MARK2

Short description: Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.^[1]^[2]^[3]

Function

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.^[3]

Interactions

MARK2 has been shown to interact with AKT1.^[4]

References

↑ "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet 81 (3–4): 278–82. Oct 1998. doi:10.1159/000015046. PMID 9730619.
↑ "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet 86 (1): 66–7. Oct 1999. doi:10.1159/000015413. PMID 10516437.
↑ ^3.0 ^3.1 "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011.
↑ "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. Mar 2008. doi:10.1073/pnas.0709180105. PMID 18292230. Bibcode: 2008PNAS..105.3622D.

"Human EMK1 is located on 11q12-q13, close to COX8 and FTH1". Mamm. Genome 6 (4): 311–2. 1995. doi:10.1007/BF00352433. PMID 7613050.
"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
"Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. 1994. PMID 8274451.
"Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
"Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–65. 1997. doi:10.1006/geno.1996.0570. PMID 8938448.
"MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. 1997. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
"PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. 2001. doi:10.1038/35083016. PMID 11433294.
"Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. 2004. doi:10.1074/jbc.M312171200. PMID 14676191.
"A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. 2005. doi:10.1038/sj.emboj.7600110. PMID 14976552.
"Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients". Biochim. Biophys. Acta 1689 (1): 58–65. 2004. doi:10.1016/j.bbadis.2004.01.008. PMID 15158914.
"Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
"aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity". Curr. Biol. 14 (16): 1425–35. 2004. doi:10.1016/j.cub.2004.08.021. PMID 15324659.
"Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13792–7. 2004. doi:10.1073/pnas.0403684101. PMID 15365179. Bibcode: 2004PNAS..10113792C.
"Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. 2004. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.

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Original source: https://en.wikipedia.org/wiki/MARK2. Read more

[pmid9730619-1] "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet 81 (3–4): 278–82. Oct 1998. doi:10.1159/000015046. PMID 9730619.

[pmid10516437-2] "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet 86 (1): 66–7. Oct 1999. doi:10.1159/000015413. PMID 10516437.

[entrez-3] 3.0 ^3.1 "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011.

[pmid18292230-4] "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. Mar 2008. doi:10.1073/pnas.0709180105. PMID 18292230. Bibcode: 2008PNAS..105.3622D.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

MARK2

Topic: Biology

Contents

Function

Interactions

References

Further reading