Western African Ebola epidemic

2013–2016 major disease outbreak

Western African Ebola epidemic

Simplified Ebola virus epidemic situation map

Date| December 2013 – June 2016[1][2]
Casualties
|  Country|  Cases|  Deaths|  Outbreak end

|
|
|

Liberia|  10,675|  4,809| 9 Jun 2016[2]
Sierra Leone|  14,124|  3,956| 17 Mar 2016[3]
Guinea|  3,811|  2,543| 1 Jun 2016[4]
Nigeria|  20|  8| 19 Oct 2014[5]
Mali|  8|  6| 18 Jan 2015[6]
United States|  4|  1| 21 Dec 2014[7]
Italy|  1|  0| 20 Jul 2015[8]
United Kingdom|  1|  0| 10 Mar 2015[9]
Senegal|  1|  0| 17 Oct 2014[5]
Spain|  1|  0| 2 Dec 2014[10]
Total|  28,646|  11,323|  Jun 2016
Note: current estimates suggest that between 17 percent and 70 percent of Ebola cases were unreported,[11] suggesting a total number of cases between 34,513 and 94,486.

The 2013–2016 epidemic of Ebola virus disease, centered in West Africa, was the most widespread outbreak of the disease in history. It caused major loss of life and socioeconomic disruption in the region, mainly in Guinea, Liberia and Sierra Leone. The first cases were recorded in Guinea in December 2013; the disease spread to neighbouring Liberia and Sierra Leone,[12] with minor outbreaks occurring in Nigeria and Mali.[13][14] Secondary infections of medical workers occurred in the United States and Spain.[15][16] Isolated cases were recorded in Senegal,[17] the United Kingdom and Italy.[18][19] The number of cases peaked in October 2014 and then began to decline gradually, following the commitment of substantial international resources.

It caused significant mortality, with a considerable case fatality rate.[12][18][20][note 1] By the end of the epidemic, 28,616 people had been infected; of these, 11,310 had died, for a case-fatality rate of 40%.[21] As of 8 May 2016[update], the World Health Organization (WHO) and respective governments reported a total of 28,646 suspected cases and 11,323 deaths[22] (39.5%), though the WHO believes that this substantially understates the magnitude of the outbreak.[23][24] On 8 August 2014, a Public Health Emergency of International Concern was declared[25] and on 29 March 2016, the WHO terminated the Public Health Emergency of International Concern status of the outbreak.[26][27][28] Subsequent flare-ups occurred; the epidemic was finally declared over on 9 June 2016, 42 days after the last case tested negative on 28 April 2016 in Monrovia.[29]

The outbreak left about 17,000 survivors of the disease, many of whom report post-recovery symptoms termed post-Ebola syndrome, often severe enough to require medical care for months or even years. An additional cause for concern is the apparent ability of the virus to "hide" in a recovered survivor's body for an extended period and then become active months or years later, either in the same individual or in a sexual partner.[30] In December 2016, the WHO announced that a two-year trial of the rVSV-ZEBOV vaccine appeared to offer protection from the variant of EBOV responsible for the Western Africa outbreak. The vaccine is considered to be effective and is the only prophylactic that offers protection; hence, 300,000 doses have been stockpiled.[31][32] rVSV-ZEBOV received regulatory approval in 2019.[33][34]

## Epidemiology

[edit]

### Outbreak

[edit]

See also: Ebola virus epidemic in West Africa timeline

Ebola outbreak worldwide

Widespread outbreak

Limited outbreak

Isolated cases

Medically evacuated cases

The 2013–2016 outbreak, caused by Ebola virus (EBOV),[35] was the first anywhere in the world to reach epidemic proportions. Extreme poverty, dysfunctional healthcare systems, distrust of government after years of armed conflict, and the delay in responding for several months, all contributed to the failure to control the epidemic. Other factors, per media reports, included local burial customs of washing the body and the unprecedented spread of Ebola to densely populated cities.[36][37][38][39][40]

It is generally believed that a one or two-year-old boy,[41][42] later identified as Emile Ouamouno, who died in December 2013 in the village of Méliandou in Guinea,[43] was the index case.[44] His mother, sister, and grandmother later became ill with similar symptoms and also died; people infected by these initial cases spread the disease to other villages.[45][46] These early cases were diagnosed as other conditions more common to the area and the disease had several months to spread before it became recognised as Ebola.[44][45]

Monthly aggregate Ebola cases in the Western Africa epidemic 2014–15 Monthly aggregate Ebola deaths in the Western Africa epidemic 2014–15

On 25 March 2014, the WHO indicated that Guinea's Ministry of Health had reported an outbreak of Ebola virus disease in four southeastern districts and that suspected cases in the neighbouring countries of Liberia and Sierra Leone were being investigated. In Guinea, a total of 86 suspected cases, including 59 deaths, had been reported as of 24 March.[47] By late May, the outbreak had spread to Conakry, Guinea's capital—a city of about two million people.[47] On 28 May, the total number of reported cases had reached 281, with 186 deaths.[47]

In Liberia, the disease was reported in four counties by mid-April 2014 and cases in Liberia's capital Monrovia were reported in mid-June.[48] The outbreak then spread to Sierra Leone and progressed rapidly. By 17 July, the total number of suspected cases in the country stood at 442, surpassing those in Guinea and Liberia.[49] By 20 July, additional cases of the disease had been reported by the media in the Bo District, while the first case in Freetown, Sierra Leone's capital, was reported in late July.[50][51]

As the epidemic progressed, a small outbreak occurred in Nigeria that resulted in 20 cases and another in Mali with seven cases. Four other countries (Senegal, Spain, the United Kingdom and the United States) also reported cases imported from Western Africa, with widespread and intense transmission.[52][53][54]

On 28 January 2015, the WHO reported that for the first time since the week ending 29 June 2014, there had been fewer than 100 new confirmed cases reported in a week in the three most-affected countries. The response to the epidemic then moved to a second phase, as the focus shifted from slowing transmission to ending the epidemic.[55] On 8 April 2015, the WHO reported a total of only 30 confirmed cases,[56] and the weekly update for 29 July reported only seven new cases.[57] Cases continued to gradually dwindle and on 7 October 2015, all three of the most seriously affected countries, per media reports, recorded their first joint week without any new cases.[58] However, sporadic new cases were still being recorded, frustrating hopes that the epidemic could be declared over.[59] On 31 March 2015, one year after the first report of the outbreak, the total number of cases was over 25,000—with over 10,000 deaths.[60] As the main epidemic was coming to an end in December 2015, the UN announced that 22,000 children had lost one or both parents to Ebola.[61]

On 14 January 2016, after all the previously infected countries had been declared Ebola-free, the WHO reported that "all known chains of transmission have been stopped in Western Africa", but cautioned that further small outbreaks of the disease could occur.[62] The following day, Sierra Leone confirmed its first new case since September 2015.[28]

### Countries that experienced widespread transmission

[edit]

Outbreak distribution map affected part of Western Africa (17 December 2014)

#### Guinea

[edit]

Further information: Ebola virus epidemic in Guinea

On 25 March 2014, the WHO reported an outbreak of Ebola virus disease in four southeastern districts of Guinea with a total of 86 suspected cases, including 59 deaths. MSF assisted the Ministry of Health by establishing Ebola treatment centres in the epicentre of the outbreak.[47] On 31 March, the U.S. Centers for Disease Control and Prevention (CDC) sent a team to assist in the response.[47] Thinking that the spread of the virus had been contained, MSF closed its treatment centres in May, leaving only a skeleton staff to handle the Macenta region. However, in late August, according to media reports, large numbers of new cases reappeared in the region.[63]

In February 2015, Guinea recorded a rise in cases; health authorities stated that this was related to the fact that they "were only now gaining access to faraway villages", where violence had previously prevented them from entering.[64] On 14 February, violence erupted and an Ebola treatment centre near the centre of the country was destroyed. Guinean Red Cross teams said they had suffered an average of 10 attacks a month over the previous year;[65] MSF reported that acceptance of Ebola education remained low and that further violence against their workers might force them to leave.[66]

Resistance to interventions by health officials among the Guinean population remained greater than in Sierra Leone and Liberia, per media reports, raising concerns over its impact on ongoing efforts to halt the epidemic; in mid-March, there were 95 new cases, and on 28 March, and a 45-day "health emergency" was declared in five regions of the country.[66][67] On 25 May, six persons were placed in prison isolation after they were found travelling with the corpse of an individual who had died of the disease.[68] On 1 June, it was reported that violent protests in a north Guinean town at the border with Guinea-Bissau had caused the Red Cross to withdraw its workers.[69]

In late June 2015, the WHO reported that "weekly case incidence has stalled at between 20 and 27 cases since the end of May, whilst cases continue to arise from unknown sources of infection, and to be detected only after post-mortem testing of community deaths".[70] On 29 July, a sharp decline in cases was reported;[57] the number of cases eventually plateaued at one or two cases per week in early August.[71] On 28 October, an additional three cases were reported in the Forécariah Prefecture by the WHO.[72] On 6 November, a media report indicated Tana village to be the last known place with Ebola in the country,[73] and on 11 November, WHO indicated that no Ebola cases were reported in Guinea; this was the first time since the epidemic began that no cases had been reported in any country.[74] On 17 November, the last Ebola patient in Guinea had recovered,[75][76][77] and was discharged from the hospital on 28 November.[78] On 29 December 2015, the WHO declared Guinea Ebola-free.[79]

On 17 March 2016, the government of Guinea reported that two people had again tested positive for Ebola virus in Korokpara.[80] [81] On 19 March, it was also reported by the media that another individual had died due to the virus at the treatment centre in Nzerekore,[82] consequently, the country's government quarantined an area around the home where the cases took place.[83] On 22 March, the media reported that medical authorities in Guinea had quarantined 816 suspected contacts of the prior cases;[84][85] the same day, Liberia ordered its border with Guinea closed.[86] On 29 March, it was reported that about 1,000 contacts had been identified,[26] and on 30 March three more confirmed cases were reported.[87] On 1 April, it was reported by the media, that possible contacts, which numbered in the hundreds, had been given an experimental vaccine using a ring vaccination approach.[88][89]

On 5 April 2016, it was reported via the media, that there had been nine new cases of Ebola since the virus resurfaced, out of which eight were fatal;[90] on 1 June, after the stipulated waiting period, the WHO again declared Guinea Ebola-free.[91]

In September 2016, findings were published suggesting that the resurgence in Guinea was caused by an Ebola survivor who, after eight months of abstinence, had sexual relations with several partners, including the first victim in the new outbreak.[92][93] The disease was also spread to Liberia.[94]

#### Sierra Leone

[edit]

Further information: Ebola virus epidemic in Sierra Leone

Kenema Hospital, Sierra Leone

The first person reported infected in Sierra Leone, according to media reports, was a tribal healer who had been treating Ebola patients from across the nearby border with Guinea and who died on 26 May 2014; according to tribal tradition, her body was washed for burial, and this appears to have led to infections in women from neighbouring towns.[95] On 11 June Sierra Leone shut its borders for trade with Guinea and Liberia and closed some schools in an attempt to slow the spread of the virus;[96] on 30 July the government began to deploy troops to enforce quarantines.[97]

During the first week of November, reports told of a worsening situation due to intense transmission in Freetown. According to the Disaster Emergency Committee, food shortages resulting from aggressive quarantines were making the situation worse,[98] and on 4 November media reported that thousands had violated quarantine in search of food in the town of Kenema.[99] With the number of cases continuing to increase, an MSF coordinator described the situation in Sierra Leone as "catastrophic", saying, "there are several villages and communities that have been basically wiped out ... Whole communities have disappeared but many of them are not in the statistics." In mid-November, the WHO reported that, while there was some evidence that the number of cases was no longer rising in Guinea and Liberia, steep increases persisted in Sierra Leone.[52]

Ebola crisis: More UK aid arrives in Sierra Leone

On 9 December 2014 news reports described the discovery of "a grim scene"—piles of bodies, overwhelmed medical personnel and exhausted burial teams—in the remote eastern Kono District.[100] On 15 December the CDC indicated that their main concern was Sierra Leone, where the epidemic had shown no signs of abating as cases continued to rise exponentially; by the second week of December, Sierra Leone had reported nearly 400 cases—more than three times the number reported by Guinea and Liberia combined. According to the CDC, "the risk we face now [is] that Ebola will simmer along, become native and be a problem for Africa and the world, for years to come".[101] On 17 December President Koroma of Sierra Leone launched "Operation Western Area Surge" and workers went door-to-door in the capital city looking for possible cases.[102][103] The operation led to 403 new reports of cases between 14 and 17 December.[102][104]

According to the 21 January 2015 WHO Situation Report, the case incidence was rapidly decreasing in Sierra Leone.[105][106][107] However, in February and March reports indicated another rise in the number of cases.[108][109][110][111] The WHO weekly update for 29 July reported a total of only three new cases, the lowest in more than a year.[57] On 17 August the country marked its first week with no new cases,[112] and one week later the last patients were released.[113] However, a new case emerged on 1 September, when a patient from Kambia District tested positive for the disease after her death;[114] her case eventually resulted in three other infections among her contacts.[115]

On 14 September 2015 Sierra Leone's National Ebola Response Centre confirmed the death of a 16-year-old in a village in the Bombali District.[116] It is suspected that she contracted the disease from the semen of an Ebola survivor who had been discharged in March 2015.[117] On 7 November 2015 the country was declared Ebola-free.[118][119]

Sierra Leone had entered a 90-day period of enhanced surveillance that was scheduled to end on 5 February 2016, when, on 14 January, a new Ebola death was reported in the Tonkolili District.[120][121] Before this case, the WHO had advised that "we still anticipate more flare-ups and must be prepared for them. A massive effort is underway to ensure robust prevention, surveillance, and response capacity across all three countries by the end of March."[122] On 16 January aid workers reported that a woman had died of the virus and that she may have exposed several individuals; the government later announced that 100 people had been quarantined.[123] Investigations indicated that the deceased was a student from Lunsar who had gone to Kambia District on 28 December 2015 before returning symptomatic. She had also visited Bombali District to consult a herbalist and had later gone to a government hospital in Magburaka. The WHO indicated that there were 109 contacts and another three missing contacts, and that the source or route of transmission that caused the fatality was unknown.[124] A second new case—a relative and caregiver of the aforementioned victim—had become symptomatic on 20 January while under observation at a quarantine centre.[125][126] On 26 January WHO Director-General, Dr Margaret Chan officially confirmed that the outbreak was not yet over;[28] that same day, it was also reported that Ebola restrictions had halted market activity in Kambia District amid protests.[127] On 8 February the last Ebola patient was also released.[128]

On 4 February 2016 the last known case tested negative for a second consecutive time and Sierra Leone commenced another 42-day countdown towards being declared Ebola-free.[129][130] On 17 March 2016 the WHO announced that the Sierra Leone flare-up was over and that no other chains of transmission were known to be active at that time.[131] By 15 July the country had discontinued testing corpses for the virus.[132]

#### Liberia

[edit]

Further information: Ebola virus epidemic in Liberia

An Ebola treatment unit in Liberia

In Liberia, the disease was reported in both Lofa and Nimba counties in late March 2014.[133] On 27 July, President Ellen Johnson Sirleaf announced that Liberia would close its borders, with the exception of a few crossing points such as Roberts International Airport, where screening centres would be established.[134] Schools and universities were closed,[135][136] and the worst-affected areas in the country were placed under quarantine.[137]

With only 50 physicians in the entire country—one for every 70,000 citizens—Liberia was already in a healthcare crisis.[138] In September, the CDC reported that some hospitals had been abandoned, while those still functioning lacked basic facilities and supplies.[139] In October, the Liberian ambassador in Washington was reported as saying that he feared that his country may be "close to collapse";[138] by 24 October, all 15 counties had reported cases.[5][140]

By November 2014, the rate of new infections in Liberia appeared to be declining and the state of emergency was lifted. The drop in cases was believed to be related to an integrated strategy combining isolation and treatment with community behaviour change, including safe burial practices, case finding and contact tracing.[141][142] Roselyn Nugba-Ballah, leader of the Safe & Dignified Burial Practices Team during the crisis, was awarded the Florence Nightingale Medal in 2017 for her work during the crisis.[143]

In January 2015, the MSF field coordinator reported that Liberia was down to only five confirmed cases.[144] In March, after two weeks of not reporting any new cases, three new cases were confirmed.[145] On 8 April, a new health minister was named to end Ebola in the country and on 26 April, MSF handed the Ebola treatment facility over to the government.[146] On 30 April, the US shut down a special Ebola treatment unit in Liberia.[147] The last known case of Ebola died on 27 March,[148] and the country was officially declared Ebola-free on 9 May 2015. The WHO congratulated Liberia saying, "reaching this milestone is a testament to the strong leadership and coordination of Liberian President Ellen Johnson Sirleaf and the Liberian Government, the determination and vigilance of Liberian communities, the extensive support of global partners, and the tireless and heroic work of local and international health teams."[149]

After three months with no new reports of cases, on 29 June Liberia reported that the body of a 17-year-old boy, who had been treated for malaria, tested positive for Ebola. The WHO said the boy had been in close contact with at least 200 people,[150] who they were following up, and that "the case reportedly had no recent history of travel, contact with visitors from affected areas, or funeral attendance." A second case was confirmed on 1 July.[151][152] After a third new case was confirmed on 2 July, and it was discovered that all three new cases had shared a meal of dog meat, researchers looked at the possibility that the meat may have been involved in the transfer of the virus.[153][154] Testing of the dog's remains, however, was negative for the Ebola virus.[155] By 9 July three more cases were discovered, bringing the total number of new cases to five, all from the same area.[156] On 14 July, a woman died of the disease in the county of Montserrado, bringing the total to 6.[157] On 20 July, the last patients were discharged,[158] and on 3 September 2015, Liberia was declared Ebola-free again.[159]

After two months of being Ebola-free, a new case was confirmed on 20 November 2015, when a 15-year-old boy was diagnosed with the virus[160][161] and two family members subsequently tested positive.[162][163] Health officials were concerned because the child had not recently travelled or been exposed to someone with Ebola and the WHO stated that "we believe that this is probably again, somehow, someone who has come in contact with a virus that had been persisting in an individual, who had suffered the disease months ago."[164] The infected boy died on 24 November,[165] and on 3 December two remaining cases were released after recovering.[166] On 16 December, the WHO reaffirmed that the cases in Liberia were the result of re-emergence of the virus in a previously infected person,[167] and there was speculation that the boy may have been infected by an individual who became infectious once more due to pregnancy, which may have weakened her immune system.[168] On 18 December, the WHO indicated that it still considered Ebola in Western Africa a public health emergency, though progress had been made.[169]

After having completed the 42 days, Liberia was declared free from the virus on 14 January 2016, effectively ending the outbreak that had started in neighbouring Guinea two years earlier. Liberia began a 90-day period of heightened surveillance, scheduled to conclude on 13 April 2016,[170] but on 1 April, it was reported that a new Ebola fatality had occurred,[171] and on 3 April, a second case was reported in Monrovia.[172] On 4 April, it was reported that 84 individuals were under observation due to contact with the two confirmed Ebola cases.[173] By 7 April, Liberia had confirmed three new cases since the virus resurfaced, and a total of 97 contacts, including 15 healthcare workers, were being monitored.[174] The index case of the new flareup was reported to be the wife of a patient who died from Ebola in Guinea; she had travelled to Monrovia after the funeral but died from the disease.[175]

On 29 April, WHO reported that Liberia had discharged the last patient. According to the WHO, tests indicated that the flare-up was likely due to contact with a prior Ebola survivor's infected body fluids.[94] On 9 June, the flare-up was declared over, and the country Ebola-free.[176][177]

### Western African countries with limited local cases

[edit]

#### Senegal

[edit]

In March 2014, Senegal closed its southern border with Guinea,[178] but on 29 August, the health minister announced the country's first case, who was being treated in a Dakar hospital.[179] The patient was a native of Guinea who had travelled to Dakar, arriving on 20 August.[179] On 28 August 2014, authorities in Guinea issued an alert that a person who had been in close contact with an Ebola-infected patient had escaped their surveillance system. The alert prompted testing for Ebola at the Dakar laboratory, and the positive result launched an investigation, triggering urgent contact tracing.[179] On 10 September, it was reported that the initial case had recovered.[180] No further cases were reported,[181] and on 17 October 2014, the WHO officially declared that the outbreak in Senegal had ended.[5]

#### Nigeria

[edit]

Further information: Ebola virus disease in Nigeria

The first case in Nigeria was a Liberian-American, who flew from Liberia to Nigeria's most populated city of Lagos on 20 July 2014. On 6 August 2014, the Nigerian health minister told reporters that one of the nurses who attended to the Liberian had died from the disease. Five newly confirmed cases were being treated at an isolation ward.[182]

On 22 September 2014, the Nigerian health ministry announced, "As of today, there is no case of Ebola in Nigeria." According to the WHO, 20 cases and 8 deaths were confirmed, including the imported case, who also died. Four of the dead were health workers who had cared for the index case.[183]

The WHO's representative in Nigeria officially declared the country Ebola-free on 20 October 2014, stating it was a "spectacular success story".[184] Nigeria was the first African country to be declared Ebola-free.[185] This was largely due to the early quarantine efforts of Dr. Ameyo Stella Adadevoh.[186]

#### Mali

[edit]

Malian regions with Ebola cases (Kayes/Bamako), November 2014

Further information: Ebola virus disease in Mali

On 23 October 2014, the first case of Ebola virus disease in Mali was confirmed in the city of Kayes—a two-year-old girl who had arrived from Guinea and died the next day.[187][188] Her father had worked for the Red Cross in Guinea and also in a private health clinic; he had died earlier in the month, likely from an Ebola infection contracted in the private clinic. It was later established that several family members had also died of Ebola. The family had returned to Mali after the father's funeral. All contacts were followed for 21 days, with no further spread of the disease reported.[189]

On 12 November 2014, Mali reported deaths from Ebola in an outbreak unconnected with the first case in Kayes. The first probable case was an imam who had fallen ill on 17 October in Guinea and was transferred to the Pasteur Clinic in Mali's capital city, Bamako, for treatment. He was treated for kidney failure but was not tested for Ebola; he died on 27 October and his body returned to Guinea for burial.[190] A nurse and a doctor who had treated the imam subsequently fell ill with Ebola and died.[191][192] The next three cases were a man who had visited the imam while he was in hospital, his wife and his son. On 22 November, the final case related to the imam was reported—a friend of the Pasteur Clinic nurse who had died from the Ebola virus.[193] On 12 December, the last case in treatment recovered and was discharged, "so there are no more people sick with Ebola in Mali", according to a Ministry of Health source.[194] On 18 January 2015 the country was declared Ebola-free.[13]

### Other countries with limited local cases

[edit]

#### United Kingdom

[edit]

Further information: Ebola virus disease in the United Kingdom

On 29 December 2014, Pauline Cafferkey, a British aid worker who had just returned to Glasgow from Sierra Leone, was diagnosed with Ebola.[195] She was treated and released from hospital on 24 January 2015.[9][196] On 8 October, she was readmitted for complications caused by the virus.[197] On 14 October, her condition was listed as "critical"[198] and 58 individuals were being monitored and 25 received an experimental vaccination, being close contacts.[199][200] On 21 October, it was reported that she had been diagnosed with meningitis caused by the virus persisting in her brain.[201] On 12 November, she was released from hospital after making a full recovery.[202] However, on 23 February, Cafferkey was admitted for a third time, "under routine monitoring by the Infectious Diseases Unit ... for further investigations".[203][204]

#### Italy

[edit]

On 12 May 2015, it was reported that a nurse, who had been working in Sierra Leone, had been diagnosed with Ebola after returning home to the Italian island of Sardinia. He was treated at Spallanzani Hospital, the national reference centre for Ebola patients.[205] On 10 June, it was reported that he had recovered and was released from the hospital.[206]

#### Spain

[edit]

Further information: Ebola virus disease cases in Spain

On 5 August 2014, the Brothers Hospitallers of Saint John of God confirmed that Brother Miguel Pajares, who had been volunteering in Liberia, had become infected. He was evacuated to Spain and died on 12 August.[207] On 21 September it was announced that Brother Manuel García Viejo, another Spanish citizen who was medical director at the St John of God Hospital Sierra Leone in Lunsar, had been evacuated to Spain from Sierra Leone after being infected with the virus. His death was announced on 25 September.[208]

