(S)-2-hydroxy-acid oxidase

(S)-2-hydroxy-acid oxidase
Glycolate oxidase tetramer, Human
Identifiers
EC number	1.1.3.15
CAS number	9037-63-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxy acid + O₂ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxo acid + H₂O₂

Thus, the two substrates of this enzyme are (S)-2-hydroxy acid and O₂, whereas its two products are 2-oxo acid and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-2-hydroxy-acid:oxygen 2-oxidoreductase. Other names in common use include glycolate oxidase, hydroxy-acid oxidase A, hydroxy-acid oxidase B, oxidase, L-2-hydroxy acid, hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, and L-2-hydroxy acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, FMN.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1AL7, 1AL8, 1GYL, 1TB3, and 2NZL.

References

• "l-Hydroxy acid oxidase". J. Biol. Chem. 163 (1): 137–144. 1946. doi:10.1016/S0021-9258(17)41353-6. PMID 21023634. http://www.jbc.org/content/163/1/137.full.pdf. 
• "Preparation and some properties of crystalline glycolic acid oxidase of spinach". J. Biol. Chem. 231 (1): 135–57. 1958. doi:10.1016/S0021-9258(19)77292-5. PMID 13538955. 
• "The oxidation of glycolic acid by a liver enzyme". J. Biol. Chem. 210 (1): 269–80. 1954. doi:10.1016/S0021-9258(18)65451-1. PMID 13201588. 
• "Crystalline mammalian L-amino acid oxidase from rat kidney mitochondria". J. Biol. Chem. 241 (9): 2075–83. 1966. doi:10.1016/S0021-9258(18)96668-8. PMID 5946631. 
• "Aliphatic L-alpha-hydroxyacid oxidase from rat livers: purification and properties". Biochim. Biophys. Acta 167 (1): 9–22. 1968. doi:10.1016/0005-2744(68)90273-8. PMID 5686300. 
• "Purification and characterization of glycolic acid oxidase from pig liver". Biochim. Biophys. Acta 227 (3): 500–20. 1971. doi:10.1016/0005-2744(71)90003-9. PMID 5569122. https://deepblue.lib.umich.edu/bitstream/2027.42/33685/1/0000197.pdf. 
• "The self-association of L-alpha hydroxyacid oxidase". Biochim. Biophys. Acta 427 (2): 679–87. 1976. doi:10.1016/0005-2795(76)90211-7. PMID 1268224. 
• "Experimental and computational investigation of enzyme functional annotations uncovers misannotation in the EC 1.1.3.15 enzyme class". PLOS Comput Biol 17 (9): e1009446. 2021. doi:10.1371/journal.pcbi.1009446. PMID 34555022. 

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