TNF receptor associated factor
Topic: Biology
From HandWiki - Reading time: 3 min
TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.[1]
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.
Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.
See also
- Tumor necrosis factors
References
- ↑ "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling". Exp. Cell Res. 254 (1): 14–24. January 2000. doi:10.1006/excr.1999.4733. PMID 10623461.
External links
- TRAF+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
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