In October 2014, a nursing assistant, Teresa Romero, who had cared for these patients became unwell and on 6 October tested positive for Ebola,[209][210] making this the first confirmed case of Ebola transmission outside of Africa. On 19 October, it was reported that Romero had recovered, and on 2 December the WHO declared Spain Ebola-free.[211]

#### United States

[edit]

Further information: Ebola virus cases in the United States

On 30 September 2014, the CDC declared its first case of Ebola virus disease. Thomas Eric Duncan became infected in Liberia and travelled to Dallas, Texas, on 20 September. On 26 September, he fell ill and sought medical treatment, but was sent home with antibiotics. He returned to the hospital by ambulance on 28 September and was placed in isolation and tested for Ebola.[212][213] He died on 8 October.[214] Two cases stemmed from Duncan, when two nurses that had treated him tested positive for the virus;[215] they were declared Ebola-free on 24 and 22 October, respectively.[216][217]

A fourth case was identified on 23 October 2014, when Craig Spencer, an American physician who had returned to the United States after treating Ebola patients in Western Africa, tested positive for the virus.[218] Spencer recovered and was released from hospital on 11 November.[219]

### Countries with medically evacuated cases

[edit]

Many people who had become infected with Ebola were medically evacuated for treatment in isolation wards in Europe or the US. They were mostly health workers with one of the NGOs in Western Africa. Except for a single isolated case in Spain, no secondary infections occurred as a result of the medical evacuations. The US accepted four evacuees and three were flown to Germany.[220][221][222] France,[223][224] Italy,[225] the Netherlands,[226] Norway,[227][228] Switzerland,[229] and the United Kingdom received two patients (and five who were exposed).[230][231]

### Unrelated outbreak in the Democratic Republic of the Congo

[edit]

Further information: 2014 Democratic Republic of the Congo Ebola virus outbreak

In August 2014, the WHO reported an outbreak of the Ebola virus in the Boende District, part of the northern Équateur province of the Democratic Republic of the Congo (DRC), where 13 people were reported to have died of Ebola-like symptoms.[232] Genetic sequencing revealed that this outbreak was caused by the Zaire Ebola species, which is native to the DRC; there have been seven previous Ebola outbreaks in the country since 1976. The virology results and epidemiological findings indicated no connection to the epidemic in Western Africa.[232][233] The WHO declared the outbreak over on 21 November 2014, after a total of 66 cases and 49 deaths.[234][235]

## Virology

[edit]

See also: Ebola virus disease § Virology, and Ebola virus

Ebola virus particles using electron micrograph

Of the four disease-causing viruses in the genus Ebolavirus, Ebola virus (or the Zaire Ebola virus) is dangerous and is the virus responsible for the epidemic in Western Africa.[236][237] Since the discovery of the viruses in 1976, Ebola virus disease has been confined to areas in Middle Africa, where it is native. The epidemic was initially thought to be caused by a new species native to Guinea, rather than being imported from Middle to Western Africa.[44] However, further studies have shown that the outbreak was likely caused by an Ebola virus lineage that spread from Middle Africa via an animal host within the last decade, with the first viral transfer to humans in Guinea.[236][238] and with 341 genetic changes in the virion.[236]

In a report released in August 2014, researchers tracked the spread of Ebola in Sierra Leone from the group first infected—13 women who had attended the funeral of the traditional healer, where they contracted the disease. This provided "the first time that the real evolution of the Ebola virus [could] be observed in humans." The research showed that the outbreak in Sierra Leone was sparked by at least two distinct lineages introduced from Guinea at about the same time. It is not clear whether the traditional healer was infected with both variants or if perhaps one of the women attending the funeral was independently infected. As the Sierra Leone epidemic progressed, one virus lineage disappeared from patient samples, while a third one appeared.[239][240][241][242]

In January 2015, the media stated researchers in Guinea had reported mutations in the virus samples that they were looking at. According to them, "We've now seen several cases that don't have any symptoms at all, asymptomatic cases. These people may be the people who can spread the virus better, but we still don't know that yet. A virus can change itself to [become] less deadly, but more contagious and that's something we are afraid of."[243] A 2015 study suggested that accelerating the rate of mutation of the Ebola virus could make the virus less capable of infecting humans. In this animal study, the virus became practically non-viable, consequently increasing survival.[244]

## Transmission

[edit]

See also: Ebola virus disease § Transmission

### Animal to human transmission

[edit]

The life cycles of the Ebolavirus

The initial infection is believed to occur after an Ebola virus is transmitted to a human by contact with an infected animal's body fluids. Evidence strongly implicates bats as the reservoir hosts.[245][246] Bats drop partially eaten fruit and pulp, and then land mammals feed on this fallen fruit. This chain of events forms a possible indirect means of transmission from the natural host to animal populations.[247] As primates in the area were not found to be infected and fruit bats do not live near the location of the initial zoonotic transmission event in Meliandou, Guinea, it is suspected that the index case occurred after a child had contact with an insectivorous bat from a colony near the village.[248]

The continent of Africa has experienced deforestation in several areas or regions; this may contribute to recent outbreaks, including this epidemic, as initial cases have been in the proximity of deforested lands where fruit-eating bats' natural habitat may be affected, though 100% of evidence does not as yet exist.[249][250]

### Human-to-human transmission

[edit]

Before this outbreak, it was believed that human-to-human transmission occurred only via direct contact with blood or bodily fluids from an infected person who is showing symptoms of infection, by contact with the body of a person who had died of Ebola, or by contact with objects recently contaminated with the body fluids of an actively ill infected person.[251][252] It is now known that the Ebola virus can be transmitted sexually. Studies have suggested that the virus can persist in seminal fluid, with a study released in September 2016 suggesting that the virus may survive more than 530 days after infection.[93] EBOV RNA in semen is not the same as perseverance of EBOV in semen, however the "clinical significance of low levels of virus RNA in convalescent" healthy individuals is unknown.[253][254]

In September 2014, the WHO reported: "No formal evidence exists of sexual transmission, but sexual transmission from convalescent patients cannot be ruled out. There is evidence that the live Ebola virus can be isolated in seminal fluids of convalescent men for 82 days after the onset of symptoms. Evidence is not available yet beyond 82 days."[255] In April 2015, following a report that the RNA virus had been detected in a semen sample six months after a man's recovery, the WHO issued a statement: "Ebola survivors should consider correct and consistent use of condoms for all sexual acts beyond three months until more information is available."[256][257]

The WHO based their new recommendations on a March 2015 case, in which a Liberian woman who had no contact with the disease other than having had unprotected sex with a man who had had the disease in October 2014, was diagnosed with Ebola.[258] On 14 September 2015, the body of a girl who had died in Sierra Leone tested positive for Ebola[116] and it was suspected that she may have contracted the disease from the semen of an Ebola survivor who was discharged in March 2015.[117] According to some news reports, a new study to be published in the New England Journal of Medicine indicated that the RNA virus could remain in the semen of survivors for up to six months,[259][260] and according to other researchers, the RNA virus could continue in semen for 82 days and maybe longer. Furthermore, Ebola RNA had been found up to 284 days post-onset of viral symptoms.[261]

## Containment and control

[edit]

Main article: Prevention of viral hemorrhagic fever

See also: Ebola virus disease § Prevention

Nigerian doctors training on PPE by WHO

In August 2014, the WHO published a road map of the steps required to bring the epidemic under control and to prevent further transmission of the disease within Western Africa; the coordinated international response worked towards realising this plan.[262]

### Surveillance and contact tracing

[edit]

Contact tracing is an essential method of preventing the spread of the disease. This requires effective community surveillance so that a possible case of Ebola can be registered and accurately diagnosed as soon as possible, and subsequently finding everyone who has had close contact with the case and tracking them for 21 days. However, this requires careful record-keeping by properly trained and equipped staff.[263][264] WHO Assistant Director-General for Global Health Security, Keiji Fukuda, said on 3 September 2014, "We don't have enough health workers, doctors, nurses, drivers, and contact tracers to handle the increasing number of cases."[265] There was a massive effort to train volunteers and health workers, sponsored by United States Agency for International Development (USAID).[266] According to WHO reports, 25,926 contacts from Guinea, 35,183 from Liberia and 104,454 from Sierra Leone were listed and traced as of 23 November 2014.[53]

Ebola control is hindered by the fact that current diagnostic tests require specialised equipment and highly trained personnel. Since there are few suitable testing centres in Western Africa, this delays diagnosis. As of February 2015[update] many rapid diagnostic tests were under trial.[267] In September 2015, a new chip-based testing method that can detect Ebola accurately was reported. This new device allows for the use of portable instruments that can provide immediate diagnosis.[268][269]

Difficulties in attempting to halt transmission have also included the multiple disease outbreaks across country borders.[270] Dr Peter Piot, the scientist who co-discovered the Ebola virus, stated that the outbreak was not following its usual linear patterns as mapped out in earlier outbreaks—this time the virus was "hopping" all over the Western African epidemic region.[63] Furthermore, most past epidemics had occurred in remote regions, but this outbreak spread to large urban areas, which had increased the number of contacts an infected person might have and made transmission harder to track and break.[271] On 9 December, a study indicated that a single individual introduced the virus into Liberia, causing the most cases of the disease in that country.[272]

### Community awareness

[edit]

See also: Cultural effects of the Ebola crisis

To reduce the spread, the WHO recommended raising community awareness of the risk factors for Ebola infection and the protective measures individuals can take.[273] These include avoiding contact with infected people and regular hand washing using soap and water.[274] A condition of extreme poverty exists in many of the areas that experienced a high incidence of infections. According to the director of the NGO Plan International in Guinea, "The poor living conditions and lack of water and sanitation in most districts of Conakry pose a serious risk that the epidemic escalates into a crisis. People do not think to wash their hands when they do not have enough water to drink."[275] One study showed that once people had heard of the Ebola virus disease, hand washing with soap and water improved, though socio-demographic factors influenced hygiene.[276] Several organisations enrolled local people to conduct public awareness campaigns among the communities in Western Africa.[277]

Denial in some affected countries also made containment efforts difficult.[278] Language barriers and the appearance of medical teams in protective suits sometimes increased fears of the virus.[279] In Liberia, a mob attacked an Ebola isolation centre, stealing equipment and "freeing" patients while shouting "There's no Ebola."[280] Red Cross staff were forced to suspend operations in southeast Guinea after they were threatened by a group of men armed with knives.[281] In September, in the town of Womey in Guinea, suspicious inhabitants wielding machetes murdered at least eight aid workers.[282]

An August 2014 study found that nearly two-thirds of Ebola cases in Guinea were believed to be due to burial practices including washing of the body of one who had died.[38][39][40][41][50][283] In November, WHO released a protocol for the safe and dignified burial of people who die from Ebola virus disease.[284] Speaking on 27 January 2015, Guinea's Grand Imam, the country's highest cleric, gave a very strong message saying, "There is nothing in the Koran that says you must wash, kiss or hold your dead loved ones," and he called on citizens to do more to stop the virus by practising safer burying rituals that do not compromise tradition.[285]

During the height of the epidemic, most schools in the three most affected countries were shut down and remained closed for several months. During the period of closure UNICEF and its partners established strict hygiene protocols to be used when the schools were reopened in January 2015. Their efforts included installing hand-washing stations and distributing millions of bars of soap and chlorine and plans for taking the temperature of children and staff at the school gate. Their efforts were complicated by the fact that less than 50% of the schools in these three countries had access to running water. In August 2015, UNICEF released a report that stated, "Across the three countries, there have been no reported cases of a student or teacher being infected at a school since strict hygiene protocols were introduced when classes resumed at the beginning of the year after a months-long delay caused by the virus."[286] Researchers presented evidence indicating that infected people that lived in low socioeconomic areas were more likely to transmit the virus to other socioeconomic status (SES) communities, in contrast to individuals in higher SES areas who were infected as well.[287] A study on Nigeria's success story stated that, in this case, a prompt response by the government and proactive public health measures had resulted in the quick control of the outbreak.[288]

During the height of the crisis, Wikipedia's Ebola page received 2.5 million page views per day, making Wikipedia one of the world's most highly used sources of medical information regarding the disease.[289][290]

### Travel restrictions and quarantines

[edit]

Quarantine travel pass for individuals providing assistance

There was serious concern that the disease would spread further within Western Africa or elsewhere in the world. On 8 August 2014, a cordon sanitaire, a disease-fighting practice that forcibly isolates affected regions, was established in the triangular area where Guinea, Liberia, and Sierra Leone are separated only by porous borders and where 70 percent of the known cases had been found.[291] This was subsequently replaced by a series of checkpoints for hand-washing and measuring body temperature on major roads throughout the region, manned either by local volunteers or by the military.[292][293]

Many countries considered imposing travel restrictions to or from the region. On 2 September 2014, WHO Director-General Margaret Chan advised against this, saying that they were not justified and that they would prevent medical experts from entering the affected areas. UN officials working on the ground also criticised the travel restrictions, saying the solution was "not in travel restrictions but in ensuring that effective preventive and curative health measures are put in place".[294] MSF also spoke out against the closure of international borders, calling them "another layer of collective irresponsibility".[295] In December 2015, the CDC indicated that it would no longer make the recommendation for US citizens going to Sierra Leone to be extra careful. However, the CDC did further indicate that individuals travelling to the country should take precautions with sick people and body fluids, and avoid contact with animals.[296] There was concern that people returning from affected countries, such as health workers and reporters, may have been incubating the disease and become infectious after arriving. Guidelines for returning workers were issued by a number of agencies, including the CDC,[297] MSF,[298] Public Health England,[299] and Public Health Ontario.[300]

### Protective clothing

[edit]

Examining equipment CDC staff preparing to enter ETU in Liberia

One of the primary reasons for the spread of the disease is the low-quality health systems in the parts of Africa where the disease occurs.[301] The risk of transmission is increased among those caring for people infected. Recommended measures when caring for those who are infected include medical isolation via the proper use of boots, gowns, gloves, masks, goggles, and sterilizing all equipment and surfaces.[302] One of the biggest dangers of infection faced by medical staff requires their learning how to properly suit up and remove personal protective equipment. Full training for wearing protective body clothing can take 10 to 14 days.[303]

The Ebola epidemic caused an increasing demand for protective clothing. A full set of protective clothing includes a suit, goggles, a mask, socks and boots, and an apron. Boots and aprons can be disinfected and reused, but everything else must be destroyed after use. Health workers change garments frequently, discarding gear that has barely been used. This not only takes a great deal of time but also exposes them to the virus because, for those wearing protective clothing, one of the most dangerous moments for contracting Ebola is while suits are being removed.[304] The protective clothing sets that MSF uses cost about $75 apiece. Staff who have returned from deployments to Western Africa say the clothing is so heavy that it can be worn for only about 40 minutes at a stretch. A physician working in Sierra Leone has said: "At that point, you have to exit for your safety ... Here it takes 20–25 minutes to take off a protective suit and must be done with two trained supervisors who watch every step militarily to ensure no mistakes are made because a slip-up can easily occur and of course can be fatal."[303][305] By October, there were reports that protective outfits were beginning to be in short supply and manufacturers began to increase their production.[306]

USAID published an open competitive bidding for proposals that address the challenge of developing "new practical and cost-effective solutions to improve infection treatment and control that can be rapidly deployed; 1) to help health care workers provide better care and 2) transform our ability to combat Ebola".[307][308][309] On 12 December 2014, USAID announced the result of the first selection in a press release.[310] On 17 December 2014, a team at Johns Hopkins University developed a prototype breakaway hazmat suit, and was awarded a grant from the USAID to develop it. The prototype has a small, battery-powered cooling pack on the worker's belt.[311]

The WHO recommends the use of two pairs of gloves, with the outer pair worn over the gown. Using two pairs may reduce the risk of sharp injuries; however, no evidence using more than the recommended will give additional protection. WHO also recommends the use of a coverall, which is generally appraised in terms of its resistance to non-enveloped DNA viruses.[312] According to guidelines released by the CDC in August 2015, updates were put in place to improve the PAPR doffing method to make the steps easier, and affirm the importance of cleaning the floor where doffing has been done. Additionally, a designated doffing assistant was recommended to help in this process.[313]

## Treatment and management

[edit]

See also: Ebola virus disease treatment research and Ebola vaccine

Practising taking blood in PPE

No proven Ebola virus-specific treatment presently exists;[314][315] however, measures can be taken to improve a patient's chances of survival.[316] Symptoms usually begin with a sudden influenza-like illness characterised by feeling tired, and pain in the muscles and joints. Later symptoms often include severe vomiting and diarrhoea.[317][318] In past outbreaks, it has been noted that some patients bleed internally and/or externally; however data published in October 2014 showed that this had been a rare symptom in the Western African outbreak.[319]

Without fluid replacement, such an extreme loss of fluids leads to dehydration, which in turn may lead to hypovolaemic shock—a condition in which there is not enough blood for the heart to pump through the body. If a patient is alert and is not vomiting, oral rehydration therapy may be instituted, but patients who are vomiting or are delirious must be hydrated with intravenous (IV) therapy.[314][320] However, administration of IV fluids is difficult in the African environment. Inserting an IV needle while wearing three pairs of gloves and goggles that may be fogged is difficult, and once in place, the IV site and line must be constantly monitored. Without sufficient staff to care for patients, needles may become dislodged or pulled out by a delirious patient. A patient's electrolytes must be closely monitored to determine correct fluid administration, for which many areas did not have access to the required laboratory services.[321]

Treatment centres were overflowing with patients while others waited to be admitted; dead patients were so numerous that it was difficult to arrange for safe burials. MSF took a conservative approach. While using IV treatment for as many patients as they could manage, they argued that improperly managed IV treatment was not helpful and may even kill a patient. They also said that they were concerned about further risk to already overworked staff.[321] In 2015 experts studied the mortality rates of different treatment settings, and given the wide differences in variables that affected outcomes, adequate information had not yet been gathered to make a definitive statement about what constituted optimal care in the Western African setting.[322] Paul Farmer of Partners in Health, an NGO that began to treat Ebola patients in January 2015, strongly supported IV therapy for all Ebola patients stating: "What if the fatality rate isn't the virulence of disease but the mediocrity of the medical delivery?" Farmer suggested that every treatment facility should have a team that specializes in inserting IVs, or better yet, peripherally inserted central catheter lines.[321] In 2020, viewing the information gathered from the pandemic Farmer noted that there were almost no deaths in the U.S. and European patients because they had received optimal care.[323]

### Post-Ebola virus syndrome

[edit]

See also: Post-Ebola virus syndrome

There are at least 17,000 people who have survived infection from the Ebola virus in Western Africa; some of them have reported lingering health effects.[324] In early November, a WHO consultant reported: "Many of the survivors are discharged with the so-called Post-Ebola Syndrome. We want to ascertain whether these medical conditions are due to the disease itself, the treatment given or chlorine used during disinfection of the patients. This is a new area for research; little is known about the post-Ebola symptoms."[325][326] In August 2015, the WHO held a meeting to work out a "Comprehensive care plan for Ebola survivors" and identify research needed to optimise clinical care and social well-being. Stating that "the Ebola outbreak has decimated families, health systems, economies, and social structures", the WHO called the aftermath of the epidemic "an emergency within an emergency."[327][328] On 22 January, the WHO issued Clinical Care for Survivors of Ebola Virus Disease: Interim Guidance. The guidance covers specific issues like musculoskeletal pain, which is reported in up to 75% of survivors. The pain is symmetrical and more pronounced in the morning, with the larger joints most affected. There is also possible periarticular tenosynovitis affecting the shoulders. The WHO guidelines advise to distinguish non-inflammatory arthralgia from inflammatory arthritis. Concerning ocular problems, sensitivity to light and blurry vision have been indicated among survivors. Among the aftereffects of Ebola virus disease, uveitis and optic nerve disease could appear after an individual is discharged. Ocular problems could threaten sight in survivors, thus the need for prompt treatment. In treating such individuals, the WHO recommends urgent intervention if uveitis is suspected. Hearing loss has been reported in Ebola survivors 25% of the time.[329]

In February 2015, a Sierra Leone physician said about half of the recovered patients she saw reported declining health and that she had seen survivors go blind.[330][331] In May 2015, a senior consultant to the WHO said that the reports of eye problems were especially worrying because "there are hardly any ophthalmologists in Western Africa, and only they have the skills and equipment to diagnose conditions like uveitis that affect the inner chambers of the eye."[332]

### Level of care

[edit]

WHO workers gear up to go to Ebola ward Nigeria, 2014

As the outbreak progressed, the media reports, many hospitals, short on both staff and supplies, were overwhelmed and closed down, leading some health experts to state that the inability to treat other medical needs may have been causing "an additional death toll [that is] likely to exceed that of the outbreak itself".[333][334] There were also reports that adequate personal protection equipment was not being provided for medical personnel.[335] The Director-General of MSF said: "Countries affected to date simply do not have the capacity to manage an outbreak of this size and complexity on their own. I urge the international community to provide this support on the most urgent basis possible."[270]

Hospital workers, who worked closely with the highly contagious body fluids of the victims, were especially vulnerable to contracting the virus; in August 2014, the WHO reported that ten percent of the dead had been healthcare workers.[336] In late August, MSF called the situation "chaotic" and the medical response "inadequate." They reported that they had expanded their operations, but couldn't keep up with the rapidly increasing need for assistance, which had forced them to reduce the level of care: "It is not currently possible, for example, to administer intravenous treatments." Calling the situation "an emergency within the emergency", MSF reported that many hospitals had shut down due to a lack of staff or fears of the virus among patients and staff, which had left people with other health problems without any care at all. Speaking from a remote region, an MSF worker said that a shortage of protective equipment was making the medical management of the disease difficult and that they had limited capacity to safely bury bodies.[337] In September 2014, it was estimated that the affected countries' capacity for treating Ebola patients was insufficient by the equivalent of 2,122 beds.[338] Speaking on 12 September, WHO Director-General, Margaret Chan, said: "In the three hardest hit countries, Guinea, Liberia and Sierra Leone, the number of new cases is moving far faster than the capacity to manage them in the Ebola-specific treatment centres. Today, there is not one single bed available for the treatment of an Ebola patient in the entire country of Liberia."[339] According to a WHO report released on 19 September, Sierra Leone was meeting only 35% of its need for patient beds, while for Liberia it was just 20%.[340]

By December 2014 there were enough beds to treat and isolate all reported cases, although the uneven distribution of cases was resulting in serious shortfalls in some areas.[338] Similarly, all affected countries had sufficient and widespread capacity to bury reported deaths; however, because not all deaths were reported, it was possible that the reverse could have been the case in some areas. WHO also reported that every district had access to a laboratory to confirm cases of Ebola within 24 hours of sample collection and that all three countries had reported that more than 80% of registered contacts associated with known cases of Ebola virus disease were being traced, although contact tracing was still a challenge in areas of intense transmission and those with community resistance.[338] It has been suggested that the loss of human life was not limited to Ebola victims alone. Many hospitals had to shut down, leaving people with other medical needs without care. A spokesperson for the UK-based health foundation, the Wellcome Trust, said in October 2014 that "the additional death toll from malaria and other diseases [is] likely to exceed that of the outbreak itself".[333] Dr Paul Farmer stated: "Most of Ebola's victims may well be dying from other causes: women in childbirth, children from diarrhoea, people in road accidents or from trauma of other sorts."[334] As the epidemic drew to a close in 2015, a report from Sierra Leone showed that the fear and mistrust of hospitals generated by the epidemic had resulted in an 11% decline in facility-based births and that those receiving care before or after birth fell by about a fifth. Consequently, between May 2014 and April 2015, the deaths of women during or just after childbirth rose by almost a third and those of newborns by a quarter, compared to the previous year.[341]

### Healthcare settings

[edit]

Ebola treatment centre built by the UK in Kerry Town, Sierra Leone, in 2014

Several Ebola treatment centres were set up in the area, supported by international aid organisations and staffed by a combination of local and international staff. An important part of each centre is an arrangement for the safe burial or cremation of bodies, required to prevent further infection.[342][343] In January 2015, a new treatment and research centre was built by Rusal and Russia in the city of Kindia in Guinea. It is one of the most modern medical centres in Guinea.[344][345] Also in January, MSF admitted its first patients to a new treatment centre in Kissy, an Ebola hotspot on the outskirts of Freetown, Sierra Leone. The centre has a maternity unit for pregnant women with the virus.[346][347]

