Branchpoint Binding Protein

Short description: Oren mRNA processing factor

Branchpoint Binding Protein (BBP) is an Orem RNA processing factor found in yeast. The protein complex binds to the branchpoint sequence (BPS) in the pre-mRNA, aiding in splice site recognition.^[1] In mammals, the homologous protein splicing factor 1, has a similar role.^[2]

The role of the protein in yeast cells has been the subject of study.^[2] The BPS that the protein binds to in yeast is UACUAAC.^[3]

References

↑ "BBP Involved in Splice Site Recognition". http://www.umbc.edu/bioclass/biol414/wiki/index.php?page=BBP_Involved_in_Splice_Site_Recognition.
↑ ^2.0 ^2.1 Rymond, B. C. (2010). The branchpoint binding protein: in and out of the spliceosome cycle. Adv Exp Med Biol. 693. pp. 123–41. doi:10.1007/978-1-4419-7005-3_9.
↑ Berglund, J.Andrew; Chua, Katrin; Abovich, Nadja; Reed, Robin; Rosbash, Michael (1997). "The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC". Cell 89 (5): 781–787. doi:10.1016/S0092-8674(00)80261-5. PMID 9182766.

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[1] "BBP Involved in Splice Site Recognition". http://www.umbc.edu/bioclass/biol414/wiki/index.php?page=BBP_Involved_in_Splice_Site_Recognition.

[Rymond2010-2] 2.0 ^2.1 Rymond, B. C. (2010). The branchpoint binding protein: in and out of the spliceosome cycle. Adv Exp Med Biol. 693. pp. 123–41. doi:10.1007/978-1-4419-7005-3_9.

[3] Berglund, J.Andrew; Chua, Katrin; Abovich, Nadja; Reed, Robin; Rosbash, Michael (1997). "The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC". Cell 89 (5): 781–787. doi:10.1016/S0092-8674(00)80261-5. PMID 9182766.

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Branchpoint Binding Protein

Topic: Biology

References