Outer membrane efflux proteins

Outer membrane efflux protein
Identifiers
Symbol	OEP
Pfam	PF02321
InterPro	IPR003423
SCOP2	1ek9 / SCOPe / SUPFAM
TCDB	1.B.17
OPM superfamily	34
OPM protein	1yc9
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Proteins in the outer membrane efflux protein family form trimeric (three-piece) channels that allow export of a variety of substrates in gram-negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12-stranded beta-barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

References

• "Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps". Journal of Molecular Biology 287 (3): 695–715. April 1999. doi:10.1006/jmbi.1999.2630. PMID 10092468. 

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