Although the WHO does not advise caring for Ebola patients at home, in some cases it became a necessity when no hospital treatment beds were available. For those being treated at home, the WHO advised informing the local public health authority and acquiring appropriate training and equipment.[348][349] UNICEF, USAID and Samaritan's Purse began to take measures to provide support for families that were forced to care for patients at home by supplying caregiver kits intended for interim home-based interventions. The kits included protective clothing, hydration items, medicines, and disinfectant, among other items.[350][351] Even where hospital beds were available, it was debated whether conventional hospitals are the best place to care for Ebola patients, as the risk of spreading the infection is high.[352] In October, the WHO and non-profit partners launched a program in Liberia to move infected people out of their homes into ad hoc centres that could provide rudimentary care.[353] Health facilities with low-quality systems for preventing infection were involved as sites of amplification during viral outbreaks.[354]

In the hardest hit areas there have historically been only one or two doctors available to treat 100,000 people and these doctors are heavily concentrated in urban areas.[271] Ebola patients' healthcare providers, as well as family and friends, are at highest risk of getting infected because they are more likely to come in direct contact with their blood or body fluids. In some places affected by the outbreak, care may have been provided in clinics with limited resources, and workers could be in these areas for several hours with many Ebola-infected patients.[355] According to the WHO, the high proportion of infected medical staff could be explained by a lack of adequate manpower to manage such a large outbreak, shortages of protective equipment or improper use of what was available, and "the compassion that causes medical staff to work in isolation wards far beyond the number of hours recommended as safe".[271] In August 2014, healthcare workers represented nearly 10 percent of cases and fatalities—significantly impairing the capacity to respond to an outbreak in an area already facing severe shortages.[356] By 1 July 2015, the WHO reported that a total of 874 health workers had been infected, of which 509 had died.[357]

Basing their choice on "the person or persons who most affected the news and our lives, for good or ill, and embodied what was important about the year", the editors of Time magazine in December 2014 named the Ebola health workers as Person of the Year. Editor Nancy Gibbs said: "The rest of the world can sleep at night because a group of men and women are willing to stand and fight. For tireless acts of courage and mercy, for buying the world time to boost its defences, for risking, for persisting, for sacrificing and saving, the Ebola fighters are Time's 2014 Person of the Year."[358] According to an October 2015 report by the CDC, Guinean healthcare workers had 42.2 times higher Ebola infection rates than non-healthcare workers, and male healthcare workers were more affected than their female counterparts. The report indicated that 27% of Ebola infections among healthcare workers in Guinea occurred among doctors. The CDC further indicated that healthcare workers in Guinea were less likely to report contact with an infected individual than non-healthcare workers.[359]

### Experimental treatments

[edit]

Researcher working on Ebola virus

Further information: Ebola virus disease treatment research

There is no confirmed medication or treatment for Ebola virus disease.[360][361] A number of experimental treatments are undergoing clinical trials.[362][363][364] During the epidemic some patients received experimental blood transfusions from Ebola survivors, but a later study found that the treatment did not provide significant benefit.[365]

## Vaccines

[edit]

Further information: Ebola vaccine

Several Ebola vaccine candidates had been developed in the decade before 2014 and had been shown to protect nonhuman primates against infection, but none had yet been approved for clinical use in humans.[366][367][368][369] About 15 different vaccines were in preclinical stages of development,[370] and there were two phase III studies being conducted with two different vaccines.[370]

In July 2015, researchers announced that a vaccine trial in Guinea had been completed that appeared to give protection from the virus. The vaccine, rVSV-ZEBOV,[371] had shown high efficacy in individuals, but more conclusive evidence was needed regarding its capacity to protect populations through herd immunity. The vaccine trial employed ring vaccination, in which health workers control an outbreak by vaccinating all suspected infected individuals within the surrounding area.[372][373][374][375] In December 2016, the results of the two-year Guinea trial were published announcing that rVSV-ZEBOV had been found to protect people who had been exposed to cases of Ebola.[31] In addition to showing high efficacy among those vaccinated, the trial also showed that unvaccinated people were indirectly protected from the Ebola virus through herd immunity. The vaccine has not yet had regulatory approval, but it is considered to be so effective that 300,000 doses have already been stockpiled. Not yet known is the length of time that a vaccination will be effective and whether it will prove effective for the Sudan virus.[32][376] In April 2018 rVSV-ZEBOV Ebola vaccine was used to stop an outbreak for the first time, the 2018 Équateur province Democratic Republic of the Congo Ebola virus outbreak.[377] rVSV-ZEBOV received regulatory approval in 2019.[33][34]

## Outlook

[edit]

From the beginning of the outbreak, there existed considerable difficulty in getting reliable estimates—both of the number of people affected and of its geographical extent.[378] The three most affected countries—Guinea, Liberia and Sierra Leone—are among the poorest in the world, with extremely low levels of literacy, few hospitals or doctors, low-quality physical infrastructure, and weakly functioning government institutions.[379] One study yielded results of the spatio-temporal evolution of the viral outbreak. With the use of heat maps, it was determined that the outbreak did not uniformly unfold over the affected community areas, indicating that monitoring the outbreak at the district level was important. The study showed that accurate predictions of growth were improbable.[380]

Calculating the case fatality rate (CFR) accurately is difficult in an ongoing epidemic due to differences in testing policies, the inclusion of probable and suspected cases, and the inclusion of new cases that have not run their course. Ebola virus disease has a high CFR, which in past outbreaks varied between 25% and 90%, with an average of about 50%.[381] In August 2014, the WHO made an initial CFR estimate of 53%, though this included suspected cases.[382][383] In September and December 2014, the WHO released revised and more accurate CFR figures of 70.8% and 71% respectively, using data from patients with definitive clinical outcomes.[12][20][18] The CFR among hospitalised patients, based on the three intense-transmission countries, was between 57% and 59% in January 2015.[384] Care settings that have access to medical expertise may increase survival by providing good maintenance of hydration, circulatory volume, and blood pressure.[319] The disease affects males and females equally and the majority of those who contract Ebola disease are between 15 and 45 years of age.[12] For those over 45 years, a fatal outcome was more likely in the Western African epidemic, as was also noted in preceding outbreaks.[319] Only rarely do pregnant women survive—a midwife who worked with MSF in a Sierra Leone treatment centre stated that she knew of "no reported cases of pregnant mothers and unborn babies surviving Ebola in Sierra Leone."[385]

The basic reproduction number, R0, is a statistical measure of the average number of people infected by a single infectious individual in a population with no prior immunity. If the basic reproduction number is less than 1, the epidemic will die out; if it is greater than 1, the epidemic will continue to spread—with exponential growth in the number of cases.[386] In September 2014, the estimated values of R0 were 1.71 (95% CI, 1.44 to 2.01) for Guinea, 1.83 (95% CI, 1.72 to 1.94) for Liberia, and 2.02 (95% CI, 1.79 to 2.26) for Sierra Leone.[12][387][388]

In October 2014, the WHO noted that exponential increase of cases continued in the three countries with the most intense transmission.[389]

### Projections of future cases

[edit]

On 28 August 2014, the WHO released its first estimate of the possible total cases from the outbreak as part of its roadmap for stopping the transmission of the virus. It stated:

> This Roadmap assumes that in many areas of intense transmission, the actual number of cases may be two- to fourfold higher than that currently reported. It acknowledges that the aggregate caseload of Ebola could exceed 20,000 over the course of this emergency. The Roadmap assumes that a rapid escalation of the complementary strategies in intense transmission, resource-constrained areas will allow the comprehensive application of more standard containment strategies within three months.

The report included an assumption that some country or countries would pay the required cost of their plan, estimated at half a billion US dollars.[262]

When the WHO released these estimates, a number of epidemiologists presented data to show that the WHO projection of a total of 20,000 cases was likely an underestimate.[390][391] On 9 September, Jonas Schmidt-Chanasit of the Bernhard Nocht Institute for Tropical Medicine in Germany, controversially announced that the containment fight in Sierra Leone and Liberia had already been "lost" and that the disease would "burn itself out".[392] On 23 September 2014, the WHO revised their previous projection, stating that they expected the number of Ebola cases in Western Africa to be in excess of 20,000 by 2 November 2014.[12] They further stated, that if the disease was not adequately contained it could become native in Guinea, Sierra Leone and Liberia, "spreading as routinely as malaria or the flu",[393] and according to an editorial in the New England Journal of Medicine, eventually to other parts of Africa and beyond.[394]

In a report released on 23 September 2014, the CDC analysed the impact of under-reporting, which required the correction of case numbers by a factor of up to 2.5. With this correction factor, approximately 21,000 total cases were estimated for the end of September 2014 in Liberia and Sierra Leone alone. The same report predicted that total cases, including unreported cases, could reach 1.4 million in Liberia and Sierra Leone by the end of January 2015 if no improvement in intervention or community behaviour occurred.[23] However, at a congressional hearing on 19 November, the Director of the CDC said that the number of Ebola cases was no longer expected to exceed 1 million, moving away from the worst-case scenario that had been previously predicted.[395]

A study published in December 2014 found that transmission of the Ebola virus occurs principally within families, in hospitals, and at funerals. The data, gathered during three weeks of contact tracing in August, showed that the third person in any transmission chain often knew both the first and second person. The authors estimated that between 17% and 70% of cases in Western Africa were unreported—far fewer than had been estimated in prior projections. The study concluded that the epidemic would not be as difficult to control as feared if rapid, vigorous contact tracing and quarantines were employed.[396]

Projections of future cases should also reflect the possibility that deforestation might have a hand in terms of the more recent Ebola outbreaks. It has been suggested that due to the clearing of forests for commercial use, bats may be taken out of their natural habitat and therefore into closer and potential contact with civilisation.[250][249]

## Economic effects

[edit]

United Nations Development Group

In March 2015, the United Nations Development Group reported that due to a decrease in trade, the closing of borders, flight cancellations, and a drop in foreign investment and tourism activity fuelled by stigma, the epidemic had resulted in vast economic consequences in both the affected areas in Western Africa and other African nations with no cases of Ebola.[397] A September 2014 report in the Financial Times suggested that the economic impact of the Ebola outbreak could kill more people than the disease itself.[398]

Concerning Ebola and economic activity in the country of Liberia, a study found that 8% of automotive firms, 8% of construction firms, 15% of food businesses, and 30% of restaurants had closed due to the Ebola outbreak. Montserrado County experienced up to 20% firm closure. This indicated a decline in the Liberian national economy during the outbreak, as well as an indication that the county of Montserrado was hardest hit economically. The capital city Monrovia suffered the most construction and restaurant unemployment, while outside the capital, the food and beverage sectors suffered economically. The World Bank had projected an estimated loss of $1.6 billion in productivity for all three affected Western African countries combined for 2015. In Liberian counties that were less affected by the outbreak, the number of individuals employed fell by 24%. Montserrado saw a 47% decline in employment per firm from before the Ebola outbreak.[399]

Another study showed that the economic effect of the Ebola outbreak would be felt for years due to preexisting social vulnerability. The economic effects were being felt nationwide in Liberia, such as the termination of expansions in the mining business. Initial scenarios had placed expected economic losses at $25 billion; however subsequent World Bank estimates were much lower, at about 12% of the combined GDP of the three worst hit countries.[400] Despite the end of civil violence in 2003 and inflows from international donors, the reconstruction of Liberia had been very slow and non-productive—water delivery systems, sanitation facilities, and centralised electricity were practically non-existent, even in Monrovia. Even before the outbreak, medical facilities did not have potable water, lighting, or refrigeration. The authors indicated that lack of food and other economic effects would probably continue in the rural population long after the Ebola outbreak had ended.[400]

Other economic impacts were as follows:

* Many airlines suspended flights to the area.[401]

* Markets and shops closed due to travel restrictions, a cordon sanitaire, or fear of human contact, which led to loss of income for producers and traders.[402]

* Movement of people away from affected areas disturbed agricultural activities.[403][404] The FAO warned that the outbreak could endanger harvests and food security in Western Africa,[405] and that with all the quarantines and movement limitations placed on them, more than 1 million people could be food insecure by March 2015.[406] By 29 July, the World Bank had given 10,500 tons of maize and rice seed to the 3 hardest-hit countries to help them to rebuild their agricultural systems.[407]
* Tourism was directly impacted in the affected countries.[408] In April 2014, Nigeria reported that 75% of hotel business had been lost due to fears of the outbreak;[409] the limited Ebola outbreak had cost that country ₦8 billion.[410] Other African countries that were not directly affected by the virus also reported adverse effects on tourism,[411][412][413] including Gambia,[414][415] Ghana,[416] Kenya,[417] Zimbabwe,[418] Senegal, Zambia, and Tanzania.[419]
* Some foreign mining companies withdrew all non-essential personnel, deferred new investment, and cut back operations.[404][420][421]

In January 2015, Oxfam, a UK-based disaster relief organisation, indicated that a "Marshall Plan" (a reference to the massive plan to rebuild Europe after World War II) was needed so that countries could begin to financially assist those that had been worst hit by the virus.[422] The call was repeated in April 2015 when the most-affected Western African countries asked for an $8 billion "Marshall Plan" to rebuild their economies. Speaking at the World Bank and the International Monetary Fund (IMF), Liberian president Ellen Johnson Sirleaf said the amount was needed because "[o]ur health systems collapsed, investors left our countries, revenues declined and spending increased."[423] The IMF has been criticised for its lack of assistance in the efforts to combat the epidemic. In December 2014, a Cambridge University study linked IMF policies with the financial difficulties that prevented a strong Ebola response in the three most heavily affected countries,[424] and they were urged by both the UN and NGOs who had worked in the affected countries to grant debt relief rather than low-interest loans. According to one advocacy group, "yet the IMF, which has made a $9 billion surplus from its lending over the last three years, is considering offering loans, not debt relief and grants, in response".[425][426] On 30 January 2015, the IMF reported it was close to reaching a deal on debt forgiveness.[427] On 22 December, it was reported that the IMF had given Liberia an additional $10 million due to the economic impact of the Ebola virus outbreak.[428]

In October 2014, a World Bank report estimated overall economic impacts of between $3.8 billion and $32.6 billion, depending on the extent of the outbreak and speed of containment. It expected the most severe losses in the three affected countries, with a wider impact across the broader Western African region.[429][430] On 13 April 2015, the World Bank said that they would soon announce a major new effort to rebuild the economies of the three hardest-hit countries.[431] On 23 July, a World Bank poll warned that "we are not ready for another Ebola outbreak".[432] On 15 December, the World Bank indicated that by 1 December 2015, it had marshalled $1.62 billion in financing for the Ebola outbreak response.[433]

On 6 July 2015, UN Secretary-General Ban Ki-moon announced that he would host an Ebola recovery conference to raise funds for reconstruction, stating that the three countries hardest hit by Ebola needed about $700 million to rebuild their health services over a two-year period.[434] On 10 July, it was announced that the countries most affected by the Ebola epidemic would receive $3.4 billion to rebuild their economies.[435][436] On 29 September, the leaders of both Sierra Leone and Liberia indicated at the UN General Assembly the launch of a "Post-Ebola Economic Stabilization and Recovery Plan".[437] On 24 November, it was reported that due to the decrease in commodity prices and the Western African Ebola epidemic, China's investment in the continent had declined 43% in the first 6 months of 2015.[438] On 25 January, the IMF projected a GDP growth of 0.3% for Liberia, that country indicating it would cut spending by 11 per cent due to a stagnation in the mining sector, which would cause a domestic revenues drop of $57 million.[439]

## Responses

[edit]

Further information: Responses to the Ebola virus epidemic in West Africa

In July 2014, the WHO convened an emergency meeting of health ministers from eleven countries and announced collaboration on a strategy to coordinate technical support to combat the epidemic. In August they published a road map to guide and coordinate the international response to the outbreak, aiming to stop ongoing Ebola transmission worldwide within 6–9 months, and formally designated the outbreak as a Public Health Emergency of International Concern.[440] This is a legal designation used only twice before (for the 2009 H1N1 (swine flu) pandemic and the 2014 resurgence of poliomyelitis) that invokes legal measures on disease prevention, surveillance, control, and response, by 194 signatory countries.[441][442]

In September 2014, the United Nations Security Council declared the Ebola virus outbreak in Western Africa "a threat to international peace and security" and unanimously adopted a resolution urging UN member states to provide more resources to fight the outbreak.[443][444] In October, WHO and the UN Mission for Ebola Emergency Response announced a comprehensive 90-day plan to control and reverse the Ebola epidemic. The ultimate goal was to have capacity in place for the isolation of 100% of Ebola cases and the safe burial of 100% of casualties by 1 January 2015 (the 90-day target).[445] Many nations and charitable organisations cooperated to realise the plan,[446] and a WHO situation report published mid-December indicated that the international community was on track to meet the 90-day target.[447]

On 5 November 2014, Australian Prime Minister Tony Abbott announced that Australian health services company Aspen Medical would be staffing a 100-bed hospital in Sierra Leone after an agreement was reached with the United Kingdom to treat any infected Australian workers.[448]

From 2014 to 2015, China's People's Liberation Army deployed 524 medical staff on a rotational basis to combat the outbreak in Liberia, Sierra Leone, Guinea, and Guinea-Bissau.[449]: 245

In May 2015, Dr. Margaret Chan indicated, "demands on WHO was more than ten times greater than ever experienced in the almost 70-year history of this Organization"[450][451] and on 23 March, she stated that "the world remains woefully ill-prepared to respond to outbreaks that are both severe and sustained."[452]

### Criticism of WHO

[edit]

WHO flag

The WHO has been widely criticised for its delay in taking action to address the epidemic.[453] By September 2014, Médecins Sans Frontières/Doctors Without Borders (MSF), the non-governmental organisation with the largest working presence in the affected countries, had grown increasingly critical of the international response. Speaking on 3 September, the International President of MSF spoke out concerning the lack of assistance from United Nations (UN) member countries: "Six months into the worst Ebola epidemic in history, the world is losing the battle to contain it."[295]

In a 26 September statement, the WHO stated that "[t]he Ebola epidemic ravaging parts of Western Africa is the most severe acute public health emergency seen in modern times" and its Director-General called the outbreak "the largest, most complex and most severe we've ever seen".[454] In October 2014, the Associated Press reported in an internal draft document that the WHO admitted "nearly everyone" involved in the Ebola response failed to notice factors that turned the outbreak into the largest on record, and that they had missed chances to stop the spread of Ebola due to "incompetent staff, bureaucracy and a lack of reliable information".[455] Peter Piot, co-discoverer of the Ebola virus, called the WHO regional office in Africa "really not competent."[456] In April 2015, the WHO admitted very serious failings in handling the crisis and indicated reforms for any future crises; "we did not work effectively in coordination with other partners, there were shortcomings in risk communications and there was confusion of roles and responsibilities".[457] The Ebola crisis was discussed at the June 2015 G7 meeting. The leaders pledged to assist in carrying out WHO regulations. Critics criticised the G7 leaders, saying they were not committed enough in the fight against the possibility of future pandemics.[458][459] In 2015 a panel of experts looked at the ways of preventing small outbreaks from becoming large epidemics. According to the panel, the epidemic had exposed problems in the national (and international) institutions responsible for protecting the public from the human consequences of infectious disease outbreaks such as the Ebola epidemic. The panel was highly critical of the WHO's management of the Ebola crisis noting that it took them months to respond and when they did they were slow to act, poorly co-ordinated and inadequately informed. The report pointed out that the committee responsible for checking the WHO's actions during the outbreak (i.e. the WHO Ebola Interim Assessment Panel) had delayed responses due to worries about political resistance from the Western African leaders, economic consequences, and a system within the WHO that discouraged open debate about issues such as emergency declarations. The WHO may also have hesitated because it was criticised for creating panic by declaring a public health emergency during the relatively mild 2009 H1N1 pandemic. This, the report states, showed the risks of having such consequential decision-making power in one individual—a risk made worse when there was no mechanism of responsibility for such leadership failure.[460][461][462]

The panel outlined 10 recommendations for the prevention and handling of future infectious disease outbreaks. Included in the recommendations of the changes needed to fight future outbreaks is the creation of a U.N. Security Council health committee to expedite political attention to health issues and the establishment of a global fund to finance and accelerate the development of outbreak-relevant drugs and treatment. The report also noted that competent governance of the global system demanded political leadership and a WHO that is more focused and appropriately financed and whose integrity is restored through the application of adequate reforms and leadership.[460]

The WHO also came under fire for refusing to send Dr. Olivet Buck to Germany for experimental treatment after she contracted Ebola per the government of Sierra Leone's request. WHO claimed they could only evacuate medical professionals they had deployed to the region, not locals; Dr. Olivet Buck was the Medical Superintendent at Lumley Government Hospital in Freetown, Sierra Leone.[463]

## Timeline of reported cases and deaths

[edit]

Main article: West African Ebola virus epidemic timeline of reported cases and deaths

See also: Ebola virus epidemic in West Africa timeline

Major Ebola virus outbreaks by country and by date – to most recent WHO / Gov update- 14 January 2016
Date | Total | Guinea | Liberia | Sierra Leone | Sources

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Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths
14 January 2016 | 28,542 | 11,299 | 3,806 | 2,535 | 10,675 | 4,809 | 14,061 | 3,955 | [note 2][464]
23 December 2015 | 28,542 | 11,299 | 3,806 | 2,535 | 10,676 | 4,809 | 14,061 | 3,955 | [465]
9 December 2015 | 28,542 | 11,299 | 3,806 | 2,535 | 10,675 | 4,809 | 14,061 | 3,955 | [466]
25 November 2015 | 28,539 | 11,298 | 3,806 | 2,535 | 10,672 | 4,808 | 14,061 | 3,955 | [467]
11 November 2015 | 28,539 | 11,298 | 3,806 | 2,535 | 10,672 | 4,808 | 14,061 | 3,955 | [468]
25 October 2015 | 28,539 | 11,298 | 3,800 | 2,534 | 10,672 | 4,808 | 14,061 | 3,955 | [469]
11 October 2015 | 28,454 | 11,297 | 3,800 | 2,534 | 10,672 | 4,808 | 13,982 | 3,955 | [470]
Note 1: Cases include confirmed, probable, and suspected per the WHO, numbers are the cumulative figures as published on the given date, and due to retrospective revisions, differences between successive weekly totals are not necessarily the number of new cases that week.

Note 2: Data are from reports by the WHO Global Alert and Response Unit[Resource 1] and the WHO's Regional Office for Africa.[Resource 2] All numbers are correlated with UN Office for the Coordination of Humanitarian Affairs (OCHA), if available.[Resource 3] The reports were sourced from official information from the affected countries' health ministries. The WHO has stated that the reported numbers "vastly underestimate the magnitude of the outbreak", estimating there may be three times as many cases as officially reported.[23][471][472]
Note 3: Date is the "as of" date from the reference. A single source may report statistics for multiple "as of" dates.

Minor Ebola virus outbreaks by country and by date – 30 July 2014 to most recent WHO / Gov update 30 August 2015  Date | Aggregate total | Nigeria | Senegal | United States | Spain | Mali | United Kingdom | Italy | Refs

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Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths | Cases | Deaths
30 August 2015 | 36 | 15 | 20 | 8 | 1 | 0 | 4 | 1 | 1 | 0 | 8 | 6 | 1 | 0 | 1 | 0 | [note 3][473]
29 December 2014 | 35 | 15 | 20 | 8 | 1 | 0 | 4 | 1 | 1 | 0 | 8 | 6 | 1 | 0 | – | – | [note 4][18]
14 December 2014 | 32 | 15 | 20 | 8 | 1 | 0 | 4 | 1 | 1 | 0 | 6 | 6 | – | – | – | – | [102]
2 November 2014 | 27 | 10 | 20 | 8 | 1 | 0 | 4 | 1 | 1 | 0 | 1 | 1 | – | – | – | – | [474]
12 October 2014 | 23 | 8 | 20 | 8 | 1 | 0 | 1 | 0 | 1 | 0 | - | – | – | – | – | – | [445]
28 September 2014 | 22 | 8 | 20 | 8 | 1 | 0 | 1 | 0 | - | – | - | – | – | – | – | – | [475]
30 July 2014 | 3 | 1 | 3 | 1 | – | – | – | – | – | – | – | – | – | – | – | – | [476]
Note 1:This table contains countries that had limited local cases.[477]
Note 2:Date is the "as of" date from the reference. A single source may report statistics for multiple "as of" dates.

