Wayne Goodman

American psychiatrist and researcher

Wayne Goodman

American psychiatrist and researcher

Alma mater| Columbia University
Boston University School of Medicine
Yale School of Medicine
Known for| Obsessive Compulsive Disorder, Yale-Brown Obsessive Compulsive Scale International OCD Foundation, Deep Brain Stimulation
Scientific career
Fields| Psychiatry, Neurology
Institutions| Baylor College of Medicine, Icahn School of Medicine at Mount Sinai

Wayne Goodman is an American psychiatrist and researcher who specializes in Obsessive-Compulsive Disorder (OCD). He is the principal developer, along with his colleagues, of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).[1]

In 2016, Goodman was appointed the D.C and Irene Ellwood Professor and chair of the Menninger Department of Psychiatry and Behavioral Sciences at Baylor College of Medicine. He is also an adjunct professor in the Department of Electrical and Computer Engineering at Rice University.[2]

## Biography

[edit]

Prior to joining Baylor, Goodman was professor and chairman of the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai and The Mount Sinai Behavioral Health System for seven years. During his tenure, the department rose to be among the top ten in the nation in research funding from the National Institutes of Health.[3][4]

Goodman also served as director of the Division of Adult Translational Research and Treatment Development at the National Institute of Mental Health from 2007 to 2009. He was chairman of the Department of Psychiatry at the University of Florida in Gainesville for nine years.

A native of New York City, Goodman attended the Bronx High School of Science and graduated from Columbia University with a degree in electrical engineering. He received his medical degree from Boston University School of Medicine and completed his internship, residency, and research fellowship at Yale School of Medicine.[5]

## Major accomplishments in OCD

[edit]

### Yale-Brown Obsessive Compulsive Scale (Y-BOCS)

[edit]

In 1985, Goodman founded and served as chief of the OCD Clinic at Yale University. During this time, along with his colleagues Lawrence Price and Steven Rasmussen, he developed the Y-BOCS, which is widely used in research and clinical practice to determine the severity of OCD and to monitor improvement during treatment. It has since been translated into numerous languages.[1] A 2024 systematic review continued to support the efficacy of the Y-BOCS and its adaptations in assessing OCD severity and treatment outcomes in both adults and children.[6]

Goodman and his colleagues have also developed the Yale-Brown Obsessive-Compulsive Scale—Second Edition (Y-BOCS-II) in an effort to modify the original scale.[7] Other rating scales developed by Goodman and his colleagues include: the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS),[8] Florida Obsessive Compulsive Inventory (FOCI),[9] the Children's Florida Obsessive Compulsive Inventory (C-FOCI),[10] Level 2—Repetitive Thoughts and Behaviors (Cross-cutting symptom measure used in the DSM-5),[11] and the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP).[12]

By July 2018, Goodman's original article on the Yale-Brown Obsessive Compulsive Scale was the most cited paper on obsessive–compulsive disorder.[13][14]

### Selective serotonin reuptake inhibitors

[edit]

Goodman was one of the first investigators to test and establish the efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs) in OCD and show their comparative advantage over other antidepressant medications.[15] He also developed the use of adjunctive antipsychotic medications in SSRI-resistant OCD and found that patients with comorbid tic disorders are most likely to respond to this combination.[16]

### International OCD Foundation

[edit]

In 1986, Goodman co-founded the nonprofit OCD Foundation (now named the International OCD Foundation). While on faculty at Yale University, he had the idea to bring together a group of dedicated individuals with OCD who were participating in research studies for a self-help group. They later expanded and started a foundation to help reach a wider audience and educate the public about OCD and treatment options.[17] He served as chair of its scientific advisory board for the first ten years. Goodman received the Lifetime Career Achievement Award from the International OCD Foundation in 2012.[18]

### Deep brain stimulation

[edit]

Goodman conducts research in the use of Deep Brain Stimulation (DBS) for treatment-resistant psychiatric disorders. He has published on the use of DBS for intractable OCD.[19][20] In October 2016, The National Institute of Neurological Disorders and Stroke awarded him a grant for research aimed at developing a new generation of DBS technology. The funding, which was re-issued by the NIH for 2017, is part of President Obama's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.[21][22]

## Service with the Food and Drug Administration

[edit]

Goodman served as chair of the FDA Psychopharmacology Drug Advisory Committee (PDAC) from 2004 to 2008. During that time period, the FDA deliberated and eventually decided to require a Black Box warning on suicidality for all antidepressant drugs.[23] Goodman voted in favor of the Black Box warning for the pediatric population in 2004.[24] Two years later, he voted that the warning be extended up to age 24. He has also served on the FDA Neurological Devices Advisory Committee.[25]

