Y Y Y

Protein domain

Protein family

Y_Y_Y

Identifiers
Symbol| Y_Y_Y
Pfam| PF07495
Pfam clan| CL0159
InterPro| IPR011123
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

In molecular biology, the YYY domain is a protein domain that is considered to be important in bacterial signal transduction, however the exact function of this protein domain is not known. It is named after the three conserved tyrosines found in the alignment. The domain forms part of the periplasmic sensor domain which binds to unsaturated disaccharides.[1]

## Structure

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This region is mostly found to the C-terminus of the beta propellers (INTERPRO) in a family of two component regulators. However they are also found tandemly repeated in SWISSPROT without other signal conduction domains being present. The structure of this domain contains 8 beta strands organised into a beta sandwich Immunoglobulin-like fold.

## References

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1. ^ Lowe EC, Baslé A, Czjzek M, Firbank SJ, Bolam DN (2012). "A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system". Proc Natl Acad Sci U S A. 109 (19): 7298–303. doi:10.1073/pnas.1200479109. PMC 3358863. PMID 22532667.

This article incorporates text from the public domain Pfam and InterPro: IPR011123