## Notable patients

[edit]

* Patrick Sawyer—index case for Nigeria; died on 24 July 2014.[478]
* Sheik Umar Khan—Sierra Leonean doctor, died on 29 July 2014.[479]
* Ameyo Adadevoh—curbed spread of the virus in Nigeria; died on 19 August 2014.[480]
* Thomas Eric Duncan—first Ebola patient diagnosed in U.S.; died on 8 October 2014.[481]
* Salome Karwah—survived Ebola in 2014 and became a nurse; named co-Person of the Year by Time magazine.[482]
* Ian Crozier—contracted the disease in September 2014, and was treated at Emory University from 9 September to 19 October of that year.[483]
* Pauline Cafferkey—A British nurse and aid worker, infected in 2014, recovered but was subsequently readmitted to the hospital several times.[484]

* Samuel Brisbane—a former adviser to the Liberian Ministry of Health and Social Welfare, described as "one of Liberia's most high-profile doctors".[485]

* Mbalu Fonnie—a licensed nurse-midwife and nursing supervisor at the Kenema hospital in Sierra Leone who died after contracting Ebola while caring for a fellow nurse who was pregnant and had the disease.[486]

## See also

[edit]

* Viruses portal

* Health crisis

## Notes

[edit]

1. ^ The mortality (number of dead per number of healthy per time frame) recorded in Liberia up to 26 August 2014 was 70%.[20] However, due to the estimation method used, the estimated case fatality rate (70.8%) for this particular epidemic differs from the actual ratio between the number of deaths and the number of cases.
2. ^ 25 Oct: All governments as per WHO.
3. ^ No change in Data from 13 May till 30 Aug
4. ^ 29 December: All governments as per WHO. United Kingdom case dated 29 December.

## References

[edit]

This article was submitted to WikiJournal of Medicine for external academic peer review in 2018 (reviewer reports). The updated content was reintegrated into the Wikipedia page under a CC-BY-SA-3.0 license (2019). The version of record as reviewed is: Osmin Anis; et al. (11 May 2019). "Western African Ebola virus epidemic". WikiJournal of Medicine. 6 (1): 1. doi:10.15347/WJM/2019.001. ISSN 2002-4436. Wikidata Q63740114.

