Vitamin D analogues

Group of chemical compounds

The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions.[1][2][3][4]

## Types

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These include:

* Alfacalcidol
* Calcipotriol (calcipotriene)
* Doxercalciferol
* Falecalcitriol
* Paricalcitol
* Tacalcitol

## Mechanisms

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These modified vitamin D analogues have a side chain or other modifications. They aim to reduce the classical renal and intestinal effects of calcitriol on calcium and phosphate homeostasis, from its effects on other biologic processes.[5] They target cell proliferation and differentiation, especially in skin, or other effects in the parathyroid gland (secondary hyperparathyroidism) or bone cells.[5]

## References

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1. ^ Ashcroft DM, Po AL, Williams HC, Griffiths CE (April 2000). "Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis". BMJ (Clinical Research Ed.). 320 (7240): 963–7\. doi:10.1136/bmj.320.7240.963. PMC 27334. PMID 10753146.
2. ^ Martin KJ, González EA (November 2001). "Vitamin D analogues for the management of secondary hyperparathyroidism". American Journal of Kidney Diseases. 38 (5 Suppl 5): S34–40. doi:10.1053/ajkd.2001.28109. PMID 11689385.
3. ^ O'Neill JL, Feldman SR (May 2010). "Vitamine D analogue-based therapies for psoriasis". Drugs of Today. 46 (5): 351–60\. doi:10.1358/dot.2010.46.5.1473264. PMID 20517536.
4. ^ Birlea SA, Costin GE, Norris DA (April 2008). "Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation". Current Drug Targets. 9 (4): 345–59\. doi:10.2174/138945008783954970. PMID 18393827.
5. ^ a b Bikle DD (March 2014). "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology. 21 (3): 319–29\. doi:10.1016/j.chembiol.2013.12.016. PMC 3968073. PMID 24529992.

* v
* t
* e

Vitamin D receptor modulators

VDRTooltip Vitamin D receptor|

* Agonists: 7-Dehydrocholesterol
* 25-Hydroxyergocalciferol
* Alfacalcidol
* Calcifediol
* Calciferol
* Calcipotriol
* Calcitriol
* Cholecalciferol (vitamin D3)
* Dihydrotachysterol
* Doxercalciferol
* EB-1089
* Eldecalcitol
* Ercalcidiol
* Ercalcitriol
* Ergocalciferol (vitamin D2)
* Lithocholic acid
* Maxacalcitol
* Paricalcitol
* Tacalcitol

* Antagonists: ZK159222
* TEI-9647

See also
Receptor/signaling modulators
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*[t]: Discuss this template
*[e]: Edit this template
*[VDR]: Vitamin D receptor