Medical Research

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Medical disclaimer: This page is for educational and informational purposes only and may not be construed as medical advice. The information is not intended to replace medical advice offered by physicians. Please refer to the full text of the Wikiversity medical disclaimer.

This page lists current researches in developing cures and therapies for different pathologies.

The goal of this page is to be a tool see the current state of each research, how it's progressing or if it had failed.

Please help expand it!

# Diabetes type 1

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* Cell Based Therapeutics[1]

# Diabetes type 2

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# Kidney failure

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* Growing a Kidney In-Situ / De novo organogenesis[2]

* Cell Transplantation[2]

* Growing a Kidney In-Vitro[2]

* Reseeding a Kidney: Decellularized Scaffolds[2]

* Bioengineering a Kidney[2]

* Bioartificial Renal Epithelial Cell System (BRECS)[2]

* Implantable Renal Assist Device (iRAD)[2] / implantable bioartificial kidney (BAK)[3]

# Cancer

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# Crohn's disease

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* Bupropion[4][5][6]

# Major Depressive Disorder

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## Inflammation-related depression

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Studies shows for an elevated cytokines in depressed patients: IL-1β, IL-6, sIL-2R (soluble IL-2 receptors) and TNF-α [7] and those cytokines may reduce monoamine levels.[8]

Konsman present an important critical review paper on the subject.[9]

* Anti-inflammatory Treatment[10]

# See Also

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* Drug discovery

# References

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1. ↑ Zamboni, Fernanda; Collins, Maurice N. (2017-4). "Cell based therapeutics in type 1 diabetes mellitus". International Journal of Pharmaceutics (Elsevier) 521 (1-2): 346–356. doi:10.1016/j.ijpharm.2017.02.063. ISSN 0378-5173. PMID 28242376. https://linkinghub.elsevier.com/retrieve/pii/S037851731730162X.
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Kim, S; Fissell, WH; Humes, DH; Roy, S (2015). "Current strategies and challenges in engineering a bioartificial kidney". Frontiers in bioscience (Elite edition) 7: 215-228. 2015-01-01. ISSN 1945-0494. PMID 25553375. PMC PMC4383659. //www.ncbi.nlm.nih.gov/pmc/articles/PMCPMC4383659/.
3. ↑ Humes, HD; Buffington, D; Westover, AJ; Roy, S; Fissell, WH (March 2014). "The bioartificial kidney: current status and future promise". Pediatric Nephrology 29 (3): 343–351. doi:10.1007/s00467-013-2467-y. ISSN 0931-041X. http://link.springer.com/10.1007/s00467-013-2467-y.
4. ↑ Kast, RE; Altschuler, EL (Nov 2001). "Remission of Crohn's disease on bupropion". Gastroenterology (Elsevier) 121 (5): 1260–1261. doi:10.1053/gast.2001.29467. ISSN 0016-5085. PMID 11706830. https://linkinghub.elsevier.com/retrieve/pii/S0016508501700212.
5. ↑ Mosaic, LS. "Why a third of antidepressants are prescribed for something else". CNN. Retrieved 2019-07-06.
6. ↑ Brustolim, D; Ribeiro-dos-Santos, R; Kast, RE; Altschuler, EL; Soares, MBP (Jun 2006). "A new chapter opens in anti-inflammatory treatments:The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International Immunopharmacology (Elsevier) 6 (6): 903–907. doi:10.1016/j.intimp.2005.12.007. ISSN 1567-5769. PMID 16644475. https://linkinghub.elsevier.com/retrieve/pii/S1567576906000026.
7. ↑ Liu, Yang; Ho, Roger Chun-Man; Mak, Anselm (2012-8). "Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression". Journal of Affective Disorders 139 (3): 230–239. doi:10.1016/j.jad.2011.08.003. ISSN 1573-2517. PMID 21872339.
8. ↑ Yang, Longfei; Zhao, Yinghao; Wang, Yicun; Liu, Lei; Zhang, Xingyi; Li, Bingjin; Cui, Ranji (2015-08-31). "The Effects of Psychological Stress on Depression". Current Neuropharmacology 13 (4): 494–504. doi:10.2174/1570159x1304150831150507. PMID 26412069. PMC PMC4790405. https://www.researchgate.net/profile/Lancelot_Young/publication/281769375_The_Effects_of_Psychological_Stress_on_Depression/links/58ca4d5f92851c4b5e6f685b/The-Effects-of-Psychological-Stress-on-Depression.pdf.
9. ↑ Konsman, JP (2019-02-14). "Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation". Pharmaceuticals 12 (1). doi:10.3390/ph12010029. ISSN 1424-8247. PMID 30769887. PMC 6469164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469164/.
10. ↑ Kopschina Feltes, Paula; Doorduin, Janine; Klein, Hans C; Juárez-Orozco, Luis Eduardo; Dierckx, Rudi AJO; Moriguchi-Jeckel, Cristina M; de Vries, Erik FJ (2017-9). "Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy". Journal of Psychopharmacology (Oxford, England) 31 (9): 1149–1165. doi:10.1177/0269881117711708. ISSN 0269-8811. PMID 28653857. PMC 5606303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606303/.