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Short description: Class of prodrugs

An antipsychotic ester is an ester of an antipsychotic.^[1] They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables.^[1]

List of clinically used antipsychotic esters

Typical antipsychotics

Bromperidol decanoate
Clopentixol decanoate
Flupentixol decanoate
Fluphenazine decanoate
Fluphenazine enanthate
Haloperidol decanoate
Oxyprothepin decanoate
Perphenazine decanoate
Perphenazine enanthate
Pipotiazine palmitate
Pipotiazine undecylenate
Zuclopentixol acetate
Zuclopentixol decanoate

Atypical antipsychotics

Pharmacology

References

↑ ^1.0 ^1.1 "The pharmacokinetics of long-acting antipsychotic medications". Current Clinical Pharmacology 9 (3): 310–7. 2014. doi:10.2174/15748847113089990051. PMID 23343447.

v t e Antipsychotics (N05A)
Typical	Butyrophenones: Benperidol Bromperidol Droperidol Haloperidol^# Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines: Fluspirilene Penfluridol Pimozide Phenothiazines: Acetophenazine Butaperazine Carphenazine (carfenazine)^‡ Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Levomepromazine (methotrimeprazine) Mesoridazine Perazine Periciazine Perphenazine Piperacetazine Pipotiazine Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes: Chlorprothixene Clopenthixol Flupentixol Tiotixene (thiothixene) Zuclopenthixol
Disputed	Benzamides: Amisulpride Levosulpiride Nemonapride Remoxipride^‡ Sulpiride Sultopride Tiapride Veralipride^‡ Butyrophenones: Melperone Tricyclics: Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Others: Molindone
Atypical	Benzisoxazole/benzisothiazoles: Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone^# Ziprasidone Butyrophenones: Lumateperone^† Phenylpiperazines/quinolinones: Aripiprazole Aripiprazole lauroxil Brilaroxazine^† Brexpiprazole Cariprazine Tricyclics: Asenapine Clozapine^# Olanzapine Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole
Others	Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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Original source: https://en.wikipedia.org/wiki/Antipsychotic ester. Read more

Antipsychotic ester

Topic: Chemistry

Contents

List of clinically used antipsychotic esters

Typical antipsychotics

Atypical antipsychotics

Pharmacology

References