Flavonoid biosynthesis

Flavonoids are synthesized by the phenylpropanoid metabolic pathway in which the amino acid phenylalanine is used to produce 4-coumaroyl-CoA.^[1] This can be combined with malonyl-CoA to yield the true backbone of flavonoids, a group of compounds called chalcones, which contain two phenyl rings. Conjugate ring-closure of chalcones results in the familiar form of flavonoids, the three-ringed structure of a flavone. The metabolic pathway continues through a series of enzymatic modifications to yield flavanones → dihydroflavonols → anthocyanins. Along this pathway, many products can be formed, including the flavonols, flavan-3-ols, proanthocyanidins (tannins) and a host of other various polyphenolics.

Flavonoid Biosynthesis Diagrams

Biosynthesis of catechin

A biochemical diagram showing the class of flavonoids and their source in nature through various inter-related plant species.

Flavanoids can possess chiral carbons. Methods of analysis should take this element into account^[2] especially regarding bioactivity or enzyme stereospecificity.^[3]

The biosynthesis of flavonoids involves several enzymes.

• Anthocyanidin reductase
• Chalcone isomerase
• Dihydrokaempferol 4-reductase
• Flavone synthase
• Flavonoid 3'-monooxygenase
• Flavonol synthase
• Flavanone 3-dioxygenase
• Flavanone 4-reductase
• Leucoanthocyanidin reductase
• Leucocyanidin oxygenase
• Naringenin-chalcone synthase

• Apigenin 4'-O-methyltransferase
• Luteolin O-methyltransferase
• Quercetin 3-O-methyltransferase

• Anthocyanidin 3-O-glucosyltransferase
• Flavone 7-O-beta-glucosyltransferase
• Flavone apiosyltransferase
• Flavonol-3-O-glucoside L-rhamnosyltransferase
• Flavonol 3-O-glucosyltransferase

• Isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase

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