1. ^ "WHO Director-General addresses the Executive Board". Archived from the original on 26 January 2016. Retrieved 9 June 2016.
2. ^ a b Brice, Makini (9 June 2016). "WHO declares Liberia free of active Ebola virus transmission". Thomson Reuters Foundation. Retrieved 16 October 2016.
3. ^ "Ebola Situation Report – 16 March 2016 | Ebola". World Health Organization. Archived from the original on 18 March 2016. Retrieved 28 October 2016.
4. ^ "End of Ebola transmission in Guinea". WHO Regional Office for Africa. 2015. Archived from the original on 2 June 2016. Retrieved 9 June 2016.
5. ^ a b c d Ebola Response Roadmap Situation Report (PDF) (Report). WHO. 22 October 2014. Retrieved 22 October 2014.
6. ^ "Ebola situation report" (PDF). World Health Organization. 21 January 2015. Retrieved 22 January 2015.
7. ^ "Ebola response roadmap – Situation report 24 December 2014". World Health Organization. 26 December 2014. Archived from the original on 30 December 2014. Retrieved 29 December 2014.
8. ^ "Ebola situation report". World Health Organization. 22 July 2015. Archived from the original on 26 July 2015.
9. ^ a b United Kingdom is declared free of Ebola virus disease (Report). WHO Europe. Retrieved 11 March 2015.
10. ^ "Situation summary". World Health Organization. 5 December 2014. Retrieved 6 December 2014.
11. ^ Donald G. McNeil Jr. (16 December 2015). "Fewer Ebola cases go unreported than thought, study finds". The New York Times. Retrieved 23 July 2015.
12. ^ a b c d e f WHO Ebola Response Team (23 September 2014). "Ebola virus disease in West Africa – the first 9 months of the epidemic and forward projections". The New England Journal of Medicine. 371 (16): 1481–1495. doi:10.1056/NEJMoa1411100. PMC 4235004. PMID 25244186. "... we estimate that the case fatality rate is 70.8% (95% confidence interval [CI], 69 to 73) among persons with known clinical outcome of infection."
13. ^ a b "End of Ebola transmission in Guinea" (Press release). World Health Organization, Africa. 1 June 2016. Retrieved 13 August 2024.
14. ^ Penney, Joe; Diallo, Tiemoko (12 November 2014). "UPDATE 1--Mali confirms new case of Ebola, locks down Bamako clinic". Reuters. Writing and additional reporting by David Lewis; editing by Grant McCool and G Crosse. Archived from the original on 5 March 2016. Retrieved 15 November 2014.
15. ^ "Una enfermera que atendió al misionero fallecido García Viejo, contagiada de ébola" [A nursing assistant who attended to the deceased missionary García Viejo, infected with Ebola]. El Mundo (in Spanish). 6 October 2014. Retrieved 13 August 2024.
16. ^ Ebola outbreak situation report (PDF) (Report). WHO. 8 October 2014. Retrieved 15 October 2014.
17. ^ Ebola response roadmap situation report update (PDF) (Report). WHO. 7 November 2014. Retrieved 7 November 2014.
18. ^ a b c d Ebola response roadmap situation report (PDF) (Report). WHO. 31 December 2014. Archived from the original (PDF) on 31 December 2014. Retrieved 1 January 2015. "The reported case fatality rate in the three intense-transmission countries among all cases for whom a definitive outcome is known is 71%."
19. ^ "Ebola virus disease – Italy". WHO. Archived from the original on 16 May 2015. Retrieved 28 October 2016.
20. ^ a b c "Case Fatality Rate for ebolavirus". University of Edinburgh. 2015. Archived from the original on 29 August 2014. Retrieved 28 January 2015.
21. ^ Wappes J. "US health worker monitored as DRC Ebola nears 600 cases". CIDRAP. Retrieved 23 January 2019.
22. ^ Ebola virus disease (Report). World Health Organization. Retrieved 6 June 2019.
23. ^ a b c Meltzer, Martin I.; Atkins, Charisma Y.; Santibanez, Scott; et al. (26 September 2014). "Estimating the future number of cases in the Ebola epidemic – Liberia and Sierra Leone, 2014–2015". Morbidity and Mortality Weekly Report. 63 (3): 1–14. PMID 25254986.
24. ^ Worl, Justin (2014). "New Ebola Cases Could Hit 10,000 Per Week". Time. Retrieved 28 October 2016.
25. ^ Statement on the 1st meeting of the IHR Emergency Committee on the 2014 Ebola outbreak in West Africa (Report). WHO. Archived from the original on 8 August 2014. Retrieved 13 January 2019.
26. ^ a b WHO Director-General briefs media on the outcome of Ebola Emergency Committee (Report). WHO. Retrieved 2 April 2016.
27. ^ Interim advice on the sexual transmission of the Ebola virus disease (Report). WHO. Retrieved 28 October 2016.
28. ^ a b c WHO Director-General addresses the Executive Board (Report). WHO. Archived from the original on 26 January 2016. Retrieved 27 January 2016.
29. ^ WHO (10 June 2016). Situation Report Ebola (PDF) (Report). WHO. Retrieved 11 November 2016.
30. ^ Yasmin, Seema (29 February 2016). "Why Ebola Survivors Struggle with New Symptoms". Scientific American. Retrieved 9 September 2016.
31. ^ a b Geisbert, Thomas W. (December 2016). "First Ebola virus vaccine to protect human beings?". The Lancet. 389 (10068): 479–480. doi:10.1016/S0140-6736(16)32618-6. PMID 28017402.
32. ^ a b "Ebola vaccine results are encouraging – but preliminary". PBS. 23 December 2016.
33. ^ a b "Ervebo". EMA. 12 December 2019. Retrieved 2 February 2020.
34. ^ a b "First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health preparedness and response". FDA. 19 December 2019. Retrieved 2 February 2020.
35. ^ Becker, Stephan; Matrosovich, Mikhail; Krähling, Verena; Schudt, Gordian; Dietzel, Erik (15 January 2017). "Functional Characterization of Adaptive Mutations during the West African Ebola Virus Outbreak". Journal of Virology. 91 (2): e01913–e01916. doi:10.1128/JVI.01913-16. PMC 5215343. PMID 27847361.
36. ^ Ebola response roadmap situation report (PDF) (Report). WHO. p. 6. Retrieved 25 September 2014.
37. ^ "Runaway doctors and missing supplies cripple care in Ebola-hit Liberia". NBC News. Retrieved 8 October 2014.
38. ^ a b Ebola virus disease, West Africa (Report). WHO. 3 July 2014. Archived from the original on 28 July 2014. Retrieved 18 September 2014.
39. ^ a b "8 Ebola suspects freed by relatives in Sierra Leone". Global Post. Xinhua. 28 May 2014. Archived from the original on 31 May 2014. Retrieved 21 June 2014.
40. ^ a b "Growing Ebola outbreak threatens to overwhelm volunteers". Today Health. 8 June 2014. Retrieved 21 June 2014.
41. ^ a b Kevin Sack; Sheri Fink; Pam Belluck; Adam Nossiter (29 December 2014). "How Ebola Roared Back". The New York Times. Retrieved 30 December 2014. "The messages about don't touch the dead, wash your hands, if somebody is sick, leave them—these were all strange things, completely contrary to our tradition and culture."
42. ^ Holly Yan; Esprit Smith (28 October 2014). "Ebola: Patient zero was a toddler in Guinea". CNN. Retrieved 14 April 2020.
43. ^ "2014-2016 Ebola Outbreak in West Africa | History | Ebola (Ebola Virus Disease) | CDC". www.cdc.gov. 17 March 2020. Retrieved 27 April 2022.
44. ^ a b c Baize, Sylvain; Pannetier, Delphine; Oestereich, Lisa; Rieger, Toni (16 April 2014). "Emergence of Zaire Ebola Virus Disease in Guinea – Preliminary Report". New England Journal of Medicine. 371 (15): 1418–1425. doi:10.1056/NEJMoa1404505. PMID 24738640. S2CID 34198809.
45. ^ a b Grady, Denise; Fink, Sheri (9 August 2014). "Tracing Ebola's Breakout to an African 2-Year-Old". The New York Times. Retrieved 11 April 2015.
46. ^ Nassos Stylianou (27 November 2014). "How world's worst Ebola outbreak began with one boy's death". BBC News. Retrieved 11 April 2015.
47. ^ a b c d e Previous Updates: 2014 West Africa Outbreak (Report). CDC. Retrieved 11 April 2015.
48. ^ Ebola virus disease, West Africa (Situation as of 16 April 2014) (Report). WHO. Archived from the original on 6 October 2014. Retrieved 18 September 2014.
49. ^ Ebola virus disease, West Africa (Report). WHO. 18 July 2014. Archived from the original on 25 July 2014. Retrieved 18 September 2014.
50. ^ a b "Sierra Leone hunts Ebola patient kidnapped in Freetown". BBC News. 25 July 2014. Retrieved 27 July 2014.
51. ^ "Ebola outbreak: Sierra Leone escaped patient dies". BBC News. 27 July 2014. Retrieved 27 July 2014.
52. ^ a b Ebola response roadmap situation report (Report). WHO. 12 November 2014. Archived from the original on 12 November 2014. Retrieved 16 November 2014.
53. ^ a b Ebola response roadmap situation report (PDF) (Report). WHO. 26 November 2014. Retrieved 27 November 2014.
54. ^ Situation summary Data published on 2 December 2014 (Report). WHO. 2 December 2014. Retrieved 2 December 2014.
55. ^ Ebola situation report (Report). WHO. 28 January 2015. Archived from the original on 31 January 2015. Retrieved 5 February 2015.
56. ^ Ebola situation report (PDF) (Report). WHO. 8 April 2015. Retrieved 14 April 2015.
57. ^ a b c "Ebola numbers drop sharply in Guinea, Sierra Leone". CIDRAP. 29 July 2015. Retrieved 30 July 2015.
58. ^ "Ebola countries record first week with no new cases". BBC News. 7 October 2015. Retrieved 8 October 2015.
59. ^ "Liberian official urges calm as three new Ebola cases confirmed". The Guardian. Retrieved 21 November 2015.
60. ^ Ebola data and statistics (Report). WHO. Retrieved 28 October 2016.
61. ^ "UN declares end to Ebola virus transmission in Guinea; first time all three host countries free". UN News Center. Retrieved 30 December 2015.
62. ^ "West Africa declared free of Ebola transmission, but UN health agency warns new flare-ups possible". UN News. United Nations. 14 January 2016. Retrieved 6 March 2019.
63. ^ a b "Ebola virus is surging in places where it was beaten back: experts". CTV News. 8 September 2014. Retrieved 8 September 2014.
64. ^ "In Guinea, Ebola Infections Double as Hidden Cases Discovered". VOA. 6 February 2015. Retrieved 8 February 2015.
65. ^ "Crowds attack Ebola facility, health workers in Guinea". Reuters. 14 February 2015. Retrieved 19 February 2015.
66. ^ a b "Guinea declares Ebola 'health emergency' in five regions". BBC News. 29 March 2015. Retrieved 29 March 2015.
67. ^ Fox, Maggie (13 May 2015). "Ebola Epidemic Slows Even More, WHO Says". NBC News.
68. ^ "Ebola crisis: Guineans jailed for putting corpse in taxi". BBC News. 25 May 2015. Retrieved 27 May 2015.
69. ^ "Ebola threat to Guinea Bissau rises as border zone heats up". Yahoo! News. 2 June 2015. Retrieved 3 June 2015.
70. ^ "United Nations News Centre". UN News Service Section. 24 June 2015. Retrieved 28 June 2015.
71. ^ Ebola situation reports Archive (Report). WHO. 17 September 2015. Archived from the original on 2 September 2015. Retrieved 20 September 2015.
72. ^ Ebola Situation Report (PDF) (Report). WHO. 28 October 2015.
73. ^ Searcey, Dionne (6 November 2015). "The Last Place on Earth With Ebola: Getting Guinea to Zero". The New York Times. ISSN 0362-4331. Retrieved 8 November 2015.
74. ^ Ebola Situation Report (Report). WHO. 11 November 2015. Archived from the original on 11 November 2015. Retrieved 6 March 2019.
75. ^ "Guinea's last Ebola case, a baby girl, leaves hospital". Reuters. 28 November 2015. Retrieved 29 November 2015.
76. ^ Ebola Situation Report (Report). WHO. 2 December 2015. Archived from the original on 8 December 2015.
77. ^ Criteria for declaring the end of the Ebola outbreak in Guinea, Liberia or Sierra Leone (Report). WHO. Archived from the original on 17 October 2014. Retrieved 10 December 2015.
78. ^ Zoroya, Greg (17 November 2015). "Last known Ebola patient in West Africa recovers". USA Today. Retrieved 20 November 2015.
79. ^ "End of Ebola transmission in Guinea". WHO. Retrieved 6 March 2019.
80. ^ "Guinea says two people tested positive for Ebola". Reuters. 17 March 2016.
81. ^ Reilly, Katie. "2 Test Positive for Ebola in Guinea". Time. Retrieved 2 April 2016.
82. ^ "Fourth person dies of Ebola in Guinea". ABC News. ABC News Australia. 19 March 2016. Retrieved 2 April 2016.
83. ^ "Ebola clinic reopens in Guinea after virus resurfaces". Yahoo! news. Retrieved 2 April 2016.
84. ^ Hundreds of contacts identified and monitored in new Ebola flare-up in Guinea (Report). WHO. Archived from the original on 26 March 2016. Retrieved 2 April 2016.
85. ^ "Africa highlights: Tuesday 22 March 2016 as it happened". BBC News. Retrieved 2 April 2016.
86. ^ "Liberia Closes Border With Guinea After Ebola Flare-up". Voice of America. 22 March 2016. Retrieved 2 April 2016.
87. ^ Ebola Situation Report (Report). WHO. 30 March 2016. Archived from the original on 1 April 2016. Retrieved 9 June 2016.
88. ^ "Hundreds in Guinea get Ebola vaccine in fight against flare-up". Fox News. 1 April 2016. Retrieved 2 April 2016.
89. ^ Kucharski, Adam J.; Eggo, Rosalind M.; Watson, Conall H.; Camacho, Anton; Funk, Sebastian; Edmunds, W. John (2016). "Effectiveness of Ring Vaccination as Control Strategy for Ebola Virus Disease". Emerging Infectious Diseases. 22 (1): 105–108. doi:10.3201/eid2201.151410. PMC 4696719. PMID 26691346.
90. ^ "Ebola claims another victim in Guinea as vaccinations ramped up". Yahoo! News. 5 April 2016. Archived from the original on 5 May 2019. Retrieved 6 April 2016.
91. ^ "2 Test Positive for Ebola in Guinea". Time. Retrieved 31 October 2018.
92. ^ Duraffour, Sophie; Rambaut, Andrew; Günther, Stephan; Keïta, Sakoba; Formenty, Pierre; Diarra, Abdoulaye; Djingarey, Mamoudou Harouna; Aylward, Raymond Bruce; Carroll, Miles W. (15 November 2016). "Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days". Clinical Infectious Diseases. 63 (10): 1353–1356. doi:10.1093/cid/ciw601. PMC 5091350. PMID 27585800.
93. ^ a b Diallo, Boubacar; Sissoko, Daouda; Loman, Nicholas J.; Bah, Hadja Aïssatou; Bah, Hawa; Worrell, Mary Claire; Conde, lya Saidou; Sacko, Ramata; Mesfin, Samuel; Loua, Angelo; Kalonda, Jacques Katomba; Erondu, Ngozi A.; Dahl, Benjamin A.; Handrick, Susann; Goodfellow, Ian; Meredith, Luke W.; Cotten, Matthew; Jah, Umaru; Guetiya Wadoum, Raoul Emeric; Rollin, Pierre; Magassouba, N'Faly; Malvy, Denis; Anglaret, Xavier; Carroll, Miles W.; Aylward, Raymond Bruce; Djingarey, Mamoudou Harouna; Diarra, Abdoulaye; Formenty, Pierre; Keïta, Sakoba; Günther, Stephan; Rambaut, Andrew; Duraffour, Sophie (15 November 2016). "Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days". Clinical Infectious Diseases. 63 (10): 1353–1356. doi:10.1093/cid/ciw601. PMC 5091350. PMID 27585800.
94. ^ a b Liberia and Guinea discharge final Ebola patients in latest flare-up and begin 42 days of heightened surveillance (Report). WHO. Retrieved 9 June 2016.
95. ^ "Sierra Leone 'hero' doctor's death exposes slow Ebola response". Fox News. 25 August 2014. Retrieved 25 August 2014.
96. ^ "Sierra Leone shuts borders, closes schools to fight Ebola". Reuters. 11 June 2014. Archived from the original on 24 January 2016. Retrieved 11 April 2015.
97. ^ "Sierra Leone, Liberia deploy troops for Ebola". News 24. 4 August 2014. Archived from the original on 5 May 2019. Retrieved 11 April 2015.
98. ^ "The Ebola Outbreak Is Getting Worse in Sierra Leone". VICE News. 6 November 2014. Retrieved 10 November 2014.
99. ^ DiLorenzo, Sarah (4 November 2014). "Thousands in Sierra Leone break Ebola quarantine". Associated Press. Retrieved 5 November 2014.
100. ^ "Ebola crisis: Sierra Leone hit by largely hidden outbreak; WHO says scores of bodies piled up". ABC News. 10 December 2014. Retrieved 11 December 2014.
101. ^ Doucleff, Michaeleen (15 December 2014). "Endless Ebola Epidemic? That's The 'Risk We Face Now,' CDC Says". NPR. Retrieved 18 December 2014.
102. ^ a b c Sierra Leone: Ebola Virus Disease – Situation Report (PDF) (Report). Sierra Leone Ministry of Health and Sanitation. 15 December 2014. Archived from the original (PDF) on 20 December 2014. Retrieved 15 December 2014.
103. ^ "Ebola: Sierra Leone begins house-to-house searches". BBC News. 17 December 2014. Retrieved 18 December 2014.
104. ^ Ebola Virus Disease – Situation Report (PDF) (Report). Sierra Leone Ministry of Health and Sanitation. 18 December 2014. Archived from the original (PDF) on 19 December 2014. Retrieved 19 December 2014.
105. ^ "Ebola Could be 'Levelling Off' in Sierra Leone: WHO". Newsweek. 8 January 2015. Retrieved 11 January 2015.
106. ^ "Sierra Leone predicts no new Ebola cases by March end (+video)". Christian Science Monitor. The Christian Science Monitor. 14 January 2015. Retrieved 15 January 2015.
107. ^ Ebola Situation Report (Report). WHO. 21 January 2015. Archived from the original on 1 February 2015. Retrieved 27 January 2019.
108. ^ Gregg Zoroya (5 February 2015). "Downward Ebola trend suddenly reverses itself". USA Today. Retrieved 6 February 2015.
109. ^ "Ebola-hit Sierra Leone to Reopen Schools March 30". VOA. 5 February 2015. Retrieved 7 February 2015.
110. ^ "Decline in Ebola cases flattens, raising UN concern". Philadelphia Star. Retrieved 22 February 2015.
111. ^ "More Ebola in Guinea, Sierra Leone last week, no Liberia cases says WHO". gnnliberia.com. Archived from the original on 2 April 2015. Retrieved 7 March 2015.
112. ^ Alexandra Sifferlin (17 August 2015). "Sierra Leone Has First Week of No New Ebola Cases". Time. Retrieved 19 August 2015.
113. ^ Sierra Leone begins 42-day countdown to be declared free of Ebola virus transmission. UN News Centre. 26 August 2015.
114. ^ "New Ebola death in Sierra Leone sets back efforts to beat epidemic". News 24. 1 September 2015. Retrieved 1 September 2015.
115. ^ "Sierra Leone officials confirm 3 new cases of Ebola among high risk contacts with fatal case". Associated Press. 8 September 2015. Archived from the original on 21 November 2015. Retrieved 9 September 2015.
116. ^ a b "New Ebola death reported in northern Sierra Leone". CTV News. 14 September 2015. Retrieved 14 September 2015.
117. ^ a b "Hundreds quarantined as Ebola returns to north Sierra Leone district". Reuters. 14 September 2015. Retrieved 14 September 2015.
118. ^ "Anticipation Grows as Sierra Leone Readies to be Declared Ebola-free". VOA. 6 November 2015. Retrieved 8 November 2015.
119. ^ Ebola Situation Report (Report). WHO. 11 November 2015. Archived from the original on 11 November 2015. Retrieved 27 January 2016.
120. ^ "Ebola Situation Report". 9 December 2015. Archived from the original on 11 December 2015. Retrieved 17 December 2015.
121. ^ "Ebola virus: New case emerges in Sierra Leone". BBC News. 15 January 2016.
122. ^ Latest Ebola outbreak over in Liberia; West Africa is at zero, but new flare-ups are likely to occur (Report). WHO.
123. ^ "Sierra Leone puts more than 100 people in quarantine after new Ebola death". The Guardian. 17 January 2016.
124. ^ Government Press Statement: Confirmation of EVD Death in Sierra Leone (Report). WHO. 16 January 2016. Archived from the original on 22 January 2016. Retrieved 21 January 2016.
125. ^ "Sierra Leone confirms second case of Ebola in a week". Yahoo! News. 20 January 2016. Retrieved 21 January 2016.
126. ^ Ebola in Sierra Leone: New case spreads community fear (Report). WHO. Retrieved 22 January 2016.
127. ^ "Health Index". ABC News. Retrieved 9 June 2016.
128. ^ "Sierra Leone discharges last known Ebola patient". Reuters. 8 February 2016. Retrieved 9 June 2016.
129. ^ Ebola Situation Report (Report). WHO. 17 February 2016. Archived from the original on 20 February 2016. Retrieved 9 June 2016.
130. ^ WHO statement on the end of Ebola flare-up in Sierra Leone (Report). WHO. Retrieved 9 June 2016.
131. ^ "Sierra Leone Ebola flare-up over, virus no longer spreading: WHO". Yahoo! News. Retrieved 17 March 2016.
132. ^ "Sierra Leone Stops Mandatory Testing Of Corpses For Ebola". Agence France Presse. Retrieved 1 August 2016.
133. ^ "2 of 5 Test Positive for Ebola in Liberia". Liberian Observer. 31 March 2014. Archived from the original on 9 July 2014. Retrieved 6 July 2014.
134. ^ "Ebola outbreak: Liberia shuts most border points". BBC News. 28 July 2014. Retrieved 28 July 2014.
135. ^ Kwanue, C.Y. (1 August 2014). "In Compliance with Sirleaf's Mandate, UL Closed". Liberian Observer. Archived from the original on 8 August 2014. Retrieved 2 August 2014.
136. ^ "Liberia shuts schools, quarantines communities in bid to halt Ebola". Reuters. 30 July 2014. Retrieved 30 July 2014.
137. ^ "Ebola outbreak: Liberia shuts most border points". BBC News. 28 July 2014. Retrieved 28 July 2014.
138. ^ a b Katty, Kay (7 October 2014). "Ebola outbreak: Liberia 'close to collapse' – ambassador". BBC News Africa. Retrieved 8 October 2014.
139. ^ "Runaway Doctors and Missing Supplies Cripple Care in Ebola-Hit Liberia". NBC News. 8 October 2014. Retrieved 8 October 2014.
140. ^ Liberia Ebola SitRep no. 157 (PDF) (Report). Liberia Ministry of Health and Social Welfare. 24 October 2014. Archived from the original (PDF) on 4 December 2014. Retrieved 24 October 2014.
141. ^ Cumming-Bruce, Nick (29 October 2014). "Ebola Slowing in Liberia, WHO Says, but International Support Is Still Necessary". The New York Times. Retrieved 3 November 2014.
142. ^ "Ebola state of emergency lifted in Liberia". CBS News. 14 November 2014. Retrieved 14 November 2014.
143. ^ Harmon, William Q. (1 December 2017). ""A True Patriot," Nurse Roselyn Ballah, Gets Nightingale Award Presented". Liberian Observer. Archived from the original on 14 April 2021. Retrieved 23 May 2020.
144. ^ "Ebola outbreak eases as world's largest treatment centre dismantled". ABC News. 29 January 2015. Retrieved 29 January 2015.
145. ^ "Three New Ebola Cases in Liberia". The Disease Daily. 27 March 2015. Archived from the original on 30 March 2015. Retrieved 28 March 2015.
146. ^ "allAfrica.com: Liberia: MSF Hands Over ELWA – 3 to Liberian Ministry of Health". allAfrica.com. Retrieved 29 April 2015.
147. ^ "US Shuts Down Ebola Treatment Center in Liberia". ABC News. Retrieved 2 May 2015.
148. ^ "Liberia names new health minister as it seeks to beat Ebola". Yahoo! News. 8 April 2015. Retrieved 16 April 2015.
149. ^ How Liberia got to zero cases of Ebola (Report). WHO. 9 May 2015. Archived from the original on 10 May 2015. Retrieved 10 May 2015.
150. ^ Gladstone, Rick (3 July 2015). "Liberia: 200 Reportedly Had Contact With Ebola Victim". The New York Times.
151. ^ Doucleff, Michaeleen (30 June 2015). "Ebola Returns To Liberia With A Mysterious Case Near Monrovia". NPR. Retrieved 1 July 2015.
152. ^ "Liberia Reports Second Case of Ebola". NBC News. 1 July 2015.
153. ^ "Liberia investigating animal link after Ebola re-emerges". Reuters. 2 July 2015.
154. ^ Sena Quashie (2 July 2015). "In Liberia: Dog meat identified as possible source of Ebola". pulse.com.gh. Retrieved 4 July 2015.
155. ^ Reuters. (7 July 2015)."Liberia: Dog Suspected in New Ebola Case Tests Negative for the Virus". The New York Times.
156. ^ "Liberia Confirms 2 New Ebola Cases". ABC News. 9 July 2015. Retrieved 9 July 2015.
157. ^ Tanya Basu (14 July 2015). "Ebola". Time.
158. ^ Reuters. (20 July 2015)."Liberia: Ebola Patients Discharged, Last of the Country's Latest Wave". The New York Times.
159. ^ Ebola transmission in Liberia over: Nation enters 90-day intensive surveillance period (Report). WHO. 3 September 2015. Archived from the original on 5 September 2015.
160. ^ "New Ebola case confirmed in Liberia". Los Angeles Times. 20 November 2015. Retrieved 15 January 2017.
161. ^ "Liberia: Fears of Deadly Ebola Virus Reportedly Resurface in Liberia". allAfrica.com. Retrieved 21 November 2015.
162. ^ Maggie Fox. "Ebola Returns to Liberia, Again". NBC News. Retrieved 21 November 2015.
163. ^ "Liberian health officials move to control Ebola outbreak in Monrovia". The Guardian. 22 November 2015. Retrieved 23 November 2015.
164. ^ "Liberia Seeks US Help to Determine Cause of New Ebola Cases". Associated Press. 23 November 2015. Retrieved 24 November 2015.
165. ^ "Liberia Records 1st Ebola Death Since July". ABC News. Retrieved 26 November 2015.
166. ^ "Liberia's last two Ebola patients recover, leave hospital". Yahoo! News. 3 December 2015. Retrieved 4 December 2015.
167. ^ Ebola Situation Report (Report). WHO. 16 December 2015. Archived from the original on 18 December 2015. Retrieved 25 December 2015.
168. ^ Emma Farge; James Harding Giahyue (17 December 2015). "Female survivor may be cause of Ebola flare-up in Liberia". Reuters. Retrieved 22 December 2015.
169. ^ Statement on the 8th meeting of the IHR Emergency Committee regarding the Ebola outbreak in West Africa (Report). WHO. Archived from the original on 22 December 2015. Retrieved 23 December 2015.
170. ^ Alexandra Sifferlin. "West Africa to Be Declared Ebola-Free, Health Officials Say". Time. Retrieved 14 January 2016.
171. ^ "Liberia records new Ebola death, months after end of its outbreak". Thomson Reuters Foundation. Reuters. Archived from the original on 24 April 2016. Retrieved 9 June 2016.
172. ^ "International News | World News". ABC News. Retrieved 15 January 2017.
173. ^ Emergency response to Ebola flare underway in Liberia. Case investigation widens to Guinea (Report). WHO. Archived from the original on 8 April 2016. Retrieved 9 June 2016.
174. ^ "Liberia records 97 Ebola contacts". The New Dawn Liberia. 7 April 2016. Archived from the original on 9 April 2016. Retrieved 7 April 2016.
175. ^ Liberia and Guinea step up coordination to stem new cases of Ebola (Report). WHO. 8 April 2016. Archived from the original on 8 April 2016. Retrieved 7 April 2016.
176. ^ Farge, Emma. "Female survivor may be cause of Ebola flare-up in Liberia". Reuters. Retrieved 30 October 2018.
177. ^ WHO declares the end of the most recent Ebola virus disease outbreak in Liberia (Report). WHO. Archived from the original on 10 June 2016. Retrieved 9 June 2016.
178. ^ Camara, Ougna (29 March 2014). "Ebola Death Toll in Guinea Rises to 70 as Senegal Closes Border". Bloomberg News. Retrieved 31 March 2014.
179. ^ a b c Ebola virus disease – Senegal (Report). WHO. 29 March 2014. Archived from the original on 5 September 2014. Retrieved 1 September 2014.
180. ^ "Guinean Who Brought Ebola To Senegal Recovers From Virus". Business Insider. Archived from the original on 24 September 2014. Retrieved 20 September 2014.
181. ^ Ebola Response Roadmap Update, 22 September 2014 (PDF) (Report). WHO. 22 September 2014. Retrieved 22 September 2014.
182. ^ Mark, Monica (6 August 2014). "Ebola Outbreak: Nurse who Treated First Victim in Nigeria Dies". The Guardian (Nigeria). Retrieved 7 August 2014.
183. ^ "Nigeria in first step towards all-clear on Ebola". Yahoo News. 23 September 2014. Retrieved 26 September 2014.
184. ^ Nigeria is now free of Ebola virus transmission (Report). WHO. 20 October 2014. Archived from the original on 21 October 2014. Retrieved 20 May 2015.
185. ^ WHO Declares Nigeria Ebola-Free (Report). WHO. Archived from the original on 24 October 2014. Retrieved 22 July 2016.
