White cerebellum sign

Pattern seen in radiologic examinations

The white cerebellum sign, also known as reversal sign or dense cerebellum sign, is a radiological sign denoting the relatively white appearance of the cerebellum due to a generalized decrease in density of the supratentorial brain structures caused by extensive edema.[1]

## Causes

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White cerebellum sign can be associated with raised intracranial pressure[2] that occurs due to anoxic or ischemic changes in the brain.[3] It can be found in:

* Birth asphyxia
* Status epilepticus
* Bacterial meningitis
* Encephalitis
* Severe head trauma
* Post-cardiac arrest hypoxia
* Drowning

## Pathophysiology

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Diffuse brain edema is the likely cause of this radiological change observed in CT or MRI.[2]

## Prognosis

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It was considered to indicate a bad prognosis.[4] However, evidence suggests that it could be a non-specific indicator of diffuse brain edema which might not be as ominous as previously thought.[2]

## References

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1. ^ Chavhan, GB; Shroff, MM (2008). "Twenty classic signs in neuroradiology: A pictorial essay". The Indian Journal of Radiology & Imaging. 19 (2): 135–45\. doi:10.4103/0971-3026.50835. PMC 2765171. PMID 19881070.135-45&rft.date=2008&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765171#id-name=PMC&rft_id=info:pmid/19881070&rft_id=info:doi/10.4103/0971-3026.50835&rft.aulast=Chavhan&rft.aufirst=GB&rft.au=Shroff,+MM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765171&rfr_id=info:sid/en.wikipedia.org:White+cerebellum+sign" class="Z3988">
2. ^ a b c Chalela, JA; Rothlisberger, J; West, B; Hays, A (June 2013). "The white cerebellum sign: an under recognized sign of increased intracranial pressure". Neurocritical Care. 18 (3): 398–9\. doi:10.1007/s12028-013-9836-z. PMID 23589182. S2CID 2152985.398-9&rft.date=2013-06&rft_id=https://api.semanticscholar.org/CorpusID:2152985#id-name=S2CID&rft_id=info:pmid/23589182&rft_id=info:doi/10.1007/s12028-013-9836-z&rft.aulast=Chalela&rft.aufirst=JA&rft.au=Rothlisberger,+J&rft.au=West,+B&rft.au=Hays,+A&rfr_id=info:sid/en.wikipedia.org:White+cerebellum+sign" class="Z3988">
3. ^ Han, BK; Towbin, RB; De Courten-Myers, G; McLaurin, RL; Ball WS, Jr (1988). "Reversal sign on CT: effect of anoxic/ischemic cerebral injury in children". AJNR. American Journal of Neuroradiology. 10 (6): 1191–8\. PMC 8332434. PMID 2512781.1191-8&rft.date=1988&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332434#id-name=PMC&rft_id=info:pmid/2512781&rft.aulast=Han&rft.aufirst=BK&rft.au=Towbin,+RB&rft.au=De+Courten-Myers,+G&rft.au=McLaurin,+RL&rft.au=Ball+WS,+Jr&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332434&rfr_id=info:sid/en.wikipedia.org:White+cerebellum+sign" class="Z3988">
4. ^ Krishnan, P; Chowdhury, SR (October 2014). ""White cerebellum" sign - A dark prognosticator". Journal of Neurosciences in Rural Practice. 5 (4): 433. doi:10.4103/0976-3147.140015. PMC 4173255. PMID 25288860.

## External resources

[edit]

Jha, Praveen. "White cerebellum sign | Radiology Reference Article | Radiopaedia.org". radiopaedia.org. Retrieved 2017-03-26.

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