16β,17α-Epiestriol

16β,17α-Epiestriol
Names
	IUPAC name Estra-1,3,5(10)-triene-3,16β,17α-triol
	Systematic IUPAC name (1S,2S,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,2,7-triol
Identifiers
CAS Number	793-89-5;
3D model (JSmol)	Interactive image;
ChemSpider	13628086;
PubChem CID	21252247;
	InChI InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,17-,18+/m1/s1;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H]([C@H]2O)O)CCC4=C3C=CC(=C4)O;
Properties
Chemical formula	C18H24O3
Molar mass	288.387 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

16β,17α-Epiestriol, or 16,17-epiestriol, also known as 16β-hydroxy-17α-estradiol, as well as estra-1,3,5(10)-triene-3,16β,17α-triol, is a minor and weak endogenous steroidal estrogen that is related to 17α-estradiol and estriol.^[1]^[2] Along with estriol, 16β,17α-epiestriol has been detected in the urine of women during the late pregnancy stage.^[2] It shows preferential affinity for the ERβ over the ERα.^[3]

References

↑ Vitamins and Hormones. Academic Press. 18 April 1972. pp. 233–. ISBN 978-0-08-086626-0. https://books.google.com/books?id=iQZgQRUI_CgC&pg=PA233.
↑ ^2.0 ^2.1 Ryō Satō; Ryūichi Katō (1982). Microsomes, drug oxidations, and drug toxicity. Japan Scientific Societies Press. p. 273. ISBN 978-0-471-87285-6. https://books.google.com/books?id=t7PwAAAAMAAJ.
↑ "Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding". Endocrinology 147 (9): 4132–50. 2006. doi:10.1210/en.2006-0113. PMID 16728493.

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[1] Vitamins and Hormones. Academic Press. 18 April 1972. pp. 233–. ISBN 978-0-08-086626-0. https://books.google.com/books?id=iQZgQRUI_CgC&pg=PA233.

[SatōKatō1982-2] 2.0 ^2.1 Ryō Satō; Ryūichi Katō (1982). Microsomes, drug oxidations, and drug toxicity. Japan Scientific Societies Press. p. 273. ISBN 978-0-471-87285-6. https://books.google.com/books?id=t7PwAAAAMAAJ.

[pmid16728493-3] "Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding". Endocrinology 147 (9): 4132–50. 2006. doi:10.1210/en.2006-0113. PMID 16728493.

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16β,17α-Epiestriol

Topic: Chemistry

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References