SPA1

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene. [1] [2] The product of this gene regulates cell differentiation. [3] It is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [2] [4]

## References

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1. ↑ Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N (Mar 1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics 39 (1): 66–73. doi:10.1006/geno.1996.4464. PMID 9027487.
2. ↑ 2.0 2.1 "Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1".
3. ↑ http://www.si-rna.com/showabstract.php?pmid=18033671
4. ↑ http://en.wikipedia.org/wiki/SIPA1