Alverine

Alverine

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A03AX08 (WHO)
Legal status
Legal status	UK: General sales list (GSL, OTC)
Identifiers
IUPAC name N-Ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine
CAS Number	150-59-4 Y
PubChem CID	3678
DrugBank	DB01616 Y
ChemSpider	3550 Y
UNII	46TIR1560O
KEGG	D07440 Y
ChEBI	CHEBI:518413 Y
ChEMBL	ChEMBL253371 Y
Chemical and physical data
Formula	C20H27N
Molar mass	281.443 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccccc1CCCN(CC)CCCc2ccccc2
InChI InChI=1S/C20H27N/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20/h3-8,11-14H,2,9-10,15-18H2,1H3 Y Key:ZPFXAOWNKLFJDN-UHFFFAOYSA-N Y
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Alverine is a drug used for functional gastrointestinal disorders. Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus.

Adverse effects

The side effects of alverine include:^[1][2]

• Difficulties in breathing or shortness of breath, wheezing, swelling of the face or other parts of the body (associated with serious allergic reaction)
• Yellowing of the whites of the eyes and the skin, due to liver inflammation
• A feeling of nausea or dizziness
• Headache
• Minor allergic reaction (skin rash/itching)

It was reported that alverine may induce toxic hepatitis.^[3][4]

Mechanism of action

Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease.^[5] Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome, the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Alverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).

Alverine capsules^[6] are now available in the market. There are two strengths of capsule - 60 mg and 120 mg. The common dosage for adults and children over 12 years is 60–120 mg taken one, two or three a day, either before or after meals. Alverine is not suitable for those aged under 12 years. Women who are pregnant or breast-feeding should follow the instruction of doctors for the drug.

Development and marketing

A combination of alverine citrate and simeticone (ACS) for irritable bowel syndrome therapy were compared with placebo in a phase IV clinical trial.^[7] At week 4, the alverine citrate and simeticone group had lower VAS scores for abdominal pain/discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%, OR = 1.3; P = 0.01) as compared with the placebo group.^[8]

The drug was firstly authorized for marketing on 03/06/2014. The marketing authorisation holder is Dr. Reddy's Laboratories (UK) Ltd.^[9]

References

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