186. ^ Green, Andrew (2014). "Remembering health workers who died from Ebola in 2014". The Lancet. 384 (9961): 2201–2206. doi:10.1016/S0140-6736(14)62417-X. PMID 25625389. S2CID 23124192.
187. ^ Mali case, Ebola imported from Guinea Ebola situation assessment – 10 November 2014 (Report). WHO. Archived from the original on 11 November 2014. Retrieved 11 November 2014.
188. ^ "Ebola Outbreak 2014". NBC News. Retrieved 24 October 2014.
189. ^ "Mali: Situation de la lutte contre la maladie à virus Ebola au Mali à la date du mercredi 19 novembre 2014" (in French). maliactu. 19 November 2014. Archived from the original on 14 December 2014. Retrieved 26 November 2014.
190. ^ Mali confirms its second fatal case of Ebola virus disease (Report). WHO. Archived from the original on 13 November 2014. Retrieved 14 November 2014.
191. ^ "Update 2 – Doctor who treated source of second Mali Ebola outbreak dies". Reuters. 21 November 2014. Retrieved 21 November 2014.
192. ^ "Ebola crisis: Third death confirmed in Mali". BBC News. 12 November 2014. Retrieved 12 November 2014.
193. ^ "Mali records new Ebola case, linked to dead nurse". Reuters. 22 November 2014. Retrieved 22 November 2014.
194. ^ "Africa – Mali nears Ebola-free status as last patient leaves hospital". France 24. 12 December 2014. Archived from the original on 27 December 2014. Retrieved 12 December 2014.
195. ^ Cooper, Charlie (31 December 2014). "Ebola in the UK: Infected nurse Pauline Cafferkey treated with survivors' blood plasma and experimental drugs". The Independent. London. Retrieved 1 January 2015.
196. ^ "Ebola nurse: Pauline Cafferkey 'happy to be alive'". BBC News. 24 January 2015. Retrieved 11 April 2015.
197. ^ "Ebola nurse Pauline Cafferkey 'in serious condition'". BBC News. 9 October 2015. Retrieved 9 October 2015.
198. ^ Botelho, Greg (14 October 2015). "UK's first Ebola patient 'critically ill,' in isolation". CNN. Retrieved 16 October 2015.
199. ^ "Ebola nurse's close contacts identified". BBC News. 12 October 2015. Retrieved 16 October 2015.
200. ^ "Ebola Nurse: 58 Monitored For Deadly Virus". Yahoo! News UK. 13 October 2015. Retrieved 16 October 2015.
201. ^ "U.K. Ebola nurse has meningitis caused by persisting Ebola, doctors say". CBC. 21 October 2015. Retrieved 27 October 2015.
202. ^ Wilcock, David (12 November 2015). "Ebola nurse Pauline Cafferkey released from London hospital after 'full recovery'". The Independent.
203. ^ "Ebola nurse Pauline Cafferkey flying back to Royal Free Hospital amid ongoing tests". The Telegraph. 23 February 2016. Archived from the original on 23 February 2016. Retrieved 28 October 2016.
204. ^ "Ebola nurse Pauline Cafferkey 'stable' after night in London hospital". BBC News. 24 February 2016. Retrieved 28 October 2016.
205. ^ "Nurse in Italy tests positive for Ebola; was in Sierra Leone". The San Diego Union-Tribune. 12 May 2015. Retrieved 13 May 2015.
206. ^ Italian nurse cured of Ebola, AFP, 10 June 2015
207. ^ "Muere el religioso español Miguel Pajares a causa del ébola". RTVE. 12 August 2014. Retrieved 12 August 2014.
208. ^ "Ebola Outbreak: Spanish Missionary Manuel Garcia Viejo Dies of Deadly Virus in Madrid". International Business Times. 25 September 2014. Retrieved 25 September 2014.
209. ^ "Nurse 'infected with Ebola' in Spain". BBC News. Retrieved 6 October 2014.
210. ^ "La enfermera ingresada en Alcorcón da positivo por ébola – La segunda prueba ha dado positivo y confirma el diagnóstico". Cadena Ser. 6 October 2014. Archived from the original on 27 August 2021. Retrieved 11 April 2015.
211. ^ "WHO Says Spain Ebola-Free Following Nurse Recovery". ABC News. 2 December 2014. Retrieved 2 December 2014.
212. ^ CDC and Texas Health Department Confirm First Ebola Case Diagnosed in the U.S. (Report). CDC. 1 October 2014. Retrieved 1 October 2014.
213. ^ Nick Allen (1 October 2014). "First Ebola victim in America was sent home with antibiotics". The Telegraph. London. Archived from the original on 12 January 2022. Retrieved 11 April 2015.
214. ^ "Thomas Eric Duncan: First Ebola death in U.S." CNN. 8 October 2014. Retrieved 8 October 2014.
215. ^ Fernandez, Manny (12 October 2014). "Texas Health Worker Tests Positive for Ebola". The New York Times. Retrieved 12 October 2014.
216. ^ "Virus Free: Ebola-Infected Nurse Nina Pham to Go Home". NBC News. 24 October 2014. Retrieved 11 April 2015.
217. ^ "Nurse Amber Vinson free of Ebola virus, family says". Yahoo! News. 23 October 2014. Retrieved 23 October 2014.
218. ^ "New York Doctor Just Back From Africa Has Ebola". NBC News. 23 October 2014. Retrieved 23 October 2014.
219. ^ Hartocollis, Anemona (10 November 2014). "Craig Spencer, New York Doctor With Ebola, Will Leave Bellevue Hospital". The New York Times. Retrieved 11 April 2015.
220. ^ "Infektion: Ebola-Patient in Leipziger Klinik gestorben". Die Zeit. De Zeit. 14 October 2014. Retrieved 14 October 2014.
221. ^ "Ugandan doctor cured of Ebola in German hospital". Yahoo! News. 4 December 2014. Retrieved 4 December 2014.
222. ^ "Hamburg clinic dismisses Ebola patient" (in German). 4 October 2014. Retrieved 4 October 2014.
223. ^ "French MSF nurse cured of Ebola". 4 October 2014. Archived from the original on 4 October 2014. Retrieved 4 October 2014.
224. ^ "Ebola: l'agent de l'Unicef soigné à l'hôpital Bégin a quitté la France "guéri"" (in French). Retrieved 24 November 2014.
225. ^ "Italy doctor with Ebola has recovered: reports". Deccan Chronicle. 2 January 2015. Retrieved 2 January 2015.
226. ^ "UN: Nigerian peacekeeper recovers from Ebola". The San Diego Union-Tribune. 23 December 2014. Retrieved 28 December 2014.
227. ^ "– Jeg er utrolig takknemlig" (in Norwegian). 20 October 2014. Retrieved 20 October 2014.
228. ^ "Norwegian Ebola Patient Cured". Yahoo! News. 20 October 2014. Retrieved 20 October 2014.
229. ^ "Felix Baez, Cuban doctor with Ebola, recovers in Geneva". CBC News. 6 December 2014. Retrieved 6 December 2014.
230. ^ "BBC News – Ebola: Seventh British health worker sent home". BBC News. 16 March 2015. Retrieved 19 March 2015.
231. ^ "British medic declared free of Ebola". BBC News. 27 March 2015. Retrieved 27 March 2015.
232. ^ a b Ebola virus disease – Democratic Republic of Congo E-mail Print Epidemiology and surveillance (Report). WHO (WHO). Archived from the original on 30 August 2014. Retrieved 11 April 2015.
233. ^ Virological analysis: no link between Ebola outbreaks in west Africa and Democratic Republic of Congo (Report). WHO. 2 September 2014. Archived from the original on 5 September 2014. Retrieved 7 September 2014.
234. ^ WHO declares end of Ebola outbreak in the Democratic Republic of Congo (Report). WHO. Archived from the original on 21 November 2014. Retrieved 22 November 2014.
235. ^ Ebola response roadmap situation report update (PDF) (Report). WHO. 29 October 2014. Retrieved 3 November 2014.
236. ^ a b c Gire, S. K.; Goba, A.; Andersen, K. G.; Sealfon, R. S. G.; Park, D. J.; Kanneh, L.; Jalloh, S.; Momoh, M.; Fullah, M.; Dudas, G.; Wohl, S.; Moses, L. M.; Yozwiak, N. L.; Winnicki, S.; Matranga, C. B.; Malboeuf, C. M.; Qu, J.; Gladden, A. D.; Schaffner, S. F.; Yang, X.; Jiang, P.-P.; Nekoui, M.; Colubri, A.; Coomber, M. R.; Fonnie, M.; Moigboi, A.; Gbakie, M.; Kamara, F. K.; Tucker, V.; Konuwa, E.; Saffa, S.; Sellu, J.; Jalloh, A. A.; Kovoma, A.; Koninga, J.; Mustapha, I.; Kargbo, K.; Foday, M.; Yillah, M.; Kanneh, F.; Robert, W.; Massally, J. L. B.; Chapman, S. B.; Bochicchio, J.; Murphy, C.; Nusbaum, C.; Young, S.; Birren, B. W.; Grant, D. S.; Scheiffelin, J. S.; Lander, E. S.; Happi, C.; Gevao, S. M.; Gnirke, A.; Rambaut, A.; Garry, R. F.; Khan, S. H.; Sabeti, P. C. (28 August 2014). "Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak". Science. 345 (6202): 1369–1372. Bibcode:2014Sci...345.1369G. doi:10.1126/science.1259657. PMC 4431643. PMID 25214632.
237. ^ Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I.; Netesov, Sergey V.; Nichol, Stuart T.; Palacios, Gustavo; Peters, Clarence J.; Tenorio, Antonio; Volchkov, Viktor E.; Jahrling, Peter B. (30 October 2010). "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. PMC 3074192. PMID 21046175.
238. ^ Schoepp, Randal J.; Rossi, Cynthia A.; Khan, Sheik H.; Goba, Augustine; Fair, Joseph N. (2014). "Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone". Emerging Infectious Diseases. 20 (7): 1176–1182. doi:10.3201/eid2007.131265. PMC 4073864. PMID 24959946.
239. ^ Vogel, Gretchen (29 August 2014). "Genomes reveal start of Ebola outbreak". Science. 345 (6200): 989–990. Bibcode:2014Sci...345..989V. doi:10.1126/science.345.6200.989. PMID 25170128.
240. ^ Public Health England. PHE study finds Ebola virus mutated slower than first thought (Report). Public Health England. Retrieved 15 July 2015.
241. ^ "Scientists Release Ebola Sequencing Data to Global Research Community Online". Drug Discovery & Development. 3 June 2015. Retrieved 7 June 2015.
242. ^ Simon-Loriere, Etienne; Faye, Ousmane; Faye, Oumar; Koivogui, Lamine; Magassouba, Nfaly; Keita, Sakoba; Thiberge, Jean-Michel; Diancourt, Laure; Bouchier, Christiane; Vandenbogaert, Matthias; Caro, Valérie; Fall, Gamou; Buchmann, Jan P.; Matranga, Christan B.; Sabeti, Pardis C.; Manuguerra, Jean-Claude; Holmes, Edward C.; Sall, Amadou A. (6 August 2015). "Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic". Nature. 524 (7563): 102–104. Bibcode:2015Natur.524..102S. doi:10.1038/nature14612. PMC 10601606. PMID 26106863.
243. ^ Kevin McSpadden (29 January 2015). "Ebola Virus has Mutated, Scientists Say". Time. Retrieved 31 January 2015.
244. ^ Alfson, K. J.; Worwa, G.; Carrion, R. Jr.; Griffiths, A. (16 December 2015). "Determination of the Spontaneous Mutation Frequency of Ebola virus and Exploitation of this Therapeutically". Journal of Virology. 90 (5): 2345–2355. doi:10.1128/JVI.02701-15. PMC 4810732. PMID 26676781.
245. ^ Griensven, Johan van; Günther, Stephan; Clerck, Hilde de; McElroy, Anita K.; Malvy, Denis (2 March 2019). "Ebola virus disease". The Lancet. 393 (10174): 936–948. doi:10.1016/S0140-6736(18)33132-5. PMID 30777297.
246. ^ Ng, Melinda; Ndungo, Esther; Kaczmarek, Maria E; Herbert, Andrew S; Binger, Tabea; Kuehne, Ana I; Jangra, Rohit K; Hawkins, John A; Gifford, Robert J (23 December 2015). "Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats". eLife. 4: e11785. doi:10.7554/eLife.11785. PMC 4709267. PMID 26698106.
247. ^ Gonzalez, J. P.; Pourrut, X.; Leroy, E. (2007). "Ebolavirus and Other Filoviruses". In Childs, J. E.; Mackenzie, J. S.; Richt, J. A. (eds.). Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission. Current Topics in Microbiology and Immunology. Vol. 315\. pp. 363–387. doi:10.1007/978-3-540-70962-6_15. ISBN 978-3-540-70961-9. PMC 7121322. PMID 17848072.
248. ^ Mari Saez, A.; Weiss, S.; Nowak, K.; Lapeyre, V.; Zimmermann, F.; Dux, A.; Kuhl, H. S.; Kaba, M.; Regnaut, S.; Merkel, K.; Sachse, A.; Thiesen, U.; Villanyi, L.; Boesch, C.; Dabrowski, P. W.; Radonic, A.; Nitsche, A.; Leendertz, S. A. J.; Petterson, S.; Becker, S.; Krahling, V.; Couacy-Hymann, E.; Akoua-Koffi, C.; Weber, N.; Schaade, L.; Fahr, J.; Borchert, M.; Gogarten, J. F.; Calvignac-Spencer, S.; Leendertz, F. H. (30 December 2014). "Investigating the zoonotic origin of the West African Ebola epidemic". EMBO Molecular Medicine. 7 (1): 17–23. doi:10.15252/emmm.201404792. PMC 4309665. PMID 25550396. "The severe Ebola virus disease epidemic occurring in West Africa likely stems from a single zoonotic transmission event involving a 2‐year‐old boy in Meliandou, Guinea, who might have been infected by hunting or playing with insectivorous free‐tailed bats living in a nearby hollow tree"
249. ^ a b D'Odorico, Paolo; Hayman, David T. S.; Santini, Monia; Rulli, Maria Cristina (14 February 2017). "The nexus between forest fragmentation in Africa and Ebola virus disease outbreaks". Scientific Reports. 7: 41613. Bibcode:2017NatSR...741613R. doi:10.1038/srep41613. ISSN 2045-2322. PMC 5307336. PMID 28195145.
250. ^ a b Nasi, Robert; Sheil, Douglas; Leendertz, Siv Aina; King, Shona; Suter, Jamison; Park, Douglas; Salim, Mohammad A.; Gaveau, David; Vargas, J. Mario; Farfán, Miguel A.; Márquez, Ana L.; Real, Raimundo; Fa, John E.; Olivero, Jesús (30 October 2017). "Recent loss of closed forests is associated with Ebola virus disease outbreaks". Scientific Reports. 7 (1): 14291. Bibcode:2017NatSR...714291O. doi:10.1038/s41598-017-14727-9. ISSN 2045-2322. PMC 5662765. PMID 29085050.
251. ^ CDC Telebriefing on Ebola outbreak in West Africa (Report). CDC. 28 July 2014. Retrieved 3 August 2014.
252. ^ Osterholm, MT; Moore, KA; Kelley, NS; Brosseau, LM; Wong, G; Murphy, FA; Peters, CJ; LeDuc, JW; Russell, PK; Van Herp, M; Kapetshi, J; Muyembe, JJ; Ilunga, BK; Strong, JE; Grolla, A; Wolz, A; Kargbo, B; Kargbo, DK; Formenty, P; Sanders, DA; Kobinger, GP (19 February 2015). "Transmission of Ebola viruses: what we know and what we do not know". mBio. 6 (2): e00137. doi:10.1128/mBio.00137-15. PMC 4358015. PMID 25698835.
253. ^ Broadhurst, M. Jana; Brooks, Tim J. G.; Pollock, Nira R. (October 2016). "Diagnosis of Ebola Virus Disease: Past, Present, and Future". Clinical Microbiology Reviews. 29 (4): 773–793. doi:10.1128/CMR.00003-16. PMC 5010747. PMID 27413095.
254. ^ Bausch, Daniel G. (2017). "West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis". In Mühlberger, Elke; Hensley, Lisa L.; Towner, Jonathan S. (eds.). Marburg- and Ebolaviruses: From Ecosystems to Molecules. Current Topics in Microbiology and Immunology. Vol. 411\. Springer. p. 79\. doi:10.1007/82_2017_69. ISBN 978-3-319-68948-7. PMID 29071473. Retrieved 14 January 2019.
255. ^ Ebola media centre fact sheets (Report). WHO. Retrieved 21 September 2014.
256. ^ Interim advice on the sexual transmission of the Ebola virus disease (Report). WHO. Retrieved 28 October 2016.
257. ^ Deen, Gibrilla F.; Knust, Barbara; Broutet, Nathalie; Sesay, Foday R.; Formenty, Pierre; Ross, Christine; Thorson, Anna E.; Massaquoi, Thomas A.; Marrinan, Jaclyn E.; Ervin, Elizabeth; Jambai, Amara; McDonald, Suzanna L.R.; Bernstein, Kyle; Wurie, Alie H.; Dumbuya, Marion S.; Abad, Neetu; Idriss, Baimba; Wi, Teodora; Bennett, Sarah D.; Davies, Tina; Ebrahim, Faiqa K.; Meites, Elissa; Naidoo, Dhamari; Smith, Samuel; Banerjee, Anshu; Erickson, Bobbie Rae; Brault, Aaron; Durski, Kara N.; Winter, Jorn; Sealy, Tara; Nichol, Stuart T.; Lamunu, Margaret; Ströher, Ute; Morgan, Oliver; Sahr, Foday (14 October 2015). "Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Preliminary Report". New England Journal of Medicine. 377 (15): 1428–1437. doi:10.1056/NEJMoa1511410. PMC 5798881. PMID 26465681.
258. ^ "Why Testicles Are The Perfect Hiding Spot For Ebola". Popular Science. Retrieved 7 May 2015.
259. ^ "Sex and masturbation may hamper Ebola eradication efforts". Reuters. 9 September 2015. Archived from the original on 10 April 2016. Retrieved 14 September 2015.
260. ^ Deen, Gibrilla F.; Broutet, Nathalie; Xu, Wenbo; Knust, Barbara; Sesay, Foday R.; McDonald, Suzanna L.R.; Ervin, Elizabeth; Marrinan, Jaclyn E.; Gaillard, Philippe; Habib, Ndema; Liu, Hongtu; Liu, William; Thorson, Anna E.; Yamba, Francis; Massaquoi, Thomas A.; James, Faustin; Ariyarajah, Archchun; Ross, Christine; Bernstein, Kyle; Coursier, Antoine; Klena, John; Carino, Marylin; Wurie, Alie H.; Zhang, Yong; Dumbuya, Marion S.; Abad, Neetu; Idriss, Baimba; Wi, Teodora; Bennett, Sarah D.; Davies, Tina; Ebrahim, Faiqa K.; Meites, Elissa; Naidoo, Dhamari; Smith, Samuel J.; Ongpin, Patricia; Malik, Tasneem; Banerjee, Anshu; Erickson, Bobbie R.; Liu, Yongjian; Liu, Yang; Xu, Ke; Brault, Aaron; Durski, Kara N.; Winter, Jörn; Sealy, Tara; Nichol, Stuart T.; Lamunu, Margaret; Bangura, James; Landoulsi, Sihem; Jambai, Amara; Morgan, Oliver; Wu, Guizhen; Liang, Mifang; Su, Qiudong; Lan, Yu; Hao, Yanzhe; Formenty, Pierre; Ströher, Ute; Sahr, Foday (12 October 2017). "Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report". New England Journal of Medicine. 377 (15): 1428–1437. doi:10.1056/NEJMoa1511410. PMC 5798881. PMID 26465681.
261. ^ Broutet, Nathalie; Lofthouse, Clare; Formenty, Pierre; Thorson, Anna (2016). "Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations". BMJ Open. 6 (1): e008859. doi:10.1136/bmjopen-2015-008859. PMC 4716240. PMID 26743699.
262. ^ a b Ebola response Roadmap (PDF) (Report). WHO. Retrieved 21 June 2016.
263. ^ Contact tracing (Report). WHO. Retrieved 27 January 2019.
264. ^ "The reason Ebola isn't being stopped". CNN. Retrieved 16 September 2014.
265. ^ UN senior leaders outline needs for global Ebola response (Report). WHO. Archived from the original on 7 September 2014. Retrieved 16 September 2014.
266. ^ Fact sheet: U.S. Response to the Ebola Epidemic in West Africa. whitehouse.gov (Report). Retrieved 2 November 2014 - via National Archives.
267. ^ Butler, Declan (2014). "Ebola Experts Seek to Expand Testing". Nature. 516 (7530): 154–155. Bibcode:2014Natur.516..154B. doi:10.1038/516154a. PMID 25503213. Retrieved 11 December 2014.
268. ^ H. Cai; J. W. Parks; T. A. Wall; M. A. Stott; A. Stambaugh; K. Alfson; A. Griffiths; R. A. Mathies; R. Carrion; J. L. Patterson; A. R. Hawkins; H. Schmidt (25 September 2015). "Optofluidic analysis system for amplification-free, direct detection of Ebola infection". Scientific Reports. 5: 14494. Bibcode:2015NatSR...514494C. doi:10.1038/srep14494. PMC 4585921. PMID 26404403.
269. ^ "Chip-based technology allows fast, accurate Ebola detection". UPI. Retrieved 26 September 2015.
270. ^ a b "Doctors Without Borders: West Africa's Ebola Outbreak is Totally Out of Control". CTVNews. 20 June 2014. Retrieved 21 June 2014.
271. ^ a b c Unprecedented number of medical staff infected with Ebola (Report). WHO. 25 August 2014. Archived from the original on 27 August 2014. Retrieved 27 August 2014.
272. ^ Ladner, Jason T; Wiley, Michael R; Mate, Suzanne; Dudas, Gytis; Prieto, Karla; Lovett, Sean; Nagle, Elyse R; Beitzel, Brett; Gilbert, Merle L; Fakoli, Lawrence; Diclaro, Joseph W; Schoepp, Randal J; Fair, Joseph; Kuhn, Jens H; Hensley, Lisa E; Park, Daniel J; Sabeti, Pardis C; Rambaut, Andrew; Sanchez-Lockhart, Mariano; Bolay, Fatorma K; Kugelman, Jeffrey R; Palacios, Gustavo (2015). "Evolution and Spread of Ebola Virus in Liberia, 2014–2015". Cell Host & Microbe. 18 (6): 659–669. doi:10.1016/j.chom.2015.11.008. PMC 4711363. PMID 26651942.
273. ^ Ebola virus disease Fact sheet N°103 (Report). WHO. Retrieved 6 September 2014.
274. ^ "Ebola – 5 tips to avoid the deadly disease". Plan International. 6 September 2014. Retrieved 11 April 2015.
275. ^ Diallo, Boubacar (29 March 2014). "Ebola en Guinée: l'ONG Plan Guinée craint une aggravation de l'épidemie" [Ebola in Guinea: the NGO Plan Guinea fears a worsening of the epidemic] (in French). Africa guinée. Archived from the original on 3 April 2014. Retrieved 31 March 2014.
276. ^ Ilesanmi, OS; Alele, FO (2015). "The effect of Ebola Virus Disease outbreak on hand washing among secondary school students in Ondo State Nigeria, October, 2014". Pan Afr Med J. 22 (Suppl 1): 24. doi:10.11694/pamj.supp.2015.22.1.6614 (inactive 1 November 2024). PMC 4695531. PMID 26740852.`{{cite journal}}`: CS1 maint: DOI inactive as of November 2024 (link)
277. ^ "Encounters during the Ebola awareness campaign". PLAN International. Retrieved 2 November 2014.
278. ^ Ofeibea Quist-Arcton (6 August 2014). "Skeptics In Sierra Leone Doubt Ebola Virus Exists". NPR.org. NPR.
279. ^ Anja Wolz (15 July 2014). "Fighting fear, denial and death on Ebola frontline". New Scientist. Retrieved 11 April 2015.
280. ^ "Patients reported missing after Ebola clinic attacked in Liberia". The Age. Melbourne. 18 August 2014. Retrieved 18 August 2014.
281. ^ "Red Cross suspends Ebola operations in southeast Guinea after threats". Reuters. 2 July 2014. Retrieved 4 July 2014.
282. ^ "At least 8 Ebola aid workers reportedly killed 'in cold blood' by villagers in Guinea". Fox News. 19 September 2014. Retrieved 19 September 2014.
283. ^ Chan, M (20 August 2014). "Ebola Virus Disease in West Africa – No Early End to the Outbreak". The New England Journal of Medicine. 371 (13): 1183–5. doi:10.1056/NEJMp1409859. PMID 25140856. S2CID 205110836.
284. ^ How to conduct safe and dignified burial of a patient who has died from suspected or confirmed Ebola virus disease (PDF). Global Alert and Response (Report). WHO. Retrieved 14 December 2014.
285. ^ "Guinea's Grand Imam Pulls No Punches In His Ebola Message". NPR.org. NPR. 26 January 2015. Retrieved 3 February 2015.
286. ^ "Hygiene practices have helped keep Ebola out of the classroom". UNICEF. 12 August 2015. Archived from the original on 15 August 2015. Retrieved 14 August 2015.
287. ^ Mosoka P. Fallah; Laura A. Skrip; Shai Gertler; Dan Yamin; Alison P. Galvani (31 December 2015). "Quantifying Poverty as a Driver of Ebola Transmission". PLOS Neglected Tropical Diseases. 9 (12): e0004260. doi:10.1371/journal.pntd.0004260. PMC 4697799. PMID 26720278.
288. ^ Onyeonoro, UU; Ekpemiro, UC; Abali, C; Nwokeukwu, HI (2015). "Ebola epidemic – the Nigerian experience". Pan Afr Med J. 22 (Suppl 1): 17. doi:10.11694/pamj.supp.2015.22.1.6625 (inactive 1 November 2024). PMC 4695530. PMID 26740845.`{{cite journal}}`: CS1 maint: DOI inactive as of November 2024 (link)
289. ^ Wikipedia is already the world's 'Dr Google' - it's time for doctors and researchers to make it better Huffington Post. Conversation Global Editorial Group. 18 October 2016. Downloaded 22 October 2017.
290. ^ Wikipedia Emerges as Trusted Internet Source for Ebola Information By Noam Cohen. 26 October 2014. Downloaded 22 October 2017.
291. ^ McNeil, Donald G. Jr. (13 August 2014). "Using a Tactic Unseen in a Century, Countries Cordon Off Ebola-Racked Areas". The New York Times. Retrieved 14 August 2014.
292. ^ "In Sierra Leone's Ebola hot zone: A series of reports". UN Office for the Coordination of Humanitarian Affairs. 9 October 2014. Retrieved 2 November 2014.
293. ^ "Rally around West African communities to fight Ebola". The Seattle Times. Retrieved 2 November 2014.
294. ^ McCauley, Lauren (3 September 2014). "As Ebola Outbreak Surges, Health Officials Slam International 'Coalition of Inaction'". Common Dreams. Retrieved 7 September 2014.
295. ^ a b "Ebola: the failures of the international outbreak response". Médecins Sans Frontières. Retrieved 5 March 2019.
296. ^ Removed: Ebola in Sierra Leone – Watch – Level 1, Practice Usual Precautions – Travel Health Notices – Travelers (Report). CDC. Retrieved 9 June 2016.
297. ^ Interim U.S. Guidance for Monitoring and Movement of Persons with Potential Ebola Virus Exposure (Report). CDC. Retrieved 2 November 2014.
298. ^ "MSF Protocols for Staff Returning from Ebola-Affected Countries". Doctors without Borders. Archived from the original on 2 November 2014. Retrieved 2 November 2014.
299. ^ Public health recommendations for returning workers who are asymptomatic contacts of Ebola virus disease (PDF) (Report). Public Health England. 10 December 2014. Retrieved 11 April 2015.
300. ^ "Ebola virus disease (EVD): Advice for returning travellers from countries/areas affected by EVD" (PDF). Public Health Ontario. Archived from the original (PDF) on 2 November 2014. Retrieved 2 November 2014.
301. ^ Salaam-Blyther, Tiaji (26 August 2014). "The 2014 Ebola Outbreak: International and U.S. Responses" (PDF). Retrieved 9 September 2014.
302. ^ Prevention of Ebola Hemorrhagic Fever (Report). CDC. Retrieved 28 October 2016.
303. ^ a b Ebola medics 'better trained in Sierra Leone than Spain' The Telegraph, by Fiona Govan, 11 October 2014
304. ^ "How not to catch Ebola". BBC News. 7 October 2014. Retrieved 13 October 2014.
305. ^ "Ebola Protective Suits Are In Short Supply". NPR.org. NPR. 7 October 2014. Retrieved 13 October 2014.
306. ^ "Ebola Suit Maker Triples Output". ABC-News. 9 October 2014. Retrieved 13 October 2014.
307. ^ "Innovating to Fight Ebola". The White House – Office of Science and Technology Policy. 29 October 2014. Retrieved 4 November 2014.
308. ^ "Obama Tries A 'Throw Everything Against The Wall' Approach To Ebola". The Huffington Post. 31 October 2014. Retrieved 10 November 2014.
309. ^ Ravindranath, Mohana (24 November 2014). "USAID seeks help from 'maker movement' in Ebola outbreak". The Washington Post. Retrieved 26 November 2014.
310. ^ "United States Announces Results of Grand Challenge to Fight Ebola" (Press release). USAID. 12 December 2014. Archived from the original on 9 January 2015. Retrieved 12 January 2015.
311. ^ "Dreaming Up A Safer, Cooler PPE For Ebola Fighters". NPR. 17 December 2014. Retrieved 18 December 2014.
312. ^ William A. Fischer II; David J. Weber; David A. Wohl (1 November 2015). "Personal Protective Equipment: Protecting Health Care Providers in an Ebola Outbreak". Clinical Therapeutics. 37 (11): 2402–10. doi:10.1016/j.clinthera.2015.07.007. PMC 4661082. PMID 26452427. Retrieved 27 January 2016.
313. ^ Guidance on Personal Protective Equipment (PPE) To Be Used By Healthcare Workers During Management of Patients with Confirmed Ebola or Persons Under Investigation (PUIs) for Ebola who are Clinically Unstable or Have Bleeding, Vomiting, or Diarrhea in U.S. Hospitals, Including Procedures for Donning and Doffing PPE (Report). CDC. Retrieved 27 January 2016.
314. ^ a b Treatment of Ebola (Report). CDC. 22 May 2018. Retrieved 23 January 2019.
315. ^ Choi JH, Croyle MA (December 2013). "Emerging targets and novel approaches to Ebola virus prophylaxis and treatment". BioDrugs. 27 (6): 565–83. doi:10.1007/s40259-013-0046-1. PMC 3833964. PMID 23813435.
316. ^ Makiko Kitamura (8 June 2014). "Sierra Leone Is Epicenter of Ebola as Guinea Clinic Shut". Archived from the original on 24 October 2014. Retrieved 30 July 2014.
317. ^ Signs and Symptoms of Ebola Hemorrhagic Fever (Report). CDC. 30 May 2018. Retrieved 27 January 2019.
318. ^ Magill, Alan (2013). Hunter's tropical medicine and emerging infectious diseases (9th ed.). New York: Saunders. p. 332\. ISBN 978-1-4160-4390-4.
319. ^ a b c Schieffelin, John S; Shaffer, Jeffrey G; Goba, Augustine; et al. (29 October 2014). "Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone". The New England Journal of Medicine. 371 (22): 2092–2100. doi:10.1056/NEJMoa1411680. PMC 4318555. PMID 25353969.
320. ^ West, T. Eoin; von Saint André-von Arnim, Amélie (1 November 2014). "Clinical Presentation and Management of Severe Ebola Virus Disease". Annals of the American Thoracic Society. 11 (9): 1341–1350. doi:10.1513/AnnalsATS.201410-481PS. ISSN 2329-6933. PMID 25369317.
