Holin superfamily VI

The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily VI includes two TC families:^[1]

• 1.E.12 - The φAdh Holin (φAdh Holin) Family
• 1.E.26 - The Holin LLH (Holin LLH) Family

Superfamily VI includes families with members only from Bacillota. These proteins appear to have one N-terminal transmembrane segment (TMS), followed by an amphipathic, weakly hydrophobic peak that was not predicted to be transmembrane by the topological programs used by Reddy and Saier (2013).^[2] The average sizes of the members of the two families belonging to the Holin superfamily VI are 135 ± 11 and 130 ± 26 amino acyl residues (aas), respectively.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

References

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