Benanserin

Benanserin, also known as benzyl antiserotonin (BAS), by its developmental code name MC-4788 or Sq-4788, and by its chemical name 1-benzyl-2-methyl-5-methoxytryptamine, is a serotonin receptor antagonist and described tranquilizer of the tryptamine and 5-methoxytryptamine families.^[1]^[2]^[3]^[4] It is the derivative of 5-methoxytryptamine with a benzyl group at the 1 position and a methyl group at the 2 position.^[1]^[3] The drug is said to be active in humans at a dose of 10 to 35 mg orally or intravenously.^[2] In contrast to certain other serotonin receptor antagonists like chlorpromazine, benanserin does not antagonize the subjective effects of the serotonergic psychedelic LSD.^[4] It was first described in the scientific literature by at least 1955 and was one of the first serotonin antagonists.^[1]^[5]

References

↑ ^1.0 ^1.1 ^1.2 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA125. Retrieved 28 June 2025.
↑ ^2.0 ^2.1 Psychotropic Drugs and Related Compounds. National Institute of Mental Health. 1972. https://books.google.com/books?id=7Kxz_xcLr9sC&pg=PA121. Retrieved 28 June 2025.
↑ ^3.0 ^3.1 Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. 2001. pp. 2442. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ. Retrieved 28 June 2025.
↑ ^4.0 ^4.1 "Pharmacology and Classification of LSD-like Hallucinogens". Drug Addiction II: Amphetamine, Psychotogen, and Marihuana Dependence. Berlin, Heidelberg: Springer Berlin Heidelberg. 1977. pp. 305–368. doi:10.1007/978-3-642-66709-1_3. ISBN 978-3-642-66711-4. https://books.google.com/books?id=gb_uCAAAQBAJ&pg=PA312.
↑ "The Synthesis of Tryptamines Related to Serotonin". Journal of the American Chemical Society 77 (16): 4319–4324. 1955. doi:10.1021/ja01621a042. ISSN 0002-7863. Bibcode: 1955JAChS..77.4319S. https://pubs.acs.org/doi/abs/10.1021/ja01621a042. Retrieved 28 June 2025.

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[Elks_2014-1] 1.0 ^1.1 ^1.2 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA125. Retrieved 28 June 2025.

[Usdin_1972-2] 2.0 ^2.1 Psychotropic Drugs and Related Compounds. National Institute of Mental Health. 1972. https://books.google.com/books?id=7Kxz_xcLr9sC&pg=PA121. Retrieved 28 June 2025.

[Negwer_2001-3] 3.0 ^3.1 Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. 2001. pp. 2442. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ. Retrieved 28 June 2025.

[Martin_1977-4] 4.0 ^4.1 "Pharmacology and Classification of LSD-like Hallucinogens". Drug Addiction II: Amphetamine, Psychotogen, and Marihuana Dependence. Berlin, Heidelberg: Springer Berlin Heidelberg. 1977. pp. 305–368. doi:10.1007/978-3-642-66709-1_3. ISBN 978-3-642-66711-4. https://books.google.com/books?id=gb_uCAAAQBAJ&pg=PA312.

[Shaw_1955-5] "The Synthesis of Tryptamines Related to Serotonin". Journal of the American Chemical Society 77 (16): 4319–4324. 1955. doi:10.1021/ja01621a042. ISSN 0002-7863. Bibcode: 1955JAChS..77.4319S. https://pubs.acs.org/doi/abs/10.1021/ja01621a042. Retrieved 28 June 2025.

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Benanserin

Topic: Chemistry

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References