## References

[edit]

1. ^ a b Goodman, W.K; Price, L.H; Rasmussen, S.A; et al. (1989). "The Yale–Brown Obsessive–Compulsive Scale. I. Development, use, and reliability". Arch Gen Psychiatry. 46 (11): 1006–1011\. doi:10.1001/archpsyc.1989.01810110048007. PMID 2684084.
2. ^ "Goodman named chair of psychiatry and behavioral sciences at Baylor College of Medicine". BCM. 28 Jul 2016.
3. ^ "Wayne K. Goodman, MD, Renowned Expert on Obsessive Compulsive Disorder, Joins Mount Sinai as Chair of Psychiatry". PRWeb. 4 May 2009. Archived from the original on May 10, 2009.
4. ^ "Ranking Tables of National Institutes of Health (NIH) Award Data 2014". brimr.org.
5. ^ "Wayne Goodman - The Mount Sinai Hospital". The Mount Sinai Hospital. Archived from the original on 2016-08-27. Retrieved 2015-07-29.
6. ^ Steele, Dale W.; Caputo, Eduardo L.; Kanaan, Ghid; Zahradnik, Michael L.; Brannon, Elizabeth; Freeman, Jennifer B.; Balk, Ethan M.; Trikalinos, Thomas A.; Adam, Gaelen P. (2024-12-06). Diagnosis and Management of Obsessive Compulsive Disorders in Children: A Systematic Review (Report). Agency for Healthcare Research and Quality (AHRQ). doi:10.23970/ahrqepccer276.
7. ^ Storch EA1, Rasmussen SA; Price, LH; Larson, MJ; Murphy, TK; Goodman, WK (Jun 2010). "Development and psychometric evaluation of the Yale-Brown Obsessive-Compulsive Scale--Second Edition". Psychol Assess. 22 (2): 223–32\. doi:10.1037/a0018492. PMID 20528050.`{{cite journal}}`: CS1 maint: numeric names: authors list (link)
8. ^ Scahill, L; Riddle, MA; McSwiggin-Hardin, M; Ort, SI; King, RA; Goodman, WK; Cicchetti, D; Leckman, JF (Jun 1997). "Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity". J Am Acad Child Adolesc Psychiatry. 36 (6): 844–52\. doi:10.1097/00004583-199706000-00023. PMID 9183141.
9. ^ Storch, EA; Kaufman, DA; Bagner, D; Merlo, LJ; Shapira, NA; Geffken, GR; Murphy, TK; Goodman, WK (Sep 2007). "Florida Obsessive-Compulsive Inventory: development, reliability, and validity". J Clin Psychol. 63 (9): 851–9\. doi:10.1002/jclp.20382. PMID 17674398.
10. ^ Storch EA1, Khanna M; Merlo, LJ; Loew, BA; Franklin, M; Reid, JM; Goodman, WK; Murphy, TK (Sep 2009). "Children's Florida Obsessive Compulsive Inventory: psychometric properties and feasibility of a self-report measure of obsessive-compulsive symptoms in youth". Child Psychiatry Hum Dev. 40 (3): 467–83\. doi:10.1007/s10578-009-0138-9. PMID 19326209. S2CID 17195058.`{{cite journal}}`: CS1 maint: numeric names: authors list (link)
11. ^ American Psychiatric Association.(2013).Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC.
12. ^ Bussing R, Murphy TK, Storch EA, McNamara JP, Reid AM, Garvan CW, Goodman WK (2013). "Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD". Psychiatry Res. 205 (3): 253–61\. doi:10.1016/j.psychres.2012.09.019. PMC 3540123. PMID 23031804.
13. ^ Goodman, Wayne K.; Rasmussen, Steven; Mazure, Carolyn (1989-11-01). "The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability". Archives of General Psychiatry. 46 (11): 1006. doi:10.1001/archpsyc.1989.01810110048007. ISSN 0003-990X.
14. ^ Parmar, Arpit; Ganesh, Ragul; Mishra, Ashwani Kumar (April 2019). "The top 100 cited articles on Obsessive Compulsive Disorder (OCD): A citation analysis". Asian Journal of Psychiatry. 42: 34–41\. doi:10.1016/j.ajp.2019.03.025.
15. ^ Goodman, WK; Price, LH; Delgado, PL; Palumbo, J; Krystal, JH; Nagy, LM; Rasmussen, SA; Heninger, GR; Charney, DS (Jun 1990). "Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine". Arch Gen Psychiatry. 47 (6): 577–85\. doi:10.1001/archpsyc.1990.01810180077011. PMID 2112374.
16. ^ McDougle CJ1, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry. 1994 Apr;51(4):302-8. PBMI 8161290
17. ^ "History of the Clinic". yale.edu.
18. ^ "Wayne Goodman, MD, Receives Career Achievement Award from International OCD Foundation". The Mount Sinai Hospital. Archived from the original on 2017-08-02. Retrieved 2015-07-29.
19. ^ Goodman, WK; Alterman, RL (2012). "Deep brain stimulation for intractable psychiatric disorders". Annu Rev Med. 63: 511–24\. doi:10.1146/annurev-med-052209-100401. PMID 22034866.
20. ^ Goodman, WK; Foote, KD; Greenberg, BD; Ricciuti, N; Bauer, R; Ward, H; Shapira, NA; Wu, SS; Hill, CL; Rasmussen, SA; Okun, MS (Mar 2010). "Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design". Biol Psychiatry. 67 (6): 535–42\. doi:10.1016/j.biopsych.2009.11.028. PMC 5796545. PMID 20116047.
21. ^ "Baylor College of Medicine researcher and collaborators awarded grant through NIH BRAIN Initiative". BCM.
22. ^ "Funded Awards". NIH. Archived from the original on November 15, 2015.
23. ^ Goodman WK1, Murphy TK; Storch, EA (Mar 2007). "Risk of adverse behavioral effects with pediatric use of antidepressants". Psychopharmacology. 191 (1): 87–96\. doi:10.1007/s00213-006-0642-6. PMID 17180618. S2CID 21055530.`{{cite journal}}`: CS1 maint: numeric names: authors list (link)
24. ^ "Food and Drug Administration". fda.gov. Archived from the original on October 30, 2004.
25. ^ "Archived copy" (PDF). Food and Drug Administration. Archived from the original (PDF) on 2017-05-09. Retrieved 2019-12-16.`{{cite web}}`: CS1 maint: archived copy as title (link)