321. ^ a b c Donald G. McNeil Jr. (1 January 2015). "Ebola Doctors Are Divided on IV Therapy in Africa". The New York Times. Retrieved 3 January 2015.
322. ^ "IV Therapy for Ebola". Communities/Ebola Response. January 2015. Retrieved 7 January 2015.
323. ^ Johnson, Steven (17 November 2020). "The Deadliness of the 2014 Ebola Outbreak Was Not Inevitable". The New York Times. Retrieved 18 February 2021.
324. ^ Carod-Artal FJ (2015). "Post-Ebolavirus disease syndrome: what do we know?". Expert Rev Anti Infect Ther. 13 (10): 1185–7. doi:10.1586/14787210.2015.1079128. PMID 26293407.
325. ^ A story of Ebola survival and return (Report). WHO. 14 November 2014. Retrieved 5 February 2015.
326. ^ "Mystery 'post-Ebola syndrome' emerges in West Africa". The Japan Times. 10 May 2013. Archived from the original on 21 May 2015. Retrieved 21 May 2015.
327. ^ "An emergency within an emergency: caring for Ebola survivors" (Press release). WHO. 7 August 2015. Archived from the original on 13 August 2015. Retrieved 19 August 2015.
328. ^ Burki, Talha Khan (1 July 2016). "Post-Ebola syndrome". The Lancet Infectious Diseases. 16 (7): 780–781. doi:10.1016/S1473-3099(15)00259-5. PMID 27352759.
329. ^ Clinical care for survivors of Ebola virus disease (PDF) (Report). WHO. 11 April 2016.
330. ^ "Ebola outbreak: Doctors warn of 'post-Ebola syndrome' among survivors in West Africa". ABC News. ABC News (Australia). 5 February 2015. Retrieved 5 February 2015.
331. ^ "Thousands of Ebola survivors face severe pain, possible blindness". Yahoo! News. 8 August 2015. Retrieved 9 August 2015.
332. ^ Grady, Denise (7 May 2015). "After Nearly Claiming His Life, Ebola Lurked in a Doctor's Eye". The New York Times. Retrieved 6 March 2019.
333. ^ a b Cooper, Charlie (27 October 2014). "Ebola outbreak: Deaths from malaria and other diseases could soar while Africa's over-stretched healthcare systems fight the virus, expert warns". The Independent. London. Retrieved 28 October 2014.
334. ^ a b Farmer, Paul (23 October 2014). "Diary". London Review of Books. Retrieved 25 October 2014.
335. ^ "Liberia: Unheralded Fear – Ebola Pose Risks for Liberia Health Workers". FrontPage Africa. 19 June 2014. Retrieved 21 June 2014 - via AllAfrica.com.
336. ^ McCauley, Lauren (3 September 2014). "As Ebola outbreak surges, health officials slam international 'Coalition of Inaction'". Common Dreams. Retrieved 7 September 2014.
337. ^ "MSF's new Ebola management centers already overwhelmed". Médecins Sans Frontières. Retrieved 11 April 2015.
338. ^ a b c Ebola response roadmap situation report (PDF) (Report). WHO. 10 December 2014. Retrieved 11 December 2014.
339. ^ Payne, Ed (12 September 2014). "West African health centers can't keep up with Ebola outbreak, WHO says". CNN Health. Retrieved 15 September 2014.
340. ^ Ebola Response Roadmap Situation Report 18 September 2014 (PDF) (Report). WHO. 18 September 2014. Retrieved 19 September 2014.
341. ^ "Baby and maternal deaths soar in Sierra Leone amid Ebola fears – researchers". The Guardian. 7 October 2015. Retrieved 8 October 2015.
342. ^ "An Ebola treatment center". The Washington Post. Archived from the original on 27 September 2014. Retrieved 1 October 2014.
343. ^ Guidance for Safe Handling of Human Remains of Ebola Patients in U. S. Hospitals and Mortuaries (Report). Centers for Disease Control. Retrieved 1 October 2014.
344. ^ "В Гвинее открылся построенный РУСАЛом медцентр по борьбе с вирусом Эбола". Sdelanounas. 17 January 2015. Retrieved 18 January 2015.
345. ^ "Russia opens Ebola center in Guinea". Russia Beyond The Headlines. 17 January 2015. Archived from the original on 4 February 2016. Retrieved 18 January 2015.
346. ^ "Sierra Leone: MSF opens maternity unit for pregnant women with Ebola". Médecins Sans Frontières. Retrieved 30 January 2015.
347. ^ "Ebola: MSF opens new treatment centre in Kissy, Sierra Leone". Médecins Sans Frontières. 8 January 2015. Retrieved 11 April 2015.
348. ^ Frequently asked questions on Ebola virus disease (Report). WHO. 8 August 2014. Archived from the original on 20 April 2014. Retrieved 3 October 2014.
349. ^ "Woman saves three relatives from Ebola". CNN. 26 September 2014. Retrieved 14 October 2014.
350. ^ "Ebola Supplies Arrive in Liberia". Samaritan's Purse. 2 October 2014. Retrieved 3 October 2014.
351. ^ "In Order To Contain Ebola 9,000 Household Kits Arrive". Daily Observer. 25 September 2014. Archived from the original on 6 October 2014. Retrieved 4 October 2014.
352. ^ "Are Hospitals Part of the Ebola Problem? Charity Wants New Strategy". NBC News. 15 September 2013. Retrieved 3 October 2014.
353. ^ Bernstein, Lenny (22 September 2014). "New effort to fight Ebola in Liberia would move infected patients out of their homes". The Washington Post. Retrieved 2 October 2014.
354. ^ Youkee, Daniel; Brown, Colin S.; Lilburn, Paul; Shetty, Nandini; Brooks, Tim; Simpson, Andrew; Bentley, Neil; Lado, Marta; Kamara, Thaim B.; Walker, Naomi F.; Johnson, Oliver (21 December 2015). "Assessment of Environmental Contamination and Environmental Decontamination Practices within an Ebola Holding Unit, Freetown, Sierra Leone". PLOS ONE. 10 (12): e0145167. Bibcode:2015PLoSO..1045167Y. doi:10.1371/journal.pone.0145167. ISSN 1932-6203. PMC 4687095. PMID 26692018.
355. ^ Ebola (Ebola Virus Disease) (Report). CDC. Retrieved 28 October 2014.
356. ^ Chan, Margaret (12 August 2014). WHO Director-General briefs Geneva UN missions on the Ebola outbreak (Report). WHO. Archived from the original on 14 August 2014. Retrieved 14 August 2014.
357. ^ "Ebola Situation Report" (PDF). 1 July 2015. Retrieved 4 July 2015.
358. ^ McLaughlin, Eliott C. (10 December 2014). "Ebola fighters are Time's 'Person of the Year'". CNN World. Retrieved 10 December 2014.
359. ^ Ebola Virus Disease in Health Care Workers — Guinea, 2014 (Report). CDC. Retrieved 27 January 2016.
360. ^ Choi JH, Croyle MA; Croyle (December 2013). "Emerging targets and novel approaches to Ebola virus prophylaxis and treatment". BioDrugs. 27 (6): 565–83. doi:10.1007/s40259-013-0046-1. PMC 3833964. PMID 23813435.
361. ^ Clark DV, Jahrling PB, Lawler JV (September 2012). "Clinical management of filovirus-infected patients". Viruses. 4 (9): 1668–86. doi:10.3390/v4091668. PMC 3499825. PMID 23170178.
362. ^ "Ebola: The race for drugs and vaccines". BBC. 27 March 2015.
363. ^ Rush, James (13 November 2014). "Ebola virus: Clinical trials of three new treatments for disease to start in West Africa". The Independent. London. Retrieved 13 November 2014.
364. ^ "Genetic mutations in deadly Ebola virus appear to block antibody-based treatments". News-Medical.net. 14 September 2015. Retrieved 16 September 2015.
365. ^ van Griensven, Johan; Edwards, Tansy; de Lamballerie, Xavier; Semple, Malcolm G.; Gallian, Pierre; Baize, Sylvain; Horby, Peter W.; Raoul, Hervé; Magassouba, N'Faly; Antierens, Annick; Lomas, Carolyn; Faye, Ousmane; Sall, Amadou A.; Fransen, Katrien; Buyze, Jozefien; Ravinetto, Raffaella; Tiberghien, Pierre; Claeys, Yves; De Crop, Maaike; Lynen, Lutgarde; Bah, Elhadj Ibrahima; Smith, Peter G.; Delamou, Alexandre; De Weggheleire, Anja; Haba, Nyankoye (7 January 2016). "Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea". New England Journal of Medicine. 374 (1): 33–42. doi:10.1056/NEJMoa1511812. ISSN 0028-4793. PMC 5856332. PMID 26735992.
366. ^ Fausther-Bovendo H, Mulangu S, Sullivan NJ (June 2012). "Ebolavirus vaccines for humans and apes". Curr Opin Virol. 2 (3): 324–29. doi:10.1016/j.coviro.2012.04.003. PMC 3397659. PMID 22560007.
367. ^ Grady, Denise (22 April 2015). "Ebola Drug Works Against West African Strain in Study of Monkeys". The New York Times.
368. ^ Lai, Lilin; Davey, Richard; Beck, Allison; Xu, Yongxian; Suffredini, Anthony F.; Palmore, Tara; Kabbani, Sarah; Rogers, Susan; Kobinger, Gary; Alimonti, Judie; Link, Charles J.; Rubinson, Lewis; Ströher, Ute; Wolcott, Mark; Dorman, William; Uyeki, Timothy M.; Feldmann, Heinz; Lane, H. Clifford; Mulligan, Mark J. (5 March 2015). "Emergency Postexposure Vaccination With Vesicular Stomatitis Virus–Vectored Ebola Vaccine After Needlestick". JAMA. 313 (12): 1249–55. doi:10.1001/jama.2015.1995. PMC 4874522. PMID 25742465.
369. ^ Smart, Ben; Lucas, Liza (17 July 2015). "Results are in: Inhalable Ebola vaccine, Lyme disease". CNN.
370. ^ a b Sridhar, S (2015). "Clinical development of Ebola vaccines". Ther Adv Vaccines. 3 (5–6): 125–38. doi:10.1177/2051013615611017. PMC 4667768. PMID 26668751.
371. ^ "Vesicular Stomatitis Virus–Based Ebola Vaccines With Improved Cross-Protective Efficacy". The Oxford Press. Archived from the original on 12 October 2014. Retrieved 1 August 2015.
372. ^ Henao-Restrepo, Ana Maria; Longini, Ira M; Egger, Matthias; Dean, Natalie E; Edmunds, W John; Camacho, Anton; Carroll, Miles W; Doumbia, Moussa; Draguez, Bertrand; Duraffour, Sophie; Enwere, Godwin; Grais, Rebecca; Gunther, Stephan; Hossmann, Stefanie; Kondé, Mandy Kader; Kone, Souleymane; Kuisma, Eeva; Levine, Myron M; Mandal, Sema; Norheim, Gunnstein; Riveros, Ximena; Soumah, Aboubacar; Trelle, Sven; Vicari, Andrea S; Watson, Conall H; Kéïta, Sakoba; Kieny, Marie Paule; Røttingen, John-Arne (August 2015). "Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial". The Lancet. 386 (9996): 857–866. doi:10.1016/S0140-6736(15)61117-5. hdl:10144/575218. PMID 26248676. S2CID 40830730.
373. ^ "World on the verge of an effective Ebola vaccine" (Press release). WHO. Archived from the original on 31 July 2015. Retrieved 31 July 2015.
374. ^ Chappell, Bill (31 July 2015). "New Ebola Vaccine Has '100 Percent' Effectiveness In Early Results". NPR. Retrieved 31 July 2015.
375. ^ Ben Hirschler; Kate Kelland (20 January 2016). "Vaccines alliance signs $5 million advance deal for Merck's Ebola shot". Reuters. Retrieved 27 January 2016.
376. ^ "Final trial results confirm Ebola vaccine provides high protection against disease". 23 December 2006.
377. ^ "Democratic Republic of Congo: Ebola Virus Disease - External Situation Report 17: Declaration of End of Ebola Virus Disease Outbreak". ReliefWeb. Retrieved 26 July 2018.
378. ^ Why the Ebola outbreak has been underestimated (Report). WHO. Archived from the original on 23 August 2014. Retrieved 9 October 2014.
379. ^ "West & Central Africa – Information by Country". UNICEF. Archived from the original on 7 October 2014. Retrieved 9 October 2014.
380. ^ Santermans, Eva; Robesyn, Emmanuel; Ganyani, Tapiwa; Sudre, Bertrand; Faes, Christel; Quinten, Chantal; Bortel, Wim Van; Haber, Tom; Kovac, Thomas; Reeth, Frank Van; Testa, Marco; Hens, Niel; Plachouras, Diamantis (15 January 2016). "Spatiotemporal Evolution of Ebola Virus Disease at Sub-National Level during the 2014 West Africa Epidemic: Model Scrutiny and Data Meagreness". PLOS ONE. 11 (1): e0147172. Bibcode:2016PLoSO..1147172S. doi:10.1371/journal.pone.0147172. ISSN 1932-6203. PMC 4714854. PMID 26771513.
381. ^ Ebola Virus Factsheet (Report). WHO. September 2014. Retrieved 28 October 2014.
382. ^ Rambaut, Andrew (7 August 2014). "Case Fatality Rate for ebolavirus". Epidemic. Archived from the original on 29 August 2014. Retrieved 16 September 2014.
383. ^ Ebola Response Roadmap Situation Report 2, 5 September 2014 (Report). WHO. Archived from the original on 4 September 2014. Retrieved 18 September 2014.
384. ^ Ebola Situation report (Report). WHO. 12 January 2015. Archived from the original on 5 September 2014. Retrieved 28 January 2015.
385. ^ Bailes, Adam (22 October 2014). "Ebola Increases Threat to Sierra Leone Pregnancies". Voice of America. Retrieved 26 October 2014.
386. ^ "Basic Reproductive Rate (Ro)". University of Michigan. Archived from the original on 4 November 2014. Retrieved 16 September 2014.
387. ^ Althaus, Christian L. (2014). "Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa". PLOS Currents. 6. arXiv:1408.3505. Bibcode:2014arXiv1408.3505A. doi:10.1371/currents.outbreaks.91afb5e0f279e7f29e7056095255b288. PMC 4169395. PMID 25642364.
388. ^ Hunt, Allen G. (11 October 2014). "Exponential growth in Ebola outbreak since May 14, 2014". Complexity. 20 (2): 8–11. Bibcode:2014Cmplx..20b...8H. doi:10.1002/cplx.21615.
389. ^ WHO Virtual Press Conference on the third meeting of the International Health Regulations Emergency Committee regarding the 2014 Ebola outbreak in West Africa (PDF) (Report). WHO. Retrieved 5 November 2014.
390. ^ Kupferschmidt, Kai (31 August 2014). "Disease modelers project a rapidly rising toll from Ebola". Science (news). Retrieved 11 April 2015.
391. ^ Nishiura, H; Chowell, G (11 September 2014). "Early Transmission Dynamics of Ebola Virus Disease (EVD), West Africa, March to August 2014". Eurosurveillance. 19 (36): 20894. doi:10.2807/1560-7917.ES2014.19.36.20894. PMID 25232919.
392. ^ "Virologist: Fight against Ebola in Sierra Leone and Liberia is lost". Deutsche Welle. 11 September 2014. Retrieved 11 September 2014.
393. ^ Szabo, Liz (22 September 2014). "Could the Ebola outbreak last forever?". USA Today. Retrieved 22 September 2014.
394. ^ Farrar, Jeremy J. (23 September 2014). "The Ebola Emergency — Immediate Action, Ongoing Strategy" (PDF). New England Journal of Medicine. 371 (16): 1545–1546. doi:10.1056/NEJMe1411471. PMID 25244185. S2CID 29201795.
395. ^ "Overnight Health: Congress begs for attention on Ebola". The Hill. 19 November 2014. Retrieved 20 November 2014.
396. ^ McNeil, Donald G. Jr. (16 December 2014). "Fewer Ebola Cases Go Unreported Than Thought, Study Finds". The New York Times. Retrieved 11 April 2015.
397. ^ "West African economies feeling ripple effects of Ebola, says UN" (Press release). United Nations Development Programme. 12 March 2015. Archived from the original on 18 March 2015. Retrieved 20 March 2015.
398. ^ "IMF says Ebola impacted West African nations may need economic assistance". Australian News.Net.
399. ^ Jeremy Bowles (2016). "Ebola, jobs and economic activity in Liberia". Journal of Epidemiology and Community Health. 70 (3): 271–277. doi:10.1136/jech-2015-205959. PMC 4789821. PMID 26438188.
400. ^ a b Stanturf, John A.; Goodrick, Scott L.; Warren, Melvin L. Jr.; Charnley, Susan; Stegall, Christie M. (1 September 2015). "Social Vulnerability and Ebola Virus Disease in Rural Liberia". PLOS ONE. 10 (9): e0137208. Bibcode:2015PLoSO..1037208S. doi:10.1371/journal.pone.0137208. ISSN 1932-6203. PMC 4556488. PMID 26325519.
401. ^ Mark Anderson (22 August 2014). "Ebola: airlines cancel more flights to affected countries". The Guardian. Retrieved 25 August 2014.
402. ^ "Ebola Wreaks Economic Woe In West Africa". NPR.org. NPR. 17 July 2014. Retrieved 25 August 2014.
403. ^ Lomax, Selma (20 August 2014). "Liberia: Ebola Outbreak Affects Agriculture in Lofa County". allAfrica.com. Retrieved 25 August 2014.
404. ^ a b "First WHO worker infected by Ebola, DR Congo reports cases". Rappler.com. 15 August 2014. Retrieved 25 August 2014.
405. ^ "Ebola threatens food security in West Africa: FAO". Reuters. 2 September 2014. Archived from the original on 22 December 2015. Retrieved 3 September 2014.
406. ^ "Ebola Threatens Millions With Food Insecurity". VOA. 17 December 2014. Retrieved 19 December 2014.
407. ^ The Christian Science Monitor (29 July 2015). "How West Africa is ramping up food security after Ebola outbreak". Christian Science Monitor. The Christian Science Monitor. Retrieved 10 August 2015.
408. ^ "Ebola Virus Eats Into West Africa's Economic Growth". AFKInsider. 21 August 2014. Archived from the original on 27 August 2014. Retrieved 25 August 2014.
409. ^ "Impact of Ebola on e-commerce in Nigeria". CNBC Africa. Archived from the original on 29 November 2014. Retrieved 16 December 2014.
410. ^ "Nigeria: Lagos Hotels Lose N8 Billion Over Ebola Outbreak". allAfrica.com. Retrieved 3 May 2015.
411. ^ Brock, Joe (20 August 2014). "Ebola fears slowing tourist flow to Africa". Reuters. Archived from the original on 6 March 2016. Retrieved 25 August 2014.
412. ^ "Video: Impact of Ebola on e-commerce in Nigeria". CNBC Africa. Archived from the original on 29 November 2014. Retrieved 16 December 2014.
413. ^ "Mixed grill for businesses as Ebola impacts economy". Vanguard News. 15 September 2014. Retrieved 16 December 2014.
414. ^ Williams, Briohny (7 January 2015). "The Gambia's tourist industry reels from Ebola fallout". BBC News. Retrieved 13 January 2015.
415. ^ Ghana News Agency (24 February 2015). "Ebola scares tourist from Cape Coast Castle in 2014". spyghana.com. Archived from the original on 2 April 2015. Retrieved 28 February 2015.
416. ^ Tom Murphy (May 2015). "Tourists abandon Ghana despite its successes against Ebola". Humanosphere. Archived from the original on 3 May 2015. Retrieved 10 May 2015.
417. ^ "Kenya Tourism Board releases Sh140 million for tourism campaigns". Standard Digital News. 8 March 2015. Retrieved 8 March 2015.
418. ^ "Tourism receipts down 3%". The Standard. 29 March 2015. Retrieved 10 April 2015.
419. ^ Sharon Gilbert-Rivett (15 April 2015). "Africa Travel Week focuses on sustainable tourism". The M&G Online. Retrieved 16 April 2015.
420. ^ "UK employees leave Sierra Leone over Ebola threat". BBC News. 3 June 2014. Retrieved 25 August 2014.
421. ^ "West Africa Ebola outbreak forces miners to lock down operations, delay projects". MINING.com. 10 August 2014. Retrieved 25 August 2014.
422. ^ "Ebola crisis: Oxfam calls for recovery Marshall Plan". BBC News. 27 January 2015. Retrieved 27 January 2015.
423. ^ "Ebola-hit countries call for $8 bn aid plan". newvision.co.ug. Archived from the original on 18 April 2015. Retrieved 19 April 2015.
424. ^ "IMF policies blamed for weak Ebola response". The Telegraph. London. 22 December 2014. Archived from the original on 12 January 2022. Retrieved 23 December 2014.
425. ^ "Ghana, Business Advice, Jobs, News, Business Directory, Real Estate, Finance, Forms, Auto". Business Ghana. Retrieved 20 December 2014.
426. ^ AFP. "IMF under pressure to cancel Ebola-hit countries' debts". Times LIVE. Retrieved 5 January 2015.
427. ^ "IMF hopes for deal soon on debt forgiveness for Ebola countries". Reuters. 30 January 2015. Archived from the original on 2 February 2015. Retrieved 3 February 2015.
428. ^ "IMF increases support to Liberian economy following Ebola outbreak". Public Finance International. Retrieved 14 January 2016.
429. ^ Titcomb, James (8 October 2014). "World Bank rings alarm over £20bn worst-case Ebola scenario". The Telegraph. London. Archived from the original on 12 January 2022. Retrieved 8 October 2014.
430. ^ "New World Bank Group Study Forecasts Billions in Economic Loss". World Bank. Retrieved 8 October 2014.
431. ^ "Liberia: Rebuilding Ebola-Hit Economy – Focus of World Bank Spring Event". allAfrica.com. Retrieved 16 April 2015.
432. ^ Alexandra Sifferlin (23 July 2015). "'We Are Not Prepared For Another Epidemic': World Bank Survey". Time. Retrieved 3 August 2015.
433. ^ "World Bank Group Ebola Response Fact Sheet". World Bank. 15 December 2015. Retrieved 20 December 2015.
434. ^ Flynn, Daniel (6 July 2015). "Ebola-stricken nations need $700 million to rebuild healthcare". Reuters. Retrieved 8 July 2015.
435. ^ "Ebola-Hit Countries Get Pledges of $3.4 Billion to Rebuild - ABC News". 11 July 2015. Archived from the original on 11 July 2015. Retrieved 27 March 2019.
436. ^ Betsy McKay (11 July 2015). "Donors Pledge $3.4 Billion for Ebola Recovery Plan". The Wall Street Journal.
437. ^ "United Nations News Centre". UN News Service Section. 29 September 2015. Retrieved 4 October 2015.
438. ^ "China's investment in Africa down 43%". The Irish Times. 24 November 2015. Retrieved 7 December 2015.
439. ^ "Update 1 – Liberia to slash spending 11 pct amid mining slowdown". Reuters. 25 January 2016. Retrieved 9 June 2016.
440. ^ WHO Statement on the Meeting of the International Health Regulations Emergency Committee Regarding the 2014 Ebola Outbreak in West Africa (Report). WHO. 8 August 2014. Archived from the original on 8 August 2014. Retrieved 8 August 2014.
441. ^ "WHO says Ebola outbreak could strike 20,000 people". Reuters. 28 August 2014. Retrieved 28 August 2014.
442. ^ Dopplick, Renée (29 April 2009). "Swine Flu: Legal Obligations and Consequences When the WHO Declares a "Public Health Emergency of International Concern"". Inside Justice. Retrieved 6 June 2014.
443. ^ "Ebola 'threat to world security'- UN Security Council". BBC News. 18 September 2014. Retrieved 18 September 2014.
444. ^ "WHO warns Ebola response could cost $1B". The Hill. 16 September 2014. Retrieved 16 September 2014.
445. ^ a b Ebola Response Roadmap Situation Report 15 October 2014 (PDF) (Report). WHO. p. 5. Retrieved 29 October 2014.
446. ^ "Global Response". United Nations Mission for Ebola Emergency Response. Retrieved 29 October 2014.
447. ^ Ebola response roadmap situation report 17 December 2014 (Report). WHO. Archived from the original on 19 December 2014. Retrieved 19 December 2014.
448. ^ Lewis, Rosie (5 November 2014). "Tony Abbott ramps up Ebola response with medics and money". theaustralian.com.au. Retrieved 18 March 2024.
449. ^ Shinn, David H.; Eisenman, Joshua (2023). China's Relations with Africa: a New Era of Strategic Engagement. New York: Columbia University Press. ISBN 978-0-231-21001-0.
450. ^ "Ebola". Pandemic. internationalsos.com. Retrieved 22 May 2015.
451. ^ Bruce-Cunning, Nick. (18 May 2015). WHO Leader Outlines Changes in Response to Ebola Epidemic. The New York Times.
452. ^ WHO Director-General addresses high-level conference on global health security (Report). WHO. Archived from the original on 29 March 2016. Retrieved 28 October 2016.
453. ^ Cheng, Maria; Satter, Raphael (20 March 2015). "Emails: UN health agency resisted declaring Ebola emergency". Associated Press. Retrieved 21 March 2015.
454. ^ "UN senior leaders outline needs for global Ebola response" (Press release). WHO. 3 September 2014. Archived from the original on 7 September 2014. Retrieved 7 September 2014.
455. ^ "WHO chief promises transparency on Ebola failures". Associated Press. Archived from the original on 1 January 2015. Retrieved 31 December 2014.
456. ^ McVeigh, Tracy (18 October 2014). "Oxfam calls for troops in Africa as criticism of 'inadequate' Ebola response mounts". The Guardian. Retrieved 24 October 2014.
457. ^ "WHO leadership admits failings over Ebola, promises reform". Reuters. Retrieved 16 January 2016.
458. ^ Sarah Boseley (18 May 2015). "Plan to reform WHO after Ebola to be unveiled by Angela Merkel". The Guardian. Retrieved 19 May 2015.
459. ^ "G7 underwhelms with Ebola response". Politico. 8 June 2015. Retrieved 17 June 2015.
460. ^ a b Moon, Suerie; Sridhar, Devi; Pate, Muhammad A; Jha, Ashish K; Clinton, Chelsea; Delaunay, Sophie; Edwin, Valnora; Fallah, Mosoka; Fidler, David P; Garrett, Laurie; Goosby, Eric; Gostin, Lawrence O; Heymann, David L; Lee, Kelley; Leung, Gabriel M; Morrison, J Stephen; Saavedra, Jorge; Tanner, Marcel; Leigh, Jennifer A; Hawkins, Benjamin; Woskie, Liana R; Piot, Peter (2015). "Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola". The Lancet. 386 (10009): 2204–2221. doi:10.1016/S0140-6736(15)00946-0. PMC 7137174. PMID 26615326.
461. ^ "Ebola crisis: WHO slammed by Harvard-convened panel over slow response". CNN. 23 November 2015. Retrieved 23 November 2015.
462. ^ "Ebola global response was 'too slow', say health experts". BBC News. 23 November 2015. Retrieved 23 November 2015.
463. ^ Green, Andrew (20 December 2014). "Remembering health workers who died from Ebola in 2014". The Lancet. 384 (9961): 2201–2206. doi:10.1016/S0140-6736(14)62417-X. ISSN 0140-6736. PMID 25625389. S2CID 23124192.
464. ^ "Latest Ebola outbreak over in Liberia; West Africa is at zero, but new flare-ups are likely to occur". World Health Organization. Retrieved 28 October 2016.
465. ^ "Ebola Situation Report". WHO. 23 September 2015. Archived from the original on 26 September 2015. Retrieved 28 October 2016.
466. ^ "Ebola Situation Report". WHO. 9 December 2015. Archived from the original on 11 December 2015. Retrieved 28 October 2016.
467. ^ "Ebola Situation Report – 25 November 2015 | Ebola". WHO. Archived from the original on 30 November 2015. Retrieved 28 October 2016.
468. ^ "Ebola Situation Report – 11 November 2015 | Ebola". WHO. Archived from the original on 11 November 2015. Retrieved 28 October 2016.
469. ^ "Ebola Situation Report" (PDF). World Health Organization. 28 October 2015. Retrieved 30 October 2015.
470. ^ "Ebola Situation Report" (PDF). World Health Organization. 14 October 2015. Retrieved 22 October 2015.
471. ^ Miles, Tom (22 October 2014). "Official WHO Ebola toll near 5,000 with true number nearer 15,000". Reuters. Retrieved 11 April 2015.
472. ^ "Ebola virus disease, West Africa". WHO. 22 August 2014. Archived from the original on 20 September 2014. Retrieved 18 September 2014.
473. ^ "Ebola Situation Report – 26 August 2015 | Ebola". WHO. Archived from the original on 28 August 2015. Retrieved 28 October 2016.
474. ^ "Ebola Situation Response Roadmap Situation Report Update" (PDF). World Health Organization. 5 November 2014. Retrieved 5 November 2014.
475. ^ "WHO: Ebola Response Roadmap Situation Report 1 October 2014" (PDF). WHO. 2014. Retrieved 28 October 2016.
476. ^ "Ebola virus disease, West Africa – update 31 July 2014". WHO. Archived from the original on 24 September 2014. Retrieved 18 September 2014.
477. ^ "2014 Ebola Outbreak in West Africa – Outbreak Distribution Map| Ebola Hemorrhagic Fever | CDC". CDC. Retrieved 29 October 2016.
478. ^ Nnenna Ibeh (21 August 2014). "Ebola: Lagos hospital which treated Patrick Sawyer to receive N4m". The Premium Times.
479. ^ "Ebola's heavy toll on study authors". 28 August 2014. Retrieved 18 October 2014.
480. ^ "Dr Ameyo Adadevoh dies from Ebola virus infection YNaija l The Internet Newspaper for Young Nigerians". Ynaija.com. 19 August 2014. Retrieved 20 August 2014.
481. ^ "Texas Ebola Patient Thomas Eric Duncan Has Died". ABC News. 8 October 2014. Retrieved 8 October 2014.
482. ^ Baker, Aryn (27 February 2017). "Liberian Ebola Fighter, a TIME Person of the Year, Dies in Childbirth". Time. Retrieved 15 March 2017.
483. ^ Raab, Lauren (8 December 2014). "With Ian Crozier's reveal, here are the 10 Ebola patients treated in U.S." Los Angeles Times. Retrieved 8 May 2015.
484. ^ Nicolson, Stuart (18 August 2016). "Profile: Ebola nurse Pauline Cafferkey". BBC News. Retrieved 8 December 2016.
485. ^ "Liberia: top doctor becomes latest Ebola victim". The Guardian. 27 July 2014. Retrieved 28 July 2014.
486. ^ Vogel, Gretchen (28 August 2014). "Ebola's heavy toll on study authors". AAAS. Retrieved 12 January 2015.

