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Bezuclastinib

Topic: Chemistry

 From HandWiki - Reading time: 1 min

Bezuclastinib is an investigational new drug that is being evaluated for the treatment of gastrointestinal stromal tumors and systemic mastocytosis. It acts as an inhibitor of tyrosine-protein kinase KIT.[1][2] [3][4]


References

  1. ↑ "Bezuclastinib - Cogent Biosciences". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800042241. 
  2. ↑ "Systemic Mastocytosis: State of the Art". Current Hematologic Malignancy Reports 19 (5): 197–207. August 2024. doi:10.1007/s11899-024-00737-8. PMID 39187708. 
  3. ↑ "Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial". JAMA Oncology 7 (9): 1343–1350. September 2021. doi:10.1001/jamaoncol.2021.2086. PMID 34236401. 
  4. ↑ "Cogent Biosciences Announces Submission of New Drug Application for Bezuclastinib in Gastrointestinal Stromal Tumors (GIST)". 2026-04-01. https://www.drugs.com/nda/bezuclastinib_260401.html. 



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