ProP (transporter)

Proline/betaine transporter
Identifiers
Organism	Escherichia coli
Symbol	ProP
PDB	1R48 (ECOD)
UniProt	P0C0L7
Search for
Structures	Swiss-model
Domains	InterPro

ProP is a bacterial membrane protein that is a member of the major facilitator superfamily. It functions as an osmosensory and osmoregulatory transporter, responding to changes in osmotic pressure by importing compatible solutes such as proline or glycine betaine;^[1] most substrates for ProP are zwitterions.^[2] The activity of ProP increases with osmotic pressure in cells and proteoliposomes.^[3]^[4] ProP is a symporter of hydrogen ions and compatible solutes, and is responsive to potassium concentrations.^[2]

Activity of ProP has been associated with the ability of pathogenic E. coli to colonize the urinary tract.^[3]

References

↑ "Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP". Journal of Molecular Biology 229 (1): 268–76. January 1993. doi:10.1006/jmbi.1993.1030. PMID 8421314.
↑ ^2.0 ^2.1 "The ion coupling and organic substrate specificities of osmoregulatory transporter ProP in Escherichia coli". Biochimica et Biophysica Acta (BBA) - Biomembranes 1420 (1–2): 30–44. August 1999. doi:10.1016/s0005-2736(99)00085-1. PMID 10446288.
↑ ^3.0 ^3.1 "Osmoregulatory transporter ProP influences colonization of the urinary tract by Escherichia coli". Microbiology 144 ( Pt 1) (1): 91–102. January 1998. doi:10.1099/00221287-144-1-91. PMID 9467901.
↑ "Purification and reconstitution of an osmosensor: transporter ProP of Escherichia coli senses and responds to osmotic shifts". Biochemistry 38 (6): 1676–84. February 1999. doi:10.1021/bi981279n. PMID 10026245.

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