
NP_001245187.1

n/a

Location (UCSC)| Chr Y: 13.23 – 13.48 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Histone demethylase UTY, or Ubiquitously transcribed tetratricopeptide repeat, Y chromosome, is an enzyme that in humans is encoded by the UTY gene.[3][4][5]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

The X-chromosome version of this gene is called UTX.

## Interactions

[edit]

UTY has been shown to interact with TLE1[6] and WDR90.[7]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183878 – Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8\. doi:10.1038/ng1296-474. PMID 8944031. S2CID 9994966.
4. ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42\. doi:10.1093/hmg/7.4.737. PMID 9499428.
5. ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
6. ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7\. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
7. ^ "STRING: functional protein association networks". string-db.org. Archived from the original on 2013-05-15. Retrieved 2015-05-07.

## Further reading

[edit]

* Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80\. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
* Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7\. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
* Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (March 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14\. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
* Foresta C, Ferlin A, Moro E (May 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9\. doi:10.1093/hmg/9.8.1161. PMID 10767340.
* Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (June 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9\. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
* Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (November 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32\. doi:10.1182/blood.V96.9.3126. PMID 11049993.
* Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9\. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
* Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96\. doi:10.1093/molbev/msh027. PMID 14660691.
* Gerrard DT, Filatov DA (June 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32\. doi:10.1093/molbev/msi128. PMID 15758204.

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