DEDD

識別號
别名| DEDD；, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
外部ID| OMIM：606841 MGI：1333874 HomoloGene：7980 GeneCards：DEDD
| 基因位置（人类）

染色体| 1號染色體[1]

基因座| 1q23.3| 起始| 161,120,974 bp[1]
终止| 161,132,688 bp[1]
| 基因位置（小鼠）

染色体| 小鼠1号染色体[2]

基因座| 1 H3|1 79.34 cM| 起始| 171,156,713 bp[2]
终止| 171,169,899 bp[2]
RNA表达模式

查阅更多表达数据
| 基因本體

分子功能| • 血浆蛋白结合
• DNA结合

細胞組分| • 細胞質
• 细胞核
• 核仁

生物學過程| • regulation of apoptotic process
• regulation of transcription, DNA-templated
• transcription, DNA-templated
• 细胞凋亡
• 精子发生
• extrinsic apoptotic signaling pathway via death domain receptors
• negative regulation of protein catabolic process
• 蛻膜化
• negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

Sources:Amigo / QuickGO
直系同源
物種| 人類| 小鼠
Entrez| |

9191

21945

Ensembl| |

ENSG00000158796

ENSMUSG00000013973

UniProt| |

O75618

Q9Z1L3

mRNA​序列| |

​NM_001039711
​NM_001039712
​NM_004216
​NM_032998
​NM_001330765

| NM_001128609
​NM_011615
​NM_001357550
​NM_001357551
​NM_001357552

​NM_001357553

蛋白序列| |

NP_001034800
​NP_001034801
​NP_001317694
​NP_127491

| NP_001122081
​NP_035745
​NP_001344479
​NP_001344480
​NP_001344481

​NP_001344482

基因位置​（UCSC）| Chr 1: 161.12 – 161.13 Mb| Chr 1: 171.16 – 171.17 Mb
PubMed​查找| [3]| [4]
維基數據
| 檢視/編輯人類| 檢視/編輯小鼠

|

含死亡效应结构域蛋白（英語：Death effector domain containing protein）是人类中由DEDD基因编码的蛋白质。[5][6][7]

## 相互作用[编辑]

DEDD已被证明可以与以下基因产生相互作用：

* CFLAR[8][9]
* 胱天蛋白酶8[8][10][11]
* FADD[5][9]

## 参考资料[编辑]

1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158796 \- Ensembl, May 2017
2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 \- Ensembl, May 2017
3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ 5.0 5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
6. ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .
7. ^ Entrez Gene: DEDD death effector domain containing.
8. ^ 8.0 8.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
9. ^ 9.0 9.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .
10. ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
11. ^ Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

## 延伸阅读[编辑]

* Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 .
* Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
* Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 . PMID 12235123. doi:10.1083/jcb.200112124.
* Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
* Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 .
* Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .