CP-93129

CP-93129
Identifiers
	IUPAC name 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one;
CAS Number	127792-75-0 ;
PubChem CID	124007;
IUPHAR/BPS	11;
ChemSpider	110524;
UNII	Y4BW369LGS;
Chemical and physical data
Formula	C12H13N3O
Molar mass	215.256 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C3CNCC=C3c(c1n2)cnc1ccc2=O;

Short description: Chemical compound

CP-93129 is a drug which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.^[1] It is used in the study of 5-HT_1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.^[2]^[3]^[4]^[5]

References

↑ "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry 33 (8): 2087–93. August 1990. doi:10.1021/jm00170a007. PMID 2374139.
↑ "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology 476 (1–2): 71–7. August 2003. doi:10.1016/s0014-2999(03)02154-x. PMID 12969751.
↑ "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology 14 (3): 217–25. May 2004. doi:10.1016/S0924-977X(03)00106-8. PMID 15056481.
↑ "5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus". Journal of Neurophysiology 93 (6): 3157–64. June 2005. doi:10.1152/jn.00770.2004. PMID 15716370. https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1252&context=vetscipapers.
↑ "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology 101 (3): 1361–74. March 2009. doi:10.1152/jn.90750.2008. PMID 19144744.

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[1] "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry 33 (8): 2087–93. August 1990. doi:10.1021/jm00170a007. PMID 2374139.

[2] "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology 476 (1–2): 71–7. August 2003. doi:10.1016/s0014-2999(03)02154-x. PMID 12969751.

[3] "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology 14 (3): 217–25. May 2004. doi:10.1016/S0924-977X(03)00106-8. PMID 15056481.

[4] "5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus". Journal of Neurophysiology 93 (6): 3157–64. June 2005. doi:10.1152/jn.00770.2004. PMID 15716370. https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1252&context=vetscipapers.

[5] "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology 101 (3): 1361–74. March 2009. doi:10.1152/jn.90750.2008. PMID 19144744.

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Identifiers

IUPAC name 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one
CAS Number	127792-75-0^Y
PubChem CID	124007
IUPHAR/BPS	11
ChemSpider	110524
UNII	Y4BW369LGS
Chemical and physical data
Formula	C₁₂H₁₃N₃O
Molar mass	215.256 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C3CNCC=C3c(c1n2)cnc1ccc2=O

CP-93129

Topic: Chemistry

References