CBiPES

CBiPES
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-(4'-cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)ethanesulfonamide;
CAS Number	353235-01-5 ;
PubChem CID	9864510;
IUPHAR/BPS	3372;
ChemSpider	8040202;
UNII	TQ25KB5NW9;
Chemical and physical data
Formula	C21H19N3O2S
Molar mass	377.46 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc1ccc(cc1)-c(ccc2)cc2N(S(=O)(=O)CC)Cc3cccnc3;
	InChI InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3; Key:HDVYXILCBYGKGU-UHFFFAOYSA-N;

Short description: Chemical compound

CBiPES is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR₂. It has potentially antipsychotic effects in animal models, and is used for researching the role of mGluR₂ receptors in schizophrenia and related disorders.^[1]^[2]^[3]

References

↑ "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)". Psychopharmacology 179 (1): 271–83. April 2005. doi:10.1007/s00213-004-2099-9. PMID 15717213.
↑ "Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge". Neuropharmacology 58 (3): 632–9. March 2010. doi:10.1016/j.neuropharm.2009.11.014. PMID 19951716.
↑ "Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR". Neuropharmacology 66: 264–73. March 2013. doi:10.1016/j.neuropharm.2012.05.023. PMID 22659090.

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Original source: https://en.wikipedia.org/wiki/CBiPES. Read more

[1] "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)". Psychopharmacology 179 (1): 271–83. April 2005. doi:10.1007/s00213-004-2099-9. PMID 15717213.

[2] "Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge". Neuropharmacology 58 (3): 632–9. March 2010. doi:10.1016/j.neuropharm.2009.11.014. PMID 19951716.

[3] "Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR". Neuropharmacology 66: 264–73. March 2013. doi:10.1016/j.neuropharm.2012.05.023. PMID 22659090.

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[2]

[3]

Clinical data

ATC code	none
Identifiers
IUPAC name N-(4'-cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)ethanesulfonamide
CAS Number	353235-01-5^Y
PubChem CID	9864510
IUPHAR/BPS	3372
ChemSpider	8040202
UNII	TQ25KB5NW9
Chemical and physical data
Formula	C₂₁H₁₉N₃O₂S
Molar mass	377.46 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#Cc1ccc(cc1)-c(ccc2)cc2N(S(=O)(=O)CC)Cc3cccnc3
InChI InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3 Key:HDVYXILCBYGKGU-UHFFFAOYSA-N

CBiPES

Topic: Chemistry

References