Urea carboxylase

Class of enzymes

urea carboxylase

Identifiers
EC no.| 6.3.4.6
CAS no.| 9058-98-4
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction

ATP + urea + HCO3\-  ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + urea-1-carboxylate

The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate (allophanate).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.

## See also

[edit]

* Allophanate hydrolase

## References

[edit]

* Roon RJ; Levenberg B (1970). "[37a] ATP: Urea amidolyase (ADP) (Candida utilis)". Metabolism of Amino Acids and Amines Part A. Methods in Enzymology. Vol. 17A. pp. 317–324\. doi:10.1016/0076-6879(71)17204-7. ISBN 9780121818746.
* Roon RJ, Levenberg B (1972). "Urea amidolyase. I. Properties of the enzyme from Candida utilis". J. Biol. Chem. 247 (13): 4107–13\. doi:10.1016/S0021-9258(19)45046-1. PMID 4556303.
* Sumrada RA, Cooper TG (1982). "Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast". J. Biol. Chem. 257 (15): 9119–27\. doi:10.1016/S0021-9258(18)34251-0. PMID 6124544.
* Kanamori T, Kanou N, Atomi H, Imanaka T (2004). "Enzymatic characterization of a prokaryotic urea carboxylase". J. Bacteriol. 186 (9): 2532–9\. doi:10.1128/JB.186.9.2532-2539.2004. PMC 387783. PMID 15090492.

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Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen|

* Aminoacyl tRNA synthetase
* Alanine
* Arginine
* Asparagine
* Aspartate
* Cysteine
* D-Alanine—poly(phosphoribitol) ligase
* Glutamate
* Glutamine
* Glycine
* Histidine
* Isoleucine
* Leucine
* Lysine
* Methionine
* Phenylalanine
* Proline
* Serine
* Threonine
* Tryptophan
* Tyrosine
* Valine

6.2: Carbon-Sulfur|

* (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
* 2-furoate—CoA ligase
* 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
* 3-hydroxybenzoate—CoA ligase
* 3-hydroxypropionyl-CoA synthase
* 4-chlorobenzoate—CoA ligase
* 4-Coumarate-CoA ligase
* 4-hydroxybenzoate—CoA ligase
* 6-carboxyhexanoate—CoA ligase
* Acetate—ACP ligase
* Acetate—CoA ligase (ADP-forming)
* Acetoacetate—CoA ligase
* Acetyl—CoA synthetase
* Acid—CoA ligase (GDP-forming)
* Anthranilate—CoA ligase
* Arachidonate—CoA ligase
* Benzoate—CoA ligase
* Biotin—CoA ligase
* (butirosin acyl-carrier protein)—L-glutamate ligase
* Butyrate—CoA ligase
* Cholate—CoA ligase
* Citrate—CoA ligase
* (citrate (pro-3S)-lyase) ligase
* Dicarboxylate—CoA ligase
* Glutarate—CoA ligase
* Long-chain-fatty-acid—ACP ligase
* Long-chain-fatty-acid—CoA ligase
* Malate—CoA ligase
* Malonate—CoA ligase
* o-Succinylbenzoate—CoA ligase
* Oxalate—CoA ligase
* Phenylacetate—CoA ligase
* Phytanate—CoA ligase
* Propionate—CoA ligase
* Succinate—CoA ligase (ADP-forming)
* Succinate—CoA ligase (GDP-forming)
* Succinyl—CoA synthetase
* trans-Feruloyl—CoA synthase

6.3: Carbon-Nitrogen|

* Glutamine synthetase
* Ubiquitin ligase
* Cullin
* Von Hippel–Lindau tumor suppressor
* UBE3A
* Mdm2
* Anaphase-promoting complex
* UBR1
* Glutathione synthetase
* CTP synthetase
* Adenylosuccinate synthase
* Argininosuccinate synthase
* Holocarboxylase synthetase
* GMP synthase
* Asparagine synthetase
* Carbamoyl phosphate synthetase
* I
* II
* Glutamate–cysteine ligase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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