Bing Xia

Bing Xia is a Chinese American scientist and professor at the Rutgers Cancer Institute of New Jersey, where he directs the Xia Laboratory. He is best known for his discovery of the PALB2 tumor suppressor gene, a notable scientific advance in the field of cancer genetics.

Background

Xia was born and raised in China and earned a B.S. degree in biochemistry from Wuhan University in 1992. He migrated to United States to pursue his graduate education at the University of Medicine and Dentistry of New Jersey (now Rutgers Biomedical and Health Sciences) in 1996. He completed his Ph.D. degree in biochemistry and molecular biology in 2001, and subsequently completed postdoctoral work at Dana-Farber Cancer Institute and Harvard Medical School. In 2007, Xia returned to New Jersey and started his independent laboratory at Rutgers Cancer Institute of New Jersey and has been there ever since. He was promoted to associate professor in 2013 and full professor in 2019.^[1]

Work

Xia is a researcher focused on elucidating the molecular mechanisms and developmental path for PALB2/BRCA associated cancers with the goal of enhancing cancer treatment or prevention.^[2]

Publications

• Xia, Bing; Sheng, Qing; Nakanishi, Koji; Ohashi, Akihiro; Wu, Jianmin; Christ, Nicole; Liu, Xinggang; Jasin, Maria et al. (2006-06-23). "Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2". Molecular Cell 22 (6): 719–729. doi:10.1016/j.molcel.2006.05.022. ISSN 1097-2765. PMID 16793542. https://pubmed.ncbi.nlm.nih.gov/16793542. 
• Erkko, Hannele; Xia, Bing; Nikkilä, Jenni; Schleutker, Johanna; Syrjäkoski, Kirsi; Mannermaa, Arto; Kallioniemi, Anne; Pylkäs, Katri et al. (2007-03-15). "A recurrent mutation in PALB2 in Finnish cancer families". Nature 446 (7133): 316–319. doi:10.1038/nature05609. ISSN 1476-4687. PMID 17287723. Bibcode: 2007Natur.446..316E. https://pubmed.ncbi.nlm.nih.gov/17287723. 
• Rahman, Nazneen; Seal, Sheila; Thompson, Deborah; Kelly, Patrick; Renwick, Anthony; Elliott, Anna; Reid, Sarah; Spanova, Katarina et al. (February 2007). "PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene". Nature Genetics 39 (2): 165–167. doi:10.1038/ng1959. ISSN 1061-4036. PMID 17200668. 
• Xia, Bing; Dorsman, Josephine C.; Ameziane, Najim; de Vries, Yne; Rooimans, Martin A.; Sheng, Qing; Pals, Gerard; Errami, Abdellatif et al. (February 2007). "Fanconi anemia is associated with a defect in the BRCA2 partner PALB2". Nature Genetics 39 (2): 159–161. doi:10.1038/ng1942. ISSN 1061-4036. PMID 17200672. https://pubmed.ncbi.nlm.nih.gov/17200672. 
• Tischkowitz, Marc; Xia, Bing; Sabbaghian, Nelly; Reis-Filho, Jorge S.; Hamel, Nancy; Li, Guilan; van Beers, Erik H.; Li, Lili et al. (2007-04-17). "Analysis of PALB2/FANCN-associated breast cancer families". Proceedings of the National Academy of Sciences of the United States of America 104 (16): 6788–6793. doi:10.1073/pnas.0701724104. ISSN 0027-8424. PMID 17420451. Bibcode: 2007PNAS..104.6788T. 
• Jones, Siân; Hruban, Ralph H.; Kamiyama, Mihoko; Borges, Michael; Zhang, Xiaosong; Parsons, D. Williams; Lin, Jimmy Cheng-Ho; Palmisano, Emily et al. (2009-04-10). "Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene". Science 324 (5924): 217. doi:10.1126/science.1171202. ISSN 1095-9203. PMID 19264984. Bibcode: 2009Sci...324..217J. 
• Yang, Xin; Leslie, Goska; Doroszuk, Alicja; Schneider, Sandra; Allen, Jamie; Decker, Brennan; Dunning, Alison M.; Redman, James et al. (2020-03-01). "Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families". Journal of Clinical Oncology 38 (7): 674–685. doi:10.1200/JCO.19.01907. ISSN 1527-7755. PMID 31841383. 

References

External links

• PubMed search for Bing Xia

0.00 (0 votes) Original source: https://en.wikipedia.org/wiki/Bing Xia. Read more