Zinc-activated ion channel

ZACN

Identifiers
Aliases| ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs| OMIM: 610935 HomoloGene: 52296 GeneCards: ZACN
| Gene location (Human)

Chr.| Chromosome 17 (human)[1]

Band| 17q25.1| Start| 76,071,961 bp[1]
End| 76,083,666 bp[1]
| RNA expression pattern

Bgee| | Top expressed in

* Brodmann area 9

* anterior pituitary

* prefrontal cortex

* hypothalamus

* amygdala

* nucleus accumbens

* putamen

* caudate nucleus

* right lobe of thyroid gland

* Ganglionic eminence

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* extracellular ligand-gated ion channel activity
* zinc ion binding
* ligand-gated ion channel activity
* ion channel activity
* serotonin-gated cation-selective channel activity
* transmembrane signaling receptor activity

Cellular component|

* integral component of membrane
* plasma membrane
* membrane
* integral component of plasma membrane
* neuron projection
* synapse

Biological process|

* response to zinc ion
* ion transport
* signal transduction
* ion transmembrane transport
* serotonin receptor signaling pathway
* chemical synaptic transmission
* regulation of membrane potential
* nervous system process

Sources:Amigo / QuickGO
Orthologs
Species| Human| Mouse
Entrez| |

353174

n/a

Ensembl| |

ENSG00000186919

n/a

UniProt| |

Q401N2

n/a

RefSeq (mRNA)| |

NM_180990

n/a

RefSeq (protein)| |

NP_851321

n/a

Location (UCSC)| Chr 17: 76.07 – 76.08 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[3]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[3][4] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[3]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186919 \- Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
4. ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.

* v
* t
* e

Ion channel, cell surface receptor: ligand-gated ion channels

Cys-loop receptors|

| 5-HT/serotonin|

* 5-HT3
* A
* B
* C
* D
* E

|

GABA|

* GABAA
* α1
* α2
* α3
* α4
* α5
* α6
* β1
* β2
* β3
* γ1
* γ2
* γ3
* δ
* ε
* π
* θ
* GABAA-ρ
* ρ1
* ρ2
* ρ3

Glycine|

* α1
* α2
* α3
* α4
* β

Nicotinic acetylcholine|

* monomers: α1
* α2
* α3
* α4
* α5
* α6
* α7
* α9
* α10
* β1
* β2
* β3
* β4
* δ
* ε

* pentamers: (α3)2(β4)3
* (α4)2(β2)3
* (α7)5
* (α1)2(β4)3 \- Ganglion type
* (α1)2β1δε - Muscle type

Zinc|

* Zinc-activated

Ionotropic glutamates|

| Ligand-gated only|

* AMPA (1
* 2
* 3
* 4)
* Kainate
* 1
* 2
* 3
* 4
* 5

|

Voltage- and ligand-gated|

* NMDA
* 1
* 2A
* 2B
* 2C
* 2D
* 3A
* 3B
* L1A
* L1B

‘Orphan’|

* GluD
* δ1
* δ2

ATP-gated channels|

| Purinergic receptors|

* P2X
* 1
* 2
* 3
* 4
* 5
* 6
* 7

|

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template