PSKH1
Topic: Biology
From HandWiki - Reading time: 5 min
Short description: Enzyme found in humans
 Generic protein structure example |
Protein Serine/threonine-protein kinase H1 is a Ser/Thr protein kinase that is encoded by the PSKH1 gene in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the Endoplasmic Reticulum.[1][2]
Interactions
PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to interact with (and be regulated by) proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and calmodulin. It is also activated by UNC119B, an acyl chain binding protein.[3] PSKH1 is closely related to the catalytically-inactive pseudokinase PSKH2, which is also membrane-localised within the secretory pathway.[4]
References
- ↑ "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet 2 (10): 1589–95. Feb 1994. doi:10.1093/hmg/2.10.1589. PMID 8268911.
- ↑ "Entrez Gene: PSKH1 protein serine kinase H1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5681.
- ↑ "PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins". PNAS 122 (8). Feb 2025. doi:10.1073/pnas.2420961122. PMID 39964718.
- ↑ "Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2". Biochemical Journal 480 (2): 141–160. Jan 2023. doi:10.1042/BCJ20220474. PMID 39964718.
Further reading
- "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. 1987. doi:10.1073/pnas.84.2.388. PMID 2948189. Bibcode: 1987PNAS...84..388H.
- "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.". EMBO J. 18 (2): 396–410. 1999. doi:10.1093/emboj/18.2.396. PMID 9889196.
- "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes.". Nucleic Acids Res. 28 (21): 4113–24. 2000. doi:10.1093/nar/28.21.4113. PMID 11058107.
- "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization.". Genomics 70 (1): 82–92. 2001. doi:10.1006/geno.2000.6365. PMID 11087665.
- "PSKH1, a novel splice factor compartment-associated serine kinase.". Nucleic Acids Res. 30 (23): 5301–9. 2002. doi:10.1093/nar/gkf648. PMID 12466556.
- "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus.". Exp. Cell Res. 291 (2): 299–312. 2004. doi:10.1016/j.yexcr.2003.07.009. PMID 14644153.
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