XPO6

Protein-coding gene in the species Homo sapiens

XPO6

Identifiers
Aliases| XPO6, EXP6, RANBP20, exportin 6
External IDs| OMIM: 608411; MGI: 2429950; HomoloGene: 12544; GeneCards: XPO6; OMA:XPO6 - orthologs
| Gene location (Human)

Chr.| Chromosome 16 (human)[1]

Band| 16p12.1| Start| 28,097,976 bp[1]
End| 28,211,965 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 F3| Start| 125,700,887 bp[2]
End| 125,799,673 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* blood

* granulocyte

* left testis

* right testis

* spleen

* epithelium of colon

* C1 segment

* tibial nerve

* upper lobe of left lung

* right frontal lobe

| Top expressed in

* tail of embryo

* genital tubercle

* granulocyte

* spermatocyte

* dentate gyrus of hippocampal formation granule cell

* ventricular zone

* spermatid

* yolk sac

* epiblast

* seminiferous tubule

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protein binding
* nuclear export signal receptor activity

Cellular component|

* plasma membrane
* nucleolus
* nucleus
* cytoplasm
* cytosol
* protein-containing complex

Biological process|

* protein transport
* intracellular protein transport
* protein export from nucleus

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

23214

74204

Ensembl| |

ENSG00000169180

ENSMUSG00000000131

UniProt| |

Q96QU8

Q924Z6

RefSeq (mRNA)| |

NM_001270940
NM_015171

NM_028816
NM_001311143

RefSeq (protein)| |

NP_001257869
NP_055986

NP_001298072
NP_083092

Location (UCSC)| Chr 16: 28.1 – 28.21 Mb| Chr 7: 125.7 – 125.8 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.[5][6]

Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of Ran-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169180 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000131 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Stuven T, Hartmann E, Gorlich D (Oct 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
6. ^ a b "Entrez Gene: XPO6 exportin 6".

## Further reading

[edit]

* Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
* Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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