Corticosteroid receptor
Topic: Biology
From HandWiki - Reading time: 7 min
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The corticosteroid receptors are receptors for corticosteroids.[1] Corticosteroid receptors mediate the target organ response to the major products of the adrenal cortex, glucocorticoids (principally cortisol in man), and mineralocorticoids (principally aldosterone). They are members of the intracellular receptor superfamily which is highly evolutionarily conserved, and includes receptors for thyroid hormones, vitamin D, sex steroids, and retinoids.[2] They include the following two nuclear receptors:[1][3][4]
- Glucocorticoid receptor (type I) – glucocorticoids like cortisol
- Mineralocorticoid receptor (type I) – mineralocorticoids like aldosterone
There are also membrane corticosteroid receptors, including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized at present.[5][6][7]
References
- ↑ 1.0 1.1 Scott T. Brady; George J. Siegel; Robert Wayne Albers; Donald Lowell Price (2012). Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Academic Press. pp. 522–. ISBN 978-0-12-374947-5. https://books.google.com/books?id=NPqgM38h4LsC&pg=PA522.
- ↑ Walker, Brian R.; Stewart, Paul M.; Edwards, Christopher R.W. (1997), "Enzyme Modulation of Access to Corticosteroid Receptors", Molecular and Cellular Endocrinology, Principles of Medical Biology (Elsevier) 10: pp. 297–310, doi:10.1016/s1569-2582(97)80038-4, ISBN 978-1-55938-815-3, https://doi.org/10.1016/S1569-2582(97)80038-4, retrieved 2024-07-15
- ↑ Eugenia Wang; D. Stephen Snyder (13 August 1998). Handbook of the Aging Brain. Academic Press. pp. 22–. ISBN 978-0-08-053322-3. https://books.google.com/books?id=KdQN6ERV33IC&pg=PA22.
- ↑ Hormones, Brain and Behavior, Five-Volume Set. Academic Press. 18 June 2002. pp. 267–. ISBN 978-0-08-053415-2. https://books.google.com/books?id=6GgHpQdk8vYC&pg=PA267.
- ↑ "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling". Mol. Cell. Endocrinol. 350 (2): 299–309. 2012. doi:10.1016/j.mce.2011.06.020. PMID 21736918.
- ↑ "Minireview: rapid glucocorticoid signaling via membrane-associated receptors". Endocrinology 147 (12): 5549–56. 2006. doi:10.1210/en.2006-0981. PMID 16946006.
- ↑ "Non-genomic actions of aldosterone: from receptors and signals to membrane targets". Mol. Cell. Endocrinol. 350 (2): 223–34. 2012. doi:10.1016/j.mce.2011.07.019. PMID 21801805. https://figshare.com/articles/journal_contribution/10787066.
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