Chris Sander is a computational biologist based at the Dana-Farber Cancer Center. Previously he was chair of the Computational Biology Programme at the Memorial Sloan–Kettering Cancer Center in New York City .[5][6][7][8][9][10][11] Recently, he moved his lab to the Dana–Farber Cancer Institute[12] and the Cell Biology Department at Harvard Medical School.[13]
Sander originally trained as a physicist receiving his undergraduate degree from the University of Berlin in 1967.[14] After a period studying at the University of California, Berkeley and the Niels Bohr Institute in Copenhagen,[14][15] he gained his PhD degree in theoretical physics from the State University of New York in 1975. His thesis was titled Analytic properties of bound state wave functions.[16]
Research
Sander credits his move from theoretical physics to computational biology to Fred Sanger's 1977 landmark paper in Nature,[17] in which the nucleotide sequence of bacteriophage φX174 was published.[14] Sander has made many contributions to the field of structural bioinformatics including developing tools such as the Families of Structurally Similar Proteins (FSSP) database[18] and the DSSP algorithm for assigning secondary structure to the amino acids of a protein, given the atomic-resolution coordinates of that protein.[19]
Sander has also worked at the European Bioinformatics Institute, has served as chief information officer for the biopharmaceutical company Millennium Pharmaceuticals and has been an advisor to IBM's Deep Computing Initiative, which produced the Deep Blue chess computer.[20]
Awards and Honours
Sander is a former Executive Editor for the journal Bioinformatics. In 2014 he was appointed one of the first Honorary Editors of Bioinformatics.[21]
↑Ouzounis, Christos (1993). The role of sequence conservation in the prediction of protein structure (PhD thesis). University of York. OCLC53486615. EThOSuk.bl.ethos.387193.
↑{{DBLP}} template missing ID and not present in Wikidata.
↑Rost, B.; Sander, C. (1993). "Prediction of Protein Secondary Structure at Better than 70% Accuracy". Journal of Molecular Biology232 (2): 584–599. doi:10.1006/jmbi.1993.1413. PMID8345525.
↑Sander, C.; Schulz, G. E. (1979). "Degeneracy of the information contained in amino acid sequences: Evidence from overlaid genes". Journal of Molecular Evolution13 (3): 245–252. doi:10.1007/BF01739483. PMID228047. Bibcode: 1979JMolE..13..245S.
↑Sanger, F.; Air, G. M.; Barrell, B. G.; Brown, N. L.; Coulson, A. R.; Fiddes, J. C.; Hutchison, C. A.; Slocombe, P. M. et al. (24 February 1977). "Nucleotide sequence of bacteriophage φX174 DNA". Nature265 (5596): 687–695. doi:10.1038/265687a0. PMID870828. Bibcode: 1977Natur.265..687S.
↑Kabsch, W.; Sander, C. (1983). "Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features". Biopolymers22 (12): 2577–2637. doi:10.1002/bip.360221211. PMID6667333.