## Further reading

[edit]

* Fevers, Feuds, and Diamonds: Ebola and the Ravages of History. Paul Farmer. New York: Farrar, Straus and Giroux, 2020. ISBN 978-0-374-23432-4

* Bullard, Stephan Gregory. 2018. A Day-by-Day Chronicle of the 2013–2016 Ebola Outbreak. Springer.

* Carroll, Miles W.; Matthews, David A.; Hiscox, Julian A.; et al. (6 August 2015). "Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa". Nature. 524 (7563): 97–101. Bibcode:2015Natur.524...97C. doi:10.1038/nature14594. hdl:10144/575409. ISSN 1476-4687. PMC 10601607. PMID 26083749.
* Ruibal, Paula; Oestereich, Lisa; Lüdtke, Anja; et al. (2016). "Unique human immune signature of Ebola virus disease in Guinea". Nature. 533 (7601): 100–104. Bibcode:2016Natur.533..100R. doi:10.1038/nature17949. hdl:10144/612892. PMC 4876960. PMID 27147028.
* "CDC Press Releases Detailed History of the 2014–2016 Ebola Response in MMWR". Centers for Disease Control and Prevention. January 2016. Retrieved 9 July 2016.
* Guidelines on Core Components of Infection Prevention and Control Programmes at the National and Acute Health Care Facility Level. World Health Organization. 2016. ISBN 978-92-4-154992-9. PMID 27977095. Retrieved 18 December 2016.
* Mulangu, Sabue; Alfonso, Vivian H.; Hoff, Nicole A.; et al. (10 January 2018). "Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo". The Journal of Infectious Diseases. 217 (4): 529–537. doi:10.1093/infdis/jix619. ISSN 1537-6613. PMC 5853806. PMID 29329455.
* "The role of training in the West Africa Ebola response World Health Organization A review of the role of training in WHO Ebola emergency response" (PDF). Weekly Epidemiological Record. April 2016. Retrieved 24 April 2016.
* Dickson, S. J.; Clay, K. A.; Adam, M.; et al. (14 December 2017). "Enhanced case management can be delivered for patients with EVD in Africa: Experience from a UK military Ebola treatment centre in Sierra Leone". The Journal of Infection. 76 (4): 383–392. doi:10.1016/j.jinf.2017.12.006. ISSN 1532-2742. PMC 5903873. PMID 29248587.
* Kateh, Francis; Nagbe, Thomas; Kieta, Abraham; et al. (27 February 2015). "Rapid response to Ebola outbreaks in remote areas - Liberia, July-November 2014/Centers for Disease Control and Prevention". MMWR. Morbidity and Mortality Weekly Report. 64 (7): 188–192. ISSN 1545-861X. PMC 5779593. PMID 25719682.
* Park, Daniel J.; Dudas, Gytis; Wohl, Shirlee; et al. (18 June 2015). "Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone(Free edition PMC)". Cell. 161 (7): 1516–1526. doi:10.1016/j.cell.2015.06.007. ISSN 1097-4172. PMC 4503805. PMID 26091036.
* Walker, N. F.; Brown, C. S.; Youkee, D.; et al. (26 March 2015). "Evaluation of a point-of-care blood test for identification of Ebola virus disease at Ebola holding units, Western Area, Sierra Leone, January to February 2015". Euro Surveillance. 20 (12): 21073. doi:10.2807/1560-7917.es2015.20.12.21073. ISSN 1560-7917. PMID 25846490.
* Yang, Shu; Xu, Miao; Lee, Emily M.; et al. (2018). "Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry". Cell Discovery. 4: 31. doi:10.1038/s41421-018-0034-1. ISSN 2056-5968. PMC 5986771. PMID 29872540.

## External links

[edit]

Scholia has a topic profile for Western African Ebola epidemic.

Ebola virus epidemic in West Africa at Wikipedia's sister projects

* Media from Commons
* Quotations from Wikiquote
* Data from Wikidata

* "Ebola response roadmap – Situation reports". WHO. Archived from the original on 17 June 2016. Retrieved 11 April 2015.
* "Outbreak Updates". World Health Organization (WHO). Archived from the original on 24 April 2015. Retrieved 11 April 2015.
* "Outbreak Updates". US Centers for Disease Control and Prevention (CDC). Retrieved 11 April 2015.
* "Ebola Outbreak in West Africa Updates". Food and Agriculture Organization of the UN (FAO). Archived from the original on 19 April 2015. Retrieved 11 April 2015.
* "2014 Ebola Outbreak – detail timeline and projection". healthmap.org. Retrieved 11 April 2015.
* "Platform to share communication materials regarding the Ebola epidemic". Ebola Communication Network. Retrieved 11 April 2015.
* "Fighting Ebola: A Grand Challenge for Development – Platform to collect and distribute ideas to stop the Ebola epidemic". USAID. Archived from the original on 4 January 2016. Retrieved 11 April 2015.
* "Ebola outbreak in West Africa". European Centre for Disease Prevention and Control (ECDC). 27 August 2010. Retrieved 11 April 2015.
* "Ebolafacts – a simple FAQ in English & French". Retrieved 11 April 2015.

* "Battling the Ebola Outbreak in West Africa". MSF USA. Doctors Without Borders/Médecins Sans Frontières. 25 July 2014. Archived from the original on 12 June 2018. Retrieved 9 June 2018.

### Resources

[edit]

1. ^ "Disease Outbreak News (DONs)". Global Alert and Response (GAR). WHO. Archived from the original on 25 January 2003. Retrieved 11 April 2015. This website's content changes frequently.
2. ^ "Disease Outbreak News". Regional Office for Africa. WHO. Archived from the original on 24 April 2015. Retrieved 11 April 2015. This website's content changes frequently.
3. ^ "West and Central Africa". HumanitarianResponse.info. OCHA. Retrieved 11 April 2015.

* v
* t
* e

Filoviridae

Ebolavirus|

| Outbreaks|

* 1976 Sudan outbreak
* 1976 Zaire outbreak
* 2013−2016 West African Ebola virus epidemic
* Timeline
* Reported cases and deaths
* Responses
* United Nations Ebola Response Fund
* Operation United Assistance
* in Guinea
* in Liberia
* in Mali
* in Nigeria
* in Sierra Leone
* in Spain
* in the US
* in the UK
* Ouse to Ouse Tock
* Womey massacre
* Recent DR Congo outbreaks and epidemics
* 2014
* 2017
* 2018 Équateur
* Kivu epidemic
* 2020 Équateur
* 2021 North Kivu

|

Species|

* Bundibugyo ebolavirus
* BDBV
* Reston ebolavirus
* RESTV
* Sudan ebolavirus
* SUDV
* Taï Forest ebolavirus
* TAFV
* Zaire ebolavirus
* EBOV

Drug candidates|

* BCX4430
* Brincidofovir
* DZNep
* Favipiravir
* FGI-103
* FGI-104
* FGI-106
* JK-05
* Lamivudine
* mAb114
* TKM-Ebola (failed)
* Triazavirin
* ZMapp
* Vaccines
* cAd3-ZEBOV

Drugs|

* Vaccines
* rVSV-ZEBOV

Notable people|

* Ebola researchers
* William Close
* Jean-Jacques Muyembe-Tamfum
* Peter Piot
* Ebola patients
* Ameyo Adadevoh
* Kent Brantly
* Pauline Cafferkey
* Thomas Eric Duncan
* Salome Karwah
* Sheik Umar Khan
* Matthew Lukwiya
* Mayinga N'Seka
* Patrick Sawyer

Popular culture|

* The Hot Zone (1995 book by Richard Preston)
* Outbreak (1995 film)
* Ebola Syndrome (1996 film)
* Executive Orders (1996 novel)
* Ebola-chan (2014 meme)
* 93 Days (2016 film)
* The Hot Zone (2019 miniseries based on Preston book)

Miscellaneous|

* Ebola virus disease
* Ebola virus disease treatment research
* Ebola River

Marburgvirus|

| Outbreaks|

* 1967 Marburg virus outbreak in West Germany
* 2017 Uganda Marburg virus outbreak
* 2021 Marburg virus disease outbreak in Guinea
* 2022 Marburg virus disease outbreak in Ghana
* 2023 Marburg virus disease outbreak in Equatorial Guinea
* 2023 Marburg virus disease outbreak in Tanzania
* 2024 Marburg virus disease outbreak in Rwanda

|

Species|

* Marburg marburgvirus
* MARV
* RAVV

Drug candidates|

* BCX4430
* FGI-103
* FGI-106

Popular culture|

* The Hot Zone (1995 book)

Miscellaneous|

* Marburg virus disease
* Marburg

Cuevavirus|

| Species|

* Lloviu cuevavirus (LLOV)

|

Dianlovirus|

| Species|

* Mengla virus (MLAV)

|

Striavirus|

| Species|

* Xilang striavirus

|

Thamnovirus|

| Species|

* Huangjiao thamnovirus

|

* Commons
* Wikispecies

* v
* t
* e

Pandemics, epidemics and notable disease outbreaks

* List of epidemics and pandemics

Local|

| Ancient|

* Hittite plague (c. 1330 BC)
* Plague of Athens (429–426 BC)
* Antonine Plague (165–180 AD)
* Plague of Cyprian (250–266)

|

Post-
classical|

* Plague of Justinian (541–542)
* Roman Plague (590)
* Plague of Sheroe (627–628)
* Plague of Amwas (638–639)
* Plague of 664 (664–689)
* Japanese smallpox (735–737)
* Black Death (1346–1353)
* Sweating sickness (1485–1551)

Early
modern|

| 16th century|

* Influenza pandemic (1510)
* Mexican smallpox (1520)
* "Cocoliztli" epidemics in colonial Mexico (1545, 1576)
* Influenza pandemic (1557–1559)
* London plague (1563–1564)
* Maltese plague (1592–1593)
* London plague (1592–1593)

|

17th century|

* London plague (1603)
* Maltese plague (1623)
* Italian plague (1629–1631)
* Massachusetts smallpox (1633)
* Great Plague in the late Ming dynasty (1633–1644)
* Great Plague of Seville (1647–1652)
* Maltese plague (1655)
* Naples Plague (1656)
* Great Plague of London (1665–1666)
* Maltese plague (1675–1676)
* Great Plague of Vienna (1679)

18th century|

* Iceland smallpox epidemic (1707–1708)
* Great Northern War plague (1710–1712)
* Great Plague of Marseille (1720–1722)
* Great Plague of 1738 (1738)
* Russian plague (1770–1772)
* Persian Plague (1772)
* North American smallpox (1780–1782)
* Philadelphia yellow fever (1793–1798)

Modern|

| 19th century|

* Ottoman plague (1812–1819)
* Maltese plague (1813–1814)
* Caragea's plague (1813)
* Groningen epidemic (1829)
* Great Plains smallpox (1837–1838)
* Typhus (1847–1848)
* Copenhagen cholera (1853)
* Stockholm cholera (1853)
* Broad Street cholera (1854)
* Guam smallpox (1856)
* Pacific Northwest smallpox (1862–1863)
* Barcelona yellow fever (1870)
* Buenos Aires yellow fever (1871)
* Hong Kong plague (1894)

|

20th century|

* San Francisco plague (1900–1904)
* Manchurian plague (1910–1911)
* LA pneumonic plague (1924)
* Croydon typhoid (1937)
* NYC smallpox (1947)
* Wrocław smallpox (1963)
* Yugoslav smallpox (1972)
* London flu (1972–1973)
* Indian smallpox (1974)
* Surat plague (1994)
* Malaysian Nipah virus (1998–1999)

21st century|

* SARS (2002–2004)
* Midwest monkeypox (2003)
* Bird flu (2003–2005)
* Singaporean dengue (2005)
* Indian dengue (2006)
* Chikungunya outbreaks (2006)
* Pakistani dengue (2006)
* Iraqi cholera (2007)
* Zimbabwean cholera (2008–2009)
* Madagascar plague (2008–2017)
* Bolivian dengue (2009)
* Gujarat hepatitis (2009)
* Western African meningitis (2009–2010)
* Haiti cholera (2010–2019)
* Pakistani dengue (2011)
* Darfur yellow fever (2012)
* MERS (2012)
* Singaporean dengue (2013)
* Swansea measles (2013)
* Chikungunya (2013–2014)
* Western African Ebola (2013–2016)
* DR Congo Ebola (2014)
* Madagascar plague (2014)
* Odisha hepatitis (2014)
* Polio declaration (2014)
* Indian swine flu (2015)
* South Korean MERS (2015)
* Zika (2015–2016)
* Angolan yellow fever (2016)
* Yemeni cholera (2016–2022)
* Gorakhpur Japanese encephalitis (2017)
* Saudi Arabian MERS (2018)
* Kerala Nipah virus (2018)
* Équateur province Ebola (2018)
* Kivu Ebola (2018–2020)
* Madagascar measles (2018)
* Samoa measles (2019)
* Philippine measles (2019)
* Pacific NW measles (2019)
* New York measles (2019)
* Kuala Koh measles (2019)
* Tonga measles (2019)
* DRC measles (2019–2020)
* New Zealand measles (2019–2020)
* Singaporean dengue (2020)
* Uganda Ebola (2022–2023)
* Jamaica dengue (2023)
* Bangsamoro measles (2023–present)
* 2024 Latin American dengue
* Argentina (2024)

Global|

* First plague pandemic (541–767)
* Second plague pandemic (1348–19th century)
* Influenza pandemic (1510)
* Influenza pandemic (1557–1559)
* First cholera pandemic (1816–1826)
* Second cholera pandemic (1829–1851)
* Third cholera pandemic (1852–1860)
* Third plague pandemic (1855–1860)
* Fourth cholera pandemic (1863–1879)
* Fifth cholera pandemic (1881–1896)
* Russian flu (1889–1890)
* Sixth cholera pandemic (1899–1923)
* Spanish flu (1918–1920)
* encephalitis lethargica epidemic (1919–1930)
* Asian flu (1957–1958)
* Seventh cholera pandemic (1961–1975)
* Hong Kong flu (1968–1970)
* Russian flu pandemic (1977–1979)
* HIV/AIDS (1981–present)
* Swine flu (2009–2010)
* COVID-19 (2019–present*)
* Mpox (clade II) outbreak (2022–2023)
* Mpox (clade Ib) epidemic (2023–2024)

* v
* t
* e

Humanitarian aid

* Humanitarian aid
* in conflict zones
* Humanitarianism
* Humanitarian principles
* International humanitarian law

History|

| 1850s, Creation of
the Red Cross|

* Henry Dunant
* Battle of Solferino
* A Memory of Solferino
* Red Cross Movement
* Geneva Conventions
* International Humanitarian Fact-Finding Commission

|

Post WWII|

* History of the United Nations
* 1951 Refugee Convention

21st-century
reform attempts|

* World Humanitarian Summit
* Grand Bargain
* Localisation
* Humanitarian-Development Nexus
* Inter-Agency Standing Committee
* Humanitarian Cluster System

Humanitarian
organizations|

| UN agencies|

* UNHCR
* OCHA
* IOM
* WFP
* UNICEF
* WHO

|

Red Cross Movement|

* Seville Agreement
* ICRC
* The Federation (IFRC)
* National Societies
* Protective Emblems

International agencies|

* Action Against Hunger
* Catholic Relief Services
* CARE
* Danish Refugee Council
* International Medical Corps
* International Rescue Committee
* Islamic Relief
* Médecins du Monde
* Médecins Sans Frontières
* Mercy Corps
* Norwegian Refugee Council
* Oxfam
* Guardian Girls
* Save the Children
* World Vision
* Koyamada International Foundation

Consortiums|

* NEAR Network
* CALP
* Global Refugee-Led Network

Local agencies|

* BRAC
* Adeso
* Network for Refugee Voices
* Yemen Relief and Reconstruction Foundation

Analysis and reporting|

* ODI
* ALNAP
* The State of the Humanitarian System
* The New Humanitarian
* ReliefWeb
* Global Humanitarian Overview

Notable people|

* Degan Ali
* Jan Egeland
* Christos Christou
* Winnie Byanyima
* Martin Griffiths
* Jemilah Mahmood
* Hugo Slim
* Peter Maurer
* James Orbinski
* Rachel Kiddell-Monroe
* MacKenzie Scott
* Melinda Gates
* Jamshedji Tata
* Michael Bloomberg
* Warren Buffett
* Bill Gates

Donors and funding|

* CERF
* USAID
* Japan
* FCDO (UK)
* Norway
* ECHO (EU)
* Canada
* Turkey
* France
* OECD
* Bill and Melinda Gates Foundation
* Yield Giving

Major emergencies|

* Chinese Famine of 1870s
* Great Indian Famine of 1870s
* Ethiopian famine 1980s
* 2004 tsunami
* 2010 Haiti earthquake
* 2011 East Africa drought
* Typhoon Haiyan
* Central African Republic Civil War
* Western African Ebola outbreak
* Iraq War
* South Sudanese Civil War
* Rohingya genocide
* Syrian civil war
* Yemeni Civil War

Standards,
power, abuse|

* CHS Alliance
* Sexual exploitation and abuse
* Core Humanitarian Standard
* Sphere (organization)
* Sphere Handbook
* The State of the World's Cash 2020

Aid worker safety|

* Attacks on humanitarian workers
* Aid Worker Security Database
* World Humanitarian Day
* Health Care In Danger Campaign
* Kunduz hospital airstrike
* Airstrikes on Yemen
* Dolo hospital airstrike

Related fields|

* Human Rights
* International development
* Peacekeeping
* Neocolonialism

Related articles|

* 2015 European migrant crisis
* Detention Centres in Libya
* Crisis mapping
* Humanitarian Networks and Partnerships Weeks
* United Nations response to the COVID-19 pandemic
* Aid effectiveness

World portal

Topics of most severely affected countries

* v
* t
* e

Guinea articles

History|

* Regional history
* Songhai Empire
* Imamate of Futa Jallon
* Wassoulou Empire
* African slave trade
* French West Africa
* Rivières du Sud
* French Guinea
* Sékou Touré's rule
* Guinea-Bissau War of Independence
* Portuguese invasion
* Camp Boiro
* 1984 coup d'état
* 2007 protests
* 2008 military unrest
* 2008 coup d'état
* 2009 protests
* 2014 Ebola virus epidemic
* 2020 coronavirus pandemic
* 2021 coup d'état

Geography|

* Biosphere reserves
* Borders
* Cities
* Ecoregions
* Mountains
* Protected areas
* Rivers
* Wildlife

Politics|

* Administrative divisions
* Cabinet
* Elections
* Foreign relations
* Human rights
* LGBT
* Military
* Parliament
* Political parties
* President
* Prime Minister

Economy|

* Agriculture
* Central bank
* Energy
* Franc (currency)
* Mining
* Telecommunications
* Trade unions
* Transport

Society|

* Abortion
* Demographics
* Education
* Ethnic groups
* Health
* Languages
* Religion

Culture|

* Anthem
* Cinema
* Cuisine
* Coat of arms
* Flag
* Music
* Polygamy
* Sports

* Outline
* Index

* Category
* Portal

* v
* t
* e

Liberia articles

History|

* Colonization (1821–1847)
* Americo-Liberian rule (1847–1980)
* 1871 coup d'état
* 1980 coup d'état
* Samuel Doe era (1980–1989)
* 1985 coup attempt
* First Civil War (1989–1997)
* 1994 coup attempt
* 1998 Monrovia clashes
* Second Civil War (1999–2003)
* 2014 Ebola virus epidemic
* 2020 coronavirus pandemic

Geography|

* Cities
* Borders
* Environmental issues (Climate change)
* Forests
* Islands
* Mountains
* Rivers
* Wildlife

Politics|

* Administrative divisions
* Constitution
* Elections
* Cabinet
* Foreign relations
* Government ministries
* Human rights
* LGBT
* Judiciary
* Supreme Court
* Chief Justice
* Military
* Chief of Staff
* Parliament
* Police
* Political parties
* President
* Vice President

Economy|

* Agriculture
* Central bank
* Communications
* Dollar (currency)
* Energy
* Mining
* Tourism
* Transport

Society|

* Abortion
* Corruption
* Crime
* Demographics
* Education
* Ethnic groups
* Gender inequality
* Health
* Languages
* Public holidays
* Religion
* Squatting
* Women

Culture|

* Cinema
* Coat of arms
* Cuisine
* Flag
* Media
* Music
* Polygamy
* Sport

* Outline
* Index

* Category
* Portal

* v
* t
* e

Mali articles

History|

* Ghana Empire
* Pre-Imperial Mali
* Mali Empire
* History of the Mali Empire
* Songhai Empire
* Bamana Empire
* Kénédougou Kingdom
* Kaarta
* Massina Empire
* Toucouleur Empire
* Wassoulou Empire
* French Sudan
* Mali Federation
* 2012 Tuareg rebellion
* 2012 coup
* Mali War
* Ebola disease event
* 2020 protests
* 2020 coup
* 2021 coup

Geography|

* Borders
* Cercles
* Cities
* Communes
* Environmental issues
* Mountains
* National parks
* Regions
* Rivers
* Wildlife

Politics|

* Constitution
* Elections
* Foreign relations
* Human rights
* LGBT rights
* Law enforcement
* Military
* National Assembly
* Political parties
* President
* Prime Minister
* Vice President

Economy|

* Foreign aid
* Telecommunications
* Tourism
* Transport

Society|

* Child marriage
* Demographics
* Ethnic groups
* Education
* Health
* Human trafficking
* Languages
* Prostitution
* Religion
* Slavery
* Women

Culture|

* Cuisine
* Films
* Flag
* Literature
* Media
* Music
* Polygamy
* Public holidays

* Outline
* Index

* Category
* Portal

* v
* t
* e

Nigeria articles

History|

* Kingdoms
* Empires

* Aro
* Benin
* Kanem-Bornu
* Nri
* Oyo
* Hausa kingdoms
* Kano
* Daura
* Katsina
* Zazzau
* Gobir
* Biram
* Rano
* Sokoto
* Kebbi
* Kwararafa

|

* Timeline
* Early history
* before 1500
* 1500-1800
* Colonial Nigeria
* Northern Nigeria
* Southern Nigeria
* First Republic
* Military dictatorship
* Civil War
* Second Republic
* Third Republic
* Fourth Republic

Geography|

* Adamawa Plateau
* Borders
* Cities
* Climate change
* Ecoregions
* Environmental issues
* Islands
* Jos Plateau
* Mountains
* National parks
* Niger Delta
* Rivers
* Niger
* Benue
* Wildlife
* Wildlife conservation

Politics|

* Administrative divisions
* Villages
* Cabinet
* Constitution
* Elections
* Federal Executive Council
* Foreign relations
* Human rights
* LGBT rights
* Human trafficking
* Law enforcement
* Military
* National Assembly
* House of Representatives
* Senate
* Political parties
* PDP
* APC
* President
* Vice-President
* Supreme Court

Economy|

* Agriculture
* Brain Drain
* Central Bank
* Corruption
* Economic history
* Energy
* Mining
* Naira (currency)
* Petroleum
* Stock Exchange
* Telecommunications
* Tourism
* Transport

Society|

* Abortion
* Censorship
* Baby factories
* Capital punishment
* Child labour (Girl child labour)
* Child marriage
* Child sexual abuse
* Corruption
* Crime
* Demographics
* Diaspora
* Domestic violence
* Education
* Ethnic groups
* MASSOB
* MOSOP
* Oodua Peoples Congress
* Female genital mutilation
* Gender inequality
* Health
* Languages
* Polygamy
* Poverty
* Prostitution
* Protests
* Refugees
* Social class
* Slavery
* Sustainable Development Goals
* Water supply and sanitation
* Women
* Youth

* Conflicts

* Communal conflicts in Nigeria (Herder–farmer conflicts in Nigeria)
* Islamist insurgency
* Niger Delta conflicts
* 2016 conflict

|

Culture|

* Anthem
* Cinema
* Coat of arms
* Cuisine
* Flag
* List of Nigerians
* Literature
* Media
* Music
* Public holidays
* Religion (Sharia)
* Smoking
* Video gaming

* Outline
* Index

* Category
* Portal

* v
* t
* e

Sierra Leone articles

History|

* Atlantic slave trade
* (1600–1787)
* British colony (1787–1961)
* Sierra Leone in World War II (1939–1945)
* Early independence (1961–1978)
* 1961–71
* Civil War (1991–2002)
* 2002 to present
* 2014 Ebola virus epidemic
* COVID-19 pandemic

Geography|

* Borders
* Cities and towns
* Climate
* Protected areas
* Upper Guinean forests
* Water supply
* Wildlife

Politics|

* Administrative divisions
* Cabinet
* Chief Minister
* Elections
* Foreign relations
* Government
* Human rights
* Judiciary
* Law enforcement
* Military
* Chief of the Defence Staff
* Parliament
* Political parties
* President
* Special Court
* Supreme Court
* Vice-President

Economy|

* Agriculture
* Banking
* Central bank
* Leone (currency)
* Mining
* Telecommunications
* Tourism
* Trade unions
* Transport

Society|

* Abortion
* Child marriage
* Demographics
* Disability
* Education
* Ethnic groups
* Female genital mutilation
* Health
* Human trafficking
* Languages
* LGBT rights
* Polygamy
* Prostitution
* Religion
* Women

Culture|

* Anthem
* Art
* Coat of arms
* Cuisine
* Flag
* Media
* Music
* Sports

* Outline

* Category
* Portal

Portals:

* Africa
* Current events
* Medicine
* Viruses

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