AR420626
Topic: Chemistry
From HandWiki - Reading time: 2 min
AR420626 is an experimental drug which acts as a reasonably potent and highly selective agonist for the free fatty acid receptor FFAR3 (GPR41).[1][2] It has been used to research the role of FFAR3 in various disease processes such as diabetes,[3] asthma,[4] eczema[4] and some forms of cancer,[5] as well as regulation of gastrointestinal hormone release.[6]
Further reading
- "FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats". Digestive Diseases and Sciences 62 (8): 1944–1952. August 2017. doi:10.1007/s10620-017-4600-4. PMID 28523577.
- "Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin". Biochemical and Biophysical Research Communications 608: 66–72. June 2022. doi:10.1016/j.bbrc.2022.03.117. PMID 35390674. Bibcode: 2022BBRC..608...66Y.
References
- ↑ "Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands". Molecular Pharmacology 86 (2): 200–210. August 2014. doi:10.1124/mol.114.093294. PMID 24870406.
- ↑ "Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators". Journal of Medicinal Chemistry 63 (7): 3577–3595. April 2020. doi:10.1021/acs.jmedchem.9b02036. PMID 32141297.
- ↑ "Gαi -coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals". Obesity (Silver Spring, Md.) 31 (7): 1871–1883. July 2023. doi:10.1002/oby.23786. PMID 37309717.
- ↑ 4.0 4.1 "Free fatty acid 3 receptor agonist AR420626 reduces allergic responses in asthma and eczema in mice". International Immunopharmacology 127. January 2024. doi:10.1016/j.intimp.2023.111428. PMID 38159551.
- ↑ "AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition". Therapeutic Advances in Medical Oncology 12. 2020. doi:10.1177/1758835920913432. PMID 33014144.
- ↑ "Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon". Neurogastroenterology and Motility 30 (1). January 2018. doi:10.1111/nmo.13157. PMID 28714277.
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