Pantetheine hydrolase

From HandWiki - Reading time: 2 min

Short description: Class of enzymes
Vanin-1 structure from PDB 4CYF.png
Structure of the pantetheinase vanin-1 from PDB: 4CYF​. Catalytic residues and sugars are shown in sticks, sugar-binding residues in lines.
Identifiers
EC number3.5.1.92
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction

(R)-pantetheine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (R)-pantothenate + 2-aminoethanethiol

Thus, the two substrates of this enzyme are (R)-pantetheine and H2O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1. This enzyme participates in pantothenate and CoA biosynthesis.

Further reading





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