* v
* t
* e

Obsessive–compulsive disorder

History|

* Dimensional Obsessive-Compulsive Scale
* Yale–Brown Obsessive Compulsive Scale
* OCD Awareness Week

Biology|

| Neuroanatomy|

* Basal ganglia (striatum)
* Orbitofrontal cortex
* Cingulate cortex
* Brain-derived neurotrophic factor

|

Receptors|

* 5-HT1Dβ
* 5-HT2A
* 5-HT2C
* μ Opioid
* H2
* NK1
* M4
* NMDA

Symptoms|

* Obsessions (associative
* counting
* diagnostic
* injurious
* pathogenic
* sexual
* scrupulous
* symmetry)
* Compulsions (impulses
* rituals
* tics)
* Thought suppression (Experiential avoidance)
* Hoarding (animals
* books
* data
* possessions
* decluttering)

Treatment|

| Serotonergics|

| Selective serotonin reuptake inhibitors|

* Escitalopram
* Fluoxetine
* Fluvoxamine
* Paroxetine
* Sertraline
* Citalopram
* Nefazodone

|

Monoamine oxidase inhibitors|

* Phenelzine

Tricyclic antidepressants|

* Clomipramine

Atypical antipsychotics|

* Aripiprazole

Other|

* Inositol
* Deep brain stimulation

Behavioral|

* Acceptance and commitment therapy
* Cognitive behavioral therapy (Exposure and response prevention)
* Inference-based therapy
* Metacognitive therapy

Popular culture|

| Literature|

| Fictional|

* Matchstick Men
* Plyushkin
* Xenocide

|

Nonfiction|

* Everything in Its Place
* Just Checking

Media|

* As Good as It Gets
* The Aviator
* Matchstick Men
* Adrian Monk
* Pure
* "$pringfield"
* Straight Up

Related|

* Guilt (emotion)
* Illusion of control
* Obsessive–compulsive personality disorder
* Obsessional jealousy
* PANDAS
* Primarily Obsessional OCD
* Questionable cause
* Relationship obsessive–compulsive disorder
* Social anxiety disorder
* Superstition
* Tourette syndrome
* University of Florida Obsessive–Compulsive Disorder Program

Category

Authority control databases

International|

* ISNI
* VIAF
* WorldCat

National|

* United States
* Netherlands
* Israel

Academics|

* ORCID

Other|

* IdRef
* Yale LUX

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