Lengsin
Topic: Biology
From HandWiki - Reading time: 1 min
 Generic protein structure example |
Lengsin is a protein that in humans is encoded by the LGSN gene.
Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[1] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.
References
- ↑ "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry 283 (10): 6607–15. March 2008. doi:10.1074/jbc.M709144200. PMID 18178558.
Further reading
- "Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens". Structure (London, England) 14 (12): 1823–34. December 2006. doi:10.1016/j.str.2006.10.008. PMID 17161372.
External links
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